ES8600263A1 - Un compuesto. - Google Patents
Un compuesto.Info
- Publication number
- ES8600263A1 ES8600263A1 ES524274A ES524274A ES8600263A1 ES 8600263 A1 ES8600263 A1 ES 8600263A1 ES 524274 A ES524274 A ES 524274A ES 524274 A ES524274 A ES 524274A ES 8600263 A1 ES8600263 A1 ES 8600263A1
- Authority
- ES
- Spain
- Prior art keywords
- preparation
- furanone derivatives
- salts
- new
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
- C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
- C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/12—Ophthalmic agents for cataracts
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
- C07C43/14—Unsaturated ethers
- C07C43/164—Unsaturated ethers containing six-membered aromatic rings
- C07C43/166—Unsaturated ethers containing six-membered aromatic rings having unsaturation outside the aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/32—Oxygen atoms
- C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/58—One oxygen atom, e.g. butenolide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/60—Two oxygen atoms, e.g. succinic anhydride
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
- C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
- C12N1/145—Fungal isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- C12P17/04—Oxygen as only ring hetero atoms containing a five-membered hetero ring, e.g. griseofulvin, vitamin C
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/645—Fungi ; Processes using fungi
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- Ophthalmology & Optometry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Tropical Medicine & Parasitology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Botany (AREA)
- Mycology (AREA)
- Veterinary Medicine (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Furan Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE FURANONA DE FORMULA GENERAL (I) Y SUS SALES FARMACEUTICAMENTE ACEPTABLES.CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (II) O UNA DE SUS SALES, CON UN AGENTE ALQUILANTE APROPIADO SELECCIONADO ENTRE UN DIAZOALCANO, UN HALURO DE ALQUILO O UN SULFATO DE DIALQUILO, EN UN DISOLVENTE INERTE A LA REACCION Y EN PRESENCIA DE UNA BASE.DE APLICACION COMO FARMACOS PARA EL TRATAMIENTO DE CATARATAS DIABETICAS Y NEUROPATIA.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP57126599A JPS5916884A (ja) | 1982-07-19 | 1982-07-19 | 新規フラン化合物 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8600263A1 true ES8600263A1 (es) | 1985-05-01 |
ES524274A0 ES524274A0 (es) | 1985-05-01 |
Family
ID=14939171
Family Applications (5)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES524274A Granted ES524274A0 (es) | 1982-07-19 | 1983-07-19 | Un compuesto. |
ES530709A Expired ES8600401A1 (es) | 1982-07-19 | 1984-03-16 | Un procedimiento para la preparacion de nuevos derivados de furanona (sustancia fr 51785) |
ES530708A Expired ES8604551A1 (es) | 1982-07-19 | 1984-03-16 | Un procedimiento para la preparacion de nuevos derivados de furanona |
ES530707A Granted ES530707A0 (es) | 1982-07-19 | 1984-03-16 | Un procedimiento para la preparacion de nuevos derivados de furanona |
ES530710A Expired ES8604552A1 (es) | 1982-07-19 | 1984-03-16 | Un procedimiento para la preparacion de nuevos derivados de furanona |
Family Applications After (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES530709A Expired ES8600401A1 (es) | 1982-07-19 | 1984-03-16 | Un procedimiento para la preparacion de nuevos derivados de furanona (sustancia fr 51785) |
ES530708A Expired ES8604551A1 (es) | 1982-07-19 | 1984-03-16 | Un procedimiento para la preparacion de nuevos derivados de furanona |
