SE8304361D0 - Novel 1-acylpiperazine derivatives novel 1-acylpiperazine derivatives - Google Patents
Novel 1-acylpiperazine derivatives novel 1-acylpiperazine derivativesInfo
- Publication number
- SE8304361D0 SE8304361D0 SE8304361A SE8304361A SE8304361D0 SE 8304361 D0 SE8304361 D0 SE 8304361D0 SE 8304361 A SE8304361 A SE 8304361A SE 8304361 A SE8304361 A SE 8304361A SE 8304361 D0 SE8304361 D0 SE 8304361D0
- Authority
- SE
- Sweden
- Prior art keywords
- hydrogen
- derivatives
- different
- lower alkyl
- novel
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
- C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/205—Radicals derived from carbonic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/21—Radicals derived from sulfur analogues of carbonic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/28—Radicals substituted by nitrogen atoms
Priority Applications (19)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE8304361A SE8304361D0 (sv) | 1983-08-10 | 1983-08-10 | Novel 1-acylpiperazine derivatives novel 1-acylpiperazine derivatives |
IL72563A IL72563A (en) | 1983-08-10 | 1984-08-01 | 1-piperazinecarboxamide derivatives,their preparation and pharmaceutical compositions containing them |
DE8484850237T DE3480395D1 (en) | 1983-08-10 | 1984-08-02 | 1-piperazine carboxamide derivatives, their preparation and their use in pharmaceutical compositions |
JP59503010A JPH0723364B2 (ja) | 1983-08-10 | 1984-08-02 | 新規な1−ピペラジンカルボキサミド誘導体 |
PCT/SE1984/000269 WO1985000811A1 (en) | 1983-08-10 | 1984-08-02 | Novel 1-piperazinecarboxamide derivatives |
HU843341A HU196977B (en) | 1983-08-10 | 1984-08-02 | Process for producing new 1-piperazin-carboxamide derivatives |
AU32111/84A AU569537B2 (en) | 1983-08-10 | 1984-08-02 | Novel 1-piperazinecarboxamide derivatives |
AT84850237T ATE47850T1 (de) | 1983-08-10 | 1984-08-02 | 1-piperazinkarboxamid-derivate, verfahren zu ihrer herstellung und ihre verwendung in pharmazeutischen praeparaten. |
EP84850237A EP0136274B1 (en) | 1983-08-10 | 1984-08-02 | 1-piperazine carboxamide derivatives, their preparation and their use in pharmaceutical compositions |
ES535027A ES8705411A1 (es) | 1983-08-10 | 1984-08-09 | Procedimiento para preparar derivados de 1-piperazinacarboxamida |
NZ209166A NZ209166A (en) | 1983-08-10 | 1984-08-09 | 1-piperazinecarboxamides and pharmaceutical compositions |
CA000460595A CA1253148A (en) | 1983-08-10 | 1984-08-09 | 1-piperazinecarboxamide derivatives |
IE205084A IE58065B1 (en) | 1983-08-10 | 1984-08-09 | 1-Piperazine carboxamide derivatives, their preparation and their use in pharmaceutical compositions |
FI851350A FI80449C (sv) | 1983-08-10 | 1985-04-03 | Förfarande för framställning av nya terapeutiskt användbara 1-piperazi nkarboxamidderivat |
DK157485A DK157864C (da) | 1983-08-10 | 1985-04-09 | Hidtil ukendte 1-piperazincarboxamidderivater substitueret paa det basiske nitrogenatom samt farmaceutiske praeparater og sammensaetninger indeholdende disse |
NO851409A NO166410C (no) | 1983-08-10 | 1985-04-09 | Analogifremgangsmaate ved fremstilling av terapeutisk aktive 1-piperazinkarboksamidderivater. |
ES552001A ES8704917A1 (es) | 1983-08-10 | 1986-02-14 | Procedimiento para prepararar derivados de 1-piperazinacarboximida. |
ES556989A ES8802039A1 (es) | 1983-08-10 | 1986-08-01 | Procedimiento par preparar derivados de 1-piperazinacarboxamida |
