ES8103088A1 - Metodo para preparar nuevas espiro(dihidrobenzofuran-piperi-dinas y -pirrolidinas) - Google Patents

Metodo para preparar nuevas espiro(dihidrobenzofuran-piperi-dinas y -pirrolidinas)

Info

Publication number
ES8103088A1
ES8103088A1 ES490171A ES490171A ES8103088A1 ES 8103088 A1 ES8103088 A1 ES 8103088A1 ES 490171 A ES490171 A ES 490171A ES 490171 A ES490171 A ES 490171A ES 8103088 A1 ES8103088 A1 ES 8103088A1
Authority
ES
Spain
Prior art keywords
hydrogen
compound
dihydrobenzofuranpiperidines
formula
pyrrolidines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES490171A
Other languages
English (en)
Other versions
ES490171A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of ES490171A0 publication Critical patent/ES490171A0/es
Publication of ES8103088A1 publication Critical patent/ES8103088A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/52—Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

METODO PARA PREPARAR NUEVOS ESPIRO (DIHIDROBENZOFURANPIPERIDINAS Y PIRROLIDINAS) DE FORMULA (I), O UNA SAL DE ADICION DE ACIDO DE LAS MISMAS, FARMACEUTICAMENTE ACEPTABLE. X PUEDE SER UN ATOMO DE HIDROGENO O DIVERSOS TIPOS DE RADICALES, "N" ES EL ENTERO 1 O 2. EL METODO CONSISTE EN HIDROGENAR UN COMPUESTO DE FORMULA (II), DONDE R ES BENCILO Y PROPORCIONA UN COMPUESTO DONDE R ES HIDROGENO. TAMBIEN COMPRENDE HACER REACCIONAR UN COMPUESTO COMO EL ANTERIOR, DONDE R ES HIDROGENO CON DISTINTOS TIPOS DE HALUROS, PROPORCIONANDO EL COMPUESTO DESEADO. ESTE COMPUESTO TAMBIEN SE PUEDE OBTENER POR REDUCCION. ESTE PRODUCTO TIENE APLICACION COMO ANALGESICO, TRANQUILIZANTE Y COMO INTERMEDIO PARA LOS MISMOS. *FORMULA*
ES490171A 1978-04-14 1980-04-01 Metodo para preparar nuevas espiro(dihidrobenzofuran-piperi-dinas y -pirrolidinas) Expired ES8103088A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/896,622 US4166119A (en) 1978-04-14 1978-04-14 Analgesic and tranquilizing spiro[dihydrobenzofuran]piperidines and pyrrolidines

Publications (2)

Publication Number Publication Date
ES490171A0 ES490171A0 (es) 1981-02-16
ES8103088A1 true ES8103088A1 (es) 1981-02-16

Family

ID=25406518

Family Applications (3)

Application Number Title Priority Date Filing Date
ES479369A Expired ES479369A1 (es) 1978-04-14 1979-04-06 Metodo para preparar nuevas espiro (dihidrobenzofuran-pipe- ridinas y -pirrolidinas.
ES490171A Expired ES8103088A1 (es) 1978-04-14 1980-04-01 Metodo para preparar nuevas espiro(dihidrobenzofuran-piperi-dinas y -pirrolidinas)
ES490172A Granted ES490172A0 (es) 1978-04-14 1980-04-01 Metodo para preparar nuevas espiro (dihidrobenzofuran-pipe- ridinas y -pirrolidinas)

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES479369A Expired ES479369A1 (es) 1978-04-14 1979-04-06 Metodo para preparar nuevas espiro (dihidrobenzofuran-pipe- ridinas y -pirrolidinas.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES490172A Granted ES490172A0 (es) 1978-04-14 1980-04-01 Metodo para preparar nuevas espiro (dihidrobenzofuran-pipe- ridinas y -pirrolidinas)

Country Status (7)

Country Link
US (1) US4166119A (es)
EP (1) EP0004952B1 (es)
JP (1) JPS54145661A (es)
AT (1) AT372683B (es)
CA (1) CA1132987A (es)
DE (1) DE2962426D1 (es)
ES (3) ES479369A1 (es)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4302590A (en) * 1979-02-23 1981-11-24 Hoechst-Roussel Pharmaceuticals, Inc. Intermediates for the preparation of 4-aryloxy-3-phenylpiperidines
US4268515A (en) * 1980-02-04 1981-05-19 Hoechst-Roussel Pharmaceuticals Inc. Spiro[dihydrobenzofuran-piperidines and-pyrrolidines], pharmaceutical compositions thereof and methods of use thereof
US4410699A (en) * 1981-08-07 1983-10-18 Hoechst-Roussel Pharmaceuticals Inc. Substituted 1,2,3,4-tetrahydro-4-isoquinolinols
US4374137A (en) * 1981-08-07 1983-02-15 Hoechst-Roussel Pharmaceuticals Inc. Spiro[benzofuranisoquinoline]s and their use as pharmaceuticals
US4517311A (en) * 1981-10-19 1985-05-14 Hoechst-Roussel Pharmaceuticals Inc. 2'-Substituted-spiro[benzofuran-2(3H),1'-cycloalkanes] and their analgesic and anti-depressant compositions
US4404221A (en) * 1981-10-19 1983-09-13 Hoechst-Roussel Pharmaceuticals Inc. 2'-Substituted-spiro[benzofuran-2(3H),1'-cyclohexanes] and its pharmaceutical use
US4420485A (en) * 1982-09-29 1983-12-13 Hoechst-Roussel Pharmaceuticals Inc. 1'-[3-(1,2-Benzisoxazol-3-yl) proply]spiro[benzofuran-2(3H),3' or 4'-piperidines or 3'-pyrrolidines]
US4452802A (en) * 1983-08-25 1984-06-05 Hoechst-Roussel Pharmaceuticals Incorporated Antihypertensive spiro[benzofuran-azalkanes]
US5206240A (en) * 1989-12-08 1993-04-27 Merck & Co., Inc. Nitrogen-containing spirocycles
IL96507A0 (en) * 1989-12-08 1991-08-16 Merck & Co Inc Nitrogen-containing spirocycles and pharmaceutical compositions containing them
NZ243065A (en) * 1991-06-13 1995-07-26 Lundbeck & Co As H Piperidine derivatives and pharmaceutical compositions
WO1994017045A1 (en) * 1993-01-28 1994-08-04 Merck & Co., Inc. Spiro-substituted azacycles as tachykinin receptor antagonists
US5382587A (en) * 1993-06-30 1995-01-17 Merck & Co., Inc. Spirocycles
US5403846A (en) * 1993-11-22 1995-04-04 Merck & Co., Inc. Spirocycles
US5439914A (en) * 1994-02-18 1995-08-08 Merck & Co., Inc. Spirocycles
US6156783A (en) * 1996-04-30 2000-12-05 Smithkline Beecham P.L.C. Spiroazabicyclic compounds, processes for their preparation, and their pharmaceutical use
SE9902987D0 (sv) 1999-08-24 1999-08-24 Astra Pharma Prod Novel compounds
CO5300399A1 (es) * 2000-02-25 2003-07-31 Astrazeneca Ab Heterocicliocs que contienen nitrogeno, proceso para su preparacion y composiciones farmaceuticas que los contienen
GB0011838D0 (en) * 2000-05-17 2000-07-05 Astrazeneca Ab Chemical compounds
US7005439B2 (en) * 2000-06-20 2006-02-28 Astrazeneca Ab Compounds
AR028948A1 (es) 2000-06-20 2003-05-28 Astrazeneca Ab Compuestos novedosos
GB0104050D0 (en) * 2001-02-19 2001-04-04 Astrazeneca Ab Chemical compounds
AR035230A1 (es) 2001-03-19 2004-05-05 Astrazeneca Ab Compuestos de bencimidazol, proceso para su preparacion, composicion farmaceutica, proceso para la preparacion de dicha composicion farmaceutica, y usos de estos compuestos para la elaboracion de medicamentos
GB0107228D0 (en) * 2001-03-22 2001-05-16 Astrazeneca Ab Chemical compounds
SE0101038D0 (sv) 2001-03-23 2001-03-23 Astrazeneca Ab Novel compounds
WO2002102387A1 (en) * 2001-06-18 2002-12-27 H. Lundbeck A/S Treatment of neuropathic pain
SE0103818D0 (sv) * 2001-11-15 2001-11-15 Astrazeneca Ab Chemical compounds
SE0202133D0 (sv) 2002-07-08 2002-07-08 Astrazeneca Ab Novel compounds
JP2006511500A (ja) * 2002-10-30 2006-04-06 メルク　エンド　カムパニー　インコーポレーテッド γ−アミノアミド系のケモカイン受容体活性調節剤
SE0301369D0 (sv) * 2003-05-09 2003-05-09 Astrazeneca Ab Chemical compounds
SE0303090D0 (sv) 2003-11-20 2003-11-20 Astrazeneca Ab Novel compounds
SE0303541D0 (sv) 2003-12-22 2003-12-22 Astrazeneca Ab New compounds
TW200738634A (en) * 2005-08-02 2007-10-16 Astrazeneca Ab New salt

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2500714A (en) * 1944-10-30 1950-03-14 Abbott Lab 4-phenyl-1-alkyl isonipecotic acid lactones
FR1501590A (fr) * 1965-11-26 1967-11-10 Sankyo Co Nouveaux stabilisants des polyoléfines
US3649635A (en) * 1969-10-24 1972-03-14 Warner Lambert Co Spiropyranopyridines
US3686186A (en) * 1970-10-05 1972-08-22 William J Houlihan Substituted isochroman or phthalan piperidenes
US3959475A (en) * 1973-12-12 1976-05-25 American Hoechst Corporation Substituted 1,3-dihydrospiro(isobenzofuran)s
US3962259A (en) * 1973-12-12 1976-06-08 American Hoechst Corporation 1,3-Dihydrospiro[isobenzofuran]s and derivatives thereof

Also Published As

Publication number Publication date
JPS54145661A (en) 1979-11-14
ES479369A1 (es) 1980-06-16
EP0004952B1 (de) 1982-04-07
EP0004952A1 (de) 1979-10-31
ES490171A0 (es) 1981-02-16
AT372683B (de) 1983-11-10
CA1132987A (en) 1982-10-05
DE2962426D1 (en) 1982-05-19
US4166119A (en) 1979-08-28
ES8103089A1 (es) 1981-02-16
ATA281179A (de) 1983-03-15
ES490172A0 (es) 1981-02-16

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