LU91832I2 - Fingolimod et ses dérivés pharmaceutiquement acceptables (GILENYA®) - Google Patents
Fingolimod et ses dérivés pharmaceutiquement acceptables (GILENYA®)Info
- Publication number
- LU91832I2 LU91832I2 LU91832C LU91832C LU91832I2 LU 91832 I2 LU91832 I2 LU 91832I2 LU 91832 C LU91832 C LU 91832C LU 91832 C LU91832 C LU 91832C LU 91832 I2 LU91832 I2 LU 91832I2
- Authority
- LU
- Luxembourg
- Prior art keywords
- optionally substituted
- pharmaceutically acceptable
- gilenya
- fingolimod
- same
- Prior art date
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- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/325—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
- A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
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- C07C215/04—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated
- C07C215/06—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic
- C07C215/10—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic with one amino group and at least two hydroxy groups bound to the carbon skeleton
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- C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C215/04—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated
- C07C215/06—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic
- C07C215/18—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic with hydroxy groups and at least two amino groups bound to the carbon skeleton
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C215/04—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated
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- C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
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- C07C215/24—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and acyclic
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- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
- C07C215/26—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing rings other than six-membered aromatic rings
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- C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
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- C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
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- C07C215/34—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings containing hydroxy groups and carbon atoms of six-membered aromatic rings bound to the same carbon atom of the carbon skeleton and at least one hydroxy group bound to another carbon atom of the carbon skeleton
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- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C215/48—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups
- C07C215/54—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups linked by carbon chains having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
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- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
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- C07—ORGANIC CHEMISTRY
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- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/68—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings and hydroxy groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
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- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C217/28—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines
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- C07—ORGANIC CHEMISTRY
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Applications Claiming Priority (3)
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JP28328192 | 1992-10-21 | ||
JP17942793 | 1993-07-20 | ||
PCT/JP1993/001515 WO1994008943A1 (fr) | 1992-10-21 | 1993-10-18 | Compose 2-amino-1,3-propanediol et immunosuppresseur |
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LU91832I2 true LU91832I2 (fr) | 2011-08-30 |
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LU91832C LU91832I2 (fr) | 1992-10-21 | 2011-06-30 | Fingolimod et ses dérivés pharmaceutiquement acceptables (GILENYA®) |
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US (3) | US5604229A (fr) |
EP (1) | EP0627406B1 (fr) |
JP (1) | JP2579602B2 (fr) |
KR (1) | KR0155015B1 (fr) |
AT (1) | ATE172711T1 (fr) |
CA (1) | CA2126337C (fr) |
CY (2) | CY2215B1 (fr) |
DE (2) | DE122011100012I1 (fr) |
DK (1) | DK0627406T3 (fr) |
ES (1) | ES2126658T3 (fr) |
HK (1) | HK1013281A1 (fr) |
LU (1) | LU91832I2 (fr) |
WO (1) | WO1994008943A1 (fr) |
Families Citing this family (160)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5948820A (en) * | 1994-08-22 | 1999-09-07 | Yoshitomi Pharmaceutical Industries, Ltd. | Benzene compound and pharmaceutical use thereof |
KR100358922B1 (ko) * | 1994-08-22 | 2003-01-24 | 미쯔비시 웰 파마 가부시키가이샤 | 벤젠화합물및그의의약으로서의용도 |
HU224814B1 (en) * | 1995-12-28 | 2006-02-28 | Mitsubishi Pharma Corp | Use of propane-1,3-diol derivative for the preparation of a medicament useful for the topical treating of inflammatory and immune diseases |
US6476004B1 (en) | 1996-07-18 | 2002-11-05 | Mitsubishi Pharma Corporation | Pharmaceutical composition |
JPH11209277A (ja) * | 1998-01-19 | 1999-08-03 | Yoshitomi Pharmaceut Ind Ltd | 医薬組成物 |
JP2002241272A (ja) * | 1996-07-18 | 2002-08-28 | Mitsubishi Pharma Corp | 医薬処方組成物 |
GB9624038D0 (en) * | 1996-11-19 | 1997-01-08 | Sandoz Ltd | Organic compounds |
DK0990440T3 (da) * | 1997-02-27 | 2009-02-23 | Novartis Ag | Farmaceutisk sammensætning indeholdende 2-amino-2[2-(4-octylphenyl)-ethyl]-propan-1,3-diol, en lecithin og et saccharid |
ATE271028T1 (de) * | 1997-04-04 | 2004-07-15 | Mitsubishi Pharma Corp | 2-aminopropan-1,3-diol-verbindungen, ihre medizinische anwendung und zwischenprodukte zu ihrer synthese |
WO1999001420A1 (fr) * | 1997-07-03 | 1999-01-14 | Taito Co., Ltd. | Procede de preparation de derives d'acide 2-aminomalonique, et intermediaires utilises dans ce procede |
JPH1180026A (ja) | 1997-09-02 | 1999-03-23 | Yoshitomi Pharmaceut Ind Ltd | 新規免疫抑制剤、その使用方法およびその同定方法 |
ES2237970T3 (es) | 1998-11-11 | 2005-08-01 | Novartis Ag | Produccion de 2-amino-2-(2-(4-alquil c2-20-fenil)etil)propano-1,3-dioles. |
CN1144779C (zh) * | 1999-03-11 | 2004-04-07 | 杭州中美华东制药有限公司 | 制备2-[2-(4-烷基苯基)-乙基]-2-氨基-丙二醇的方法以及其中制得的中间产物 |
JP4627356B2 (ja) | 1999-06-30 | 2011-02-09 | 松森 昭 | ウイルス性心筋炎の予防または治療薬剤 |
WO2001008685A1 (fr) * | 1999-07-30 | 2001-02-08 | Vertex Pharmaceuticals Incorporated | Derives d'amines acycliques et cycliques |
SK152003A3 (en) | 2000-07-13 | 2004-07-07 | Sankyo Co | Amino alcohol derivatives |
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JPS6050186B2 (ja) * | 1980-07-15 | 1985-11-07 | 三井東圧化学株式会社 | 2−メルカプトエチルアミンハロゲン化水素酸塩類の製造法 |
JPS6050783B2 (ja) * | 1981-03-20 | 1985-11-11 | 三井東圧化学株式会社 | S,s′−ビス(2−アミノエチル)ジチオカ−ボネ−トジハイドロハライド誘導体の製造方法 |
