ES8102144A2 - Procedimiento para la preparacion de derivados de la isoqui-noleina - Google Patents
Procedimiento para la preparacion de derivados de la isoqui-noleinaInfo
- Publication number
- ES8102144A2 ES8102144A2 ES491336A ES491336A ES8102144A2 ES 8102144 A2 ES8102144 A2 ES 8102144A2 ES 491336 A ES491336 A ES 491336A ES 491336 A ES491336 A ES 491336A ES 8102144 A2 ES8102144 A2 ES 8102144A2
- Authority
- ES
- Spain
- Prior art keywords
- isoquinoline derivatives
- useful
- agents
- inflammatory
- carbon atoms
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
- C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pain & Pain Management (AREA)
- Public Health (AREA)
- Rheumatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE ISOQUINOLEINA, DE FORMULA (I), EN LA QUE A ES UN RADICAL DE FORMULA (II), DONDE R2 ES UN RADICAL ALQUILO QUE CONTIENE DE 1 A 8 ATOMOS DE CARBONO, Y N ES 1 O 2, EN LAS FORMAS (R) Y (S) Y SUS MEZCLAS EN ESTADO DE BASE O DE SAL DE ADICION CON UN ACIDO (CERTIFICADO DE ADICION A LA PATENTE N. 474.985). SE CICLA UN TETRAHIDRO-1,2,3,4 ISOQUINOLEINA, DE FORMULA (III), Y SE TRANSFORMA EVENTUALMENTE EL PRODUCTO OBTENIDO EN UNA SAL DE ADICION. LA CICLACION SE EFECTUA POR CALENTAMIENTO EN MEDIO ACIDO, O POR ACCION DEL CLORURO DE METANO SULFONILO O DEL CLORURO DE TOSILO, SEGUIDO DEL CALENTAMIENTO DEL PRODUCTO INTERMEDIO FORMADO. SE UTILIZAN COMO AGENTES ANALGESICOS. *FORMULA*
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7911706A FR2456110A2 (fr) | 1979-05-09 | 1979-05-09 | Nouveaux derives de l'isoquinoleine, leur preparation et les compositions qui les contiennent |
Publications (2)
Publication Number | Publication Date |
---|---|
ES491336A0 ES491336A0 (es) | 1980-12-16 |
ES8102144A2 true ES8102144A2 (es) | 1980-12-16 |
Family
ID=9225233
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES491336A Expired ES8102144A2 (es) | 1979-05-09 | 1980-05-09 | Procedimiento para la preparacion de derivados de la isoqui-noleina |
Country Status (20)
Country | Link |
---|---|
US (1) | US4261992A (es) |
JP (1) | JPS55151593A (es) |
AU (1) | AU533935B2 (es) |
BE (1) | BE883190A (es) |
CA (1) | CA1134360A (es) |
CH (1) | CH643852A5 (es) |
DE (1) | DE3017865A1 (es) |
DK (1) | DK200980A (es) |
ES (1) | ES8102144A2 (es) |
FI (1) | FI801506A (es) |
FR (1) | FR2456110A2 (es) |
GB (1) | GB2048878B (es) |
GR (1) | GR68072B (es) |
HU (1) | HU181543B (es) |
IT (1) | IT1131167B (es) |
LU (1) | LU82427A1 (es) |
NL (1) | NL8002538A (es) |
NO (1) | NO801360L (es) |
SE (1) | SE8003476L (es) |
ZA (1) | ZA802703B (es) |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL169076C (nl) * | 1975-08-06 | 1982-06-01 | Rhone Poulenc Ind | Werkwijze voor het bereiden of vervaardigen van farmacologische preparaten met een analgetische en antipyretische werking, alsmede werkwijze voor het bereiden van geneeskrachtige verbindingen, welke geschikt zijn voor gebruik in dergelijke preparaten. |
SU797580A3 (ru) * | 1977-11-10 | 1981-01-15 | Рон-Пуленк Эндюстри (Фирма) | Способ получени производных изохино-лиНА, иХ СОлЕй, РАцЕМАТОВ или ОпТичЕС-КиХ изОМЕРОВ |
US4188482A (en) * | 1978-05-04 | 1980-02-12 | Warner-Lambert Company | Thiazino indole compounds |
-
1979
- 1979-05-09 FR FR7911706A patent/FR2456110A2/fr active Granted
-
1980
- 1980-05-01 NL NL8002538A patent/NL8002538A/nl not_active Application Discontinuation
- 1980-05-01 GB GB8014439A patent/GB2048878B/en not_active Expired
- 1980-05-06 JP JP5987380A patent/JPS55151593A/ja active Pending
- 1980-05-06 GR GR61878A patent/GR68072B/el unknown
- 1980-05-06 AU AU58150/80A patent/AU533935B2/en not_active Expired
- 1980-05-06 US US06/147,121 patent/US4261992A/en not_active Expired - Lifetime
- 1980-05-06 ZA ZA00802703A patent/ZA802703B/xx unknown
- 1980-05-08 CA CA000351520A patent/CA1134360A/fr not_active Expired
- 1980-05-08 DK DK200980A patent/DK200980A/da unknown
- 1980-05-08 BE BE0/200531A patent/BE883190A/fr not_active IP Right Cessation
- 1980-05-08 NO NO801360A patent/NO801360L/no unknown
- 1980-05-08 HU HU801138A patent/HU181543B/hu unknown
- 1980-05-08 SE SE8003476A patent/SE8003476L/xx not_active Application Discontinuation
- 1980-05-08 CH CH361080A patent/CH643852A5/fr not_active IP Right Cessation
- 1980-05-08 LU LU82427A patent/LU82427A1/fr unknown
- 1980-05-09 IT IT21955/80A patent/IT1131167B/it active
- 1980-05-09 ES ES491336A patent/ES8102144A2/es not_active Expired
- 1980-05-09 FI FI801506A patent/FI801506A/fi not_active Application Discontinuation
- 1980-05-09 DE DE19803017865 patent/DE3017865A1/de not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
DK200980A (da) | 1980-11-10 |
LU82427A1 (fr) | 1980-12-16 |
BE883190A (fr) | 1980-11-10 |
US4261992A (en) | 1981-04-14 |
CH643852A5 (fr) | 1984-06-29 |
SE8003476L (sv) | 1980-11-10 |
GR68072B (es) | 1981-10-29 |
FI801506A (fi) | 1980-11-10 |
AU533935B2 (en) | 1983-12-22 |
GB2048878A (en) | 1980-12-17 |
NL8002538A (nl) | 1980-11-11 |
JPS55151593A (en) | 1980-11-26 |
IT8021955A0 (it) | 1980-05-09 |
FR2456110B2 (es) | 1982-05-21 |
AU5815080A (en) | 1980-11-13 |
ZA802703B (en) | 1981-05-27 |
NO801360L (no) | 1980-11-10 |
ES491336A0 (es) | 1980-12-16 |
CA1134360A (fr) | 1982-10-26 |
HU181543B (en) | 1983-10-28 |
DE3017865A1 (de) | 1980-11-20 |
IT1131167B (it) | 1986-06-18 |
FR2456110A2 (fr) | 1980-12-05 |
GB2048878B (en) | 1983-05-18 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD2A | Announcement of lapse in spain |
Effective date: 20170707 |