BG43691A3 - Method for prepring of 2, 6- naphthyridine derivatives - Google Patents
Method for prepring of 2, 6- naphthyridine derivativesInfo
- Publication number
- BG43691A3 BG43691A3 BG071530A BG7153085A BG43691A3 BG 43691 A3 BG43691 A3 BG 43691A3 BG 071530 A BG071530 A BG 071530A BG 7153085 A BG7153085 A BG 7153085A BG 43691 A3 BG43691 A3 BG 43691A3
- Authority
- BG
- Bulgaria
- Prior art keywords
- naphthyridine derivatives
- prepring
- naphthyridine
- derivatives
- alkylation
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 150000005059 2,6-naphthyridines Chemical class 0.000 title 1
- MZGYULFZYMVEMC-UHFFFAOYSA-N 1,4-dihydro-1,6-naphthyridine Chemical class C1=NC=C2CC=CNC2=C1 MZGYULFZYMVEMC-UHFFFAOYSA-N 0.000 abstract 1
- VSOSXKMEQPYESP-UHFFFAOYSA-N 1,6-naphthyridine Chemical class C1=CN=CC2=CC=CN=C21 VSOSXKMEQPYESP-UHFFFAOYSA-N 0.000 abstract 1
- 229940127291 Calcium channel antagonist Drugs 0.000 abstract 1
- YSVTYSNWZDGRKG-UHFFFAOYSA-N N1C=CCC=2C(NC=CC1=2)=O Chemical class N1C=CCC=2C(NC=CC1=2)=O YSVTYSNWZDGRKG-UHFFFAOYSA-N 0.000 abstract 1
- 238000005804 alkylation reaction Methods 0.000 abstract 1
- 230000002057 chronotropic effect Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000000297 inotrophic effect Effects 0.000 abstract 1
- 229940126601 medicinal product Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Liquid Crystal Substances (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19843431303 DE3431303A1 (de) | 1984-08-25 | 1984-08-25 | 1,6-naphthyridin-derivate, verfahren zu deren herstellung und deren verwendung |
| DE19853502790 DE3502790A1 (de) | 1985-01-29 | 1985-01-29 | 1,6-naphthyridin-derivate, verfahren zu deren herstellung und deren verwendung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BG43691A3 true BG43691A3 (en) | 1988-07-15 |
Family
ID=25824189
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BG071530A BG43691A3 (en) | 1984-08-25 | 1985-08-21 | Method for prepring of 2, 6- naphthyridine derivatives |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US4711901A (ro) |
| EP (1) | EP0173933B1 (ro) |
| KR (1) | KR890000706B1 (ro) |
| AT (1) | ATE48276T1 (ro) |
| AU (1) | AU576887B2 (ro) |
| BG (1) | BG43691A3 (ro) |
| CA (1) | CA1263118A (ro) |
| DE (1) | DE3574471D1 (ro) |
| DK (1) | DK165247C (ro) |
| ES (1) | ES8604960A1 (ro) |
| FI (1) | FI80697C (ro) |
| GR (1) | GR852040B (ro) |
| HU (1) | HU194879B (ro) |
| IE (1) | IE58364B1 (ro) |
| IL (2) | IL75987A (ro) |
| NO (1) | NO161493C (ro) |
| NZ (1) | NZ213218A (ro) |
| PH (4) | PH21177A (ro) |
| PL (1) | PL146668B1 (ro) |
| RO (1) | RO92245B (ro) |
| SU (1) | SU1395143A3 (ro) |
| YU (2) | YU45000B (ro) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3431303A1 (de) * | 1984-08-25 | 1986-02-27 | Goedecke Ag | 1,6-naphthyridin-derivate, verfahren zu deren herstellung und deren verwendung |
| DE3906460C1 (ro) * | 1989-03-01 | 1990-11-15 | Goedecke Ag, 1000 Berlin, De | |
| DE3906406C1 (ro) * | 1989-03-01 | 1990-10-25 | Goedecke Ag, 1000 Berlin, De | |
| DE102006026583A1 (de) | 2006-06-07 | 2007-12-13 | Bayer Healthcare Aktiengesellschaft | Aryl-substituierte hetero-bicyclische Verbindungen und ihre Verwendung |
