AR012878A1 - Un compuesto derivado de 5'-desoxicitidina, su uso, un proceso para fabricarlo, composiciones farmaceuticas que lo comprende, y un kit que comprende dicha composicion. - Google Patents

Un compuesto derivado de 5'-desoxicitidina, su uso, un proceso para fabricarlo, composiciones farmaceuticas que lo comprende, y un kit que comprende dicha composicion.

Info

Publication number
AR012878A1
AR012878A1 ARP980102474A ARP980102474A AR012878A1 AR 012878 A1 AR012878 A1 AR 012878A1 AR P980102474 A ARP980102474 A AR P980102474A AR P980102474 A ARP980102474 A AR P980102474A AR 012878 A1 AR012878 A1 AR 012878A1
Authority
AR
Argentina
Prior art keywords
group
substituted
manufacture
pharmaceutical compositions
atom
Prior art date
Application number
ARP980102474A
Other languages
English (en)
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of AR012878A1 publication Critical patent/AR012878A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

Compuestos derivados de 5'-desoxicitidina representados por la formula general I, en la que R1 es un átomo de hidrogeno o un grupo fácilmentehidrolizable en condiciones fisiologicas; R2 es un átomo de hidrogeno o un grupo -CO-OR4, en el queR4 es un grupo hidrocarbonado saturado o insaturado,lineal o ramificado, que consiste en de uno a quince átomos de carbono, o un grupo de formula -(CH2)n-Y (en el que Y es ciclohexilo o fenilo; n es un enterode 0 a 4); R3 es un átomo de hidrogeno, bromo, yodo o ciano, un grupo alquilo C1-4, (que puede estar substituido con átomo(s) de halogeno), un grupo vinilo oetinilo ( que puede estar substituido con atomo(s) de halogeno, alquilo C1-4, cicloalquilo, aralquilo o un anillo aromático quepuede tener uno o másheteroátomo(s)), o un grupo aralquilo que puede estar substituido, para su uso en terapia médica, especialmente en terapia antitumoral. Un proceso parafabricarlos, composiciones farmacéuticas, que los comprenden, kits quecomprenden dichas composiciones, y el uso de los compuestos para la fabricacionde un medicamento para el tratamiento de tumores.
ARP980102474A 1997-06-02 1998-05-28 Un compuesto derivado de 5'-desoxicitidina, su uso, un proceso para fabricarlo, composiciones farmaceuticas que lo comprende, y un kit que comprende dicha composicion. AR012878A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP97108791 1997-06-02

Publications (1)

Publication Number Publication Date
AR012878A1 true AR012878A1 (es) 2000-11-22

Family

ID=8226859

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP980102474A AR012878A1 (es) 1997-06-02 1998-05-28 Un compuesto derivado de 5'-desoxicitidina, su uso, un proceso para fabricarlo, composiciones farmaceuticas que lo comprende, y un kit que comprende dicha composicion.

Country Status (33)

Country Link
US (2) US6114520A (es)
JP (1) JP3081185B2 (es)
KR (1) KR100312899B1 (es)
CN (1) CN1197871C (es)
AR (1) AR012878A1 (es)
AT (1) ATE440854T1 (es)
AU (1) AU746170B2 (es)
BR (1) BR9801744A (es)
CA (1) CA2237368C (es)
CO (1) CO4940436A1 (es)
CZ (1) CZ295706B6 (es)
DE (2) DE69841086D1 (es)
ES (2) ES2329428T3 (es)
FR (1) FR2763953B1 (es)
GB (1) GB2325931B (es)
HR (1) HRP980290A2 (es)
HU (1) HU227852B1 (es)
ID (1) ID19801A (es)
IL (1) IL124661A0 (es)
IT (1) ITMI981196A1 (es)
MA (1) MA26503A1 (es)
MY (1) MY128985A (es)
NO (1) NO316609B1 (es)
NZ (1) NZ330360A (es)
PE (1) PE79599A1 (es)
PL (1) PL192832B1 (es)
RS (1) RS50010B (es)
RU (1) RU2238278C2 (es)
SA (1) SA98190103B1 (es)
SG (1) SG66466A1 (es)
TR (1) TR199800988A3 (es)
TW (1) TW584636B (es)
ZA (1) ZA984478B (es)

