ES2057101T3 - Agente terapeutico para las enfermedades del higado y derivados de la piperazina. - Google Patents
Agente terapeutico para las enfermedades del higado y derivados de la piperazina.Info
- Publication number
- ES2057101T3 ES2057101T3 ES89300743T ES89300743T ES2057101T3 ES 2057101 T3 ES2057101 T3 ES 2057101T3 ES 89300743 T ES89300743 T ES 89300743T ES 89300743 T ES89300743 T ES 89300743T ES 2057101 T3 ES2057101 T3 ES 2057101T3
- Authority
- ES
- Spain
- Prior art keywords
- group
- alkyl
- therapeutic agent
- aralkyl
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/21—Radicals derived from sulfur analogues of carbonic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
- C07D317/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F02—COMBUSTION ENGINES; HOT-GAS OR COMBUSTION-PRODUCT ENGINE PLANTS
- F02M—SUPPLYING COMBUSTION ENGINES IN GENERAL WITH COMBUSTIBLE MIXTURES OR CONSTITUENTS THEREOF
- F02M11/00—Multi-stage carburettors, Register-type carburettors, i.e. with slidable or rotatable throttling valves in which a plurality of fuel nozzles, other than only an idling nozzle and a main one, are sequentially exposed to air stream by throttling valve
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Combustion & Propulsion (AREA)
- Mechanical Engineering (AREA)
- General Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
LA INVENCION SE REFIERE A UN AGENTE TERAPEUTICO PARA ENFERMEDADES DEL HIGADO QUE CONTIENE COMO INGREDIENTE ACTIVO UN DERIVADO DE PIPERAZINA DE FORMULA(I) EN LA QUE A ES UN GRUPO FENILO, P BENZOQUINONILO O CUMARINILO QUE PUEDE TENER AL MENOS UN SUSTITUYENTE SELECCIONADO DEL GRUPO FORMADO POR HALOGENO, ALQUILO, FLUOROALQUILO, FORMILO, MERCAPTO, ALQUILTIO Y NITRO; B ES UN ENLACE SENCILLO O UN GRUPO ALQUILENO DE CADENA RECTA CONTENIENDO DE 1 A 4 C QUE PUEDEN TENER POR LO MENOS UN SUSTITUYENTE SELECCIONADO DEL GRUPO FORMADO POR ALQUILO, ARILO, ARALQUILO, HIDROXI Y OXO; R ES UN ATOMO O GRUPO SELECCIONADO DEL GRUPO FORMADO POR H, METAL ALCALINO O ALCALINOTERREO, ALQUILO CICLOALQUILO, ARALQUILO, Y ARILO, Y N ES 2 O 3, O A UNA SAL SUYA ACEPTABLE PARA EMPLEO FARMACEUTICO.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP1362288 | 1988-01-26 | ||
JP8446188 | 1988-04-05 | ||
JP8446088 | 1988-04-05 | ||
JP8445988 | 1988-04-05 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2057101T3 true ES2057101T3 (es) | 1994-10-16 |
Family
ID=27456040
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES89300743T Expired - Lifetime ES2057101T3 (es) | 1988-01-26 | 1989-01-26 | Agente terapeutico para las enfermedades del higado y derivados de la piperazina. |
Country Status (8)
Country | Link |
---|---|
US (2) | US5070089A (es) |
EP (1) | EP0326379B1 (es) |
KR (1) | KR890011868A (es) |
AT (1) | ATE106398T1 (es) |
AU (1) | AU609933B2 (es) |
CA (1) | CA1326451C (es) |
DE (1) | DE68915555T2 (es) |
ES (1) | ES2057101T3 (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9004348D0 (en) * | 1990-02-27 | 1990-04-25 | Orion Yhtymae Oy | New use of catechol derivatives and their physiologically acceptable salts and esters |
US5489614A (en) * | 1987-11-27 | 1996-02-06 | Orion-Yhtyma Oy | Catechol derivatives, their physiologically acceptable salts, esters and use |