US07/227,420 US4935419A (en) | 1983-08-10 | 1988-07-29 | Novel 1-piperazinecarboxamide derivatives |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE8304361A SE8304361D0 (sv) | 1983-08-10 | 1983-08-10 | Novel 1-acylpiperazine derivatives novel 1-acylpiperazine derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
SE8304361D0 true SE8304361D0 (sv) | 1983-08-10 |
Family
ID=20352166
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SE8304361A SE8304361D0 (sv) | 1983-08-10 | 1983-08-10 | Novel 1-acylpiperazine derivatives novel 1-acylpiperazine derivatives |
Country Status (16)
Country | Link |
---|---|
US (1) | US4935419A (sv) |
EP (1) | EP0136274B1 (sv) |
JP (1) | JPH0723364B2 (sv) |
AT (1) | ATE47850T1 (sv) |
AU (1) | AU569537B2 (sv) |
CA (1) | CA1253148A (sv) |
DE (1) | DE3480395D1 (sv) |
DK (1) | DK157864C (sv) |
ES (3) | ES8705411A1 (sv) |
FI (1) | FI80449C (sv) |
HU (1) | HU196977B (sv) |
IE (1) | IE58065B1 (sv) |
IL (1) | IL72563A (sv) |
NZ (1) | NZ209166A (sv) |
SE (1) | SE8304361D0 (sv) |
WO (1) | WO1985000811A1 (sv) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE8500573D0 (sv) * | 1985-02-08 | 1985-02-08 | Ferrosan Ab | Novel piperazinecarboxamides having a phenoxyalkyl or thiophenoxyalkyl side chain |
GB8713240D0 (en) * | 1987-06-05 | 1987-07-08 | Proteus Biotech Ltd | Hormones |
ES2057101T3 (es) * | 1988-01-26 | 1994-10-16 | Nippon Chemiphar Co | Agente terapeutico para las enfermedades del higado y derivados de la piperazina. |
US5719156A (en) * | 1995-05-02 | 1998-02-17 | Schering Corporation | Piperazino derivatives as neurokinin antagonists |
US5795894A (en) * | 1995-05-02 | 1998-08-18 | Schering Corporation | Piperazino derivatives as neurokinn antagonists |
US5892039A (en) * | 1995-08-31 | 1999-04-06 | Schering Corporation | Piperazino derivatives as neurokinin antagonists |
US5869488A (en) * | 1996-05-01 | 1999-02-09 | Schering Corporation | Piperazino derivatives as neurokinin antagonists |
US5968929A (en) * | 1996-10-30 | 1999-10-19 | Schering Corporation | Piperazino derivatives as neurokinin antagonists |
WO2000051612A1 (en) | 1999-03-03 | 2000-09-08 | Merck & Co., Inc. | Inhibitors of prenyl-protein transferase |
RU2011117935A (ru) * | 2008-10-15 | 2012-11-27 | Нитто Денко Корпорейшн | Способ получения конъюгатов полиглутаматов |
CA2782410A1 (en) * | 2009-12-16 | 2011-06-23 | Nitto Denko Corporation | Controlled synthesis of polyglutamic acid |
EP3791879A1 (en) * | 2012-04-14 | 2021-03-17 | Intra-Cellular Therapies, Inc. | Novel compositions and methods |
IL309536A (en) | 2016-01-26 | 2024-02-01 | Intra Cellular Therapies Inc | organic compounds |
US10961245B2 (en) | 2016-12-29 | 2021-03-30 | Intra-Cellular Therapies, Inc. | Substituted heterocycle fused gamma-carbolines for treatment of central nervous system disorders |
US10906906B2 (en) | 2016-12-29 | 2021-02-02 | Intra-Cellular Therapies, Inc. | Organic compounds |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3000892A (en) * | 1959-11-16 | 1961-09-19 | Paul A J Janssen | 1-aroylalkyl-4-aroylpiperazines |
GB1150245A (en) * | 1966-03-04 | 1969-04-30 | Chinoin Gyogyszer Es Vegyeszet | New Piperazine Derivatives and a Process for the Preparation thereof. |
GB1143882A (sv) * | 1966-06-21 | |||
GB1186495A (en) * | 1968-02-20 | 1970-04-02 | Delalande Sa | 0-[3-(4-Fluorobenzoyl) Proplyl]-4-Substituted Piperazines, their Acid Addition Salts and their method of preparation |
