ATE37533T1 - Derivate der 4-phenyl-4-oxo-buten-2-saeure, verfahren zu ihrer herstellung, medikamente und mischungen mit diesen derivaten. - Google Patents

Derivate der 4-phenyl-4-oxo-buten-2-saeure, verfahren zu ihrer herstellung, medikamente und mischungen mit diesen derivaten.

Info

Publication number
ATE37533T1
ATE37533T1 AT84401718T AT84401718T ATE37533T1 AT E37533 T1 ATE37533 T1 AT E37533T1 AT 84401718 T AT84401718 T AT 84401718T AT 84401718 T AT84401718 T AT 84401718T AT E37533 T1 ATE37533 T1 AT E37533T1
Authority
AT
Austria
Prior art keywords
derivatives
medications
butene
oxo
phenyl
Prior art date
Application number
AT84401718T
Other languages
English (en)
Inventor
Mario Bianchi
Fernando Barzaghi
Original Assignee
Roussel Uclaf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf filed Critical Roussel Uclaf
Application granted granted Critical
Publication of ATE37533T1 publication Critical patent/ATE37533T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/08—Preparation of carboxylic acid esters by reacting carboxylic acids or symmetrical anhydrides with the hydroxy or O-metal group of organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/738—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
AT84401718T 1983-08-25 1984-08-24 Derivate der 4-phenyl-4-oxo-buten-2-saeure, verfahren zu ihrer herstellung, medikamente und mischungen mit diesen derivaten. ATE37533T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT22648/83A IT1169783B (it) 1983-08-25 1983-08-25 Derivati dell' acido 4-fenil 4-osso-buten 2-oico, loro procedimento di preparazione e loro applicazione come prodotti medicinali
EP84401718A EP0134179B1 (de) 1983-08-25 1984-08-24 Derivate der 4-Phenyl-4-oxo-buten-2-säure, Verfahren zu ihrer Herstellung, Medikamente und Mischungen mit diesen Derivaten

Publications (1)

Publication Number Publication Date
ATE37533T1 true ATE37533T1 (de) 1988-10-15

Family

ID=11198831

Family Applications (1)

Application Number Title Priority Date Filing Date
AT84401718T ATE37533T1 (de) 1983-08-25 1984-08-24 Derivate der 4-phenyl-4-oxo-buten-2-saeure, verfahren zu ihrer herstellung, medikamente und mischungen mit diesen derivaten.

Country Status (19)

Country Link
US (1) US4594443A (de)
EP (1) EP0134179B1 (de)
JP (1) JPS6072843A (de)
KR (1) KR850001724A (de)
AT (1) ATE37533T1 (de)
AU (1) AU565492B2 (de)
CA (1) CA1216859A (de)
DE (1) DE3474298D1 (de)
ES (1) ES8505922A1 (de)
FI (1) FI79524C (de)
GR (1) GR80172B (de)
HU (1) HU191714B (de)
IL (1) IL72682A (de)
IT (1) IT1169783B (de)
MA (1) MA20210A1 (de)
NZ (1) NZ209330A (de)
PT (1) PT78942B (de)
SU (1) SU1333233A3 (de)
ZA (1) ZA846107B (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1190340B (it) * 1986-06-06 1988-02-16 Roussel Maestretti Spa Derivati dell'acido 4-fenil 4-osso 2-butenoico,loro procedimento di preparazione e loro impiego come prodotti medicinali
DK49688A (da) * 1987-03-20 1988-09-21 Hoffmann La Roche Propiolophenonderivater
HU198292B (en) * 1987-09-25 1989-09-28 Richter Gedeon Vegyeszet Process for producing salicilates and pharmaceutical compositions comprising such active ingredient
HU211731B (en) * 1992-12-29 1996-02-28 Richter Gedeon Vegyeszet Process to prepare novel salicylic acid derivs. and pharmaceutical compns. contg. them
KR960703901A (ko) * 1993-08-19 1996-08-31 로즈 암스트롱 치환된 2(5H)푸라논, 2(5H)티오페논 및 2(5H)피롤론 유도체, 그의 제조 방법 및 엔도텔린 길항제로서의 그의 용도(Substituted 2(5H)Furanone, 2(5H)Thiophenone and 2(5H)Pyrrolone Derivatives, Their Preparation and Their Use as Endothelin antagonists)
US5922759A (en) * 1996-06-21 1999-07-13 Warner-Lambert Company Butenolide endothelin antagonists
WO1997008169A1 (en) * 1995-08-24 1997-03-06 Warner-Lambert Company Furanone endothelin antagonists
US5891892A (en) * 1996-10-29 1999-04-06 Warner-Lambert Company Small molecule biaryl compounds as inhibitors of endothelin converting enzyme
US20110067969A1 (en) * 2009-09-22 2011-03-24 Gm Global Technology Operations, Inc. Non-rotating clutch
JP7046812B2 (ja) * 2015-12-23 2022-04-04 ヘンケル・アクチェンゲゼルシャフト・ウント・コムパニー・コマンディットゲゼルシャフト・アウフ・アクチェン 金属加工液

