RO92245B - Procedeu pentru prepararea unor derivati de 1,6-naftiridina - Google Patents
Procedeu pentru prepararea unor derivati de 1,6-naftiridinaInfo
- Publication number
- RO92245B RO92245B RO119914A RO11991485A RO92245B RO 92245 B RO92245 B RO 92245B RO 119914 A RO119914 A RO 119914A RO 11991485 A RO11991485 A RO 11991485A RO 92245 B RO92245 B RO 92245B
- Authority
- RO
- Romania
- Prior art keywords
- chained
- straight
- carbon atoms
- branched alkyl
- alkyl radical
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Liquid Crystal Substances (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Inventia se refera la un procedeu pentru prepararea unor derivati de la 1,6-naftiridina cu formula generala I: în care R1 este o grupa tinil, o grupa benxozadizol-4-il, o grupa piridil, o grupa fenil substituita cu unul sau doi substituenti, aceeasi sau diferiti, alesi dintre brom, clor, fluor trifluormetilt nitro, metoxi, cian difluormetoxi, metil, difluorometiltio sau metilendioxi, R2 este o grupa alchil lineara sau ramificata cu 1..4 atomi de carbon sau o grupa benzil, R3 este hidrogen, metil, sau alcoxicarbonil cu 1 ... 4 atomi de carbon în grupa alchil, o grupa benziloxicarbonil, (2-(benzil-N-metilamino-etil)-oxicarbonil, (2-dimetilaminoetil)-oxicarbonil, (2-metiltioetil)-oxicarbonic (3-dimetilaminopropil)-oxicarbonil, (2-dibenzilaminoetil)-oxicarbonil, (N-benzilpiperidinil)-oxicarbonil, prin tratarea uneinaftiridinone cu formula similara formulei generale I si având în pozitie 2 grupa cetonica cu un agent de alchilare adecvat substituentului R2.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19843431303 DE3431303A1 (de) | 1984-08-25 | 1984-08-25 | 1,6-naphthyridin-derivate, verfahren zu deren herstellung und deren verwendung |
DE19853502790 DE3502790A1 (de) | 1985-01-29 | 1985-01-29 | 1,6-naphthyridin-derivate, verfahren zu deren herstellung und deren verwendung |
Publications (2)
Publication Number | Publication Date |
---|---|
RO92245A RO92245A (ro) | 1987-07-30 |
RO92245B true RO92245B (ro) | 1987-07-31 |
Family
ID=25824189
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RO119914A RO92245B (ro) | 1984-08-25 | 1985-08-21 | Procedeu pentru prepararea unor derivati de 1,6-naftiridina |
Country Status (22)
Country | Link |
---|---|
US (1) | US4711901A (ro) |
EP (1) | EP0173933B1 (ro) |
KR (1) | KR890000706B1 (ro) |
AT (1) | ATE48276T1 (ro) |
AU (1) | AU576887B2 (ro) |
BG (1) | BG43691A3 (ro) |
CA (1) | CA1263118A (ro) |
DE (1) | DE3574471D1 (ro) |
DK (1) | DK165247C (ro) |
ES (1) | ES8604960A1 (ro) |
FI (1) | FI80697C (ro) |
GR (1) | GR852040B (ro) |
HU (1) | HU194879B (ro) |
IE (1) | IE58364B1 (ro) |
IL (2) | IL75987A (ro) |
NO (1) | NO161493C (ro) |
NZ (1) | NZ213218A (ro) |
PH (4) | PH21177A (ro) |
PL (1) | PL146668B1 (ro) |
RO (1) | RO92245B (ro) |
SU (1) | SU1395143A3 (ro) |
YU (2) | YU45000B (ro) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3431303A1 (de) * | 1984-08-25 | 1986-02-27 | Goedecke Ag | 1,6-naphthyridin-derivate, verfahren zu deren herstellung und deren verwendung |
DE3906460C1 (ro) * | 1989-03-01 | 1990-11-15 | Goedecke Ag, 1000 Berlin, De | |
DE3906406C1 (ro) * | 1989-03-01 | 1990-10-25 | Goedecke Ag, 1000 Berlin, De | |
DE102006026585A1 (de) * | 2006-06-07 | 2007-12-13 | Bayer Healthcare Aktiengesellschaft | Substituierte 4-Aryl-1,4-dihydro-1,6-naphthyridine und ihre Verwendung |
DE102006026583A1 (de) | 2006-06-07 | 2007-12-13 | Bayer Healthcare Aktiengesellschaft | Aryl-substituierte hetero-bicyclische Verbindungen und ihre Verwendung |
DE102007009494A1 (de) | 2007-02-27 | 2008-08-28 | Bayer Healthcare Ag | Substituierte 4-Aryl-1, 4-dihydro-1,6-naphthyridinamide und ihre Verwendung |
MY198066A (en) * | 2014-08-01 | 2023-07-31 | Bayer Pharma AG | Method for the preparation of (4s)- 4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carbox-amide and the purification thereof for use as an active pharmaceutical ingredient |
