KR870003974A - 비시클로 치환된 페닐아세토니트릴 유도체 - Google Patents

비시클로 치환된 페닐아세토니트릴 유도체 Download PDF

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KR870003974A
KR870003974A KR1019860008689A KR860008689A KR870003974A KR 870003974 A KR870003974 A KR 870003974A KR 1019860008689 A KR1019860008689 A KR 1019860008689A KR 860008689 A KR860008689 A KR 860008689A KR 870003974 A KR870003974 A KR 870003974A
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Prior art keywords
compound
alkyl
hydrogen
alkoxy
carbon atoms
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KR1019860008689A
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KR910000251B1 (ko
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치-딘량
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폴 디 매튜카이티스
지디썰 앤드 캄파니
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
    • C07C255/33—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring with cyano groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by saturated carbon chains

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

내용 없음

Description

비시클로 치환된 페닐아세토니트릴 유도체
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (10)

  1. 다음 일반식의 화합물
    및 제약상 허용되는 그의 염 및 수화물.
    상기 식에서, R1및 R2는 동일 또는 상이하며 각각은 수소, 할로, C1-C4알킬, C1-C4알콕시 또는 트리플루오로메틸로부터 선택되며, R3는 (a) 약 1내지 15탄소원자의 직쇄 또는 분기쇄 알킬 또는 (b) 약 2내지 15탄소원자의 직쇄 또는 분기쇄 알케닐로부터 선택되고, R4는 수소 또는 C1-C4알킬로부터 선택되며 R5는
    로부터 선택된 두고리기인데, 여기서 R6및 R7은 R1및 R2에 대해 정의한바와 같고 n은 2내지 4까지의 정수이다.
  2. 제1항에 있어서, 상기 화합물은 일반식
    로서, 여기서 R1및 R2는 둘다 수소이거나 아니면 둘다 C1-C4알콕시이며, R3는 C1-C12알킬이고 R4는 C1-C4알킬이며 R5는
    일반식
    의 기인데, 여기서 R6및 R7은 동일 또는 상이하고 수소 또는 C1-C4알콕시로부터 독립적으로 선택되는 화합물인 것을 특징으로 하는 화합물.
  3. 제1항에 있어서, 상기 화합물은
    로부터 선택되는 것을 특징으로 하는 화합물.
  4. 제3항에 있어서, 상기 화합물은 일반식
    의 화합물인 것을 특징으로 하는 화합물.
  5. 제약상 담체와 제1항에 따르는 화합물 유효량으로 이루어지는 것을 특징으로 하는 필요할 때 포유동물에서 칼슘이온 길항근 또는 항고혈압 효과를 촉진시키기 위한 의약조성물.
  6. 제항에 있어서, 상기 화합물은 일반식
    의 화합물인 것을 특징으로 하는 화합물.
  7. 제1항에 따르는 화합물 유효량을 투여하는 것으로 이루어지는 것을 특징으로 하는 필요할 때 포유동물에 칼슘이온 길항근 또는 항고혈압효과를 촉진시키는 방법.
  8. 제7항에 있어서, 상기 화합물은 경구투여 되는 것을 특징으로 하는 방법.
  9. 제7항에 있어서, 상기 화합물은 일반식
    의 화합물인 것을 특징으로 하는 화합물.
  10. 제7항에 있어서, 상기 화합물은 제약상 담체와 조합하여 투여되는 것을 특징으로 하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019860008689A 1985-10-18 1986-10-16 비시클로 치환된 페닐아세토니트릴 유도체 KR910000251B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US789,255 1985-10-18
US06/789,255 US4593042A (en) 1985-10-18 1985-10-18 Bicyclo-substituted phenylacetonitrile derivatives
US06/842,688 US4681970A (en) 1985-10-18 1986-03-21 Bicyclo-substituted phenylacetonitrile derivatives
US842,688 1986-03-21

Publications (2)

Publication Number Publication Date
KR870003974A true KR870003974A (ko) 1987-05-06
KR910000251B1 KR910000251B1 (ko) 1991-01-23

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KR1019860008689A KR910000251B1 (ko) 1985-10-18 1986-10-16 비시클로 치환된 페닐아세토니트릴 유도체

Country Status (4)

Country Link
US (2) US4593042A (ko)
JP (1) JPS62167752A (ko)
KR (1) KR910000251B1 (ko)
ZA (1) ZA867897B (ko)

Families Citing this family (26)

