BR112012026803A2 - composto - Google Patents
compostoInfo
- Publication number
- BR112012026803A2 BR112012026803A2 BR112012026803A BR112012026803A BR112012026803A2 BR 112012026803 A2 BR112012026803 A2 BR 112012026803A2 BR 112012026803 A BR112012026803 A BR 112012026803A BR 112012026803 A BR112012026803 A BR 112012026803A BR 112012026803 A2 BR112012026803 A2 BR 112012026803A2
- Authority
- BR
- Brazil
- Prior art keywords
- compound
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
- C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C17/00—Preparation of halogenated hydrocarbons
- C07C17/26—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
- C07C255/35—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by halogen atoms, or by nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10160564 | 2010-04-21 | ||
| PCT/EP2011/056224 WO2011131661A1 (en) | 2010-04-21 | 2011-04-19 | 1-(2-fluorobiphenyl-4-yl)-alkyl carboxylic acid derivatives for the therapy of transthyretin amyloidosis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112012026803A2 true BR112012026803A2 (pt) | 2016-07-12 |
Family
ID=43432362
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112012026803A BR112012026803A2 (pt) | 2010-04-21 | 2011-04-19 | composto |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US9150489B2 (pt) |
| EP (1) | EP2560942B1 (pt) |
| KR (1) | KR20130079353A (pt) |
| CN (1) | CN102844290B (pt) |
| AR (1) | AR081893A1 (pt) |
| BR (1) | BR112012026803A2 (pt) |
| CA (1) | CA2796933A1 (pt) |
| ES (1) | ES2526522T3 (pt) |
| HK (1) | HK1174609A1 (pt) |
| RU (1) | RU2565066C2 (pt) |
| WO (1) | WO2011131661A1 (pt) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2485169A (en) * | 2010-11-03 | 2012-05-09 | Univ Jw Goethe Frankfurt Main | (R)-flurbiprofen for use in the treatment of multiple sclerosis |
| US9592210B2 (en) | 2011-12-22 | 2017-03-14 | Chiesi Farmaceutici S.P.A. | 1-phenylalkanecarboxylic acid derivatives for the treatment of cognitive impairment |
| CN103266181B (zh) * | 2013-06-14 | 2014-08-13 | 中国科学院昆明动物研究所 | 一种用于检测ttr基因突变g307c的试剂盒 |
| CA2825821A1 (en) * | 2013-08-28 | 2015-02-28 | Chiesi Farmaceutici S.P.A. | 1-phenylalkanecarboxylic acid derivatives for the treatment of alzheimer's disease and multiple sclerosis |
| US20150335596A1 (en) * | 2014-05-26 | 2015-11-26 | Chiesi Farmaceutici S.P.A. | 1-(2-fluorobiphenyl-4-yl)-cyclopropanecarboxylic acid derivatives for the treatment of down's syndrome |
| CN110590548B (zh) * | 2019-09-06 | 2020-09-08 | 中国药科大学 | Akr1c3抑制剂或其可药用的盐、其制备方法及用途 |
| CN114324693B (zh) * | 2022-01-14 | 2023-01-13 | 大连博源医学科技有限公司 | 一种血液中转甲状腺素蛋白(ttr)四聚体浓度测定的预处理方法和检测方法 |
| CN115125316A (zh) * | 2022-08-19 | 2022-09-30 | 中国医学科学院北京协和医院 | 肠道菌群在诊断转甲状腺素蛋白淀粉样变性中的应用 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE405840T1 (de) | 2002-12-19 | 2008-09-15 | Scripps Research Inst | Zusammensetzungen und verfahren zur stabilisierung von transthyretin und zur hemmung von transthyretin-fehlfaltung |
| WO2004071431A2 (en) * | 2003-02-05 | 2004-08-26 | Myriad Genetics, Inc. | Method and composition for treating neurodegenerative disorders |
| ITMI20030312A1 (it) | 2003-02-21 | 2004-08-22 | Chiesi Farma Spa | Derivati di acidi 2-fenil-2-alchil-acetici per il trattamento della malattia di alzheimer. |
| AU2004213145B2 (en) | 2003-02-21 | 2010-05-13 | Chiesi Farmaceutici S.P.A. | 1-Phenylalkanecarboxylic acid derivatives for the treatment of neurodegenerative diseases |
| ES2309778T3 (es) | 2004-08-03 | 2008-12-16 | Chiesi Farmaceutici S.P.A. | Derivados de acidos 1-fenilalcanocarboxilicos para el tratamiento de enfermedades neurodegenerativas. |
| WO2006020850A2 (en) * | 2004-08-11 | 2006-02-23 | Myriad Genetics, Inc. | Pharmaceutical composition and method for treating neurodegenerative disorders |
| EP1848688A2 (en) | 2005-02-08 | 2007-10-31 | The Scripps Research Institute | Inhibitors of transthyretin amyloid fibril formation |
| WO2007022138A2 (en) | 2005-08-11 | 2007-02-22 | The Scripps Research Institute | Genistein inhibition of transthyretin amyloidosis |
| GB0718718D0 (en) | 2007-09-25 | 2007-11-07 | Pentraxin Therapeutics Ltd | Compound and use thereof |
| EP2133322A1 (en) * | 2008-06-11 | 2009-12-16 | CHIESI FARMACEUTICI S.p.A. | Process of preparing derivatives of 1-(2-halobiphenyl-4-yl)-cyclopropanecarboxylic acid |
-
2011
- 2011-04-19 CN CN201180019765.4A patent/CN102844290B/zh not_active Expired - Fee Related
- 2011-04-19 KR KR1020127027432A patent/KR20130079353A/ko not_active Application Discontinuation
- 2011-04-19 EP EP11723282.7A patent/EP2560942B1/en active Active
- 2011-04-19 WO PCT/EP2011/056224 patent/WO2011131661A1/en active Application Filing
- 2011-04-19 RU RU2012144438/04A patent/RU2565066C2/ru not_active IP Right Cessation
- 2011-04-19 ES ES11723282.7T patent/ES2526522T3/es active Active
- 2011-04-19 CA CA2796933A patent/CA2796933A1/en not_active Abandoned
- 2011-04-19 BR BR112012026803A patent/BR112012026803A2/pt active Search and Examination
- 2011-04-20 AR ARP110101369A patent/AR081893A1/es unknown
- 2011-04-21 US US13/091,195 patent/US9150489B2/en not_active Expired - Fee Related
-
2013
- 2013-02-15 HK HK13101930.6A patent/HK1174609A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| KR20130079353A (ko) | 2013-07-10 |
| CN102844290A (zh) | 2012-12-26 |
| US9150489B2 (en) | 2015-10-06 |
| EP2560942A1 (en) | 2013-02-27 |
| AR081893A1 (es) | 2012-10-31 |
| WO2011131661A1 (en) | 2011-10-27 |
| CA2796933A1 (en) | 2011-10-27 |
| RU2565066C2 (ru) | 2015-10-20 |
| HK1174609A1 (en) | 2013-06-14 |
| ES2526522T3 (es) | 2015-01-13 |
| US20110263711A1 (en) | 2011-10-27 |
| RU2012144438A (ru) | 2014-04-27 |
| EP2560942B1 (en) | 2014-11-26 |
| CN102844290B (zh) | 2015-06-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07D | Technical examination (opinion) related to article 229 of industrial property law |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS. |
|
| B08F | Application fees: dismissal - article 86 of industrial property law | ||
| B08K | Lapse as no evidence of payment of the annual fee has been furnished to inpi (acc. art. 87) | ||
| B07E | Notice of approval relating to section 229 industrial property law |