ES530707A Granted ES530707A0 (es) | 1982-07-19 | 1984-03-16 | Un procedimiento para la preparacion de nuevos derivados de furanona |
ES530710A Expired ES8604552A1 (es) | 1982-07-19 | 1984-03-16 | Un procedimiento para la preparacion de nuevos derivados de furanona |
Country Status (9)
Country | Link |
---|---|
US (2) | US4585789A (es) |
EP (1) | EP0099692B1 (es) |
JP (1) | JPS5916884A (es) |
KR (1) | KR840005439A (es) |
AT (1) | ATE25977T1 (es) |
CA (1) | CA1221929A (es) |
DE (1) | DE3370327D1 (es) |
DK (1) | DK330783A (es) |
ES (5) | ES524274A0 (es) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5916884A (ja) * | 1982-07-19 | 1984-01-28 | Fujisawa Pharmaceut Co Ltd | 新規フラン化合物 |
EP0189272A3 (en) * | 1985-01-17 | 1987-08-19 | Fujisawa Pharmaceutical Co., Ltd. | New furanone derivatives, processes for preparation thereof and use thereof |
US4707499A (en) * | 1985-12-02 | 1987-11-17 | G. D. Searle & Co. | 3-alkyl-5-(substituted amino)methyl)dihydro-3-phenyl-2(3H)-furanones and imino analogs thereof used for treatment of arrhythmia |
DE3615157A1 (de) * | 1986-05-05 | 1987-11-12 | Schwabe Willmar Gmbh & Co | 5-arylalkyl-4-alkoxy-2(5h)-furanone, zwischenprodukte und verfahren zu ihrer herstellung sowie ihre anwendung als therapeutische wirkstoffe |
CA1320728C (en) * | 1987-09-07 | 1993-07-27 | Kazuhiko Sakaguchi | Liquid crystalline compounds and process for production thereof |
JPH0222271A (ja) * | 1988-07-11 | 1990-01-25 | Kuraray Co Ltd | 共役γ−オキシブテノライド化合物およびこれを有効成分とする抗潰瘍剤 |
JP2790335B2 (ja) * | 1989-09-20 | 1998-08-27 | 株式会社クラレ | 共役γ―オキシブテノライド化合物およびこれを有効成分とする抗潰瘍剤 |
DE4014420A1 (de) * | 1989-09-23 | 1991-04-04 | Bayer Ag | 5h-furan-2-on-derivate |
JP3068706B2 (ja) * | 1992-02-26 | 2000-07-24 | 塩野義製薬株式会社 | アルド−ス還元酵素阻害物質 |
US6492413B2 (en) | 1993-01-15 | 2002-12-10 | G.D. Searle & Co. | 3.4-diaryl thiophenes and analogs thereof having use as antiinflammatory agents |
US5474995A (en) | 1993-06-24 | 1995-12-12 | Merck Frosst Canada, Inc. | Phenyl heterocycles as cox-2 inhibitors |
KR960703901A (ko) * | 1993-08-19 | 1996-08-31 | 로즈 암스트롱 | 치환된 2(5H)푸라논, 2(5H)티오페논 및 2(5H)피롤론 유도체, 그의 제조 방법 및 엔도텔린 길항제로서의 그의 용도(Substituted 2(5H)Furanone, 2(5H)Thiophenone and 2(5H)Pyrrolone Derivatives, Their Preparation and Their Use as Endothelin antagonists) |
US5698585A (en) | 1995-04-13 | 1997-12-16 | Kikkoman Corporation | Pharmaceutical preparation for prevention and/or treatment for cataract |
US5922759A (en) * | 1996-06-21 | 1999-07-13 | Warner-Lambert Company | Butenolide endothelin antagonists |
AU6603996A (en) * | 1995-08-24 | 1997-03-19 | Warner-Lambert Company | Furanone endothelin antagonists |
GB9615867D0 (en) * | 1996-07-03 | 1996-09-11 | Merck & Co Inc | Process of preparing phenyl heterocycles useful as cox-2 inhibitors |
US5891892A (en) * | 1996-10-29 | 1999-04-06 | Warner-Lambert Company | Small molecule biaryl compounds as inhibitors of endothelin converting enzyme |
US6355593B1 (en) | 2000-09-01 | 2002-03-12 | Exxonmobil Research And Engineering Company | Fischer-Tropsch catalyst enhancement |
US6753351B2 (en) | 2002-01-29 | 2004-06-22 | Exxonmobil Research And Engineering Company | Supported catalyst activation |
US7419928B2 (en) * | 2003-04-11 | 2008-09-02 | Exxonmobil Research And Engineering Company | Fischer-Tropsch catalyst production |
US7361619B2 (en) * | 2003-04-11 | 2008-04-22 | Exxonmobil Research And Engineering Company | Fischer-Tropsch catalyst production |
EP2746266A1 (en) * | 2012-12-19 | 2014-06-25 | Basf Se | New substituted triazoles and imidazoles and their use as fungicides |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2841594A (en) * | 1958-07-01 | Production of beta-furoic acids | ||
