MA31989B1 - Dérivés d'indolinone et procédés pour leur fabrication - Google Patents
Dérivés d'indolinone et procédés pour leur fabricationInfo
- Publication number
- MA31989B1 MA31989B1 MA32974A MA32974A MA31989B1 MA 31989 B1 MA31989 B1 MA 31989B1 MA 32974 A MA32974 A MA 32974A MA 32974 A MA32974 A MA 32974A MA 31989 B1 MA31989 B1 MA 31989B1
- Authority
- MA
- Morocco
- Prior art keywords
- derivatives
- indolimone
- manufacture
- methods
- group
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Epidemiology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heat Sensitive Colour Forming Recording (AREA)
Abstract
La présente invention concerne des dérivés indolinone spécifiques, à savoir les composés de formule, dans lesquels r1 représente un atome d'hydrogène ou un groupe, et r2 et r3 représentent chacun un atome d'hydrogène ou r2 et r3 pris ensemble représentent un groupe, sous réserve que lorsque r1 représente un atome d'hydrogène, r2 et r3 pris ensemble représentent un groupe, et un procédé pour les fabriquer.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP07122123 | 2007-12-03 | ||
PCT/EP2008/066581 WO2009071524A2 (fr) | 2007-12-03 | 2008-12-02 | Dérivés indolinone et procédé pour les fabriquer |
Publications (1)
Publication Number | Publication Date |
---|---|
MA31989B1 true MA31989B1 (fr) | 2011-01-03 |
Family
ID=40718253
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA32974A MA31989B1 (fr) | 2007-12-03 | 2010-07-01 | Dérivés d'indolinone et procédés pour leur fabrication |
Country Status (36)
Country | Link |
---|---|
US (1) | US8067617B2 (fr) |
EP (1) | EP2229360B1 (fr) |
JP (2) | JP5933924B2 (fr) |
KR (2) | KR101676261B1 (fr) |
CN (1) | CN101883755B (fr) |
AR (1) | AR069531A1 (fr) |
AU (1) | AU2008333287B2 (fr) |
BR (1) | BRPI0819991B1 (fr) |
CA (1) | CA2705490C (fr) |
CL (1) | CL2008003599A1 (fr) |
CO (1) | CO6210751A2 (fr) |
CY (1) | CY1123333T1 (fr) |
DK (1) | DK2229360T3 (fr) |
EA (1) | EA016196B1 (fr) |
EC (1) | ECSP10010195A (fr) |
ES (1) | ES2818993T3 (fr) |
HK (1) | HK1145682A1 (fr) |
HR (1) | HRP20201480T1 (fr) |
HU (1) | HUE051550T2 (fr) |
IL (1) | IL205348A (fr) |
LT (1) | LT2229360T (fr) |
MA (1) | MA31989B1 (fr) |
MX (1) | MX2010005557A (fr) |
MY (1) | MY148574A (fr) |
NZ (1) | NZ585798A (fr) |
PE (1) | PE20091445A1 (fr) |
PL (1) | PL2229360T3 (fr) |
PT (1) | PT2229360T (fr) |
RS (1) | RS60818B1 (fr) |
SI (1) | SI2229360T1 (fr) |
TN (1) | TN2010000248A1 (fr) |
TW (1) | TWI432415B (fr) |
UA (1) | UA97872C2 (fr) |
UY (1) | UY31506A1 (fr) |
WO (1) | WO2009071524A2 (fr) |
ZA (1) | ZA201002723B (fr) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
UY31506A1 (es) * | 2007-12-03 | 2009-08-03 | Derivados de indolinona y procedimiento para su preparacion | |
US20170065529A1 (en) | 2015-09-09 | 2017-03-09 | Boehringer Ingelheim International Gmbh | Pharmaceutical dosage form for immediate release of an indolinone derivative |
WO2012068441A2 (fr) | 2010-11-19 | 2012-05-24 | Ratiopharm Gmbh | Sels d'intedanib et leurs formes à l'état solide |
CN103787949A (zh) * | 2012-10-31 | 2014-05-14 | 韩冰 | 一类保护移植器官的化合物及其用途 |
US20140350022A1 (en) | 2013-05-10 | 2014-11-27 | Boehringer Ingelheim International Gmbh | Efficacious treatment of NSCLC and predictive clinical marker of the responsiveness of a tumour to a treatment |
