ES468267A1 - Un procedimiento para la preparacion de nuevos derivados de acidos pirrol-1-carboxilicos - Google Patents

Un procedimiento para la preparacion de nuevos derivados de acidos pirrol-1-carboxilicos

Info

Publication number
ES468267A1
ES468267A1 ES468267A ES468267A ES468267A1 ES 468267 A1 ES468267 A1 ES 468267A1 ES 468267 A ES468267 A ES 468267A ES 468267 A ES468267 A ES 468267A ES 468267 A1 ES468267 A1 ES 468267A1
Authority
ES
Spain
Prior art keywords
pyrroyl
pyrrolo
pyrrole
dihydro
carboxylic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES468267A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syntex USA LLC
Original Assignee
Syntex USA LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex USA LLC filed Critical Syntex USA LLC
Publication of ES468267A1 publication Critical patent/ES468267A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Un procedimiento para la preparación de nuevos derivados de ácidos pirrol-1-carboxílicos de fórmula: **(Fórmula-01)** y los isómeros individuales (1)-ácidos y (d)-ácido del mismo, así como sus sales y ésteres no tóxicos y farmacéuticamente aceptables, donde cada radical R y R1 es independientemente hidrógeno o un grupo alquilo inferior de 1 a 4 átomos de carbono, cuyo procedimiento se caracteriza porque consiste en: **(Fórmula-02)** donde R es el definido anteriormente y R2 es un grupo alquilo inferior de 1 a 4 átomos de carbono, con una amida de fórmula **(Fórmula-03)** donde R, R1 y R2 son los definidos anteriormente y si se desea b) someter a reacción de hidrólisis un grupo éster alquílico para dar los correspondientes ácidos libres.
ES468267A 1977-03-31 1978-03-27 Un procedimiento para la preparacion de nuevos derivados de acidos pirrol-1-carboxilicos Expired ES468267A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/783,090 US4097579A (en) 1977-03-31 1977-03-31 5-(2-Pyrroyl)-1,2-dihydro-3H-pyrrolo 1,2-a!pyrrole-1-carboxylic acid derivatives and process for the production thereof

Publications (1)

Publication Number Publication Date
ES468267A1 true ES468267A1 (es) 1979-10-01

Family

ID=25128138

Family Applications (2)

Application Number Title Priority Date Filing Date
ES468267A Expired ES468267A1 (es) 1977-03-31 1978-03-27 Un procedimiento para la preparacion de nuevos derivados de acidos pirrol-1-carboxilicos
ES476535A Expired ES476535A1 (es) 1977-03-31 1979-01-02 Un procedimiento para la preparacion de nuevos derivados de acidos pirrol-1-carboxilicos.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES476535A Expired ES476535A1 (es) 1977-03-31 1979-01-02 Un procedimiento para la preparacion de nuevos derivados de acidos pirrol-1-carboxilicos.

Country Status (14)

