AR072776A1 - Procesos para la produccion de 2-amino-2-[2-(4-alquil c2-20-fenil)etil]propano-1,3-dioles y a compuestos intermediarios para usar con los mismos - Google Patents
Procesos para la produccion de 2-amino-2-[2-(4-alquil c2-20-fenil)etil]propano-1,3-dioles y a compuestos intermediarios para usar con los mismosInfo
- Publication number
- AR072776A1 AR072776A1 ARP090100955A AR072776A1 AR 072776 A1 AR072776 A1 AR 072776A1 AR P090100955 A ARP090100955 A AR P090100955A AR 072776 A1 AR072776 A1 AR 072776A1
- Authority
- AR
- Argentina
- Prior art keywords
- formula
- compound
- alkyl
- production
- salt
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
- C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
- C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
- C07C215/30—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings containing hydroxy groups and carbon atoms of six-membered aromatic rings bound to the same carbon atom of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/22—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/51—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Transplantation (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Reivindicacion 1: Un proceso para la produccion de un compuesto de la formula (1) o una sal del mismo aceptable desde el punto de vista farmacéutico, donde R1 es hidrogeno o alquilo C1-18; que comprende: (a) reducir un compuesto de la formula (3) en donde R2 es un grupo protector; y ô- - - -ô representa un tercer enlace opcional; para formar un compuesto de la formula (2); (b) desproteger el compuesto de formula (2) para formar un compuesto de formula (1); y (c) convertir opcionalmente el compuesto de formula (1) en una sal aceptable desde el punto de vista farmacéutico. Reivindicacion 4: Un proceso para la produccion de un compuesto de la formula (2) o una sal del mismo, donde R1 es hidrogeno o alquilo C1-18; y R2 es un grupo protector; que comprende reducir un compuesto de la formula (3) o la formula (10) donde R2 es un grupo protector; cada R3 es independientemente alquilo C1-4; y ô- - - -ô representa un tercer enlace opcional. Reivindicacion 5: Un proceso para la produccion de un compuesto de la formula (3) o una sal del mismo, donde R1 es hidrogeno o alquilo C1-18; R2 es un grupo protector; y ô- - - -ô representa un tercer enlace opcional; que comprende: (a) reaccionar un compuesto de la formula (5) donde R4 es un grupo saliente; con un compuesto de la formula (6), o (b) reducir un compuesto de la formula (10), donde cada R3 es independientemente alquilo C1-4. Reivindicacion 6: Un proceso para la produccion de un compuesto de la formula (4) o una sal del mismo, donde R1 es hidrogeno o alquilo C1-18; R2 es un grupo protector; y cada R3 es independientemente alquilo C1-4; que comprende reducir un compuesto de la formula (10) donde ô- - - -ô representa un tercer enlace opcional. Reivindicacion 8: Un proceso para la produccion de un compuesto de la formula (10) o una sal del mismo, donde R1 es hidrogeno o alquilo C1-18; R2 es un grupo protector; cada R3 es independientemente alquilo C1-4; y ô- - - -ô representa un tercer enlace opcional; que comprende reaccionar un compuesto de la formula (7) con un compuesto de la formula (6). Reivindicacion 9: Un proceso para la produccion de un compuesto de la formula (7) o una sal del mismo, donde R2 es un grupo protector; cada R3 es independientemente alquilo C1-4; y R4 es un grupo saliente; que comprende reaccionar un compuesto de la formula (8) con un compuesto de la formula (9), donde R5 es un grupo saliente. Reivindicacion 10: Un proceso para la produccion de un compuesto de la formula (10) o una sal del mismo, donde R1 es hidrogeno o alquilo C1-18; R2 es un grupo protector; cada R3 es independientemente alquilo C1-4; y ô- - - -ô representa un tercer enlace opcional; que comprende los pasos de: (a) reaccionar un compuesto de la formula (8) con un compuesto de la formula (9), donde cada R4 y R5 es un grupo saliente, para obtener un compuesto de formula (7); (b) reaccionar un compuesto de la formula (6) con el compuesto que se obtuvo en el paso (a) para obtener un compuesto de formula (10).
