CO6210751A2 - Derivados de indolinona y procedimiento para su fabricacion - Google Patents
Derivados de indolinona y procedimiento para su fabricacionInfo
- Publication number
- CO6210751A2 CO6210751A2 CO10067260A CO10067260A CO6210751A2 CO 6210751 A2 CO6210751 A2 CO 6210751A2 CO 10067260 A CO10067260 A CO 10067260A CO 10067260 A CO10067260 A CO 10067260A CO 6210751 A2 CO6210751 A2 CO 6210751A2
- Authority
- CO
- Colombia
- Prior art keywords
- represent
- group
- hydrogen atom
- procedure
- manufacturing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Epidemiology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heat Sensitive Colour Forming Recording (AREA)
Abstract
La presente invención se refiere a derivados de indolinona específicos, a saber, los compuestos de la fórmulaen la que R1 representa un átomo de hidrógeno o un grupo CI-CH2-CO, y R2 y R3 representan, cada uno, un átomo de hidrógeno, o R2 y R3, tomados conjuntamente, representan un grupo con la condición de que cuando R1 representa un átomo de hidrógeno, R2 y R3, tomados conjuntamente, representan un grupo y a un procedimiento para su fabricación. 1.- Un compuesto de la fórmulaen la que R1 representa un átomo de hidrógeno o un grupo Cl-CH2-CO, y R2 y R3 representan, cada uno, un átomo de hidrógeno, o R2 y R3, tomados conjuntamente, representan un grupo con la condición de que cuando R1 representa un átomo de hidrógeno, R2 y R3, tomados conjuntamente, representan un grupo 2.- Un compuesto de la fórmula3.- Un compuesto de la fórmula
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP07122123 | 2007-12-03 |
Publications (1)
Publication Number | Publication Date |
---|---|
CO6210751A2 true CO6210751A2 (es) | 2010-10-20 |
Family
ID=40718253
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO10067260A CO6210751A2 (es) | 2007-12-03 | 2010-06-03 | Derivados de indolinona y procedimiento para su fabricacion |
Country Status (36)
Country | Link |
---|---|
US (1) | US8067617B2 (es) |
EP (1) | EP2229360B1 (es) |
JP (2) | JP5933924B2 (es) |
KR (2) | KR101712810B1 (es) |
CN (1) | CN101883755B (es) |
AR (1) | AR069531A1 (es) |
AU (1) | AU2008333287B2 (es) |
BR (1) | BRPI0819991B1 (es) |
CA (1) | CA2705490C (es) |
CL (1) | CL2008003599A1 (es) |
CO (1) | CO6210751A2 (es) |
CY (1) | CY1123333T1 (es) |
DK (1) | DK2229360T3 (es) |
EA (1) | EA016196B1 (es) |
EC (1) | ECSP10010195A (es) |
ES (1) | ES2818993T3 (es) |
HK (1) | HK1145682A1 (es) |
HR (1) | HRP20201480T1 (es) |
HU (1) | HUE051550T2 (es) |
IL (1) | IL205348A (es) |
LT (1) | LT2229360T (es) |
MA (1) | MA31989B1 (es) |
MX (1) | MX2010005557A (es) |
MY (1) | MY148574A (es) |
NZ (1) | NZ585798A (es) |
PE (1) | PE20091445A1 (es) |
PL (1) | PL2229360T3 (es) |
PT (1) | PT2229360T (es) |
RS (1) | RS60818B1 (es) |
SI (1) | SI2229360T1 (es) |
TN (1) | TN2010000248A1 (es) |
TW (1) | TWI432415B (es) |
UA (1) | UA97872C2 (es) |
UY (1) | UY31506A1 (es) |
WO (1) | WO2009071524A2 (es) |
ZA (1) | ZA201002723B (es) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
UY31506A1 (es) * | 2007-12-03 | 2009-08-03 | Derivados de indolinona y procedimiento para su preparacion | |
US20170065529A1 (en) | 2015-09-09 | 2017-03-09 | Boehringer Ingelheim International Gmbh | Pharmaceutical dosage form for immediate release of an indolinone derivative |
WO2012068441A2 (en) | 2010-11-19 | 2012-05-24 | Ratiopharm Gmbh | Intedanib salts and solid state forms thereof |
