ES8704917A1 - Procedimiento para prepararar derivados de 1-piperazinacarboximida. - Google Patents
Procedimiento para prepararar derivados de 1-piperazinacarboximida.Info
- Publication number
- ES8704917A1 ES8704917A1 ES552001A ES552001A ES8704917A1 ES 8704917 A1 ES8704917 A1 ES 8704917A1 ES 552001 A ES552001 A ES 552001A ES 552001 A ES552001 A ES 552001A ES 8704917 A1 ES8704917 A1 ES 8704917A1
- Authority
- ES
- Spain
- Prior art keywords
- compound
- formula
- preparation
- pharmaceutical compositions
- carboxamide derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
- C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/205—Radicals derived from carbonic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/21—Radicals derived from sulfur analogues of carbonic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/28—Radicals substituted by nitrogen atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
PROCEDIMIENTO PARA PREPARAR DERIVADOS DE 1-PIPERAZINACARBOXAMIDA. CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (II) CON UN COMPUESTO DE FORMULA (III), EN PRESENCIA DE ETANOL O BENCENO, ENTRE 0 Y 250JC Y DURANTE 0,5 A 72 HORAS, PARA OBTENER UN COMPUESTO DE FORMULA (I) Y SUS SALES DE ADICION DE ACIDO FARMACEUTICAMENTE ACEPTABLES, SIENDO: R1, H, HAL O TRIFLUOROMETILO; R2 Y R3 SE ELIGEN ENTRE H Y ALQUILO INFERIOR; R4 Y R5, H, ALQUENILO Y OTROS; W, HAL O ALQUIL O ARIL-SULFONATO; X, FCO, FCHOH Y OTROS; Y, -NR4R5 Y Z, O O S. SE UTILIZAN COMO AGENTES NEUROFARMACOLOGICOS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE8304361A SE8304361D0 (sv) | 1983-08-10 | 1983-08-10 | Novel 1-acylpiperazine derivatives novel 1-acylpiperazine derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
ES552001A0 ES552001A0 (es) | 1987-04-16 |
ES8704917A1 true ES8704917A1 (es) | 1987-04-16 |
Family
ID=20352166
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES535027A Expired ES8705411A1 (es) | 1983-08-10 | 1984-08-09 | Procedimiento para preparar derivados de 1-piperazinacarboxamida |
ES552001A Expired ES8704917A1 (es) | 1983-08-10 | 1986-02-14 | Procedimiento para prepararar derivados de 1-piperazinacarboximida. |
ES556989A Expired ES8802039A1 (es) | 1983-08-10 | 1986-08-01 | Procedimiento par preparar derivados de 1-piperazinacarboxamida |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES535027A Expired ES8705411A1 (es) | 1983-08-10 | 1984-08-09 | Procedimiento para preparar derivados de 1-piperazinacarboxamida |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES556989A Expired ES8802039A1 (es) | 1983-08-10 | 1986-08-01 | Procedimiento par preparar derivados de 1-piperazinacarboxamida |
Country Status (16)
Country | Link |
---|---|
US (1) | US4935419A (es) |
EP (1) | EP0136274B1 (es) |
JP (1) | JPH0723364B2 (es) |
AT (1) | ATE47850T1 (es) |
AU (1) | AU569537B2 (es) |
CA (1) | CA1253148A (es) |
DE (1) | DE3480395D1 (es) |
DK (1) | DK157864C (es) |
ES (3) | ES8705411A1 (es) |
FI (1) | FI80449C (es) |
HU (1) | HU196977B (es) |
IE (1) | IE58065B1 (es) |
IL (1) | IL72563A (es) |
NZ (1) | NZ209166A (es) |
SE (1) | SE8304361D0 (es) |
WO (1) | WO1985000811A1 (es) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE8500573D0 (sv) * | 1985-02-08 | 1985-02-08 | Ferrosan Ab | Novel piperazinecarboxamides having a phenoxyalkyl or thiophenoxyalkyl side chain |
GB8713240D0 (en) * | 1987-06-05 | 1987-07-08 | Proteus Biotech Ltd | Hormones |
CA1326451C (en) * | 1988-01-26 | 1994-01-25 | Nippon Chemiphar Co., Ltd. | Therapeutic agent for liver disease and piperazine derivatives |
US5795894A (en) * | 1995-05-02 | 1998-08-18 | Schering Corporation | Piperazino derivatives as neurokinn antagonists |
US5719156A (en) * | 1995-05-02 | 1998-02-17 | Schering Corporation | Piperazino derivatives as neurokinin antagonists |
US5892039A (en) * | 1995-08-31 | 1999-04-06 | Schering Corporation | Piperazino derivatives as neurokinin antagonists |
US5869488A (en) * | 1996-05-01 | 1999-02-09 | Schering Corporation | Piperazino derivatives as neurokinin antagonists |
US5968929A (en) * | 1996-10-30 | 1999-10-19 | Schering Corporation | Piperazino derivatives as neurokinin antagonists |
US6355643B1 (en) | 1999-03-03 | 2002-03-12 | Merck & Co., Inc. | Inhibitors of prenyl-protein transferase |
US20100093935A1 (en) * | 2008-10-15 | 2010-04-15 | Nitto Denko Corporation | Method of preparing polyglutamate conjugates |
JP2013514443A (ja) * | 2009-12-16 | 2013-04-25 | 日東電工株式会社 | ポリグルタミン酸の制御された合成 |
ES2727815T3 (es) * | 2012-04-14 | 2019-10-18 | Intra Cellular Therapies Inc | Tratamiento del TEPT y de trastornos del control de impulsos |
BR112018015283B1 (pt) | 2016-01-26 | 2023-09-26 | Intra-Cellular Therapies, Inc | Compostos orgânicos, composição farmacêutica compreendendo os ditos compostos e uso dos mesmos para o tratamento ou profilaxia de um distúrbio do sistema nervoso central |
US10961245B2 (en) | 2016-12-29 | 2021-03-30 | Intra-Cellular Therapies, Inc. | Substituted heterocycle fused gamma-carbolines for treatment of central nervous system disorders |
WO2018126143A1 (en) | 2016-12-29 | 2018-07-05 | Intra-Cellular Therapies, Inc. | Organic compounds |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3000892A (en) * | 1959-11-16 | 1961-09-19 | Paul A J Janssen | 1-aroylalkyl-4-aroylpiperazines |
DE1670431A1 (de) * | 1966-03-04 | 1971-02-11 | Chinoin Gyogyszer Es Vegyeszet | Verfahren zur Herstellung neuer Piperazin-Derivate |
GB1143882A (es) * | 1966-06-21 | |||
GB1186495A (en) * | 1968-02-20 | 1970-04-02 | Delalande Sa | 0-[3-(4-Fluorobenzoyl) Proplyl]-4-Substituted Piperazines, their Acid Addition Salts and their method of preparation |
FR2262521A1 (en) * | 1973-08-08 | 1975-09-26 | Delalande Sa | 3-(3,4,5-Trimethoxyphenyl)piperazines - with coronary vasodilator, hypotensive, antiinflammatory, analgesic, and antiulcer activity |
AR207031A1 (es) * | 1974-03-06 | 1976-09-09 | Kyorin Seiyaku Kk | Procedimiento para preparacion de nuevos derivados de 1-(3-fenilpropil)-4-furoilpiperacina |
JPS5143772A (en) * | 1974-09-26 | 1976-04-14 | Kyorin Seiyaku Kk | 11 * 33 fuenirupuropiru * 44 furoirupiperajinjudotaino seizoho |
JPS50131974A (es) * | 1974-03-06 | 1975-10-18 | ||
JPS518283A (en) * | 1974-07-09 | 1976-01-23 | Kyorin Seiyaku Kk | 11 * 33 fuenirupuropiru * 44 karubamoirupiperajinjudotaino seizoho |
JPS5346988A (en) * | 1976-10-07 | 1978-04-27 | Kyorin Seiyaku Kk | Piperadine derivative |
NO154582C (no) * | 1978-10-20 | 1986-11-05 | Ferrosan Ab | Analogifremgangsmaate for fremstilling av terapeutisk aktive difenyl-dibutylpiperazinkarboksamider. |
WO1981003658A1 (en) * | 1980-06-16 | 1981-12-24 | Ferrosan Ab | Diphenylbutyl-1-acylpiperazines |
JPS58502056A (ja) * | 1981-12-02 | 1983-12-01 | アクチ−ボラグ フエロサン | 1−ピペラジノカルボキシレ−ト、それらの製造方法およびそれらを含む医薬組成物 |
-
1983
- 1983-08-10 SE SE8304361A patent/SE8304361D0/xx unknown
-
1984
- 1984-08-01 IL IL72563A patent/IL72563A/xx not_active IP Right Cessation
- 1984-08-02 DE DE8484850237T patent/DE3480395D1/de not_active Expired
- 1984-08-02 EP EP84850237A patent/EP0136274B1/en not_active Expired
- 1984-08-02 WO PCT/SE1984/000269 patent/WO1985000811A1/en active IP Right Grant
- 1984-08-02 AT AT84850237T patent/ATE47850T1/de not_active IP Right Cessation
- 1984-08-02 HU HU843341A patent/HU196977B/hu unknown
- 1984-08-02 JP JP59503010A patent/JPH0723364B2/ja not_active Expired - Lifetime
- 1984-08-02 AU AU32111/84A patent/AU569537B2/en not_active Expired
- 1984-08-09 IE IE205084A patent/IE58065B1/en not_active IP Right Cessation
- 1984-08-09 NZ NZ209166A patent/NZ209166A/en unknown
- 1984-08-09 ES ES535027A patent/ES8705411A1/es not_active Expired
- 1984-08-09 CA CA000460595A patent/CA1253148A/en not_active Expired
-
1985
- 1985-04-03 FI FI851350A patent/FI80449C/fi not_active IP Right Cessation
- 1985-04-09 DK DK157485A patent/DK157864C/da not_active IP Right Cessation
-
1986
- 1986-02-14 ES ES552001A patent/ES8704917A1/es not_active Expired
- 1986-08-01 ES ES556989A patent/ES8802039A1/es not_active Expired
-
1988
- 1988-07-29 US US07/227,420 patent/US4935419A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
HUT37415A (en) | 1985-12-28 |
AU569537B2 (en) | 1988-02-04 |
DK157864C (da) | 1990-07-23 |
US4935419A (en) | 1990-06-19 |
EP0136274A1 (en) | 1985-04-03 |
EP0136274B1 (en) | 1989-11-08 |
IE842050L (en) | 1985-02-10 |
HU196977B (en) | 1989-02-28 |
ES535027A0 (es) | 1987-05-01 |
ES556989A0 (es) | 1988-03-16 |
AU3211184A (en) | 1985-03-12 |
ATE47850T1 (de) | 1989-11-15 |
SE8304361D0 (sv) | 1983-08-10 |
FI80449C (fi) | 1990-06-11 |
DE3480395D1 (en) | 1989-12-14 |
IE58065B1 (en) | 1993-06-30 |
ES8705411A1 (es) | 1987-05-01 |
DK157485A (da) | 1985-04-09 |
JPH0723364B2 (ja) | 1995-03-15 |
DK157485D0 (da) | 1985-04-09 |
JPS60501956A (ja) | 1985-11-14 |
IL72563A0 (en) | 1984-11-30 |
DK157864B (da) | 1990-02-26 |
IL72563A (en) | 1988-10-31 |
FI851350L (fi) | 1985-04-03 |
WO1985000811A1 (en) | 1985-02-28 |
ES552001A0 (es) | 1987-04-16 |
FI851350A0 (fi) | 1985-04-03 |
ES8802039A1 (es) | 1988-03-16 |
NZ209166A (en) | 1987-07-31 |
CA1253148A (en) | 1989-04-25 |
FI80449B (fi) | 1990-02-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 20060220 |