ATE33831T1 - Analgesia wirkende 5-hydroxytryptophan-derivate. - Google Patents
Analgesia wirkende 5-hydroxytryptophan-derivate.Info
- Publication number
- ATE33831T1 ATE33831T1 AT83110011T AT83110011T ATE33831T1 AT E33831 T1 ATE33831 T1 AT E33831T1 AT 83110011 T AT83110011 T AT 83110011T AT 83110011 T AT83110011 T AT 83110011T AT E33831 T1 ATE33831 T1 AT E33831T1
- Authority
- AT
- Austria
- Prior art keywords
- sub
- sup
- hydroxytryptophan
- derivatives
- analgesic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- C07K5/06156—Dipeptides with the first amino acid being heterocyclic and Trp-amino acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Pharmacology & Pharmacy (AREA)
- Pain & Pain Management (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
- Indole Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/433,283 US4482567A (en) | 1982-10-07 | 1982-10-07 | N-hexanoyl to n-heptadecanoyl 5-hydroxy tryptophan-5-hydroxytryptophanamides and use as analgesics |
EP83110011A EP0106281B1 (de) | 1982-10-07 | 1983-10-06 | Analgesia wirkende 5-Hydroxytryptophan-Derivate |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE33831T1 true ATE33831T1 (de) | 1988-05-15 |
Family
ID=23719568
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT83110011T ATE33831T1 (de) | 1982-10-07 | 1983-10-06 | Analgesia wirkende 5-hydroxytryptophan-derivate. |
Country Status (6)
Country | Link |
---|---|
US (1) | US4482567A (de) |
EP (1) | EP0106281B1 (de) |
JP (1) | JPS59130267A (de) |
AT (1) | ATE33831T1 (de) |
DE (2) | DE106281T1 (de) |
IL (1) | IL69882A (de) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4658038A (en) * | 1982-10-07 | 1987-04-14 | Research Foundation For Mental Hygiene, Inc. | N-acylated 5-hydroxytryptophan amide derivatives |
IT1179866B (it) * | 1984-12-12 | 1987-09-16 | Rotta Research Lab | Derivati del triptofano farmaceuticamente attivi e composizioni farmaceutiche che li contengono |
US4639465A (en) * | 1985-08-30 | 1987-01-27 | Commonwealth Medical Corporation Of America | Method and composition for relieving pain |
US4650789A (en) * | 1985-10-15 | 1987-03-17 | Commonwealth Medical Corporation Of America | Method and composition for increasing production of serotonin |
US4757151A (en) * | 1985-11-14 | 1988-07-12 | Warner-Lambert Company | 2-substituted-[2-substituted-amino]-N-arylalkyl-3-[indol-3-yl] |
US4902708A (en) * | 1985-12-31 | 1990-02-20 | Biomeasure, Inc. | CCK antagonists |
US4814463A (en) * | 1985-12-31 | 1989-03-21 | Biomeasure, Inc. | CCK antagonists |
FR2600067B1 (fr) * | 1986-06-11 | 1988-10-28 | Sanofi Sa | Pseudopeptides inhibiteurs de la secretion gastrique |
WO1989010355A1 (en) * | 1988-04-05 | 1989-11-02 | Abbott Laboratories | Derivatives of tryptophan as cck antagonists |
CA1326108C (en) * | 1988-04-12 | 1994-01-11 | Sun Hyuk Kim | Cck antagonists |
US5010089A (en) * | 1988-08-12 | 1991-04-23 | Biomeasure, Inc. | CCK antagonists and their use in treating gastrointestinal disorders |
US5278316A (en) * | 1989-06-29 | 1994-01-11 | Warner-Lambert Company | N-substituted cycloalkyl and polycycloalkyl alpha-substituted Trp-Phe- and phenethylamine derivatives |
US5631281A (en) * | 1989-06-29 | 1997-05-20 | Warner-Lambert Company | N-substituted cycloalkyl and polycycloalkyl α-substituted Trp-Phe- and phenethylamine derivatives |
NZ234264A (en) * | 1989-06-29 | 1993-05-26 | Warner Lambert Co | N-substituted cycloalkyl and polycycloalkyl alpha-substituted trp-phe- and phenethylamine derivatives, and pharmaceutical compositions |
WO2018094005A1 (en) * | 2016-11-16 | 2018-05-24 | The General Hospital Corporation | Myeloperoxidase imaging agents |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2701800A (en) * | 1951-05-17 | 1955-02-08 | Dow Chemical Co | Production of dialkyl acetamido-(3-indolylmethyl)-malonate |
US3330857A (en) * | 1963-07-01 | 1967-07-11 | Pfizer & Co C | N-carbazoylamino acid intermediates for polypeptides |
CH614702A5 (en) * | 1975-04-08 | 1979-12-14 | Made Labor Sa | Process for the preparation of 5-hydroxytryptophan glutamate |
DE3024739A1 (de) * | 1979-07-09 | 1981-01-29 | Sandoz Ag | Langkettige fettsaeureamide von tryptophan-derivaten, verfahren zu ihrer herstellung und ihre verwendung als pharmazeutika |
-
1982
- 1982-10-07 US US06/433,283 patent/US4482567A/en not_active Expired - Fee Related
-
1983
- 1983-10-03 IL IL69882A patent/IL69882A/xx unknown
- 1983-10-06 EP EP83110011A patent/EP0106281B1/de not_active Expired
- 1983-10-06 DE DE198383110011T patent/DE106281T1/de active Pending
- 1983-10-06 DE DE8383110011T patent/DE3376421D1/de not_active Expired
- 1983-10-06 AT AT83110011T patent/ATE33831T1/de not_active IP Right Cessation
- 1983-10-07 JP JP58188282A patent/JPS59130267A/ja active Granted
Also Published As
Publication number | Publication date |
---|---|
EP0106281A2 (de) | 1984-04-25 |
EP0106281A3 (en) | 1985-01-09 |
EP0106281B1 (de) | 1988-04-27 |
JPS6317838B2 (de) | 1988-04-15 |
IL69882A (en) | 1986-11-30 |
DE106281T1 (de) | 1984-12-20 |
US4482567A (en) | 1984-11-13 |
DE3376421D1 (en) | 1988-06-01 |
JPS59130267A (ja) | 1984-07-26 |
IL69882A0 (en) | 1984-01-31 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification | ||
REN | Ceased due to non-payment of the annual fee |