KR890011868A (ko) * | 1988-01-26 | 1989-08-23 | 원본미기재 | 간질환 치료제 및 피페라진 유도체 |
HU214331B (hu) * | 1992-06-17 | 1998-03-02 | Gyógyszerkutató Intézet Kft. | Eljárás piperazin- és homopiperazinszármazékok és ezeket tartalmazó gyógyszerkészítmények előállítására |
FR2703048B1 (fr) * | 1993-03-24 | 1996-01-05 | Adir | Nouveaux composes n-benzylpiperazine, leur procede de preparation et les compositions pharmaceutiques les renfermant. |
FR2757164B1 (fr) * | 1996-12-16 | 1999-01-22 | Adir | Nouveaux derives de n-benzylpiperazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
CN1157388C (zh) * | 2001-05-29 | 2004-07-14 | 北京大学 | 哌嗪基二硫代甲酸酯类化合物,它们的制备方法和在抗肿瘤药物中的应用 |
US20110190749A1 (en) * | 2008-11-24 | 2011-08-04 | Mcmillan Kathleen | Low Profile Apparatus and Method for Phototherapy |
EP3235815A1 (de) * | 2016-04-19 | 2017-10-25 | Philipps-Universität Marburg | Wirkstoffe gegen parasitäre helminthen |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3449360A (en) * | 1965-02-17 | 1969-06-10 | Ciba Geigy Corp | Dithioacid esters |
US3740430A (en) * | 1967-12-14 | 1973-06-19 | Astra Ab | Method for inhibiting dopamine-beta-hydroxylase using piperazine derivatives of dithiocarboxylates,and pharmaceutical preparations thereof |
NO125185B (es) * | 1967-12-14 | 1972-07-31 | Astra Ab | |
GB1261345A (en) * | 1968-03-07 | 1972-01-26 | Ici Ltd | Sulphur-containing benzyl derivatives and pesticidal compositions containing them |
FR2081589A1 (en) * | 1970-03-26 | 1971-12-10 | Roussel Uclaf | N,n-hexamethylenedithiocarbamates - as hepato protective agents |
US4076814A (en) * | 1975-06-09 | 1978-02-28 | Sankyo Company Limited | Preventive and curative compositions against mycoplasmosis |
DE2713586A1 (de) * | 1976-04-09 | 1977-10-20 | Sandoz Ag | Neue organische verbindungen, verfahren zu ihrer herstellung und ihre verwendung |
SE8304361D0 (sv) * | 1983-08-10 | 1983-08-10 | Ferrosan Ab | Novel 1-acylpiperazine derivatives novel 1-acylpiperazine derivatives |
KR890011868A (ko) * | 1988-01-26 | 1989-08-23 | 원본미기재 | 간질환 치료제 및 피페라진 유도체 |
-
1989
- 1989-01-26 KR KR1019890000841A patent/KR890011868A/ko not_active Application Discontinuation
- 1989-01-26 US US07/302,552 patent/US5070089A/en not_active Expired - Fee Related
- 1989-01-26 ES ES89300743T patent/ES2057101T3/es not_active Expired - Lifetime
- 1989-01-26 AT AT89300743T patent/ATE106398T1/de active
- 1989-01-26 DE DE68915555T patent/DE68915555T2/de not_active Expired - Fee Related
- 1989-01-26 CA CA000589290A patent/CA1326451C/en not_active Expired - Fee Related
- 1989-01-26 EP EP89300743A patent/EP0326379B1/en not_active Expired - Lifetime
- 1989-01-27 AU AU28870/89A patent/AU609933B2/en not_active Ceased
-
1994
- 1994-06-07 US US08/255,120 patent/US5446146A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
KR890011868A (ko) | 1989-08-23 |
US5070089A (en) | 1991-12-03 |
EP0326379B1 (en) | 1994-06-01 |
AU609933B2 (en) | 1991-05-09 |
AU2887089A (en) | 1989-07-27 |
CA1326451C (en) | 1994-01-25 |
EP0326379A2 (en) | 1989-08-02 |
EP0326379A3 (en) | 1991-01-09 |
DE68915555T2 (de) | 1994-10-20 |
US5446146A (en) | 1995-08-29 |
ATE106398T1 (de) | 1994-06-15 |
DE68915555D1 (de) | 1994-07-07 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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