US3113939A (en) * | 1959-05-28 | 1963-12-10 | Du Pont | Substituted maleic anhydrides and the corresponding lactones of 3-formylacrylic acid |
US3509209A (en) * | 1967-01-12 | 1970-04-28 | Union Oil Co | Hydrocarboxylation of certain conjugated diolefin compounds |
US3873575A (en) * | 1967-02-17 | 1975-03-25 | Spofa Vereinigte Pharma Werke | {65 -4-N-butoxyphenyl-{60 ,{62 -dibromo-{66 {300 ,{330 -crotonic acid lactone |
US3564020A (en) * | 1968-07-17 | 1971-02-16 | Union Oil Co | Preparation of angelica lactone |
GB1228185A (es) * | 1968-09-17 | 1971-04-15 | ||
US3813416A (en) * | 1969-02-17 | 1974-05-28 | Mobil Oil Corp | Substituted gamma-butyrolactones derived from c16 and greater unsaturated acids |
DE1920176A1 (de) * | 1969-04-21 | 1970-10-22 | Thomae Gmbh Dr K | Neues Verfahren zur Herstellung von Hydroxycrotonsaeurelaktonen |
US3838168A (en) * | 1969-11-21 | 1974-09-24 | Dow Chemical Co | Alpha-methylenation of gamma-butyrolactones |
US3826839A (en) * | 1970-12-03 | 1974-07-30 | Smithkline Corp | Anti-arthritic compositions comprising ester derivatives of pulvinic acid and methods of producing anti-arthritic activity |
US3940424A (en) * | 1973-12-19 | 1976-02-24 | Monsanto Company | Lactones |
US4010170A (en) * | 1975-09-24 | 1977-03-01 | Iowa State University Research Foundation, Inc. | Butenolide synthesis via carbonylation of vinylmercurials |
US4214092A (en) * | 1979-02-21 | 1980-07-22 | Iowa State University Research Foundation, Inc. | Rearrangement of acyloxy furans and thiophenes prepared from butenolides |
FR2456097A1 (fr) * | 1979-05-07 | 1980-12-05 | Delalande Sa | Nouveaux derives de la 5 h-furanone-2 et de la 3 h-dihydrofuranone-2, leur procede de preparation et leur application en therapeutique |
US4508914A (en) * | 1979-12-22 | 1985-04-02 | Dynamit Nobel Ag | 3H-Furanones |
JPS5916884A (ja) * | 1982-07-19 | 1984-01-28 | Fujisawa Pharmaceut Co Ltd | 新規フラン化合物 |
-
1982
- 1982-07-19 JP JP57126599A patent/JPS5916884A/ja active Granted
-
1983
- 1983-06-29 US US06/508,892 patent/US4585789A/en not_active Expired - Fee Related
- 1983-07-04 EP EP83303877A patent/EP0099692B1/en not_active Expired
- 1983-07-04 AT AT83303877T patent/ATE25977T1/de active
- 1983-07-04 DE DE8383303877T patent/DE3370327D1/de not_active Expired
- 1983-07-13 CA CA000432395A patent/CA1221929A/en not_active Expired
- 1983-07-18 DK DK330783A patent/DK330783A/da not_active Application Discontinuation
- 1983-07-19 KR KR1019830003307A patent/KR840005439A/ko not_active Application Discontinuation
- 1983-07-19 ES ES524274A patent/ES524274A0/es active Granted
-
1984
- 1984-03-16 ES ES530709A patent/ES8600401A1/es not_active Expired
- 1984-03-16 ES ES530708A patent/ES8604551A1/es not_active Expired
- 1984-03-16 ES ES530707A patent/ES530707A0/es active Granted
- 1984-03-16 ES ES530710A patent/ES8604552A1/es not_active Expired
-
1987
- 1987-03-27 US US07/031,199 patent/US4797417A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
ES8604552A1 (es) | 1986-02-01 |
KR840005439A (ko) | 1984-11-12 |
ATE25977T1 (de) | 1987-04-15 |
ES530708A0 (es) | 1986-02-01 |
EP0099692A1 (en) | 1984-02-01 |
DK330783A (da) | 1984-03-05 |
US4585789A (en) | 1986-04-29 |
ES530709A0 (es) | 1985-05-16 |
EP0099692B1 (en) | 1987-03-18 |
ES530710A0 (es) | 1986-02-01 |
DE3370327D1 (en) | 1987-04-23 |
ES8604551A1 (es) | 1986-02-01 |
JPS5916884A (ja) | 1984-01-28 |
DK330783D0 (da) | 1983-07-18 |
ES8600401A1 (es) | 1985-05-16 |
ES8600264A1 (es) | 1985-05-16 |
JPH0352458B2 (es) | 1991-08-12 |
US4797417A (en) | 1989-01-10 |
CA1221929A (en) | 1987-05-19 |
ES524274A0 (es) | 1985-05-01 |
ES530707A0 (es) | 1985-05-16 |
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