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US4593042A (en) * 1985-10-18 1986-06-03 G. D. Searle & Co. Bicyclo-substituted phenylacetonitrile derivatives
US4732467A (en) * 1986-07-08 1988-03-22 Modec Corporation Automated photograph slide storage and retrieval system
DE3634389A1 (de) * 1986-10-09 1988-04-21 Knoll Ag Verwendung von anipamil
DE3642331A1 (de) * 1986-12-11 1988-06-23 Basf Ag Basisch substituierte phenylacetonitrile, ihre herstellung und diese enthaltende arzneimittel
IT1215409B (it) * 1987-04-08 1990-02-08 Alfa Chem Ital Processo per la sintesi dell'alfa-(1-metiletil)-3,4-dimetossibenzeneacetonitrile.
US4857651A (en) * 1987-07-29 1989-08-15 American Cyanamid Company α-(2,3-Di(C1 -C4 alkoxy)ethylamino)-β-cyanostyrene and β-nitrostyrene compounds useful as intermediates in the preparation of insecticidal, acaricidal and nematicidal arylpyrroles and method for the preparation thereof
DE3826796A1 (de) * 1988-08-06 1990-02-08 Basf Ag Substituierte phenylacetonitrile zur verwendung als resistenzbrecher
US5039709A (en) * 1989-11-30 1991-08-13 Basf Aktiengesellschaft Anipamil for the treatment of chronic renal failure
US5162569A (en) * 1989-12-21 1992-11-10 G. D. Searle & Co. Phenylacetonitrilealkylaminoalkyl-ortho-substituted aryl compounds as immunosuppressives
US5486539A (en) * 1989-12-21 1996-01-23 G. D. Searle & Co. Method of using phenylacetonitrilealkylaminoalkyl-ortho-substituted aryl compounds as immunosuppressives
IE904628A1 (en) * 1989-12-21 1991-07-17 Searle & Co w-Amino-Ó-Phenylalkanonitrile Derivatives
IT1241988B (it) * 1990-06-15 1994-02-02 Sigma Tau Ind Farmaceuti 2- amminotetraline-6, 7-sostituite attive come immunomodulanti e composizioni farmaceutiche che le contengono
US5247119A (en) * 1990-12-12 1993-09-21 G. D. Searle & Co. Phenylacetonitrilehydroxyalkylaminoalkyl-ortho-substituted aryl compounds as immunosuppressives
US5451604A (en) * 1993-07-26 1995-09-19 G. D. Searle & Co. Halogenated phenylacetonitrile alkylaminoalkylphenyl compounds as immunosuppressives
US6057350A (en) * 1997-06-18 2000-05-02 Merck & Co., Inc. Alpha 1a adrenergic receptor antagonists
US6268377B1 (en) 1998-09-28 2001-07-31 Merck & Co., Inc. Method for treating androgen-related conditions
CA2450073C (en) 2001-07-25 2017-08-29 Biomarin Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
JP4638146B2 (ja) * 2001-08-14 2011-02-23 ワシントン ユニバーシティ イン セント ルイス 医薬化合物をスクリーニングするためのシステムと方法
US8227240B2 (en) * 2001-08-14 2012-07-24 The Washington University Systems for screening pharmaceutical chemicals
WO2003082234A1 (fr) * 2002-03-28 2003-10-09 Shiseido Co., Ltd. Derives de phenylacetonitrile, tonique capillaire et preparations externes pour la peau contenant ces derives
PT1889198E (pt) 2005-04-28 2015-03-06 Proteus Digital Health Inc Sistema fármaco-informático
US8795627B2 (en) 2007-03-21 2014-08-05 Raptor Pharmaceuticals Inc. Treatment of liver disorders by administration of RAP conjugates
US9631169B2 (en) 2008-06-05 2017-04-25 Invivo Sciences Inc. Three dimensional tissues for high-throughput assays
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NZ596876A (en) 2009-05-06 2014-01-31 Lab Skin Care Inc Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates

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DE1154810B (de) * 1961-04-01 1963-09-26 Knoll Ag Verfahren zur Herstellung basisch substituierter Phenylacetonitrile
DE3144150A1 (de) * 1981-04-10 1982-12-09 Basf Ag, 6700 Ludwigshafen (omega)-cyan-1,(omega)-diphenyl-azaalkan-derivate, ihre herstellung und diese enthaltende arzneimittel
US4593042A (en) * 1985-10-18 1986-06-03 G. D. Searle & Co. Bicyclo-substituted phenylacetonitrile derivatives

Also Published As

Publication number Publication date
US4681970A (en) 1987-07-21
US4593042A (en) 1986-06-03
ZA867897B (en) 1987-12-30
JPS62167752A (ja) 1987-07-24
KR910000251B1 (ko) 1991-01-23

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