ES2083990T3 - Agentes antineoplasicos de quinolina triciclica. - Google Patents

Agentes antineoplasicos de quinolina triciclica.

Info

Publication number
ES2083990T3
ES2083990T3 ES90119985T ES90119985T ES2083990T3 ES 2083990 T3 ES2083990 T3 ES 2083990T3 ES 90119985 T ES90119985 T ES 90119985T ES 90119985 T ES90119985 T ES 90119985T ES 2083990 T3 ES2083990 T3 ES 2083990T3
Authority
ES
Spain
Prior art keywords
lower alkyl
group
quinoline
tricycle
phenyl group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90119985T
Other languages
English (en)
Inventor
Daniel T Chu
Jacob J Plattner
Larry L Klein
Linus L Shen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Application granted granted Critical
Publication of ES2083990T3 publication Critical patent/ES2083990T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C333/00—Derivatives of thiocarbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C333/02—Monothiocarbamic acids; Derivatives thereof
    • C07C333/06—Monothiocarbamic acids; Derivatives thereof having nitrogen atoms of thiocarbamic groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
    • C07D513/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Steroid Compounds (AREA)

Abstract

LOS DERIVADOS DE ISOTHIAZOLO-QUINOLINA SON DESCRITOS COMO CYTOTOXICOS PARA VARIAS LINEAS DE CELULAS DE TUMORES Y SON UTILES PARA EL TRATAMIENTO DE ENFERMEDADES NEOPLASTICAS.
ES90119985T 1989-10-23 1990-10-18 Agentes antineoplasicos de quinolina triciclica. Expired - Lifetime ES2083990T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/425,536 US5071848A (en) 1989-10-23 1989-10-23 Tricyclic quinoline antineoplastic agents

Publications (1)

Publication Number Publication Date
ES2083990T3 true ES2083990T3 (es) 1996-05-01

Family

ID=23686982

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90119985T Expired - Lifetime ES2083990T3 (es) 1989-10-23 1990-10-18 Agentes antineoplasicos de quinolina triciclica.

Country Status (11)

Country Link
US (1) US5071848A (es)
EP (1) EP0424802B1 (es)
JP (1) JPH03167191A (es)
AT (1) ATE131809T1 (es)
CA (1) CA2028246A1 (es)
DE (1) DE69024322T2 (es)
DK (1) DK0424802T3 (es)
ES (1) ES2083990T3 (es)
GR (1) GR3018961T3 (es)
IE (1) IE71688B1 (es)
PT (1) PT95646A (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1554572B1 (en) 2001-07-25 2009-10-14 Raptor Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
CN101120004A (zh) * 2004-11-11 2008-02-06 艾其林医药公司 用作抗感染剂的8a,9-二氢-4a-h-异噻唑[5,4-b]喹啉-3,4-二酮及相关化合物
US7659399B2 (en) * 2005-01-05 2010-02-09 Achillion Pharmaceuticals, Inc. 1-thia-2,4a-diaza-cyclopenta[b]napththalene-3,4-diones and related compounds as anti-infective agents
US7199128B2 (en) * 2005-02-02 2007-04-03 Achillion Pharmaceuticals, Inc. 8-N-substituted-2H-isothiazolo[5,4-b]quinolizine-3,4-diones and related compounds as antiinfective agents
NZ561005A (en) * 2005-02-16 2011-04-29 Achillion Pharmaceuticals Inc New isothiazoloquinolones and related compounds as anti-infective agents
CN101287411B (zh) 2005-04-28 2013-03-06 普罗秋斯生物医学公司 药物信息系统及其用途
DK1913004T3 (da) 2005-07-27 2011-01-10 Achillion Pharmaceuticals Inc 8-methoxy-9h-isothiazolo[5,4-b]quinolin-3,4-dioner og beslægtede forbindelser som antiinfektive midler
CA2663377A1 (en) 2006-09-18 2008-03-27 Raptor Pharmaceutical Inc. Treatment of liver disorders by administration of receptor-associated protein (rap)-conjugates
DE602009001114D1 (de) 2008-01-25 2011-06-09 Mitsubishi Materials Corp Reaktorreinigungsvorrichtung
NZ594310A (en) 2009-02-20 2014-02-28 To Bbb Holding B V Glutathione-based drug delivery system
CA2756701A1 (en) * 2009-04-03 2010-10-07 Achillion Pharmaceuticals, Inc. Hydroxythienoquinolones and related compounds as anti-infective agents
MX2011011833A (es) 2009-05-06 2012-01-27 Lab Skin Care Inc Composiciones de administración dérmica que comprenden complejos de partículas de fosfato de calcio-agente activo y métodos para utilizar las mismas.
WO2011031745A1 (en) 2009-09-09 2011-03-17 Achaogen, Inc. Antibacterial fluoroquinolone analogs
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
CN115650913B (zh) * 2022-10-12 2024-03-01 北京中医药大学 醌式喹啉类化合物及其制备方法和用途

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4767762A (en) * 1985-12-23 1988-08-30 Abbott Laboratories Tricyclic quinoline and naphthyride antibacterials
US4880814A (en) * 1987-11-13 1989-11-14 Abbott Laboratories 7-cycloalkyl naphthyridines
JPH01160985A (ja) * 1987-12-17 1989-06-23 Otsuka Pharmaceut Co Ltd ベンゾヘテロ環化合物
JPH01193275A (ja) * 1988-01-28 1989-08-03 Otsuka Pharmaceut Co Ltd ベンゾヘテロ環化合物
JP2681190B2 (ja) * 1988-04-13 1997-11-26 塩野義製薬株式会社 ピリドン系抗菌剤

Also Published As

Publication number Publication date
DE69024322D1 (de) 1996-02-01
GR3018961T3 (en) 1996-05-31
US5071848A (en) 1991-12-10
CA2028246A1 (en) 1991-04-24
EP0424802B1 (en) 1995-12-20
EP0424802A3 (en) 1992-05-06
EP0424802A2 (en) 1991-05-02
IE903633A1 (en) 1991-04-24
IE71688B1 (en) 1997-02-26
DE69024322T2 (de) 1996-10-31
PT95646A (pt) 1991-09-13
ATE131809T1 (de) 1996-01-15
DK0424802T3 (da) 1996-04-22
JPH03167191A (ja) 1991-07-19

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