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US20030119724A1 (en) * 1995-11-22 2003-06-26 Ts`O Paul O.P. Ligands to enhance cellular uptake of biomolecules
EP1057831B1 (en) * 1999-05-26 2004-09-22 F. Hoffmann-La Roche Ag Process for the preparation of vinyl pyrimidine derivatives
AU2002217980A1 (en) 2000-12-01 2002-06-11 Cell Works Inc. Conjugates of glycosylated/galactosylated peptide
AU2005311730B2 (en) * 2004-12-03 2011-11-17 Adherex Technologies, Inc. Methods for administering DPD inhibitors in combination with 5-FU and 5-FU prodrugs
US20060189893A1 (en) * 2005-01-06 2006-08-24 Diamics, Inc. Systems and methods for detecting abnormal cells
US20060161076A1 (en) * 2005-01-06 2006-07-20 Diamics, Inc. Systems and methods for collection of cell clusters
WO2009042064A2 (en) 2007-09-21 2009-04-02 Nektar Therapeutics Al, Corporation Oligomer-nucleoside phosphate conjugates
WO2009082844A1 (fr) * 2007-12-28 2009-07-09 Topharman Shanghai Co., Ltd Dérivé hydroxyle de la capécitabine, ses procédés de préparation et ses utilisations pour préparer la capécitabine
WO2009082846A1 (fr) * 2007-12-28 2009-07-09 Topharman Shanghai Co., Ltd. Dérivé hydroxyle de la capécitabine, ses procédés de préparation et ses utilisations pour préparer la capécitabine
WO2009094847A1 (fr) * 2007-12-28 2009-08-06 Topharman Shanghai Co., Ltd. Dérivé hydroxyle de capécitabine, procédés de préparation et d' utilisation de la capécitabine
CN101469008B (zh) * 2007-12-29 2013-08-07 上海特化医药科技有限公司 卡培他滨羟基衍生物、其制备方法和用于制备卡培他滨
WO2009114814A2 (en) 2008-03-14 2009-09-17 Retrotope, Inc. Therapeutic substances that modulate genome methylation
US8603999B2 (en) * 2008-12-05 2013-12-10 Commonwealth Scientific And Industrial Research Organisation Amphiphile prodrugs
GB0907551D0 (en) 2009-05-01 2009-06-10 Univ Dundee Treatment or prophylaxis of proliferative conditions
JP2013508293A (ja) * 2009-10-14 2013-03-07 アドヘレックス テクノロジーズ， インコーポレイテッド ５−ｆｕ又はそのプロドラッグと、ｄｐｄ阻害剤との組合せに付随した神経毒性の処置
CN104926890B (zh) * 2015-06-04 2018-04-03 新乡学院 一种1,2‑o‑二乙酰基‑3,5‑o‑二苯甲酰基核糖的合成方法
AU2019216531A1 (en) 2018-02-02 2020-09-24 Maverix Oncology, Inc. Small molecule drug conjugates of gemcitabine monophosphate
CN113321694A (zh) * 2021-06-22 2021-08-31 药康众拓(江苏)医药科技有限公司 N4-羟基胞苷衍生物及其制备方法和用途

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JPS5726278B2 (es) * 1973-03-13 1982-06-03
GB1561290A (en) * 1975-10-16 1980-02-20 Nyegaard & Co As Pyrimid - 2 - ones
US4071680A (en) * 1976-12-20 1978-01-31 Hoffmann-La Roche Inc. 5'-Deoxy-5-fluoropyrimidine nucleosides
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US4328229A (en) * 1978-03-29 1982-05-04 Taiho Pharmaceutical Company Limited Anti-cancer composition for delivering 5-fluorouracil to cancer tissues
JPS5677226A (en) * 1979-11-27 1981-06-25 Taiho Yakuhin Kogyo Kk Antitumorigenic agent
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GB9020930D0 (en) * 1990-09-26 1990-11-07 Wellcome Found Pharmaceutical combinations
KR0148589B1 (ko) * 1991-05-27 1998-11-02 고바야시 유끼오 항종양 효과의 상승 및 종양의 치료를 위한 조성물 및 키트
DE4123520A1 (de) * 1991-07-16 1993-01-21 Inst Molekularbiologie Ak Mittel zur regeneration des blutbildes durch foerderung der leukozytenproliferation
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DK0719271T3 (da) * 1993-09-14 1997-12-29 Merrell Pharma Inc 5-(1-Fluorvinyl)-1H-pyrimidin-2,4-dion-derivater som antineoplastiske midler
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Also Published As

Publication number Publication date
HU9801256D0 (en) 1998-07-28
ZA984478B (en) 1998-12-02
JP3081185B2 (ja) 2000-08-28
SG66466A1 (en) 1999-07-20
YU22598A (sh) 2001-12-26
US6211166B1 (en) 2001-04-03
ATE440854T1 (de) 2009-09-15
US6114520A (en) 2000-09-05
ITMI981196A1 (it) 1999-11-29
NO982473D0 (no) 1998-05-29
PE79599A1 (es) 1999-08-25
AU746170B2 (en) 2002-04-18
DE69841086D1 (de) 2009-10-08
IL124661A0 (en) 1998-12-06
GB9811762D0 (en) 1998-07-29
FR2763953B1 (fr) 2005-01-07
FR2763953A1 (fr) 1998-12-04
TR199800988A2 (xx) 1998-12-21
PL326604A1 (en) 1998-12-07
KR100312899B1 (ko) 2002-03-08
CN1201037A (zh) 1998-12-09
CZ295706B6 (cs) 2005-10-12
TR199800988A3 (tr) 1998-12-21
CZ167598A3 (cs) 1998-12-16
NZ330360A (en) 1999-03-29
HUP9801256A2 (hu) 1999-05-28
CN1197871C (zh) 2005-04-20
HUP9801256A3 (en) 2004-03-01
GB2325931B (en) 2001-07-25
NO982473L (no) 1998-12-03
MY128985A (en) 2007-03-30
NO316609B1 (no) 2004-03-08
MA26503A1 (fr) 2004-12-20
SA98190103B1 (ar) 2006-04-18
ES2329428T3 (es) 2009-11-25
CA2237368C (en) 2009-03-03
ID19801A (id) 1998-08-06
CA2237368A1 (en) 1998-12-02
BR9801744A (pt) 2000-03-21
KR19990006547A (ko) 1999-01-25
CO4940436A1 (es) 2000-07-24
HRP980290A2 (en) 1999-04-30
JPH10330395A (ja) 1998-12-15
HU227852B1 (en) 2012-05-02
RU2238278C2 (ru) 2004-10-20
DE19823484A1 (de) 1998-12-03
AU6798598A (en) 1998-12-03
PL192832B1 (pl) 2006-12-29
ES2142763B1 (es) 2001-04-01
GB2325931A (en) 1998-12-09
RS50010B (sr) 2008-09-29
ES2142763A1 (es) 2000-04-16
TW584636B (en) 2004-04-21

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