ES484718A1 - Un procedimiento para la preparacion de benzopiranos. - Google Patents
Un procedimiento para la preparacion de benzopiranos.Info
- Publication number
- ES484718A1 ES484718A1 ES484718A ES484718A ES484718A1 ES 484718 A1 ES484718 A1 ES 484718A1 ES 484718 A ES484718 A ES 484718A ES 484718 A ES484718 A ES 484718A ES 484718 A1 ES484718 A1 ES 484718A1
- Authority
- ES
- Spain
- Prior art keywords
- preparation
- pharmaceutical compositions
- chromanol derivatives
- carbon atoms
- chromanol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- SEBPXHSZHLFWRL-UHFFFAOYSA-N 3,4-dihydro-2,2,5,7,8-pentamethyl-2h-1-benzopyran-6-ol Chemical class O1C(C)(C)CCC2=C1C(C)=C(C)C(O)=C2C SEBPXHSZHLFWRL-UHFFFAOYSA-N 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 239000002220 antihypertensive agent Substances 0.000 abstract 1
- 229940030600 antihypertensive agent Drugs 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000002112 pyrrolidino group Chemical group [*]N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/68—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with nitrogen atoms directly attached in position 4
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Un procedimiento para la preparación de benzopiranos de fórmula I: **(formula-01)** donde los radicales pirrolidino y OR son trans y donde R es un átomo de hidrógeno o un grupo alquilo de 1 a 3 átomos de carbono o un grupo acailo de 1 a 8 átomos de carbonos; o una sal de adición de acido farmaceuticamente aceptable del mismo cuyo procedimiento comprende: a) hacer reaccionar un compuesto de fórmula (II): **(formula-02)** con pirrolidina y, b) opcionalmente, transformar el retos R=H en otro resto R1 resolver cualquier de estos compuestos y/o salificar cualquier de estos compuestos .
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB7839303 | 1978-10-04 | ||
| GB7841306 | 1978-10-20 | ||
| GB7900901 | 1979-01-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES484718A1 true ES484718A1 (es) | 1980-09-01 |
Family
ID=27260600
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES484718A Expired ES484718A1 (es) | 1978-10-04 | 1979-10-03 | Un procedimiento para la preparacion de benzopiranos. |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP0009912B1 (es) |
| AU (1) | AU526209B2 (es) |
| CA (1) | CA1145755A (es) |
| DE (1) | DE2965739D1 (es) |
| DK (1) | DK415379A (es) |
| ES (1) | ES484718A1 (es) |
| IE (1) | IE48955B1 (es) |
| IL (1) | IL58381A0 (es) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE23718T1 (de) * | 1981-09-25 | 1986-12-15 | Beecham Group Plc | Benzopyran-verbindungen mit pharmazeutischer wirkung. |
| DE3364145D1 (de) * | 1982-04-08 | 1986-07-24 | Beecham Group Plc | Antihypertensive benzopyranols |
| EP0093535B1 (en) * | 1982-04-28 | 1986-12-30 | Beecham Group Plc | Novel chromenes and chromans |
| EP0093534A1 (en) * | 1982-04-28 | 1983-11-09 | Beecham Group Plc | Novel chromanols |
| DE3364734D1 (en) * | 1982-10-19 | 1986-08-28 | Beecham Group Plc | Novel chromans and chromenes |
| GB8308063D0 (en) * | 1983-03-24 | 1983-05-05 | Beecham Group Plc | Active compounds |
| GB8308062D0 (en) * | 1983-03-24 | 1983-05-05 | Beecham Group Plc | Active compounds |
| EP0139992B1 (en) * | 1983-09-01 | 1988-12-28 | Beecham Group Plc | Chromanol derivatives |
| GB8324547D0 (en) * | 1983-09-14 | 1983-10-19 | Beecham Group Plc | Compounds |
| EP0172352B1 (en) * | 1984-06-22 | 1990-08-29 | Beecham Group Plc | Active benzopyran compounds |
| US5072006A (en) * | 1988-12-09 | 1991-12-10 | Recherche Syntex France S.A. | Novel benzopyranylpyrrolinone derivatives |
| US5239090A (en) * | 1989-02-01 | 1993-08-24 | Beecham Group P.L.C. | Certain optically active 3,4-dihydrobenzopyran-4-ols which are intermediates |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1495526A (en) * | 1974-05-31 | 1977-12-21 | Beecham Group Ltd | Chroman derivatives |
| GB1548221A (en) * | 1976-01-27 | 1979-07-04 | Beecham Group Ltd | Trans-4-heterocycyl-3,4-dihydro-2h-benzo pyran-3-ol esters |
-
1979
- 1979-09-19 DE DE7979301934T patent/DE2965739D1/de not_active Expired
- 1979-09-19 EP EP79301934A patent/EP0009912B1/en not_active Expired
- 1979-09-25 AU AU51177/79A patent/AU526209B2/en not_active Ceased
- 1979-10-01 CA CA000336767A patent/CA1145755A/en not_active Expired
- 1979-10-03 DK DK415379A patent/DK415379A/da not_active Application Discontinuation
- 1979-10-03 IE IE1881/79A patent/IE48955B1/en unknown
- 1979-10-03 IL IL58381A patent/IL58381A0/xx unknown
- 1979-10-03 ES ES484718A patent/ES484718A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| AU526209B2 (en) | 1982-12-23 |
| EP0009912A1 (en) | 1980-04-16 |
| DK415379A (da) | 1980-04-05 |
| CA1145755A (en) | 1983-05-03 |
| IL58381A0 (en) | 1980-01-31 |
| DE2965739D1 (en) | 1983-07-28 |
| AU5117779A (en) | 1980-04-17 |
| IE791881L (en) | 1980-04-04 |
| EP0009912B1 (en) | 1983-06-22 |
| IE48955B1 (en) | 1985-06-26 |
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