Country Link
US (1) US4097579A (es)
JP (1) JPS53121792A (es)
AU (1) AU518169B2 (es)
BE (1) BE865247A (es)
CA (1) CA1113938A (es)
DE (1) DE2813373A1 (es)
ES (2) ES468267A1 (es)
FR (1) FR2385719A1 (es)
GB (1) GB1581411A (es)
IE (1) IE46506B1 (es)
IT (1) IT1107833B (es)
NL (1) NL7803378A (es)
NZ (1) NZ186797A (es)
SE (1) SE436648B (es)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4140698A (en) * 1977-07-25 1979-02-20 Syntex (Usa) Inc. 1,2-Dihydro-3H-pyrrolo[1,2-a]pyrrole-1-nitriles
US4232038A (en) * 1979-08-31 1980-11-04 Syntex (U.S.A.) Inc. 5-Alkylsulfinylbenzoyl- and 5-alkylsulfonylbenzoyl-1,2-dihydro-3H-pyrrolo[1,]pyrrole-1-carboxylic acids
US4344943A (en) * 1980-06-09 1982-08-17 Syntex (U.S.A.) Inc. 6-Chloro- or 6-bromo-1,2-dihydro-3H-pyrrolo[1,2-a]-pyrrole-1-carboxylic acids and derivatives thereof
US4456759A (en) * 1980-10-20 1984-06-26 Syntex (U.S.A.) Inc. 5-Benzoyl-7-halo-1,2-dihydro-3H-pyrrolo-[1,2-a]pyrrole-1,1-dicarboxylic acids and esters thereof
US4353829A (en) * 1980-11-21 1982-10-12 Syntex (U.S.A.) Inc. Process for 5-aroylation of 1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic esters
US4434175A (en) 1981-08-10 1984-02-28 Merck & Co., Inc. Nonsteroidal compounds as anti-inflammatory and analgesic agents
WO1983001382A1 (en) * 1981-10-13 1983-04-28 Mroszczak, Edward Gastrointestinal sparing thioester pro-drugs
DE3368416D1 (en) * 1982-02-25 1987-01-29 Beecham Group Plc Aroyl pyrrolizine compounds, process for their preparation and pharmaceutical compositions containing them
US4457941A (en) * 1982-03-22 1984-07-03 Syntex (U.S.A.) Inc. Use of pyrrolo-pyrrole in treating microvascular diseases associated with diabetes
US4454151A (en) * 1982-03-22 1984-06-12 Syntex (U.S.A.) Inc. Use of pyrrolo pyrroles in treatment of ophthalmic diseases
US4612325A (en) * 1982-06-08 1986-09-16 Syntex (U.S.A) Inc. 5-Aroyl-6-alkylthio-1,2-dihydro-3H-pyrrolo(1,2-A)pyrrole-1-carboxylic acids and use thereof as analgesics and anti-inflammatories
US4511724A (en) * 1982-06-10 1985-04-16 Merck & Co., Inc. 5-(Pyrrol-2-oyl)-1,2-dihydro-3H-pyrrolo [1,2-a]pyrrole derivatives as anti-inflammatory and analgesic agents
JPS5910589A (ja) * 1982-06-10 1984-01-20 メルク　エンド　カムパニー　インコーポレーテツド 抗炎症剤および鎮痛剤として新規な５−（ピロ−ル−２−オイル）−１，２−ジヒドロ−３Ｈ−ピロロ〔１，２−ａ〕ピロ−ル誘導体
US4533671A (en) * 1982-10-08 1985-08-06 Merck & Co., Inc. 5-(2,3-Dihydro-1H-pyrrolizin-5-oyl)-2-alkanoic or carboxylic acids and analogs as anti-inflammatory and analgesic agents
US4536512A (en) * 1982-10-08 1985-08-20 Merck & Co., Inc. 5-(2,3-Dihydro-1H-pyrrolizin-5-oyl)-2,3-dihydro-1H-pyrrolizine-1-alkanoic or carboxylic acids and use thereof as anti-inflammatory and analgesic agents
EP0117675B1 (en) * 1983-02-19 1986-07-23 Beecham Group Plc Benzofuran and benzothiophene-carboxylic-acid derivatives
US4622407A (en) * 1984-04-26 1986-11-11 Merck & Co., Inc. Resolution of racemic derivatives of 5-(1-methyl-5-methylthiopyrrol-2-oyl)-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-2-carboxylic acid and analogs
US4988822A (en) * 1986-05-29 1991-01-29 Syntex (U.S.A.) Inc. Intermediates for preparing 5-aroyl-1,2-dihydro-3H-pyrrolo(1,2-A)pyrrole-1,1-dicarboxylates
US4873340A (en) * 1986-05-29 1989-10-10 Syntex (U.S.A.) Inc. Process for preparing 5-aroyl-1,2-dihydro-3H-pyrrolo[1,2-A]pyrrole-1,1-dicarboxylates
US4874872A (en) * 1987-01-14 1989-10-17 Syntex (U.S.A.) Inc. Process for preparing (+)-2,3-dihydro-1H-pyrrolo[1,2-A]pyrrole-1,7-dicarboxylates
HU198927B (en) * 1987-01-14 1989-12-28 Richter Gedeon Vegyeszet Process for producing 1-/substituted aminomethyl/-octa-hydroindolo-(2,3-a)quinolizine derivatives, pharmaceutically applicable acid addition salts thereof, as well as pharmaceutical compositions comprising same
US4835288A (en) * 1987-01-14 1989-05-30 Syntex Inc. Process for preparing (+)-2,3-dihydro-1H-pyrrolo[1,2-a]pyrrole-1,7-dicarboxylates
US4849526A (en) * 1987-01-14 1989-07-18 Syntex (U.S.A.) Inc. Process for preparing (±)-2,3-dihydro-1H-pyrrolo[1,2-A]pyrrole-1,7-dicarboxylates
US4874871A (en) * 1987-03-25 1989-10-17 Syntex (U.S.A.) Inc. Process for preparing (+)-2,3-Dihydro-1H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid and related compounds
US5110493A (en) * 1987-09-11 1992-05-05 Syntex (U.S.A.) Inc. Ophthalmic NSAID formulations containing a quaternary ammonium preservative and a nonionic surfactant
US5414011A (en) * 1987-09-11 1995-05-09 Syntex (U.S.A.) Inc. Preservative system for ophthalmic formulations
AU7255394A (en) * 1993-07-08 1995-02-06 Cygnus Therapeutic Systems Monolithic matrix transdermal delivery system
US5621115A (en) * 1996-02-21 1997-04-15 Ohmeda Pharmaceutical Products Division Inc. Methods for preparing 5-aroyl-1,2-dihydro-3H-pyrrolo-[1,2-A]pyrrole-1-carboxylic acids
US6191285B1 (en) 1997-07-03 2001-02-20 Abbott Laboratories Process for the preparation of ketorolac tromethamine

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL293572A (es) * 1962-06-07
US3846447A (en) * 1972-08-03 1974-11-05 Mcneilab Inc Preparation of 5-aroyl-pyrroles and intermediates therefor
JPS539789A (en) * 1976-07-14 1978-01-28 Syntex Inc Production of 55*22floyl** * 55*22thenoyl** * 55*33 floyl** and 55*33thenoyl** 1*22dihydroo3hhpyroro * 1*22a*pyrolee11carboxylic acid derivative

Also Published As

Publication number Publication date
SE7803549L (sv) 1978-10-01
FR2385719B1 (es) 1980-07-18
IT7867706A0 (it) 1978-03-30
IE46506B1 (en) 1983-06-29
JPS53121792A (en) 1978-10-24
NZ186797A (en) 1979-12-11
CA1113938A (en) 1981-12-08
DE2813373A1 (de) 1978-10-05
FR2385719A1 (fr) 1978-10-27
SE436648B (sv) 1985-01-14
IE780605L (en) 1978-09-30
AU518169B2 (en) 1981-09-17
ES476535A1 (es) 1979-12-01
IT1107833B (it) 1985-12-02
AU3461178A (en) 1979-10-04
US4097579A (en) 1978-06-27
JPS647997B2 (es) 1989-02-10
DE2813373C2 (es) 1989-11-09
GB1581411A (en) 1980-12-10
NL7803378A (nl) 1978-10-03
BE865247A (fr) 1978-09-25

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20001204