CN103787949A (zh) * | 2012-10-31 | 2014-05-14 | 韩冰 | 一类保护移植器官的化合物及其用途 |
US20140350022A1 (en) | 2013-05-10 | 2014-11-27 | Boehringer Ingelheim International Gmbh | Efficacious treatment of NSCLC and predictive clinical marker of the responsiveness of a tumour to a treatment |
EP3782604A1 (en) | 2013-07-31 | 2021-02-24 | Windward Pharma, Inc. | Aerosol tyrosine kinase inhibitor compounds and uses thereof |
US20140342772A1 (en) * | 2013-09-12 | 2014-11-20 | Bandwidth.Com, Inc. | Predictive Caching of IP Data |
CN104262232B (zh) * | 2014-09-09 | 2016-05-04 | 苏州明锐医药科技有限公司 | 尼泰达尼的制备方法 |
CN105712923A (zh) * | 2014-12-03 | 2016-06-29 | 江苏先声药业有限公司 | 一种尼达尼布杂质及其制备方法与应用 |
WO2016178064A1 (en) | 2015-05-06 | 2016-11-10 | Suven Life Sciences Limited | Polymorph of nintedanib ethanesulphonate, processes and intermediates thereof |
CN105001143A (zh) * | 2015-07-24 | 2015-10-28 | 南京正大天晴制药有限公司 | 一种制备高纯度乙磺酸尼达尼布的方法 |
WO2017077551A2 (en) | 2015-11-03 | 2017-05-11 | Mylan Laboratories Limited | An amorphous nintedanib esylate and solid dispersion thereof |
WO2017198202A1 (zh) * | 2016-05-19 | 2017-11-23 | 上海诚妙医药科技有限公司 | 尼达尼布的新晶型及其制备方法及其用途 |
CN106543069A (zh) * | 2016-09-20 | 2017-03-29 | 北京万全德众医药生物技术有限公司 | 6‑甲氧基羰基‑2‑氧代二氢吲哚的制备 |
CN108610308A (zh) * | 2016-12-09 | 2018-10-02 | 上海奥博生物医药技术有限公司 | 一锅法制备尼达尼布中间体的方法 |
CN106841495B (zh) * | 2017-04-21 | 2018-05-11 | 常州佳德医药科技有限公司 | 乙磺酸尼达尼布中基因毒性杂质的高灵敏度分析方法 |
WO2019048974A1 (en) * | 2017-09-06 | 2019-03-14 | Glenmark Pharmaceuticals Limited | PROCESS FOR PREPARING NINTEDANIB |
WO2019097112A1 (en) | 2017-11-17 | 2019-05-23 | Fermion Oy | Synthesis of a 2-indolinone derivative known as intermediate for preparing nintedanib |
CN110746378B (zh) * | 2018-12-03 | 2021-11-05 | 江苏豪森药业集团有限公司 | 一种胺基中间体的制备方法 |
CN111377845A (zh) * | 2018-12-27 | 2020-07-07 | 江苏先声药业有限公司 | 3-(二甲氨基(苯基)亚甲基)-2-氧化吲哚-6-羧酸甲酯及其制备方法与应用 |
CN111662223B (zh) * | 2019-03-08 | 2023-07-14 | 四川科伦药物研究院有限公司 | 二氢吲哚酮衍生物及其中间体的制备方法 |
WO2022029805A1 (en) * | 2020-08-07 | 2022-02-10 | Bdr Lifesciences Private Limited | An improved highly efficient process for the prepration of nintedanib and pharmaceutically acceptable salt thereof |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS4876863A (es) * | 1972-01-22 | 1973-10-16 | ||
US6469181B1 (en) | 1995-01-30 | 2002-10-22 | Catalytica, Inc. | Process for preparing 2-oxindoles and N-hydroxy-2-oxindoles |
GB9516943D0 (en) * | 1995-08-18 | 1995-10-18 | Cancer Soc Auckland Div Nz Inc | Novel cyclopropylindoles and their secoprecursors,and their use as prodrugs |
PL346898A1 (en) | 1998-09-25 | 2002-03-11 | Boehringer Ingelheim Pharma | Novel substituted indolinones with an inhibitory effect on various kinases and cyclin/cdk complexes |
US7291641B2 (en) * | 1999-10-11 | 2007-11-06 | Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) | Derivatives of heterocycles with 5 members, their preparation and their use as medicaments |
UA75054C2 (uk) * | 1999-10-13 | 2006-03-15 | Бьорінгер Інгельхайм Фарма Гмбх & Ко. Кг | Заміщені в положенні 6 індолінони, їх одержання та їх застосування як лікарського засобу |
DE10117204A1 (de) * | 2001-04-06 | 2002-10-10 | Boehringer Ingelheim Pharma | In 6-Stellung substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel |
DE10233500A1 (de) * | 2002-07-24 | 2004-02-19 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | 3-Z-[1-(4-(N-((4-Methyl-piperazin-1-yl)-methylcarbonyl)-N-methyl-amino)-anilino)-1-phenyl-methylen]-6-methoxycarbonyl-2-indolinon-Monoethansulfonat und dessen Verwendung als Arzneimittel |
US7148249B2 (en) | 2002-09-12 | 2006-12-12 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Indolinones substituted by heterocycles, the preparation thereof and their use as medicaments |
JP4623604B2 (ja) * | 2006-11-06 | 2011-02-02 | 株式会社セラバリューズ | 新規なオキシインドール誘導体 |
UY31506A1 (es) * | 2007-12-03 | 2009-08-03 | Derivados de indolinona y procedimiento para su preparacion | |
HUE036390T2 (hu) * | 2007-12-03 | 2018-07-30 | Boehringer Ingelheim Int | Eljárás indolinon-származék elõállítására |
-
2008
- 2008-12-01 UY UY31506A patent/UY31506A1/es not_active Application Discontinuation
- 2008-12-01 PE PE2008002005A patent/PE20091445A1/es not_active Application Discontinuation
- 2008-12-02 SI SI200832138T patent/SI2229360T1/sl unknown
- 2008-12-02 ES ES08857503T patent/ES2818993T3/es active Active
- 2008-12-02 PL PL08857503T patent/PL2229360T3/pl unknown
- 2008-12-02 AU AU2008333287A patent/AU2008333287B2/en active Active
- 2008-12-02 TW TW097146808A patent/TWI432415B/zh not_active IP Right Cessation
- 2008-12-02 MX MX2010005557A patent/MX2010005557A/es active IP Right Grant
- 2008-12-02 LT LTEP08857503.0T patent/LT2229360T/lt unknown
- 2008-12-02 PT PT88575030T patent/PT2229360T/pt unknown
- 2008-12-02 KR KR1020157026969A patent/KR101712810B1/ko active IP Right Grant
- 2008-12-02 NZ NZ585798A patent/NZ585798A/en unknown
- 2008-12-02 EA EA201000883A patent/EA016196B1/ru not_active IP Right Cessation
- 2008-12-02 DK DK08857503.0T patent/DK2229360T3/da active
- 2008-12-02 KR KR1020107012251A patent/KR101676261B1/ko active IP Right Grant
- 2008-12-02 CN CN2008801190684A patent/CN101883755B/zh active Active
- 2008-12-02 EP EP08857503.0A patent/EP2229360B1/en active Active
- 2008-12-02 CA CA2705490A patent/CA2705490C/en active Active
- 2008-12-02 WO PCT/EP2008/066581 patent/WO2009071524A2/en active Application Filing
- 2008-12-02 US US12/745,788 patent/US8067617B2/en active Active
- 2008-12-02 BR BRPI0819991-4A patent/BRPI0819991B1/pt active IP Right Grant
- 2008-12-02 AR ARP080105254A patent/AR069531A1/es unknown
- 2008-12-02 HU HUE08857503A patent/HUE051550T2/hu unknown
- 2008-12-02 CL CL2008003599A patent/CL2008003599A1/es unknown
- 2008-12-02 MY MYPI2010002337A patent/MY148574A/en unknown
- 2008-12-02 JP JP2010535407A patent/JP5933924B2/ja active Active
- 2008-12-02 UA UAA201007864A patent/UA97872C2/ru unknown
- 2008-12-02 RS RS20201116A patent/RS60818B1/sr unknown
-
2010
- 2010-04-19 ZA ZA2010/02723A patent/ZA201002723B/en unknown
- 2010-04-26 IL IL205348A patent/IL205348A/en active IP Right Grant
- 2010-05-21 EC EC2010010195A patent/ECSP10010195A/es unknown
- 2010-06-01 TN TN2010000248A patent/TN2010000248A1/fr unknown
- 2010-06-03 CO CO10067260A patent/CO6210751A2/es active IP Right Grant
- 2010-07-01 MA MA32974A patent/MA31989B1/fr unknown
- 2010-12-23 HK HK10112055.5A patent/HK1145682A1/xx not_active IP Right Cessation
-
2014
- 2014-10-27 JP JP2014218112A patent/JP6044025B2/ja active Active
-
2020
- 2020-09-08 CY CY20201100845T patent/CY1123333T1/el unknown
- 2020-09-16 HR HRP20201480TT patent/HRP20201480T1/hr unknown
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Application granted |