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP08153033 | 2008-03-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR072776A1 true AR072776A1 (es) | 2010-09-22 |
Family
ID=40848446
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP090100955 AR072776A1 (es) | 2008-03-19 | 2009-03-17 | Procesos para la produccion de 2-amino-2-[2-(4-alquil c2-20-fenil)etil]propano-1,3-dioles y a compuestos intermediarios para usar con los mismos |
Country Status (17)
Country | Link |
---|---|
US (2) | US8809571B2 (es) |
EP (1) | EP2268603B1 (es) |
JP (2) | JP5698118B2 (es) |
KR (1) | KR101641742B1 (es) |
CN (1) | CN101959845A (es) |
AR (1) | AR072776A1 (es) |
AU (1) | AU2009226975B2 (es) |
BR (1) | BRPI0908727A2 (es) |
CA (1) | CA2717934C (es) |
ES (1) | ES2536552T3 (es) |
IL (1) | IL208019A (es) |
MX (1) | MX2010009931A (es) |
PL (1) | PL2268603T3 (es) |
PT (1) | PT2268603E (es) |
RU (1) | RU2529474C2 (es) |
WO (1) | WO2009115534A1 (es) |
ZA (1) | ZA201006058B (es) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2536552T3 (es) * | 2008-03-19 | 2015-05-26 | Novartis Ag | Proceso para la preparación de 2-amino-2-[2-(4-alquil-C3-C21-fenil)etil]propano-1,3-dioles |
US8766005B2 (en) | 2009-07-24 | 2014-07-01 | Ratiopharm Gmbh | Process for producing fingolimod salts |
WO2012071524A1 (en) | 2010-11-24 | 2012-05-31 | Ratiopharm Gmbh | Arylsulfonate salts of fingolimod and processes for preparation thereof |
WO2012146980A2 (en) | 2011-04-29 | 2012-11-01 | Dr. Reddy's Laboratories Ltd. | Preparation of fingolimod and its salts |
CZ2012406A3 (cs) | 2012-06-15 | 2013-12-27 | Zentiva, K.S. | Způsob výroby fingolimodu založený na otevírání aziridinového kruhu |
JP7078190B1 (ja) | 2022-01-31 | 2022-05-31 | トヨタ自動車株式会社 | 保持部材、射出装置、及び差し込み方向ガイド方法 |
JP7268779B1 (ja) | 2022-01-31 | 2023-05-08 | トヨタ自動車株式会社 | 保持部材 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2126658T3 (es) | 1992-10-21 | 1999-04-01 | Yoshitomi Pharmaceutical | Compuesto de 2-amino-1,3-propanodiol e inmunosupresor. |
IT1265101B1 (it) * | 1993-07-23 | 1996-10-30 | Erba Carlo Spa | Derivati dell'acido 2-ammino-4-fenil-4-osso butirrico |
DK1129066T3 (da) * | 1998-11-11 | 2005-03-29 | Novartis Ag | Fremstilling af 2-amino-2-[2-(C2-20alkylphenyl)ethyl]propan-1,3-dioler |
CN1144779C (zh) | 1999-03-11 | 2004-04-07 | 杭州中美华东制药有限公司 | 制备2-[2-(4-烷基苯基)-乙基]-2-氨基-丙二醇的方法以及其中制得的中间产物 |
CN1169768C (zh) * | 2002-04-26 | 2004-10-06 | 中国科学院上海有机化学研究所 | (4-炔基)-芳香酮酸类化合物、合成方法及应用 |
JP3972021B2 (ja) | 2003-05-28 | 2007-09-05 | 東京応化工業株式会社 | プラズマディスプレイ前面板製造用未焼成積層体およびプラズマディスプレイ前面板の製造方法 |
JP2008530135A (ja) * | 2005-02-14 | 2008-08-07 | ユニバーシティ オブ バージニア パテント ファンデーション | アミノ基およびフェニル基で置換されたシクロアルカンならびに5員の複素環を含むスフィンゴシン=1−リン酸アゴニスト |