AU2014296032A1 (en) | 2013-07-31 | 2016-03-17 | Windward Pharma, Inc. | Aerosol tyrosine kinase inhibitor compounds and uses thereof |
US20140342772A1 (en) * | 2013-09-12 | 2014-11-20 | Bandwidth.Com, Inc. | Predictive Caching of IP Data |
CN104262232B (zh) * | 2014-09-09 | 2016-05-04 | 苏州明锐医药科技有限公司 | 尼泰达尼的制备方法 |
CN105712923A (zh) * | 2014-12-03 | 2016-06-29 | 江苏先声药业有限公司 | 一种尼达尼布杂质及其制备方法与应用 |
WO2016178064A1 (fr) | 2015-05-06 | 2016-11-10 | Suven Life Sciences Limited | Polymorphe d'éthanesulfonate de nintedanib, procédés et intermédiaires associés |
CN105001143A (zh) * | 2015-07-24 | 2015-10-28 | 南京正大天晴制药有限公司 | 一种制备高纯度乙磺酸尼达尼布的方法 |
WO2017077551A2 (fr) | 2015-11-03 | 2017-05-11 | Mylan Laboratories Limited | Esylate nintedanib amorphe et sa dispersion solide |
CN109415314A (zh) * | 2016-05-19 | 2019-03-01 | 上海诚妙医药科技有限公司 | 尼达尼布的新晶型及其制备方法及其用途 |
CN106543069A (zh) * | 2016-09-20 | 2017-03-29 | 北京万全德众医药生物技术有限公司 | 6‑甲氧基羰基‑2‑氧代二氢吲哚的制备 |
CN108610308A (zh) * | 2016-12-09 | 2018-10-02 | 上海奥博生物医药技术有限公司 | 一锅法制备尼达尼布中间体的方法 |
CN106841495B (zh) * | 2017-04-21 | 2018-05-11 | 常州佳德医药科技有限公司 | 乙磺酸尼达尼布中基因毒性杂质的高灵敏度分析方法 |
WO2019048974A1 (fr) * | 2017-09-06 | 2019-03-14 | Glenmark Pharmaceuticals Limited | Procédé de préparation de nintédanib |
EP3710427B1 (fr) | 2017-11-17 | 2023-03-08 | Fermion Oy | Synthèse d'un dérivé de 2-indolinone appelé intermédiaire pour la préparation de nintédanib |
CN110746378B (zh) * | 2018-12-03 | 2021-11-05 | 江苏豪森药业集团有限公司 | 一种胺基中间体的制备方法 |
CN111377845A (zh) * | 2018-12-27 | 2020-07-07 | 江苏先声药业有限公司 | 3-(二甲氨基(苯基)亚甲基)-2-氧化吲哚-6-羧酸甲酯及其制备方法与应用 |
CN111662223B (zh) * | 2019-03-08 | 2023-07-14 | 四川科伦药物研究院有限公司 | 二氢吲哚酮衍生物及其中间体的制备方法 |
EP4178555A4 (fr) * | 2020-08-07 | 2024-08-07 | Bdr Lifesciences Private Ltd | Procédé amélioré extrêmement efficace de préparation de nintédanib et d'un sel de qualité pharmaceutique de ce dernier |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS4876863A (fr) * | 1972-01-22 | 1973-10-16 | ||
US6469181B1 (en) * | 1995-01-30 | 2002-10-22 | Catalytica, Inc. | Process for preparing 2-oxindoles and N-hydroxy-2-oxindoles |
GB9516943D0 (en) * | 1995-08-18 | 1995-10-18 | Cancer Soc Auckland Div Nz Inc | Novel cyclopropylindoles and their secoprecursors,and their use as prodrugs |
ID27757A (id) * | 1998-09-25 | 2001-04-26 | Boehringer Ingelheim Pharma | Indolinona-indolinona tersubstitusi baru, preparasi dan penggunaannya sebagai obat |
US7291641B2 (en) * | 1999-10-11 | 2007-11-06 | Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) | Derivatives of heterocycles with 5 members, their preparation and their use as medicaments |
UA75054C2 (uk) * | 1999-10-13 | 2006-03-15 | Бьорінгер Інгельхайм Фарма Гмбх & Ко. Кг | Заміщені в положенні 6 індолінони, їх одержання та їх застосування як лікарського засобу |
DE10117204A1 (de) * | 2001-04-06 | 2002-10-10 | Boehringer Ingelheim Pharma | In 6-Stellung substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel |
DE10233500A1 (de) * | 2002-07-24 | 2004-02-19 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | 3-Z-[1-(4-(N-((4-Methyl-piperazin-1-yl)-methylcarbonyl)-N-methyl-amino)-anilino)-1-phenyl-methylen]-6-methoxycarbonyl-2-indolinon-Monoethansulfonat und dessen Verwendung als Arzneimittel |
