AR081893A1 - Derivados de acido 1-(2-fluorobifenil-4-il)-alquil carboxilico para la terapia de la amiloidosis transtiretina - Google Patents
Derivados de acido 1-(2-fluorobifenil-4-il)-alquil carboxilico para la terapia de la amiloidosis transtiretinaInfo
- Publication number
- AR081893A1 AR081893A1 ARP110101369A ARP110101369A AR081893A1 AR 081893 A1 AR081893 A1 AR 081893A1 AR P110101369 A ARP110101369 A AR P110101369A AR P110101369 A ARP110101369 A AR P110101369A AR 081893 A1 AR081893 A1 AR 081893A1
- Authority
- AR
- Argentina
- Prior art keywords
- amyloidosis
- transtiretine
- fluorobifenil
- rent
- carboxyl
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
- C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C17/00—Preparation of halogenated hydrocarbons
- C07C17/26—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
- C07C255/35—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by halogen atoms, or by nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Reivindicación 1: Un compuesto caracterizado porque tiene la fórmula general (1) donde R1 es hidrógeno o un alquilo C1-4 lineal o ramificado; R2 es un alquilo C1-4 lineal o ramificado; o R1 y R2, tomados junto con el átomo de carbono al que están unidos, forman un anillo de entre 3 y 6 átomos de carbono; y R3 representa uno o más grupos seleccionados independientemente entre átomos halógenos; o una forma polimórfica, una sal o una prodroga farmacéuticamente aceptable de éste, que puede usarse en la prevención y/o el tratamiento de enfermedades relacionadas con la amiloidosis transtiretina (TTR).
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP10160564 | 2010-04-21 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR081893A1 true AR081893A1 (es) | 2012-10-31 |
Family
ID=43432362
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP110101369A AR081893A1 (es) | 2010-04-21 | 2011-04-20 | Derivados de acido 1-(2-fluorobifenil-4-il)-alquil carboxilico para la terapia de la amiloidosis transtiretina |
Country Status (11)
Country | Link |
---|---|
US (1) | US9150489B2 (es) |
EP (1) | EP2560942B1 (es) |
KR (1) | KR20130079353A (es) |
CN (1) | CN102844290B (es) |
AR (1) | AR081893A1 (es) |
BR (1) | BR112012026803A2 (es) |
CA (1) | CA2796933A1 (es) |
ES (1) | ES2526522T3 (es) |
HK (1) | HK1174609A1 (es) |
RU (1) | RU2565066C2 (es) |
WO (1) | WO2011131661A1 (es) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2485169A (en) * | 2010-11-03 | 2012-05-09 | Univ Jw Goethe Frankfurt Main | (R)-flurbiprofen for use in the treatment of multiple sclerosis |
US9592210B2 (en) | 2011-12-22 | 2017-03-14 | Chiesi Farmaceutici S.P.A. | 1-phenylalkanecarboxylic acid derivatives for the treatment of cognitive impairment |
CN103266181B (zh) * | 2013-06-14 | 2014-08-13 | 中国科学院昆明动物研究所 | 一种用于检测ttr基因突变g307c的试剂盒 |
CA2825821A1 (en) * | 2013-08-28 | 2015-02-28 | Chiesi Farmaceutici S.P.A. | 1-phenylalkanecarboxylic acid derivatives for the treatment of alzheimer's disease and multiple sclerosis |
US20150335596A1 (en) * | 2014-05-26 | 2015-11-26 | Chiesi Farmaceutici S.P.A. | 1-(2-fluorobiphenyl-4-yl)-cyclopropanecarboxylic acid derivatives for the treatment of down's syndrome |