TW200702326A (en) | 2005-05-31 | 2007-01-16 | Mitsubishi Pharma Corp | 2-aminobutanol compound and its pharmaceutical use |
ES2536552T3 (es) * | 2008-03-19 | 2015-05-26 | Novartis Ag | Proceso para la preparación de 2-amino-2-[2-(4-alquil-C3-C21-fenil)etil]propano-1,3-dioles |
-
2009
- 2009-03-17 ES ES09721774.9T patent/ES2536552T3/es active Active
- 2009-03-17 CA CA2717934A patent/CA2717934C/en active Active
- 2009-03-17 CN CN2009801074160A patent/CN101959845A/zh active Pending
- 2009-03-17 MX MX2010009931A patent/MX2010009931A/es active IP Right Grant
- 2009-03-17 EP EP20090721774 patent/EP2268603B1/en active Active
- 2009-03-17 US US12/933,131 patent/US8809571B2/en not_active Expired - Fee Related
- 2009-03-17 JP JP2011500204A patent/JP5698118B2/ja not_active Expired - Fee Related
- 2009-03-17 AR ARP090100955 patent/AR072776A1/es unknown
- 2009-03-17 PT PT97217749T patent/PT2268603E/pt unknown
- 2009-03-17 WO PCT/EP2009/053163 patent/WO2009115534A1/en active Application Filing
- 2009-03-17 AU AU2009226975A patent/AU2009226975B2/en not_active Ceased
- 2009-03-17 BR BRPI0908727-3A patent/BRPI0908727A2/pt not_active Application Discontinuation
- 2009-03-17 KR KR1020107023230A patent/KR101641742B1/ko active IP Right Grant
- 2009-03-17 RU RU2010142397/04A patent/RU2529474C2/ru active
- 2009-03-17 PL PL09721774T patent/PL2268603T3/pl unknown
-
2010
- 2010-08-25 ZA ZA2010/06058A patent/ZA201006058B/en unknown
- 2010-09-06 IL IL208019A patent/IL208019A/en active IP Right Grant
-
2013
- 2013-11-08 US US14/075,066 patent/US9133096B2/en not_active Expired - Fee Related
-
2014
- 2014-09-25 JP JP2014195051A patent/JP5955364B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US20140094625A1 (en) | 2014-04-03 |
PT2268603E (pt) | 2015-06-08 |
WO2009115534A1 (en) | 2009-09-24 |
CA2717934C (en) | 2017-07-18 |
AU2009226975B2 (en) | 2012-09-06 |
EP2268603B1 (en) | 2015-04-22 |
US8809571B2 (en) | 2014-08-19 |
JP5698118B2 (ja) | 2015-04-08 |
JP2015028056A (ja) | 2015-02-12 |
ES2536552T3 (es) | 2015-05-26 |
CA2717934A1 (en) | 2009-09-24 |
EP2268603A1 (en) | 2011-01-05 |
MX2010009931A (es) | 2010-09-30 |
IL208019A (en) | 2015-10-29 |
KR101641742B1 (ko) | 2016-07-21 |
CN101959845A (zh) | 2011-01-26 |
PL2268603T3 (pl) | 2015-07-31 |
JP5955364B2 (ja) | 2016-07-20 |
AU2009226975A1 (en) | 2009-09-24 |
US20110015425A1 (en) | 2011-01-20 |
KR20100127279A (ko) | 2010-12-03 |
US9133096B2 (en) | 2015-09-15 |
IL208019A0 (en) | 2010-12-30 |
RU2529474C2 (ru) | 2014-09-27 |
JP2011515364A (ja) | 2011-05-19 |
BRPI0908727A2 (pt) | 2015-07-28 |
ZA201006058B (en) | 2011-05-25 |
RU2010142397A (ru) | 2012-04-27 |
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