FI851350L - Nya 1-piperazinkarboxiamidderivat. - Google Patents

Nya 1-piperazinkarboxiamidderivat.

Info

Publication number
FI851350L
FI851350L FI851350A FI851350A FI851350L FI 851350 L FI851350 L FI 851350L FI 851350 A FI851350 A FI 851350A FI 851350 A FI851350 A FI 851350A FI 851350 L FI851350 L FI 851350L
Authority
FI
Finland
Prior art keywords
hydrogen
different
derivatives
lower alkyl
same
Prior art date
Application number
FI851350A
Other languages
English (en)
Other versions
FI851350A0 (fi
FI80449C (fi
FI80449B (fi
Inventor
Anders Karl Konrad Bjoerk
Tomas Fex
Knut Gunnar Olsson
Aina Lisbeth Abramo
Bengt Kenneth Rolan Gustafsson
Erik Gunnar Christensson
Original Assignee
Ferrosan Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ferrosan Ab filed Critical Ferrosan Ab
Publication of FI851350A0 publication Critical patent/FI851350A0/fi
Publication of FI851350L publication Critical patent/FI851350L/fi
Application granted granted Critical
Publication of FI80449B publication Critical patent/FI80449B/fi
Publication of FI80449C publication Critical patent/FI80449C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
    • C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/205—Radicals derived from carbonic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/21—Radicals derived from sulfur analogues of carbonic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/28—Radicals substituted by nitrogen atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
FI851350A 1983-08-10 1985-04-03 Foerfarande foer framstaellning av nya terapeutiskt anvaendbara 1-piperazinkarboxamidderivat. FI80449C (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
SE8304361A SE8304361D0 (sv) 1983-08-10 1983-08-10 Novel 1-acylpiperazine derivatives novel 1-acylpiperazine derivatives
SE8304361 1983-08-10
SE8400269 1984-08-02
PCT/SE1984/000269 WO1985000811A1 (en) 1983-08-10 1984-08-02 Novel 1-piperazinecarboxamide derivatives

Publications (4)

Publication Number Publication Date
FI851350A0 FI851350A0 (fi) 1985-04-03
FI851350L true FI851350L (fi) 1985-04-03
FI80449B FI80449B (fi) 1990-02-28
FI80449C FI80449C (fi) 1990-06-11

Family

ID=20352166

Family Applications (1)

Application Number Title Priority Date Filing Date
FI851350A FI80449C (fi) 1983-08-10 1985-04-03 Foerfarande foer framstaellning av nya terapeutiskt anvaendbara 1-piperazinkarboxamidderivat.

Country Status (16)

Country Link
US (1) US4935419A (fi)
EP (1) EP0136274B1 (fi)
JP (1) JPH0723364B2 (fi)
AT (1) ATE47850T1 (fi)
AU (1) AU569537B2 (fi)
CA (1) CA1253148A (fi)
DE (1) DE3480395D1 (fi)
DK (1) DK157864C (fi)
ES (3) ES8705411A1 (fi)
FI (1) FI80449C (fi)
HU (1) HU196977B (fi)
IE (1) IE58065B1 (fi)
IL (1) IL72563A (fi)
NZ (1) NZ209166A (fi)
SE (1) SE8304361D0 (fi)
WO (1) WO1985000811A1 (fi)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8500573D0 (sv) * 1985-02-08 1985-02-08 Ferrosan Ab Novel piperazinecarboxamides having a phenoxyalkyl or thiophenoxyalkyl side chain
GB8713240D0 (en) * 1987-06-05 1987-07-08 Proteus Biotech Ltd Hormones
CA1326451C (en) * 1988-01-26 1994-01-25 Nippon Chemiphar Co., Ltd. Therapeutic agent for liver disease and piperazine derivatives
US5795894A (en) * 1995-05-02 1998-08-18 Schering Corporation Piperazino derivatives as neurokinn antagonists
US5719156A (en) * 1995-05-02 1998-02-17 Schering Corporation Piperazino derivatives as neurokinin antagonists
US5892039A (en) * 1995-08-31 1999-04-06 Schering Corporation Piperazino derivatives as neurokinin antagonists
US5869488A (en) * 1996-05-01 1999-02-09 Schering Corporation Piperazino derivatives as neurokinin antagonists
US5968929A (en) * 1996-10-30 1999-10-19 Schering Corporation Piperazino derivatives as neurokinin antagonists
CA2362494A1 (en) 1999-03-03 2000-09-08 Merck & Co., Inc. Inhibitors of prenyl-protein transferase
CA2739291A1 (en) * 2008-10-15 2010-04-22 Nitto Denko Corporation Method of preparing polyglutamate conjugates
KR20120094061A (ko) * 2009-12-16 2012-08-23 닛토덴코 가부시키가이샤 폴리글루탐산의 제어된 합성법
WO2013155506A1 (en) * 2012-04-14 2013-10-17 Intra-Cellular Therapies, Inc. Novel compositions and methods
PL3838274T3 (pl) 2016-01-26 2024-04-02 Intra-Cellular Therapies, Inc. Pochodna pirydo[3',4':4,5]pirolo[1,2,3-DE]chinoksaliny do zastosowania w leczeniu zaburzeń OUN
JP6987868B2 (ja) 2016-12-29 2022-01-05 イントラ−セルラー・セラピーズ・インコーポレイテッドIntra−Cellular Therapies, Inc. 有機化合物
WO2018126140A1 (en) 2016-12-29 2018-07-05 Intra-Cellular Therapies, Inc. Organic compounds