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB588108A (en) * 1944-10-23 1947-05-14 Roche Products Ltd Manufacture of bacteriostatic substances
US2532579A (en) * 1946-08-06 1950-12-05 Du Pont Pest control compositions containing beta-acyl acrylates
US2562208A (en) * 1947-04-14 1951-07-31 Schering Corp Fungistatic composition
DE1282644B (de) * 1962-09-08 1968-11-14 Hoechst Ag Verfahren zur Herstellung von ungesaettigten ª€-Ketocarbonsaeureestern
DE2047806A1 (en) * 1970-09-29 1972-04-06 Dr Karl Thomae GmbH, 7950 Biberach 3-aroyl-acrylic acids - pharmaceutical intermediates prepd from acetophenones and glyoxylic acid derivs
DE2103749A1 (en) * 1971-01-27 1972-08-10 Dr. Karl Thomae GmbH, 7951 Biberach 3-acyl-acrylic acids prepn - from a ketone and glyoxylic acid (deriv)
DE2116293A1 (de) * 1971-04-02 1972-10-19 Cassella Farbwerke Mainkur Ag, 6000 Frankfurt Ketonderivate und Verfahren zu ihrer Herstellung
US3753997A (en) * 1971-06-07 1973-08-21 A Ash Trifluoromethly substituted-2,6-diphenyl-4-pyridyl carbinolamine antimalarials
BE788749A (fr) * 1971-09-13 1973-03-13 Takeda Chemical Industries Ltd Acide 3-(benzoyl trisubstitue)-propionique et son procede de preparation
US4017517A (en) * 1971-09-13 1977-04-12 Takeda Chemical Industries, Ltd. 2-(Trisubstituted benzoyl)-propionic acid and a method for the production thereof
BE795893A (fr) * 1972-02-28 1973-06-18 Unicler Derives de (methylene dioxy-3,4 phenyl)-1 dimethyl-4,4 pentene-1, leur preparation et leur application en therrapeutique
GB1392100A (en) * 1972-09-13 1975-04-23 Beecham Group Ltd Insecticides
FR2270856B1 (de) * 1974-01-17 1978-07-21 Screen
US3953463A (en) * 1974-03-06 1976-04-27 The United States Of America As Represented By The Secretary Of The Army 2-Aryl-6-trifluoromethyl-4-pyridyl-carbinolamine antimalarials
US3940404A (en) * 1974-03-06 1976-02-24 The United States Of America As Represented By The Secretary Of The Army 2-Substituted phenyl-6-trifluoromethyl-4-pyridyl-carbinolamines
IT1210582B (it) * 1981-10-22 1989-09-14 Roussel Maestretti Spa Derivati di acido 4-fenil-4-ossobuten-2-oico dotati di proprieta'farmacologiche e composizioni farmaceutiche che li contengono
DE3228842A1 (de) * 1982-08-02 1984-02-02 Henkel Kgaa Sebosuppressive kosmetische mittel, enthaltend aryloxobutensaeurederivate sowie neue aryloxobutensaeurederivate

Also Published As

Publication number Publication date
FI843354A (fi) 1985-02-26
IT1169783B (it) 1987-06-03
AU3235384A (en) 1985-02-28
NZ209330A (en) 1987-09-30
GR80172B (en) 1985-01-02
EP0134179B1 (de) 1988-09-28
HUT34946A (en) 1985-05-28
FI843354A0 (fi) 1984-08-24
EP0134179A3 (en) 1986-03-26
FI79524C (fi) 1990-01-10
ES535411A0 (es) 1985-06-16
MA20210A1 (fr) 1985-04-01
AU565492B2 (en) 1987-09-17
ZA846107B (en) 1986-03-26
CA1216859A (fr) 1987-01-20
PT78942A (fr) 1984-08-01
HU191714B (en) 1987-03-30
DE3474298D1 (en) 1988-11-03
EP0134179A2 (de) 1985-03-13
FI79524B (fi) 1989-09-29
KR850001724A (ko) 1985-04-01
IL72682A (en) 1987-10-20
JPS6072843A (ja) 1985-04-24
ES8505922A1 (es) 1985-06-16
SU1333233A3 (ru) 1987-08-23
IT8322648A0 (it) 1983-08-25
IL72682A0 (en) 1984-11-30
US4594443A (en) 1986-06-10
PT78942B (fr) 1986-10-21

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee