CN109415314A - 尼达尼布的新晶型及其制备方法及其用途 - Google Patents
尼达尼布的新晶型及其制备方法及其用途 Download PDFInfo
- Publication number
- CN109415314A CN109415314A CN201780031371.8A CN201780031371A CN109415314A CN 109415314 A CN109415314 A CN 109415314A CN 201780031371 A CN201780031371 A CN 201780031371A CN 109415314 A CN109415314 A CN 109415314A
- Authority
- CN
- China
- Prior art keywords
- methyl
- values
- phenyi
- thyl
- piperazin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/32—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by aldehydo- or ketonic radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/04—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
本发明公开了3‑Z‑[1‑(4‑(N‑((4‑甲基‑哌嗪‑1‑基)‑甲基羰基)‑N‑甲基‑氨基)‑苯氨基)‑1‑苯基‑亚甲基]‑6‑甲氧羰基‑2‑吲哚满酮(尼达尼布)的新多晶型及其制备方法和药用用途。所发现尼达尼布乙磺酸盐晶型I、乙磺酸盐晶型III和双羟萘酸盐晶型I,与现有晶型相比,新晶型在溶解度、稳定性、控制释放速度或制备工艺方面具有明显优势。
Description
PCT国内申请,说明书已公开。
Claims (10)
- PCT国内申请,权利要求书已公开。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201610347601 | 2016-05-19 | ||
CN2016103476019 | 2016-05-19 | ||
PCT/CN2017/084984 WO2017198202A1 (zh) | 2016-05-19 | 2017-05-19 | 尼达尼布的新晶型及其制备方法及其用途 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN109415314A true CN109415314A (zh) | 2019-03-01 |
Family
ID=60324765
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201780031371.8A Pending CN109415314A (zh) | 2016-05-19 | 2017-05-19 | 尼达尼布的新晶型及其制备方法及其用途 |
Country Status (2)
Country | Link |
---|---|
CN (1) | CN109415314A (zh) |
WO (1) | WO2017198202A1 (zh) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112239459B (zh) * | 2019-07-19 | 2021-11-26 | 中国科学院上海药物研究所 | 稠环嘧啶氨基化合物、其制备方法、药物组合物及应用 |
CN113024439A (zh) * | 2021-03-28 | 2021-06-25 | 郑州大学 | 尼达尼布乙磺酸盐新晶型ⅰ的制备 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1671660A (zh) * | 2002-07-24 | 2005-09-21 | 贝林格尔英格海姆法玛两合公司 | 3-z-[1-(4-(n-((4-甲基-哌嗪-1-基)-甲羰基)-n-甲基-氨基)-苯氨基)-1-苯基-亚甲基]-6-甲氧羰基-2-吲哚满酮-单乙烷磺酸盐及其作为药物组合物的用途 |
CN101883756A (zh) * | 2007-12-03 | 2010-11-10 | 贝林格尔.英格海姆国际有限公司 | 制备二氢吲哚酮衍生物的方法 |
CN105001143A (zh) * | 2015-07-24 | 2015-10-28 | 南京正大天晴制药有限公司 | 一种制备高纯度乙磺酸尼达尼布的方法 |
CN105418483A (zh) * | 2015-12-15 | 2016-03-23 | 南京艾德凯腾生物医药有限责任公司 | 一种结晶型乙磺酸尼达尼布的制备方法 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PE20091445A1 (es) * | 2007-12-03 | 2009-10-19 | Boehringer Ingelheim Int | Derivados de indolinona y procedimiento para su fabricacion |
CN104844499B (zh) * | 2015-06-05 | 2017-03-08 | 北京康立生医药技术开发有限公司 | 一锅法制备尼达尼布的合成方法 |
CN105461609B (zh) * | 2015-12-25 | 2019-08-23 | 杭州新博思生物医药有限公司 | 一种尼达尼布的制备方法 |
-
2017
- 2017-05-19 WO PCT/CN2017/084984 patent/WO2017198202A1/zh active Application Filing
- 2017-05-19 CN CN201780031371.8A patent/CN109415314A/zh active Pending
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1671660A (zh) * | 2002-07-24 | 2005-09-21 | 贝林格尔英格海姆法玛两合公司 | 3-z-[1-(4-(n-((4-甲基-哌嗪-1-基)-甲羰基)-n-甲基-氨基)-苯氨基)-1-苯基-亚甲基]-6-甲氧羰基-2-吲哚满酮-单乙烷磺酸盐及其作为药物组合物的用途 |
CN101883756A (zh) * | 2007-12-03 | 2010-11-10 | 贝林格尔.英格海姆国际有限公司 | 制备二氢吲哚酮衍生物的方法 |
CN105001143A (zh) * | 2015-07-24 | 2015-10-28 | 南京正大天晴制药有限公司 | 一种制备高纯度乙磺酸尼达尼布的方法 |
CN105418483A (zh) * | 2015-12-15 | 2016-03-23 | 南京艾德凯腾生物医药有限责任公司 | 一种结晶型乙磺酸尼达尼布的制备方法 |
Also Published As
Publication number | Publication date |
---|---|
WO2017198202A1 (zh) | 2017-11-23 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US20210332013A1 (en) | Malate salt of N-(4-{[6,7-bis(methyloxy) quinolin-4-yl]oxy}phenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide, and crystalline forms therof for the treatment of cancer | |
US8673912B2 (en) | Crystalline Forms on N-[3-fluoro-4-({6-(methyloxy)-7-[(3-morpholin-4-ylpropyl)oxy]-quinolin-4-yl}oxy)phenyl]-N′-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide | |
JP2020147571A (ja) | 治療活性を有する化合物及びその使用方法 | |
US20130143881A1 (en) | Hydrated Crystalline Forms of N-[3-fluoro-4-(oxy)phenyl]-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide | |
US10513513B2 (en) | Salts of quinazoline derivative or crystals thereof, and the process for producing thereof | |
CN105025898A (zh) | 组胺h4受体的苯并咪唑-2-基嘧啶调节剂 | |
CN108658983A (zh) | 用于抑制Bcl-2蛋白的N-苯磺酰基苯甲酰胺类化合物及其组合物及应用 | |
CN110128356A (zh) | 一种吉非替尼与3-羟基苯甲酸共晶体 | |
CN110156700A (zh) | 吉非替尼与水杨酸共晶体 | |
CN109415314A (zh) | 尼达尼布的新晶型及其制备方法及其用途 | |
TW201900634A (zh) | (s)-[2-氯-4-氟-5-(7-嗎啉-4-基喹唑啉-4-基)苯基]-(6-甲氧基-嗒𠯤-3-基)-甲醇之固體型式 | |
CN103936726B (zh) | 晶体、制备方法及其用途 | |
SA109300290B1 (ar) | ملح الداي فيومارات وأشكاله البلورية | |
US20190135792A1 (en) | Crystalline form of compound suppressing protein kinase activity, and application thereof | |
JP5998933B2 (ja) | グリシン誘導体の結晶及びその医薬用途 | |
US9688687B2 (en) | Polymorphic forms of icotinib phosphate and uses thereof | |
WO2022242688A1 (zh) | 一种含氰基取代的大环类化合物的晶型及其制备方法 | |
US20190062307A1 (en) | Deuterium-substituted quinoline derivatives | |
CN116462663A (zh) | 一种嘧啶联氘代吡唑类化合物、药物组合物和用途 | |
CN109481441A (zh) | 一种紫杉醇和新型甲氧基酞嗪酮类btk抑制剂联合用药物组合物及其应用 | |
CN117915919A (zh) | 氮杂芳环类化合物及其药学上可接受的盐的多晶型物、药物组合物和应用 | |
CN109288841A (zh) | 一种紫杉醇和对苯氟酞嗪酮类btk抑制剂联合用药物组合物及其应用 | |
CN109394766A (zh) | 一种紫杉醇和对苯硝基酞嗪酮类btk抑制剂联合用药物组合物及其应用 | |
CN109223759A (zh) | 一种紫杉醇和新型酞嗪酮类btk抑制剂联合用药物组合物及其应用 | |
CN109481442A (zh) | 一种紫杉醇和邻苯基酞嗪酮类btk抑制剂联合用药物组合物及其应用 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20190301 |
|
WD01 | Invention patent application deemed withdrawn after publication |