ES2098346T3 - Inhibidores de la dihidrofolato reductasa de pneumocystis carinii. - Google Patents

Inhibidores de la dihidrofolato reductasa de pneumocystis carinii.

Info

Publication number
ES2098346T3
ES2098346T3 ES91901399T ES91901399T ES2098346T3 ES 2098346 T3 ES2098346 T3 ES 2098346T3 ES 91901399 T ES91901399 T ES 91901399T ES 91901399 T ES91901399 T ES 91901399T ES 2098346 T3 ES2098346 T3 ES 2098346T3
Authority
ES
Spain
Prior art keywords
triazine
pneumocystis carinii
reductase inhibitors
formula
carinii
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91901399T
Other languages
English (en)
Inventor
Daniel V Santi
Charles K Marlowe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis Vaccines and Diagnostics Inc
Original Assignee
Chiron Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiron Corp filed Critical Chiron Corp
Application granted granted Critical
Publication of ES2098346T3 publication Critical patent/ES2098346T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrane Compounds (AREA)

Abstract

METODO PARA INHIBIR EL CRECIMIENTO DEL PNEUMOCYSTIS CARINII EN UN HUESPED MAMIFERO, QUE COMPRENDE LA ADMINISTRACION AL HUESPED DE UNA CANTIDAD DE L FENIL INHIBIR EL CRECIMIENTO DEL P. CARINII. LOS COMPUESTOS PREFERIDOS TIENEN LA FORMULA (I), EN DONDE X, Y Y Z SE SELECCIONAN INDEPENDIENTEMENTE DE SUSTITUTOS ORGANICOS PREFERIDOS DESCRITOS EN LA ESPECIFICACION; R1 ES ALQUILO INFERIOR, Y R2 ES HIDROGENO O METILO; ASI COMO COMPUESTOS FORMADOS POR REACCION DE UN ACIDO ORGANICO O INORGANICO CON UNA TRIAZINA DE ESTA FORMULA PARA FORMAR UN AMIDO O UNA SAL DE ADICION ACIDA. LA ADMINISTRACION DE PRECURSORES QUE FORMAN LA TRIAZINA IN VIVO TAMBIEN ESTA COMPRENDIDO EN EL OBJETIVO DE ESTA INVENCION.
ES91901399T 1989-12-07 1990-12-07 Inhibidores de la dihidrofolato reductasa de pneumocystis carinii. Expired - Lifetime ES2098346T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US44718189A 1989-12-07 1989-12-07

Publications (1)

Publication Number Publication Date
ES2098346T3 true ES2098346T3 (es) 1997-05-01

Family

ID=23775321

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91901399T Expired - Lifetime ES2098346T3 (es) 1989-12-07 1990-12-07 Inhibidores de la dihidrofolato reductasa de pneumocystis carinii.

Country Status (11)

Country Link
EP (1) EP0504290B1 (es)
JP (1) JPH06504258A (es)
AT (1) ATE147938T1 (es)
CA (1) CA2069941A1 (es)
DE (1) DE69029814T2 (es)
DK (1) DK0504290T3 (es)
ES (1) ES2098346T3 (es)
GR (1) GR3023144T3 (es)
IE (1) IE904432A1 (es)
PT (1) PT96123B (es)
WO (2) WO1991008667A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR1003549B (el) * 1998-07-13 2001-03-12 Λιποφιλες σπειρανικες, 4,6-διαμινο-συμμετρικες τριαζινες και τα αντιστοιχα αλατα, τα ισομερη, στερεομερη και εναντιομερη τους, αναστολεις του ενζυμου της διυδροφολικης αναγωγασης
GR1003539B (el) * 1999-10-20 2001-03-07 Σειρα νεων λιποφιλων σπειρανικων, 4,6-διαμινο-συμμετρικων-τριαζινων και των αντιστοιχων αλατων, ισομερων, στερεομερων, εναντιομερων τους και των βασεων και συμπλοκων αυτων, αναστολεις του ενζυμου της διυδροφολικης αναγωγασης
GB0001565D0 (en) * 2000-01-24 2000-03-15 Isis Innovation Dihydrofolate reductase inhibitors
US7252679B2 (en) 2001-09-13 2007-08-07 Cordis Corporation Stent with angulated struts
US20110207926A1 (en) 2008-08-25 2011-08-25 Hamari Chemicals, Ltd. Novel dihydrotriazine derivative

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3123527A (en) * 1964-03-03 Antibacterkl compositions
US2836539A (en) * 1958-05-27 cizhiynss-hci
US3074947A (en) * 1963-01-22 Certificate of correction
US2823161A (en) * 1955-03-30 1958-02-11 Whitmoyer Lab Inc Substituted triazine compositions for chemotherapy of coccidiosis
US2959519A (en) * 1958-08-11 1960-11-08 Monsanto Chemicals Fungicidal composition comprising a 2-halo-4, 6-bis (amino)-s-triazine
US3215600A (en) * 1962-06-29 1965-11-02 Parke Davis & Co Antimalarial composition containing an acylated sulfonylaniline with triazine or pyrimidine salt, and method of use
GB1504304A (en) * 1974-02-15 1978-03-15 Ici Ltd Process of combating fungal and bacterial infections of plants with triazine dione derivatives

Also Published As

Publication number Publication date
PT96123A (pt) 1991-09-30
JPH06504258A (ja) 1994-05-19
EP0504290B1 (en) 1997-01-22
EP0504290A1 (en) 1992-09-23
WO1991008667A1 (en) 1991-06-27
PT96123B (pt) 1998-08-31
IE904432A1 (en) 1991-06-19
GR3023144T3 (en) 1997-07-30
WO1991008668A1 (en) 1991-06-27
ATE147938T1 (de) 1997-02-15
DE69029814D1 (de) 1997-03-06
CA2069941A1 (en) 1991-06-08
EP0504290A4 (en) 1993-03-24
DE69029814T2 (de) 1997-07-10
DK0504290T3 (da) 1997-08-11

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