CN110590548B (zh) * | 2019-09-06 | 2020-09-08 | 中国药科大学 | Akr1c3抑制剂或其可药用的盐、其制备方法及用途 |
CN114324693B (zh) * | 2022-01-14 | 2023-01-13 | 大连博源医学科技有限公司 | 一种血液中转甲状腺素蛋白(ttr)四聚体浓度测定的预处理方法和检测方法 |
CN115125316A (zh) * | 2022-08-19 | 2022-09-30 | 中国医学科学院北京协和医院 | 肠道菌群在诊断转甲状腺素蛋白淀粉样变性中的应用 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SI1587821T1 (sl) | 2002-12-19 | 2009-02-28 | Scripps Research Inst | Sestavki in postopki za stabiliziranje transtiretina in zaviranje napaäśnega zvijanja transtiretina |
EP1603548A4 (en) * | 2003-02-05 | 2007-10-10 | Myriad Genetics Inc | COMPOSITION AND METHOD FOR TREATING NEURODEGENERATIVE DISORDERS |
KR101152448B1 (ko) | 2003-02-21 | 2012-07-02 | 키에시 파르마슈티시 엣스. 피. 에이. | 신경 퇴행성 질환의 치료를 위한 1-페닐알캔카복실산 추출물의 제조방법 |
ITMI20030312A1 (it) | 2003-02-21 | 2004-08-22 | Chiesi Farma Spa | Derivati di acidi 2-fenil-2-alchil-acetici per il trattamento della malattia di alzheimer. |
US7531692B2 (en) | 2004-08-03 | 2009-05-12 | Chiesi Farmaceutici S.P.A. | Derivatives of 1-phenylalkanecarboxylic acids for the treatment of neurodegenerative diseases |
WO2006020850A2 (en) * | 2004-08-11 | 2006-02-23 | Myriad Genetics, Inc. | Pharmaceutical composition and method for treating neurodegenerative disorders |
EP1848688A2 (en) | 2005-02-08 | 2007-10-31 | The Scripps Research Institute | Inhibitors of transthyretin amyloid fibril formation |
US20070037875A1 (en) | 2005-08-11 | 2007-02-15 | The Scripps Research Institute | Genistein inhibition of transthyretin amyloidosis |
GB0718718D0 (en) | 2007-09-25 | 2007-11-07 | Pentraxin Therapeutics Ltd | Compound and use thereof |
EP2133322A1 (en) * | 2008-06-11 | 2009-12-16 | CHIESI FARMACEUTICI S.p.A. | Process of preparing derivatives of 1-(2-halobiphenyl-4-yl)-cyclopropanecarboxylic acid |
-
2011
- 2011-04-19 WO PCT/EP2011/056224 patent/WO2011131661A1/en active Application Filing
- 2011-04-19 RU RU2012144438/04A patent/RU2565066C2/ru not_active IP Right Cessation
- 2011-04-19 KR KR1020127027432A patent/KR20130079353A/ko not_active Application Discontinuation
- 2011-04-19 ES ES11723282.7T patent/ES2526522T3/es active Active
- 2011-04-19 BR BR112012026803A patent/BR112012026803A2/pt active Search and Examination
- 2011-04-19 CN CN201180019765.4A patent/CN102844290B/zh not_active Expired - Fee Related
- 2011-04-19 EP EP11723282.7A patent/EP2560942B1/en active Active
- 2011-04-19 CA CA2796933A patent/CA2796933A1/en not_active Abandoned
- 2011-04-20 AR ARP110101369A patent/AR081893A1/es unknown
- 2011-04-21 US US13/091,195 patent/US9150489B2/en not_active Expired - Fee Related
-
2013
- 2013-02-15 HK HK13101930.6A patent/HK1174609A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
BR112012026803A2 (pt) | 2016-07-12 |
CA2796933A1 (en) | 2011-10-27 |
CN102844290B (zh) | 2015-06-17 |
RU2012144438A (ru) | 2014-04-27 |
US9150489B2 (en) | 2015-10-06 |
RU2565066C2 (ru) | 2015-10-20 |
WO2011131661A1 (en) | 2011-10-27 |
CN102844290A (zh) | 2012-12-26 |
EP2560942B1 (en) | 2014-11-26 |
HK1174609A1 (en) | 2013-06-14 |
US20110263711A1 (en) | 2011-10-27 |
KR20130079353A (ko) | 2013-07-10 |
EP2560942A1 (en) | 2013-02-27 |
ES2526522T3 (es) | 2015-01-13 |
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