SG11201407318UA - Compositions and methods for the treatment of metabolic syndrome - Google Patents

Compositions and methods for the treatment of metabolic syndrome


Publication number
SG11201407318UA SG11201407318UA SG11201407318UA SG11201407318UA SG 11201407318U A SG11201407318U A SG 11201407318UA SG 11201407318U A SG11201407318U A SG 11201407318UA SG 11201407318U A SG11201407318U A SG 11201407318UA SG 11201407318U A SG11201407318U A SG 11201407318UA
Prior art keywords
metabolic syndrome
Prior art date
Application number
Mahesh Kandula
Original Assignee
Cellix Bio Private Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to IN1853CH2012 priority Critical
Application filed by Cellix Bio Private Ltd filed Critical Cellix Bio Private Ltd
Priority to PCT/IB2013/051596 priority patent/WO2013168016A1/en
Publication of SG11201407318UA publication Critical patent/SG11201407318UA/en



    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65586Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
    • C07D339/00Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
    • C07D339/02Five-membered rings
    • C07D339/04Five-membered rings having the hetero atoms in position 1,2, e.g. lipoic acid
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links


(12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 14 November 2013 (14.11.2013) WIPOIPCT (10) International Publication Number WO 2013/168016 A1 (51) International Patent Classification: C07F 9/09 (2006.01) A61P 3/00 (2006.01) C07C 309/63 (2006.01) A61P3/10 (2006.01) A61K31/683 (2006.01) (21) International Application Number: PCT/IB2013/051596 (22) International Filing Date: (25) Filing Language: (26) Publication Language: 28 February 2013 (28.02.2013) English English (30) Priority Data: 1853/CHE/2012 10 May 2012 (10.05.2012) IN (72) Inventor; and (71) Applicant : KANDULA, Mahesh [IN/IN]; Door No. 11- 61, Samalkot Mandal, East Godavari Dist, G.Medapadu 533 434, Andhra Pradesh (IN). (81) Designated States (unless otherwise indicated, for every kind of national protection available)'. AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available)'. ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) V© i-H o 00 i-H en i-H o CJ o & (54) Title: COMPOSITIONS AND METHODS FOR THE TREATMENT OF METABOLIC SYNDROME (57) Abstract: The invention discloses the compounds of formula (I) and formula (II) or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula (I) or formula (II), and the methods of treating or preventing or modulating metabolic syndrome may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup or injec - tion. The compositions may be used treat to fasting hyperglycemia, diabetes mellitus type 2, impaired fasting glucose, impaired glue - ose tolerance, insulin resistance, high blood pressure, central obesity, overweight with fat deposits mainly around the waist, de­ creased HDL cholesterol, elevated triglycerides, hyperuricemia, fatty liver progressing to NAFLD, polycystic ovarian syndrome, hy­ pophosphatemia, renal diseases, albuminuria, end stage renal disease and acanthosis nigricans.
SG11201407318UA 2012-05-10 2013-02-28 Compositions and methods for the treatment of metabolic syndrome SG11201407318UA (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
IN1853CH2012 2012-05-10
PCT/IB2013/051596 WO2013168016A1 (en) 2012-05-10 2013-02-28 Compositions and methods for the treatment of metabolic syndrome

Publications (1)

Publication Number Publication Date
SG11201407318UA true SG11201407318UA (en) 2014-12-30



Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201407318UA SG11201407318UA (en) 2012-05-10 2013-02-28 Compositions and methods for the treatment of metabolic syndrome

Country Status (4)

Country Link
US (1) US9403857B2 (en)
SG (1) SG11201407318UA (en)
WO (1) WO2013168016A1 (en)
ZA (1) ZA201408053B (en)

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Also Published As

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US20150080345A1 (en) 2015-03-19
WO2013168016A1 (en) 2013-11-14
ZA201408053B (en) 2016-04-28
US9403857B2 (en) 2016-08-02

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