CL2012001911A1 - Compuestos derivados de fumarato; composicion farmaceutica que los comprende; y su uso en el tratamiento de una enfermedad inflamatoria o neurodegenerativa. - Google Patents

Compuestos derivados de fumarato; composicion farmaceutica que los comprende; y su uso en el tratamiento de una enfermedad inflamatoria o neurodegenerativa.

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Publication number
CL2012001911A1
CL2012001911A1 CL2012001911A CL2012001911A CL2012001911A1 CL 2012001911 A1 CL2012001911 A1 CL 2012001911A1 CL 2012001911 A CL2012001911 A CL 2012001911A CL 2012001911 A CL2012001911 A CL 2012001911A CL 2012001911 A1 CL2012001911 A1 CL 2012001911A1
Authority
CL
Chile
Prior art keywords
inflammatory
treatment
pharmaceutical composition
fumarate
neurodegenerative disease
Prior art date
Application number
CL2012001911A
Other languages
English (en)
Inventor
Chi B Vu
Jean E Bemis
Jesse J Smith
Michael R Jirousek
Jill C Milne
Original Assignee
Catabasis Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44258993&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2012001911(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Catabasis Pharmaceuticals Inc filed Critical Catabasis Pharmaceuticals Inc
Publication of CL2012001911A1 publication Critical patent/CL2012001911A1/es

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    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
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    • C07C235/76—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
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    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
    • C07D339/02—Five-membered rings
    • C07D339/04—Five-membered rings having the hetero atoms in positions 1 and 2, e.g. lipoic acid

Abstract

La presente invención se refiere a un compuesto de Ia formula I o II, o una de sus sales, hidratos, solvatos. enantiómeros o estereoisómeros farmacéuticamente aceptables; una composición farmaceutica que los comprenda y su uso en el tratamiento de enfermedades inflamatorias o neurodegenerativas.
CL2012001911A 2010-01-08 2012-07-06 Compuestos derivados de fumarato; composicion farmaceutica que los comprende; y su uso en el tratamiento de una enfermedad inflamatoria o neurodegenerativa. CL2012001911A1 (es)

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US20110172240A1 (en) 2011-07-14
ECSP12012097A (es) 2012-09-28
EP2521447A4 (en) 2014-04-30
TW201141471A (en) 2011-12-01
CN102821602B (zh) 2016-04-20
CA2786605A1 (en) 2011-07-14
SG182414A1 (en) 2012-08-30
MX2012007981A (es) 2012-08-23
EP2521447A1 (en) 2012-11-14
RU2012134069A (ru) 2014-02-20
US9289503B2 (en) 2016-03-22
AU2011204277A1 (en) 2012-08-30
NZ601698A (en) 2015-04-24
AR080357A1 (es) 2012-04-04
JP5771627B2 (ja) 2015-09-02
US20150238618A1 (en) 2015-08-27
WO2011085211A1 (en) 2011-07-14
US8969354B2 (en) 2015-03-03
KR20120123407A (ko) 2012-11-08
EP2521447B1 (en) 2017-06-14
CR20120413A (es) 2012-12-18
IL244858A (en) 2016-12-29
DK2521447T3 (en) 2017-09-18
MX337605B (es) 2016-03-10
ES2637266T3 (es) 2017-10-11
IL244858A0 (en) 2016-05-31
US20160340294A1 (en) 2016-11-24
TWI508725B (zh) 2015-11-21
BR112012016879A2 (pt) 2015-09-01
JP2013516486A (ja) 2013-05-13
US20130065909A1 (en) 2013-03-14
MY160249A (en) 2017-02-28
CN102821602A (zh) 2012-12-12
AU2011204277B2 (en) 2015-12-24
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CO6571913A2 (es) 2012-11-30
NI201200120A (es) 2013-06-12

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