DK157864C - Hidtil ukendte 1-piperazincarboxamidderivater substitueret paa det basiske nitrogenatom samt farmaceutiske praeparater og sammensaetninger indeholdende disse - Google Patents
Hidtil ukendte 1-piperazincarboxamidderivater substitueret paa det basiske nitrogenatom samt farmaceutiske praeparater og sammensaetninger indeholdende disseInfo
- Publication number
- DK157864C DK157864C DK157485A DK157485A DK157864C DK 157864 C DK157864 C DK 157864C DK 157485 A DK157485 A DK 157485A DK 157485 A DK157485 A DK 157485A DK 157864 C DK157864 C DK 157864C
- Authority
- DK
- Denmark
- Prior art keywords
- hydrogen
- different
- lower alkyl
- compositions containing
- nitrogenatom
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
- C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/205—Radicals derived from carbonic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/21—Radicals derived from sulfur analogues of carbonic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/28—Radicals substituted by nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE8304361 | 1983-08-10 | ||
| SE8304361A SE8304361D0 (sv) | 1983-08-10 | 1983-08-10 | Novel 1-acylpiperazine derivatives novel 1-acylpiperazine derivatives |
| PCT/SE1984/000269 WO1985000811A1 (en) | 1983-08-10 | 1984-08-02 | Novel 1-piperazinecarboxamide derivatives |
| SE8400269 | 1984-08-02 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| DK157485A DK157485A (da) | 1985-04-09 |
| DK157485D0 DK157485D0 (da) | 1985-04-09 |
| DK157864B DK157864B (da) | 1990-02-26 |
| DK157864C true DK157864C (da) | 1990-07-23 |
Family
ID=20352166
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK157485A DK157864C (da) | 1983-08-10 | 1985-04-09 | Hidtil ukendte 1-piperazincarboxamidderivater substitueret paa det basiske nitrogenatom samt farmaceutiske praeparater og sammensaetninger indeholdende disse |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US4935419A (sv) |
| EP (1) | EP0136274B1 (sv) |
| JP (1) | JPH0723364B2 (sv) |
| AT (1) | ATE47850T1 (sv) |
| AU (1) | AU569537B2 (sv) |
| CA (1) | CA1253148A (sv) |
| DE (1) | DE3480395D1 (sv) |
| DK (1) | DK157864C (sv) |
| ES (3) | ES8705411A1 (sv) |
| FI (1) | FI80449C (sv) |
| HU (1) | HU196977B (sv) |
| IE (1) | IE58065B1 (sv) |
| IL (1) | IL72563A (sv) |
| NZ (1) | NZ209166A (sv) |
| SE (1) | SE8304361D0 (sv) |
| WO (1) | WO1985000811A1 (sv) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE8500573D0 (sv) * | 1985-02-08 | 1985-02-08 | Ferrosan Ab | Novel piperazinecarboxamides having a phenoxyalkyl or thiophenoxyalkyl side chain |
| GB8713240D0 (en) * | 1987-06-05 | 1987-07-08 | Proteus Biotech Ltd | Hormones |
| ES2057101T3 (es) * | 1988-01-26 | 1994-10-16 | Nippon Chemiphar Co | Agente terapeutico para las enfermedades del higado y derivados de la piperazina. |
| US5795894A (en) * | 1995-05-02 | 1998-08-18 | Schering Corporation | Piperazino derivatives as neurokinn antagonists |
| US5719156A (en) * | 1995-05-02 | 1998-02-17 | Schering Corporation | Piperazino derivatives as neurokinin antagonists |
| US5892039A (en) * | 1995-08-31 | 1999-04-06 | Schering Corporation | Piperazino derivatives as neurokinin antagonists |
| US5869488A (en) * | 1996-05-01 | 1999-02-09 | Schering Corporation | Piperazino derivatives as neurokinin antagonists |
| US5968929A (en) * | 1996-10-30 | 1999-10-19 | Schering Corporation | Piperazino derivatives as neurokinin antagonists |
| WO2000051612A1 (en) | 1999-03-03 | 2000-09-08 | Merck & Co., Inc. | Inhibitors of prenyl-protein transferase |
| EP2358396A2 (en) * | 2008-10-15 | 2011-08-24 | Nitto Denko Corporation | Method of preparing polyglutamate conjugates |
| BR112012013305A2 (pt) * | 2009-12-16 | 2016-03-01 | Nitto Denko Corp | processos para a preparação de ácido poliglutâmico |
| IN2014DN08562A (sv) * | 2012-04-14 | 2015-05-22 | Intra Cellular Therapies Inc | |
| MX2018009158A (es) | 2016-01-26 | 2018-11-19 | Intra Cellular Therapies Inc | Compuestos organicos. |
| US10961245B2 (en) | 2016-12-29 | 2021-03-30 | Intra-Cellular Therapies, Inc. | Substituted heterocycle fused gamma-carbolines for treatment of central nervous system disorders |