FR2262521A1 (en) * | 1973-08-08 | 1975-09-26 | Delalande Sa | 3-(3,4,5-Trimethoxyphenyl)piperazines - with coronary vasodilator, hypotensive, antiinflammatory, analgesic, and antiulcer activity |
AR207031A1 (es) * | 1974-03-06 | 1976-09-09 | Kyorin Seiyaku Kk | Procedimiento para preparacion de nuevos derivados de 1-(3-fenilpropil)-4-furoilpiperacina |
JPS5143772A (en) * | 1974-09-26 | 1976-04-14 | Kyorin Seiyaku Kk | 11 * 33 fuenirupuropiru * 44 furoirupiperajinjudotaino seizoho |
JPS50131974A (sv) * | 1974-03-06 | 1975-10-18 | ||
JPS518283A (en) * | 1974-07-09 | 1976-01-23 | Kyorin Seiyaku Kk | 11 * 33 fuenirupuropiru * 44 karubamoirupiperajinjudotaino seizoho |
JPS5346988A (en) * | 1976-10-07 | 1978-04-27 | Kyorin Seiyaku Kk | Piperadine derivative |
NO154582C (no) * | 1978-10-20 | 1986-11-05 | Ferrosan Ab | Analogifremgangsmaate for fremstilling av terapeutisk aktive difenyl-dibutylpiperazinkarboksamider. |
JPS57500828A (sv) * | 1980-06-16 | 1982-05-13 | ||
ATE28327T1 (de) * | 1981-12-02 | 1987-08-15 | Ferrosan Ab | 1-piperazinocarboxylate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen. |
-
1983
- 1983-08-10 SE SE8304361A patent/SE8304361D0/sv unknown
-
1984
- 1984-08-01 IL IL72563A patent/IL72563A/xx not_active IP Right Cessation
- 1984-08-02 AT AT84850237T patent/ATE47850T1/de not_active IP Right Cessation
- 1984-08-02 WO PCT/SE1984/000269 patent/WO1985000811A1/en active IP Right Grant
- 1984-08-02 HU HU843341A patent/HU196977B/hu unknown
- 1984-08-02 AU AU32111/84A patent/AU569537B2/en not_active Expired
- 1984-08-02 JP JP59503010A patent/JPH0723364B2/ja not_active Expired - Lifetime
- 1984-08-02 DE DE8484850237T patent/DE3480395D1/de not_active Expired
- 1984-08-02 EP EP84850237A patent/EP0136274B1/en not_active Expired
- 1984-08-09 CA CA000460595A patent/CA1253148A/en not_active Expired
- 1984-08-09 NZ NZ209166A patent/NZ209166A/en unknown
- 1984-08-09 IE IE205084A patent/IE58065B1/en not_active IP Right Cessation
- 1984-08-09 ES ES535027A patent/ES8705411A1/es not_active Expired
-
1985
- 1985-04-03 FI FI851350A patent/FI80449C/sv not_active IP Right Cessation
- 1985-04-09 DK DK157485A patent/DK157864C/da not_active IP Right Cessation
-
1986
- 1986-02-14 ES ES552001A patent/ES8704917A1/es not_active Expired
- 1986-08-01 ES ES556989A patent/ES8802039A1/es not_active Expired
-
1988
- 1988-07-29 US US07/227,420 patent/US4935419A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
ES8802039A1 (es) | 1988-03-16 |
IE842050L (en) | 1985-02-10 |
EP0136274A1 (en) | 1985-04-03 |
FI851350L (fi) | 1985-04-03 |
DK157864B (da) | 1990-02-26 |
ES8704917A1 (es) | 1987-04-16 |
DK157485D0 (da) | 1985-04-09 |
AU3211184A (en) | 1985-03-12 |
WO1985000811A1 (en) | 1985-02-28 |
ES556989A0 (es) | 1988-03-16 |
AU569537B2 (en) | 1988-02-04 |
FI80449C (sv) | 1990-06-11 |
IE58065B1 (en) | 1993-06-30 |
DE3480395D1 (en) | 1989-12-14 |
US4935419A (en) | 1990-06-19 |
ES535027A0 (es) | 1987-05-01 |
CA1253148A (en) | 1989-04-25 |
IL72563A0 (en) | 1984-11-30 |
JPS60501956A (ja) | 1985-11-14 |
DK157485A (da) | 1985-04-09 |
FI851350A0 (fi) | 1985-04-03 |
HU196977B (en) | 1989-02-28 |
HUT37415A (en) | 1985-12-28 |
ATE47850T1 (de) | 1989-11-15 |
DK157864C (da) | 1990-07-23 |
IL72563A (en) | 1988-10-31 |
FI80449B (fi) | 1990-02-28 |
ES552001A0 (es) | 1987-04-16 |
NZ209166A (en) | 1987-07-31 |
ES8705411A1 (es) | 1987-05-01 |
JPH0723364B2 (ja) | 1995-03-15 |
EP0136274B1 (en) | 1989-11-08 |
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