PT3337801T (pt) * | 2015-08-21 | 2019-08-05 | Bayer Pharma AG | Processo para preparar (4s)-4-(4-ciano-2-metoxifenil)-5- etoxi-2,8-dimetil-1,4-di-hidro-1,6-naftiridina-3- carboxamida e recuperar (4s)-4-(4-ciano-2-metoxifenil)-5- etoxi-2,8-dimetil-1,4-di-hidro-1,6-naftiridina-3- carboxamida por meio de métodos eletroquímicos |
PE20180554A1 (es) * | 2015-08-21 | 2018-04-02 | Bayer Pharma AG | Procedimiento para la preparacion de (4s)-4-(4-ciano-2-metoxifenilo)-5-etoxi-2,8-dimetilo-1,4-dihidro-1,6-naftiridina-3-carboxamida y su purificacion para su uso como principio activo farmaceutico |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4304914A (en) * | 1980-07-07 | 1981-12-08 | Usv Pharmaceutical Corporation | Naphthyridone derivatives |
DE3327650A1 (de) * | 1983-07-30 | 1985-02-14 | Gödecke AG, 1000 Berlin | 1,6-naphthyridinon-derivate, verfahren zu deren herstellung und deren verwendung bei der bekaempfung von gefaesserkrankungen |
-
1985
- 1985-07-31 IL IL8575987Q patent/IL75987A/xx not_active IP Right Cessation
- 1985-08-01 IL IL75987A patent/IL75987A0/xx not_active IP Right Cessation
- 1985-08-15 SU SU853936405A patent/SU1395143A3/ru active
- 1985-08-21 RO RO119914A patent/RO92245B/ro unknown
- 1985-08-21 BG BG8571530A patent/BG43691A3/xx unknown
- 1985-08-22 FI FI853233A patent/FI80697C/fi not_active IP Right Cessation
- 1985-08-22 GR GR852040A patent/GR852040B/el unknown
- 1985-08-23 DE DE8585110646T patent/DE3574471D1/de not_active Expired - Fee Related
- 1985-08-23 NO NO853329A patent/NO161493C/no unknown
- 1985-08-23 DK DK384485A patent/DK165247C/da not_active IP Right Cessation
- 1985-08-23 ES ES546366A patent/ES8604960A1/es not_active Expired
- 1985-08-23 CA CA000489290A patent/CA1263118A/en not_active Expired
- 1985-08-23 EP EP85110646A patent/EP0173933B1/de not_active Expired
- 1985-08-23 HU HU853212A patent/HU194879B/hu not_active IP Right Cessation
- 1985-08-23 PH PH32684A patent/PH21177A/en unknown
- 1985-08-23 AT AT85110646T patent/ATE48276T1/de not_active IP Right Cessation
- 1985-08-23 AU AU46626/85A patent/AU576887B2/en not_active Ceased
- 1985-08-23 NZ NZ213218A patent/NZ213218A/en unknown
- 1985-08-23 IE IE208585A patent/IE58364B1/en not_active IP Right Cessation
- 1985-08-23 PL PL1985255118A patent/PL146668B1/pl unknown
- 1985-08-23 YU YU1348/85A patent/YU45000B/xx unknown
- 1985-08-24 KR KR1019850006133A patent/KR890000706B1/ko not_active IP Right Cessation
-
1986
- 1986-07-30 US US06/891,712 patent/US4711901A/en not_active Expired - Lifetime
- 1986-10-03 PH PH34326A patent/PH23379A/en unknown
- 1986-10-03 PH PH34327A patent/PH23411A/en unknown
-
1987
- 1987-06-17 PH PH35419A patent/PH24762A/en unknown
-
1988
- 1988-01-26 YU YU14588A patent/YU47010B/sh unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES486349A1 (es) | Procedimiento para la preparacion de 5-(2-imidazolin-2-il)- aminopirimidinas | |
WO1988000042A1 (en) | New 5-alkoxy-2,4-diamino-alkyl benzols, and hair tinting means using them | |
HUT59394A (en) | Process for producing piperazine derivatives and pharmaceutical compositions comprising same | |
RO92245B (ro) | Procedeu pentru prepararea unor derivati de 1,6-naftiridina | |
CA2030732A1 (fr) | Nouveaux derives du thiophene, leur procede de preparation et les compositions pharmaceutiques les renfermant | |
HUT58086A (en) | Process for producing new thienloxyalkyl derivatives andpharmaceutical compositions comprising same | |
HU913293D0 (en) | Process for the production of pierazine derivatives and medical preparations containing them | |
HUT39158A (en) | Process for preparing carbacyclines and pharmaceutical compositions containing such compounds | |
EP0239500A3 (en) | 1-styrene-sulfonyl-2-oxo-5-hydroxy-pyrrolidine derivatives, their intermediates, process for their preparation, compositions containing them and their use as medicines | |
GR78773B (ro) | ||
EP0300850A3 (en) | 1-arylsulfonyl-1,5-dihydro 2h-pyrrol-2-one derivatives, intermediates and process for their preparation, their use as medicines and compositions containing them | |
JPS6426553A (en) | Novel derivative of 1-benzyl-2-oxo-5-alkoxy- pyrrolidine, manufacture, use as drug and composition |