RO92245B - Procedeu pentru prepararea unor derivati de 1,6-naftiridina - Google Patents

Procedeu pentru prepararea unor derivati de 1,6-naftiridina

Info

Publication number
RO92245B
RO92245B RO119914A RO11991485A RO92245B RO 92245 B RO92245 B RO 92245B RO 119914 A RO119914 A RO 119914A RO 11991485 A RO11991485 A RO 11991485A RO 92245 B RO92245 B RO 92245B
Authority
RO
Romania
Prior art keywords
chained
straight
carbon atoms
branched alkyl
alkyl radical
Prior art date
Application number
RO119914A
Other languages
English (en)
Other versions
RO92245A (ro
Inventor
Satzinger Gerhard
Hartenstein Johannes
Mannhardt Karl
Kleinschroth Jurgen
Osswald Hartmut
Weinheimer Gunter
Fritschi Edgar
Original Assignee
Godecke Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19843431303 external-priority patent/DE3431303A1/de
Priority claimed from DE19853502790 external-priority patent/DE3502790A1/de
Application filed by Godecke Aktiengesellschaft filed Critical Godecke Aktiengesellschaft
Publication of RO92245A publication Critical patent/RO92245A/ro
Publication of RO92245B publication Critical patent/RO92245B/ro

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Liquid Crystal Substances (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Inventia se refera la un procedeu pentru prepararea unor derivati de la 1,6-naftiridina cu formula generala I: în care R1 este o grupa tinil, o grupa benxozadizol-4-il, o grupa piridil, o grupa fenil substituita cu unul sau doi substituenti, aceeasi sau diferiti, alesi dintre brom, clor, fluor trifluormetilt nitro, metoxi, cian difluormetoxi, metil, difluorometiltio sau metilendioxi, R2 este o grupa alchil lineara sau ramificata cu 1..4 atomi de carbon sau o grupa benzil, R3 este hidrogen, metil, sau alcoxicarbonil cu 1 ... 4 atomi de carbon în grupa alchil, o grupa benziloxicarbonil, (2-(benzil-N-metilamino-etil)-oxicarbonil, (2-dimetilaminoetil)-oxicarbonil, (2-metiltioetil)-oxicarbonic (3-dimetilaminopropil)-oxicarbonil, (2-dibenzilaminoetil)-oxicarbonil, (N-benzilpiperidinil)-oxicarbonil, prin tratarea uneinaftiridinone cu formula similara formulei generale I si având în pozitie 2 grupa cetonica cu un agent de alchilare adecvat substituentului R2.
RO119914A 1984-08-25 1985-08-21 Procedeu pentru prepararea unor derivati de 1,6-naftiridina RO92245B (ro)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19843431303 DE3431303A1 (de) 1984-08-25 1984-08-25 1,6-naphthyridin-derivate, verfahren zu deren herstellung und deren verwendung
DE19853502790 DE3502790A1 (de) 1985-01-29 1985-01-29 1,6-naphthyridin-derivate, verfahren zu deren herstellung und deren verwendung

Publications (2)

Publication Number Publication Date
RO92245A RO92245A (ro) 1987-07-30
RO92245B true RO92245B (ro) 1987-07-31

Family

ID=25824189

Family Applications (1)

Application Number Title Priority Date Filing Date
RO119914A RO92245B (ro) 1984-08-25 1985-08-21 Procedeu pentru prepararea unor derivati de 1,6-naftiridina

Country Status (22)