JPS58101108A (ja) * | 1981-12-11 | 1983-06-16 | Unitika Ltd | キレ−ト形成基を有するフエノ−ル樹脂とその製造方法及び吸着処理方法 |
DE3420308C2 (de) * | 1983-05-31 | 1998-06-18 | Toyo Boseki | Polyurethanzusammensetzung mit verbesserten Färbeeigenschaften |
US4910218A (en) * | 1985-11-22 | 1990-03-20 | Burroughs Wellcome Co. | Phenanthro[2,3-6]thiophene derivatives, pharmaceutical compositions and use |
JPS632904A (ja) * | 1986-06-20 | 1988-01-07 | Ss Pharmaceut Co Ltd | 植物生長調節剤 |
JPS6343140A (ja) * | 1986-08-08 | 1988-02-24 | Fuji Photo Film Co Ltd | ハロゲン化銀カラ−写真感光材料の処理方法 |
EP0410176A1 (fr) * | 1989-07-07 | 1991-01-30 | Yoshitomi Pharmaceutical Industries, Ltd. | Composés dérivés de l'acide amino-2 pentanoique et leur application comme immunosuppresseurs |
EP0450527A3 (fr) * | 1990-03-30 | 1991-10-30 | Kao Corporation | Amides N-tris (hydroxyméthyl)méthyl d'acides gras et compositions cosmétiques les contenant |
JPH049309A (ja) * | 1990-04-25 | 1992-01-14 | Kao Corp | 化粧料 |
JPH0469320A (ja) * | 1990-07-06 | 1992-03-04 | Kao Corp | 毛髪化粧料 |
JP2868887B2 (ja) * | 1990-11-06 | 1999-03-10 | 花王株式会社 | 薬用化粧料 |
JPH04224548A (ja) * | 1990-12-26 | 1992-08-13 | Kao Corp | 脂肪酸アミドの製造方法 |
EP0576605A4 (en) * | 1991-03-19 | 1994-06-08 | Vithal J Rajadhyaksha | Compositions and method comprising aminoalcohol derivatives as membrane penetration enhancers |
JPH0578294A (ja) * | 1991-09-19 | 1993-03-30 | Kao Corp | 分岐脂肪酸アミド並びにその製造方法及び製造中間体 |
-
1993
- 1993-10-18 DK DK93923035T patent/DK0627406T3/da active
- 1993-10-18 KR KR1019940702174A patent/KR0155015B1/ko not_active IP Right Cessation
- 1993-10-18 US US08/244,942 patent/US5604229A/en not_active Expired - Lifetime
- 1993-10-18 JP JP6509845A patent/JP2579602B2/ja not_active Expired - Lifetime
- 1993-10-18 CA CA002126337A patent/CA2126337C/fr not_active Expired - Lifetime
- 1993-10-18 DE DE201112100012 patent/DE122011100012I1/de active Pending
- 1993-10-18 DE DE69321823T patent/DE69321823T2/de not_active Expired - Lifetime
- 1993-10-18 WO PCT/JP1993/001515 patent/WO1994008943A1/fr active IP Right Grant
- 1993-10-18 AT AT93923035T patent/ATE172711T1/de active
- 1993-10-18 ES ES93923035T patent/ES2126658T3/es not_active Expired - Lifetime
- 1993-10-18 EP EP93923035A patent/EP0627406B1/fr not_active Expired - Lifetime
-
1996
- 1996-10-02 US US08/725,890 patent/US5719176A/en not_active Expired - Lifetime
-
1997
- 1997-08-14 US US08/911,602 patent/US5952316A/en not_active Expired - Lifetime
-
1998
- 1998-12-22 HK HK98114539A patent/HK1013281A1/xx not_active IP Right Cessation
-
2000
- 2000-04-27 CY CY0000010A patent/CY2215B1/xx unknown
-
2011
- 2011-06-30 CY CY2011006C patent/CY2011006I2/el unknown
- 2011-06-30 LU LU91832C patent/LU91832I2/fr unknown
Also Published As
Publication number | Publication date |
---|---|
EP0627406A4 (fr) | 1995-04-12 |
EP0627406A1 (fr) | 1994-12-07 |
DE69321823T2 (de) | 1999-06-02 |
US5952316A (en) | 1999-09-14 |
KR0155015B1 (ko) | 1998-12-01 |
CY2215B1 (en) | 2003-04-18 |
ES2126658T3 (es) | 1999-04-01 |
CA2126337C (fr) | 2003-06-24 |
DE69321823D1 (de) | 1998-12-03 |
DK0627406T3 (da) | 1999-07-12 |
WO1994008943A1 (fr) | 1994-04-28 |
CA2126337A1 (fr) | 1994-04-28 |
CY2011006I1 (el) | 2016-12-14 |
KR940703803A (ko) | 1994-12-12 |
US5604229A (en) | 1997-02-18 |
HK1013281A1 (en) | 1999-08-20 |
EP0627406B1 (fr) | 1998-10-28 |
CY2011006I2 (el) | 2016-12-14 |
DE122011100012I1 (de) | 2011-10-20 |
JP2579602B2 (ja) | 1997-02-05 |
US5719176A (en) | 1998-02-17 |
ATE172711T1 (de) | 1998-11-15 |
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