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3000892A (en) * 1959-11-16 1961-09-19 Paul A J Janssen 1-aroylalkyl-4-aroylpiperazines
GB1150245A (en) * 1966-03-04 1969-04-30 Chinoin Gyogyszer Es Vegyeszet New Piperazine Derivatives and a Process for the Preparation thereof.
GB1143882A (fi) * 1966-06-21
GB1186495A (en) * 1968-02-20 1970-04-02 Delalande Sa 0-[3-(4-Fluorobenzoyl) Proplyl]-4-Substituted Piperazines, their Acid Addition Salts and their method of preparation
FR2262521A1 (en) * 1973-08-08 1975-09-26 Delalande Sa 3-(3,4,5-Trimethoxyphenyl)piperazines - with coronary vasodilator, hypotensive, antiinflammatory, analgesic, and antiulcer activity
AR207031A1 (es) * 1974-03-06 1976-09-09 Kyorin Seiyaku Kk Procedimiento para preparacion de nuevos derivados de 1-(3-fenilpropil)-4-furoilpiperacina
JPS5143772A (en) * 1974-09-26 1976-04-14 Kyorin Seiyaku Kk 11 * 33 fuenirupuropiru * 44 furoirupiperajinjudotaino seizoho
JPS50131974A (fi) * 1974-03-06 1975-10-18
JPS518283A (en) * 1974-07-09 1976-01-23 Kyorin Seiyaku Kk 11 * 33 fuenirupuropiru * 44 karubamoirupiperajinjudotaino seizoho
JPS5346988A (en) * 1976-10-07 1978-04-27 Kyorin Seiyaku Kk Piperadine derivative
NO154582C (no) * 1978-10-20 1986-11-05 Ferrosan Ab Analogifremgangsmaate for fremstilling av terapeutisk aktive difenyl-dibutylpiperazinkarboksamider.
AU546260B2 (en) * 1980-06-16 1985-08-22 Ferrosan A.B. Diphenylbutyl-1-acylpiperazines
IL67372A (en) * 1981-12-02 1986-04-29 Ferrosan Ab Pharmaceutical compositions comprising 4-(4,4-bis(p-fluorophenyl)butyl)-1-piperazinocarboxylates,certain such novel compounds and their preparation

Also Published As

Publication number Publication date
ES8705411A1 (es) 1987-05-01
ES8802039A1 (es) 1988-03-16
IL72563A (en) 1988-10-31
IE58065B1 (en) 1993-06-30
FI851350A0 (fi) 1985-04-03
NZ209166A (en) 1987-07-31
SE8304361D0 (sv) 1983-08-10
HUT37415A (en) 1985-12-28
AU569537B2 (en) 1988-02-04
ES8704917A1 (es) 1987-04-16
DE3480395D1 (en) 1989-12-14
EP0136274A1 (en) 1985-04-03
ES556989A0 (es) 1988-03-16
HU196977B (en) 1989-02-28
US4935419A (en) 1990-06-19
JPH0723364B2 (ja) 1995-03-15
WO1985000811A1 (en) 1985-02-28
AU3211184A (en) 1985-03-12
IL72563A0 (en) 1984-11-30
FI80449C (fi) 1990-06-11
DK157485D0 (da) 1985-04-09
CA1253148A (en) 1989-04-25
ATE47850T1 (de) 1989-11-15
DK157485A (da) 1985-04-09
ES535027A0 (es) 1987-05-01
FI80449B (fi) 1990-02-28
IE842050L (en) 1985-02-10
EP0136274B1 (en) 1989-11-08
ES552001A0 (es) 1987-04-16
DK157864C (da) 1990-07-23
DK157864B (da) 1990-02-26
JPS60501956A (ja) 1985-11-14

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Legal Events

Date Code Title Description
PC Transfer of assignment of patent

Owner name: PHARMACIA AB

MA Patent expired

Owner name: BIOVITRUM AB