ATE33831T1 - Analgesia wirkende 5-hydroxytryptophan-derivate. - Google Patents

Analgesia wirkende 5-hydroxytryptophan-derivate.

Info

Publication number
ATE33831T1
ATE33831T1 AT83110011T AT83110011T ATE33831T1 AT E33831 T1 ATE33831 T1 AT E33831T1 AT 83110011 T AT83110011 T AT 83110011T AT 83110011 T AT83110011 T AT 83110011T AT E33831 T1 ATE33831 T1 AT E33831T1
Authority
AT
Austria
Prior art keywords
sub
sup
hydroxytryptophan
derivatives
analgesic
Prior art date
Application number
AT83110011T
Other languages
English (en)
Inventor
Hadassah Tamir
Stephen E Karpiak
Meir Wilchek
Original Assignee
Yeda Res & Dev
Res Found Mental Hygiene
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yeda Res & Dev, Res Found Mental Hygiene filed Critical Yeda Res & Dev
Application granted granted Critical
Publication of ATE33831T1 publication Critical patent/ATE33831T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06156—Dipeptides with the first amino acid being heterocyclic and Trp-amino acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Indole Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Hydrogenated Pyridines (AREA)
AT83110011T 1982-10-07 1983-10-06 Analgesia wirkende 5-hydroxytryptophan-derivate. ATE33831T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/433,283 US4482567A (en) 1982-10-07 1982-10-07 N-hexanoyl to n-heptadecanoyl 5-hydroxy tryptophan-5-hydroxytryptophanamides and use as analgesics
EP83110011A EP0106281B1 (de) 1982-10-07 1983-10-06 Analgesia wirkende 5-Hydroxytryptophan-Derivate

Publications (1)

Publication Number Publication Date
ATE33831T1 true ATE33831T1 (de) 1988-05-15

Family

ID=23719568

Family Applications (1)

Application Number Title Priority Date Filing Date
AT83110011T ATE33831T1 (de) 1982-10-07 1983-10-06 Analgesia wirkende 5-hydroxytryptophan-derivate.

Country Status (6)

Country Link
US (1) US4482567A (de)
EP (1) EP0106281B1 (de)
JP (1) JPS59130267A (de)
AT (1) ATE33831T1 (de)
DE (2) DE106281T1 (de)
IL (1) IL69882A (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4658038A (en) * 1982-10-07 1987-04-14 Research Foundation For Mental Hygiene, Inc. N-acylated 5-hydroxytryptophan amide derivatives
IT1179866B (it) * 1984-12-12 1987-09-16 Rotta Research Lab Derivati del triptofano farmaceuticamente attivi e composizioni farmaceutiche che li contengono
US4639465A (en) * 1985-08-30 1987-01-27 Commonwealth Medical Corporation Of America Method and composition for relieving pain
US4650789A (en) * 1985-10-15 1987-03-17 Commonwealth Medical Corporation Of America Method and composition for increasing production of serotonin
US4757151A (en) * 1985-11-14 1988-07-12 Warner-Lambert Company 2-substituted-[2-substituted-amino]-N-arylalkyl-3-[indol-3-yl]
US4814463A (en) * 1985-12-31 1989-03-21 Biomeasure, Inc. CCK antagonists
US4902708A (en) * 1985-12-31 1990-02-20 Biomeasure, Inc. CCK antagonists
FR2600067B1 (fr) * 1986-06-11 1988-10-28 Sanofi Sa Pseudopeptides inhibiteurs de la secretion gastrique
JPH03503650A (ja) * 1988-04-05 1991-08-15 アボツト・ラボラトリーズ Ｃｃｋアンタゴニストとしてのトリプトファン誘導体
CA1326108C (en) * 1988-04-12 1994-01-11 Sun Hyuk Kim Cck antagonists
US5010089A (en) * 1988-08-12 1991-04-23 Biomeasure, Inc. CCK antagonists and their use in treating gastrointestinal disorders
NZ234264A (en) * 1989-06-29 1993-05-26 Warner Lambert Co N-substituted cycloalkyl and polycycloalkyl alpha-substituted trp-phe- and phenethylamine derivatives, and pharmaceutical compositions
US5631281A (en) * 1989-06-29 1997-05-20 Warner-Lambert Company N-substituted cycloalkyl and polycycloalkyl α-substituted Trp-Phe- and phenethylamine derivatives
US5278316A (en) * 1989-06-29 1994-01-11 Warner-Lambert Company N-substituted cycloalkyl and polycycloalkyl alpha-substituted Trp-Phe- and phenethylamine derivatives
EP3541431B1 (de) * 2016-11-16 2024-04-17 The General Hospital Corporation Myeloperoxidasekontrastmittel

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2701800A (en) * 1951-05-17 1955-02-08 Dow Chemical Co Production of dialkyl acetamido-(3-indolylmethyl)-malonate
US3330857A (en) * 1963-07-01 1967-07-11 Pfizer & Co C N-carbazoylamino acid intermediates for polypeptides
CH614702A5 (en) * 1975-04-08 1979-12-14 Made Labor Sa Process for the preparation of 5-hydroxytryptophan glutamate
DE3024739A1 (de) * 1979-07-09 1981-01-29 Sandoz Ag Langkettige fettsaeureamide von tryptophan-derivaten, verfahren zu ihrer herstellung und ihre verwendung als pharmazeutika

Also Published As

Publication number Publication date
EP0106281A3 (en) 1985-01-09
JPS6317838B2 (de) 1988-04-15
DE3376421D1 (en) 1988-06-01
US4482567A (en) 1984-11-13
EP0106281B1 (de) 1988-04-27
IL69882A (en) 1986-11-30
DE106281T1 (de) 1984-12-20
JPS59130267A (ja) 1984-07-26
IL69882A0 (en) 1984-01-31
EP0106281A2 (de) 1984-04-25

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee