DE3480395D1 - 1-piperazine carboxamide derivatives, their preparation and their use in pharmaceutical compositions - Google Patents

1-piperazine carboxamide derivatives, their preparation and their use in pharmaceutical compositions

Info

Publication number
DE3480395D1
DE3480395D1 DE8484850237T DE3480395T DE3480395D1 DE 3480395 D1 DE3480395 D1 DE 3480395D1 DE 8484850237 T DE8484850237 T DE 8484850237T DE 3480395 T DE3480395 T DE 3480395T DE 3480395 D1 DE3480395 D1 DE 3480395D1
Authority
DE
Germany
Prior art keywords
hydrogen
different
lower alkyl
derivatives
pharmaceutical compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8484850237T
Other languages
English (en)
Inventor
Anders Karl Konrad Bjork
Knut Gunnar Olsson
Aina Lisbeth Abramo
Tomas Fex
Bengt Kenneth Rolan Gustafsson
Erik Gunnar Christensson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Swedish Orphan Biovitrum AB
Original Assignee
Ferrosan AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ferrosan AB filed Critical Ferrosan AB
Application granted granted Critical
Publication of DE3480395D1 publication Critical patent/DE3480395D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
    • C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/205—Radicals derived from carbonic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/21—Radicals derived from sulfur analogues of carbonic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/28—Radicals substituted by nitrogen atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE8484850237T 1983-08-10 1984-08-02 1-piperazine carboxamide derivatives, their preparation and their use in pharmaceutical compositions Expired DE3480395D1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE8304361A SE8304361D0 (sv) 1983-08-10 1983-08-10 Novel 1-acylpiperazine derivatives novel 1-acylpiperazine derivatives

Publications (1)

Publication Number Publication Date
DE3480395D1 true DE3480395D1 (en) 1989-12-14

Family

ID=20352166

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8484850237T Expired DE3480395D1 (en) 1983-08-10 1984-08-02 1-piperazine carboxamide derivatives, their preparation and their use in pharmaceutical compositions

Country Status (16)

Country Link
US (1) US4935419A (de)
EP (1) EP0136274B1 (de)
JP (1) JPH0723364B2 (de)
AT (1) ATE47850T1 (de)
AU (1) AU569537B2 (de)
CA (1) CA1253148A (de)
DE (1) DE3480395D1 (de)
DK (1) DK157864C (de)
ES (3) ES8705411A1 (de)
FI (1) FI80449C (de)
HU (1) HU196977B (de)
IE (1) IE58065B1 (de)
IL (1) IL72563A (de)
NZ (1) NZ209166A (de)
SE (1) SE8304361D0 (de)
WO (1) WO1985000811A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8500573D0 (sv) * 1985-02-08 1985-02-08 Ferrosan Ab Novel piperazinecarboxamides having a phenoxyalkyl or thiophenoxyalkyl side chain
GB8713240D0 (en) * 1987-06-05 1987-07-08 Proteus Biotech Ltd Hormones
US5070089A (en) * 1988-01-26 1991-12-03 Nippon Chemiphar Co., Ltd. Therapeutic agent for liver disease and piperazine derivatives
US5719156A (en) * 1995-05-02 1998-02-17 Schering Corporation Piperazino derivatives as neurokinin antagonists
US5795894A (en) * 1995-05-02 1998-08-18 Schering Corporation Piperazino derivatives as neurokinn antagonists
US5892039A (en) * 1995-08-31 1999-04-06 Schering Corporation Piperazino derivatives as neurokinin antagonists
US5869488A (en) * 1996-05-01 1999-02-09 Schering Corporation Piperazino derivatives as neurokinin antagonists
US5968929A (en) * 1996-10-30 1999-10-19 Schering Corporation Piperazino derivatives as neurokinin antagonists
JP2002538120A (ja) 1999-03-03 2002-11-12 メルク エンド カムパニー インコーポレーテッド プレニルタンパク質トランスフェラーゼの阻害剤
US20100093935A1 (en) * 2008-10-15 2010-04-15 Nitto Denko Corporation Method of preparing polyglutamate conjugates
US20110144315A1 (en) * 2009-12-16 2011-06-16 Nitto Denko Corporation Controlled synthesis of polyglutamic acid
US9428506B2 (en) * 2012-04-14 2016-08-30 Intra-Cellular Therapies, Inc. Substituted pyrido[3′,4′:4,5]pyrrolo[1,2,3-de]quinoxalines for the treatment of nervous system disorders
PT3838274T (pt) 2016-01-26 2023-12-18 Intra Cellular Therapies Inc Derivado de pirido[3',4':4,5]pirrolo[1,2,3-de]quinoxalina para utilização no tratamento de distúrbios do snc
JP6987868B2 (ja) 2016-12-29 2022-01-05 イントラ−セルラー・セラピーズ・インコーポレイテッドIntra−Cellular Therapies, Inc. 有機化合物
US10961245B2 (en) 2016-12-29 2021-03-30 Intra-Cellular Therapies, Inc. Substituted heterocycle fused gamma-carbolines for treatment of central nervous system disorders