Country Link
US (1) US4711901A (ro)
EP (1) EP0173933B1 (ro)
KR (1) KR890000706B1 (ro)
AT (1) ATE48276T1 (ro)
AU (1) AU576887B2 (ro)
BG (1) BG43691A3 (ro)
CA (1) CA1263118A (ro)
DE (1) DE3574471D1 (ro)
DK (1) DK165247C (ro)
ES (1) ES8604960A1 (ro)
FI (1) FI80697C (ro)
GR (1) GR852040B (ro)
HU (1) HU194879B (ro)
IE (1) IE58364B1 (ro)
IL (2) IL75987A (ro)
NO (1) NO161493C (ro)
NZ (1) NZ213218A (ro)
PH (4) PH21177A (ro)
PL (1) PL146668B1 (ro)
RO (1) RO92245B (ro)
SU (1) SU1395143A3 (ro)
YU (2) YU45000B (ro)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3431303A1 (de) * 1984-08-25 1986-02-27 Goedecke Ag 1,6-naphthyridin-derivate, verfahren zu deren herstellung und deren verwendung
DE3906406C1 (ro) * 1989-03-01 1990-10-25 Goedecke Ag, 1000 Berlin, De
DE3906460C1 (ro) * 1989-03-01 1990-11-15 Goedecke Ag, 1000 Berlin, De
DE102006026583A1 (de) 2006-06-07 2007-12-13 Bayer Healthcare Aktiengesellschaft Aryl-substituierte hetero-bicyclische Verbindungen und ihre Verwendung
DE102006026585A1 (de) * 2006-06-07 2007-12-13 Bayer Healthcare Aktiengesellschaft Substituierte 4-Aryl-1,4-dihydro-1,6-naphthyridine und ihre Verwendung
DE102007009494A1 (de) 2007-02-27 2008-08-28 Bayer Healthcare Ag Substituierte 4-Aryl-1, 4-dihydro-1,6-naphthyridinamide und ihre Verwendung
KR20230066477A (ko) * 2014-08-01 2023-05-15 바이엘 파마 악티엔게젤샤프트 (4s)-4-(4-시아노-2-메톡시페닐)-5-에톡시-2,8-디메틸-1,4-디히드로-1,6-나프티리딘-3-카르복스아미드의 제조 방법 및 활성 제약 성분으로서 사용하기 위한 그의 정제
SG11201801378VA (en) * 2015-08-21 2018-03-28 Bayer Pharma AG Method for the preparation of (4s)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1-6-naphthyridine-3-carboxamide and recovery of (4s)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1-6-naphthyridine-3-carboxamide by electrochemical methods
RU2743429C2 (ru) * 2015-08-21 2021-02-18 Байер Фарма Акциенгезельшафт Способ получения (4s)-4-(4-циано-2-метоксифенил)-5-этокси-2,8-диметил-1,4-дигидро-1,6-нафтиридин-3-карбоксамида и его очистка для применения в качестве фармацевтического биологически активного вещества

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4304914A (en) * 1980-07-07 1981-12-08 Usv Pharmaceutical Corporation Naphthyridone derivatives
DE3327650A1 (de) * 1983-07-30 1985-02-14 Gödecke AG, 1000 Berlin 1,6-naphthyridinon-derivate, verfahren zu deren herstellung und deren verwendung bei der bekaempfung von gefaesserkrankungen

Also Published As

Publication number Publication date
FI80697B (fi) 1990-03-30
EP0173933B1 (de) 1989-11-29
NZ213218A (en) 1990-01-29
AU576887B2 (en) 1988-09-08
HU194879B (en) 1988-03-28
HUT39448A (en) 1986-09-29
AU4662685A (en) 1986-02-27
KR890000706B1 (ko) 1989-03-27
PH23379A (en) 1989-07-26
DK165247C (da) 1993-04-26
PH24762A (en) 1990-10-01
PL146668B1 (en) 1989-02-28
ATE48276T1 (de) 1989-12-15
IE58364B1 (en) 1993-09-08
PL255118A1 (en) 1986-07-29
RO92245A (ro) 1987-07-30
BG43691A3 (en) 1988-07-15
PH23411A (en) 1989-07-26
ES8604960A1 (es) 1986-03-01
SU1395143A3 (ru) 1988-05-07
IE852085L (en) 1986-02-25
FI80697C (fi) 1990-07-10
PH21177A (en) 1987-08-07
YU45000B (en) 1991-06-30
ES546366A0 (es) 1986-03-01
NO161493B (no) 1989-05-16
GR852040B (ro) 1985-12-19
DK165247B (da) 1992-10-26
CA1263118A (en) 1989-11-21
EP0173933A1 (de) 1986-03-12
IL75987A (en) 1991-07-18
DK384485D0 (da) 1985-08-23
YU47010B (sh) 1994-11-15
KR860001810A (ko) 1986-03-22
US4711901A (en) 1987-12-08
DE3574471D1 (de) 1990-01-04
DK384485A (da) 1986-02-26
NO853329L (no) 1986-02-26
YU14588A (en) 1991-02-28
YU134885A (en) 1988-10-31
FI853233A0 (fi) 1985-08-22
IL75987A0 (en) 1985-12-31
NO161493C (no) 1989-08-23
FI853233L (fi) 1986-02-26

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