| JP6987868B2 (ja) | 2016-12-29 | 2022-01-05 | イントラ−セルラー・セラピーズ・インコーポレイテッドIntra−Cellular Therapies, Inc. | 有機化合物 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3000892A (en) * | 1959-11-16 | 1961-09-19 | Paul A J Janssen | 1-aroylalkyl-4-aroylpiperazines |
| DE1670431A1 (de) * | 1966-03-04 | 1971-02-11 | Chinoin Gyogyszer Es Vegyeszet | Verfahren zur Herstellung neuer Piperazin-Derivate |
| GB1143882A (sv) * | 1966-06-21 | |||
| GB1186495A (en) * | 1968-02-20 | 1970-04-02 | Delalande Sa | 0-[3-(4-Fluorobenzoyl) Proplyl]-4-Substituted Piperazines, their Acid Addition Salts and their method of preparation |
| FR2262521A1 (en) * | 1973-08-08 | 1975-09-26 | Delalande Sa | 3-(3,4,5-Trimethoxyphenyl)piperazines - with coronary vasodilator, hypotensive, antiinflammatory, analgesic, and antiulcer activity |
| JPS5143772A (en) * | 1974-09-26 | 1976-04-14 | Kyorin Seiyaku Kk | 11 * 33 fuenirupuropiru * 44 furoirupiperajinjudotaino seizoho |
| AR207031A1 (es) * | 1974-03-06 | 1976-09-09 | Kyorin Seiyaku Kk | Procedimiento para preparacion de nuevos derivados de 1-(3-fenilpropil)-4-furoilpiperacina |
| JPS50131974A (sv) * | 1974-03-06 | 1975-10-18 | ||
| JPS518283A (en) * | 1974-07-09 | 1976-01-23 | Kyorin Seiyaku Kk | 11 * 33 fuenirupuropiru * 44 karubamoirupiperajinjudotaino seizoho |
| JPS5346988A (en) * | 1976-10-07 | 1978-04-27 | Kyorin Seiyaku Kk | Piperadine derivative |
| NO154582C (no) * | 1978-10-20 | 1986-11-05 | Ferrosan Ab | Analogifremgangsmaate for fremstilling av terapeutisk aktive difenyl-dibutylpiperazinkarboksamider. |
| EP0042366B1 (en) * | 1980-06-16 | 1984-11-07 | AB Ferrosan | Diphenylbutyl-1-acylpiperazines |
| DE3276754D1 (en) * | 1981-12-02 | 1987-08-20 | Ferrosan Ab | 1-piperazinocarboxylates, process for their preparation and pharmaceutical compositions containing them |
-
1983
- 1983-08-10 SE SE8304361A patent/SE8304361D0/sv unknown
-
1984
- 1984-08-01 IL IL72563A patent/IL72563A/xx not_active IP Right Cessation
- 1984-08-02 AU AU32111/84A patent/AU569537B2/en not_active Expired
- 1984-08-02 JP JP59503010A patent/JPH0723364B2/ja not_active Expired - Lifetime
- 1984-08-02 AT AT84850237T patent/ATE47850T1/de not_active IP Right Cessation
- 1984-08-02 DE DE8484850237T patent/DE3480395D1/de not_active Expired
- 1984-08-02 EP EP84850237A patent/EP0136274B1/en not_active Expired
- 1984-08-02 WO PCT/SE1984/000269 patent/WO1985000811A1/en active IP Right Grant
- 1984-08-02 HU HU843341A patent/HU196977B/hu unknown
- 1984-08-09 ES ES535027A patent/ES8705411A1/es not_active Expired
- 1984-08-09 CA CA000460595A patent/CA1253148A/en not_active Expired
- 1984-08-09 IE IE205084A patent/IE58065B1/en not_active IP Right Cessation
- 1984-08-09 NZ NZ209166A patent/NZ209166A/en unknown
-
1985
- 1985-04-03 FI FI851350A patent/FI80449C/sv not_active IP Right Cessation
- 1985-04-09 DK DK157485A patent/DK157864C/da not_active IP Right Cessation
-
1986
- 1986-02-14 ES ES552001A patent/ES8704917A1/es not_active Expired
- 1986-08-01 ES ES556989A patent/ES8802039A1/es not_active Expired
-
1988
- 1988-07-29 US US07/227,420 patent/US4935419A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| ES8705411A1 (es) | 1987-05-01 |
| ES556989A0 (es) | 1988-03-16 |
| WO1985000811A1 (en) | 1985-02-28 |
| EP0136274A1 (en) | 1985-04-03 |
| EP0136274B1 (en) | 1989-11-08 |
| FI851350A0 (fi) | 1985-04-03 |
| IE842050L (en) | 1985-02-10 |
| HU196977B (en) | 1989-02-28 |
| HUT37415A (en) | 1985-12-28 |
| ES8802039A1 (es) | 1988-03-16 |
| FI80449C (sv) | 1990-06-11 |
| FI851350L (fi) | 1985-04-03 |
| FI80449B (fi) | 1990-02-28 |
| ATE47850T1 (de) | 1989-11-15 |
| DK157485A (da) | 1985-04-09 |
| IE58065B1 (en) | 1993-06-30 |
| JPS60501956A (ja) | 1985-11-14 |
| NZ209166A (en) | 1987-07-31 |
| ES552001A0 (es) | 1987-04-16 |
| IL72563A (en) | 1988-10-31 |
| ES8704917A1 (es) | 1987-04-16 |
| DK157864B (da) | 1990-02-26 |
| ES535027A0 (es) | 1987-05-01 |
| US4935419A (en) | 1990-06-19 |
| SE8304361D0 (sv) | 1983-08-10 |
| DK157485D0 (da) | 1985-04-09 |
| AU3211184A (en) | 1985-03-12 |
| CA1253148A (en) | 1989-04-25 |
| JPH0723364B2 (ja) | 1995-03-15 |
| AU569537B2 (en) | 1988-02-04 |
| DE3480395D1 (en) | 1989-12-14 |
| IL72563A0 (en) | 1984-11-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PUP | Patent expired |