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3000892A (en) * 1959-11-16 1961-09-19 Paul A J Janssen 1-aroylalkyl-4-aroylpiperazines
DE1670431A1 (de) * 1966-03-04 1971-02-11 Chinoin Gyogyszer Es Vegyeszet Verfahren zur Herstellung neuer Piperazin-Derivate
GB1143882A (de) * 1966-06-21
GB1186495A (en) * 1968-02-20 1970-04-02 Delalande Sa 0-[3-(4-Fluorobenzoyl) Proplyl]-4-Substituted Piperazines, their Acid Addition Salts and their method of preparation
FR2262521A1 (en) * 1973-08-08 1975-09-26 Delalande Sa 3-(3,4,5-Trimethoxyphenyl)piperazines - with coronary vasodilator, hypotensive, antiinflammatory, analgesic, and antiulcer activity
AR207031A1 (es) * 1974-03-06 1976-09-09 Kyorin Seiyaku Kk Procedimiento para preparacion de nuevos derivados de 1-(3-fenilpropil)-4-furoilpiperacina
JPS5143772A (en) * 1974-09-26 1976-04-14 Kyorin Seiyaku Kk 11 * 33 fuenirupuropiru * 44 furoirupiperajinjudotaino seizoho
JPS50131974A (de) * 1974-03-06 1975-10-18
JPS518283A (en) * 1974-07-09 1976-01-23 Kyorin Seiyaku Kk 11 * 33 fuenirupuropiru * 44 karubamoirupiperajinjudotaino seizoho
JPS5346988A (en) * 1976-10-07 1978-04-27 Kyorin Seiyaku Kk Piperadine derivative
NO154582C (no) * 1978-10-20 1986-11-05 Ferrosan Ab Analogifremgangsmaate for fremstilling av terapeutisk aktive difenyl-dibutylpiperazinkarboksamider.
DE3167049D1 (de) * 1980-06-16 1984-12-13 Ferrosan Ab Diphenylbutyl-1-acylpiperazines
NZ202665A (en) * 1981-12-02 1986-04-11 Ferrosan Ab Diphenylbutyl-1-piperazinocarboxylate derivatives and pharmaceutical compositions

Also Published As

Publication number Publication date
DK157864B (da) 1990-02-26
DK157485A (da) 1985-04-09
ATE47850T1 (de) 1989-11-15
HU196977B (en) 1989-02-28
SE8304361D0 (sv) 1983-08-10
CA1253148A (en) 1989-04-25
FI80449C (fi) 1990-06-11
JPH0723364B2 (ja) 1995-03-15
IL72563A (en) 1988-10-31
ES8704917A1 (es) 1987-04-16
DK157864C (da) 1990-07-23
HUT37415A (en) 1985-12-28
JPS60501956A (ja) 1985-11-14
IE842050L (en) 1985-02-10
AU3211184A (en) 1985-03-12
EP0136274A1 (de) 1985-04-03
ES8802039A1 (es) 1988-03-16
FI80449B (fi) 1990-02-28
DK157485D0 (da) 1985-04-09
NZ209166A (en) 1987-07-31
ES556989A0 (es) 1988-03-16
EP0136274B1 (de) 1989-11-08
IL72563A0 (en) 1984-11-30
FI851350A0 (fi) 1985-04-03
ES535027A0 (es) 1987-05-01
US4935419A (en) 1990-06-19
ES552001A0 (es) 1987-04-16
IE58065B1 (en) 1993-06-30
WO1985000811A1 (en) 1985-02-28
FI851350L (fi) 1985-04-03
AU569537B2 (en) 1988-02-04
ES8705411A1 (es) 1987-05-01

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: BIOVITRUM AB, STOCKHOLM, SE