US7148249B2 (en) | 2002-09-12 | 2006-12-12 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Indolinones substituted by heterocycles, the preparation thereof and their use as medicaments |
CN101535302A (zh) * | 2006-11-06 | 2009-09-16 | 株式会社泰丽巴镠斯 | 新型羟基吲哚衍生物 |
PL2229359T3 (pl) * | 2007-12-03 | 2018-04-30 | Boehringer Ingelheim International Gmbh | Sposób wytwarzania pochodnej indolinonu |
UY31506A1 (es) * | 2007-12-03 | 2009-08-03 | Derivados de indolinona y procedimiento para su preparacion |
-
2008
- 2008-12-01 UY UY31506A patent/UY31506A1/es not_active Application Discontinuation
- 2008-12-01 PE PE2008002005A patent/PE20091445A1/es not_active Application Discontinuation
- 2008-12-02 DK DK08857503.0T patent/DK2229360T3/da active
- 2008-12-02 BR BRPI0819991-4A patent/BRPI0819991B1/pt active IP Right Grant
- 2008-12-02 AR ARP080105254A patent/AR069531A1/es unknown
- 2008-12-02 CL CL2008003599A patent/CL2008003599A1/es unknown
- 2008-12-02 MX MX2010005557A patent/MX2010005557A/es active IP Right Grant
- 2008-12-02 CN CN2008801190684A patent/CN101883755B/zh active Active
- 2008-12-02 SI SI200832138T patent/SI2229360T1/sl unknown
- 2008-12-02 HU HUE08857503A patent/HUE051550T2/hu unknown
- 2008-12-02 EA EA201000883A patent/EA016196B1/ru not_active IP Right Cessation
- 2008-12-02 CA CA2705490A patent/CA2705490C/fr active Active
- 2008-12-02 PT PT88575030T patent/PT2229360T/pt unknown
- 2008-12-02 UA UAA201007864A patent/UA97872C2/ru unknown
- 2008-12-02 NZ NZ585798A patent/NZ585798A/en unknown
- 2008-12-02 RS RS20201116A patent/RS60818B1/sr unknown
- 2008-12-02 JP JP2010535407A patent/JP5933924B2/ja active Active
- 2008-12-02 US US12/745,788 patent/US8067617B2/en active Active
- 2008-12-02 WO PCT/EP2008/066581 patent/WO2009071524A2/fr active Application Filing
- 2008-12-02 EP EP08857503.0A patent/EP2229360B1/fr active Active
- 2008-12-02 KR KR1020107012251A patent/KR101676261B1/ko active IP Right Grant
- 2008-12-02 KR KR1020157026969A patent/KR101712810B1/ko active IP Right Grant
- 2008-12-02 AU AU2008333287A patent/AU2008333287B2/en active Active
- 2008-12-02 PL PL08857503T patent/PL2229360T3/pl unknown
- 2008-12-02 MY MYPI2010002337A patent/MY148574A/en unknown
- 2008-12-02 LT LTEP08857503.0T patent/LT2229360T/lt unknown
- 2008-12-02 TW TW097146808A patent/TWI432415B/zh not_active IP Right Cessation
- 2008-12-02 ES ES08857503T patent/ES2818993T3/es active Active
-
2010
- 2010-04-19 ZA ZA2010/02723A patent/ZA201002723B/en unknown
- 2010-04-26 IL IL205348A patent/IL205348A/en active IP Right Grant
- 2010-05-21 EC EC2010010195A patent/ECSP10010195A/es unknown
- 2010-06-01 TN TN2010000248A patent/TN2010000248A1/fr unknown
- 2010-06-03 CO CO10067260A patent/CO6210751A2/es active IP Right Grant
- 2010-07-01 MA MA32974A patent/MA31989B1/fr unknown
- 2010-12-23 HK HK10112055.5A patent/HK1145682A1/xx not_active IP Right Cessation
-
2014
- 2014-10-27 JP JP2014218112A patent/JP6044025B2/ja active Active
-
2020
- 2020-09-08 CY CY20201100845T patent/CY1123333T1/el unknown
- 2020-09-16 HR HRP20201480TT patent/HRP20201480T1/hr unknown
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