| DE102006026585A1 (de) | 2006-06-07 | 2007-12-13 | Bayer Healthcare Aktiengesellschaft | Substituierte 4-Aryl-1,4-dihydro-1,6-naphthyridine und ihre Verwendung |
| DE102007009494A1 (de) | 2007-02-27 | 2008-08-28 | Bayer Healthcare Ag | Substituierte 4-Aryl-1, 4-dihydro-1,6-naphthyridinamide und ihre Verwendung |
| AU2015295376C1 (en) * | 2014-08-01 | 2020-07-16 | Bayer Pharma Aktiengesellschaft | Method for the preparation of (4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1-6-naphthyridine-3-carbox-amide and the purification thereof for use as an active pharmaceutical ingredient |
| CN107849043B (zh) * | 2015-08-21 | 2020-10-16 | 拜耳制药股份公司 | 用于制备(4s)-4-(4-氰基-2-甲氧基苯基)-5-乙氧基-2,8-二甲基-1,4-二氢-1,6-萘啶-3-甲酰胺的方法 |
| PE20180555A1 (es) * | 2015-08-21 | 2018-04-02 | Bayer Pharma AG | Procedimiento para la preparacion de (4s)-4-(4-ciano-2-metoxifenilo)-5-etoxi-2,8-dimetil-1,4-dihidro-1,6-naftiridina-3-carboxamida y para la recuperacion de (4s)-4-(4-ciano-2-metoxifenilo)-5-etoxi-2,8-dimetil-1,4-dihidro-1,6-naftiridina-3-carboxamida por medio de metodos electroquimicos |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4304914A (en) * | 1980-07-07 | 1981-12-08 | Usv Pharmaceutical Corporation | Naphthyridone derivatives |
| DE3327650A1 (de) * | 1983-07-30 | 1985-02-14 | Gödecke AG, 1000 Berlin | 1,6-naphthyridinon-derivate, verfahren zu deren herstellung und deren verwendung bei der bekaempfung von gefaesserkrankungen |
-
1985
- 1985-07-31 IL IL8575987Q patent/IL75987A/xx not_active IP Right Cessation
- 1985-08-01 IL IL75987A patent/IL75987A0/xx not_active IP Right Cessation
- 1985-08-15 SU SU853936405A patent/SU1395143A3/ru active
- 1985-08-21 RO RO119914A patent/RO92245B/ro unknown
- 1985-08-21 BG BG071530A patent/BG43691A3/xx unknown
- 1985-08-22 FI FI853233A patent/FI80697C/fi not_active IP Right Cessation
- 1985-08-22 GR GR852040A patent/GR852040B/el unknown
- 1985-08-23 IE IE208585A patent/IE58364B1/en not_active IP Right Cessation
- 1985-08-23 NZ NZ213218A patent/NZ213218A/en unknown
- 1985-08-23 ES ES546366A patent/ES8604960A1/es not_active Expired
- 1985-08-23 HU HU853212A patent/HU194879B/hu not_active IP Right Cessation
- 1985-08-23 AU AU46626/85A patent/AU576887B2/en not_active Ceased
- 1985-08-23 YU YU1348/85A patent/YU45000B/xx unknown
- 1985-08-23 DK DK384485A patent/DK165247C/da not_active IP Right Cessation
- 1985-08-23 AT AT85110646T patent/ATE48276T1/de not_active IP Right Cessation
- 1985-08-23 CA CA000489290A patent/CA1263118A/en not_active Expired
- 1985-08-23 EP EP85110646A patent/EP0173933B1/de not_active Expired
- 1985-08-23 PH PH32684A patent/PH21177A/en unknown
- 1985-08-23 DE DE8585110646T patent/DE3574471D1/de not_active Expired - Fee Related
- 1985-08-23 PL PL1985255118A patent/PL146668B1/pl unknown
- 1985-08-23 NO NO853329A patent/NO161493C/no unknown
- 1985-08-24 KR KR1019850006133A patent/KR890000706B1/ko not_active IP Right Cessation
-
1986
- 1986-07-30 US US06/891,712 patent/US4711901A/en not_active Expired - Lifetime
- 1986-10-03 PH PH34327A patent/PH23411A/en unknown
- 1986-10-03 PH PH34326A patent/PH23379A/en unknown
-
1987
- 1987-06-17 PH PH35419A patent/PH24762A/en unknown
-
1988
- 1988-01-26 YU YU14588A patent/YU47010B/sh unknown
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