GB588108A - Manufacture of bacteriostatic substances - Google Patents

Manufacture of bacteriostatic substances

Info

Publication number
GB588108A
GB588108A GB2054744A GB2054744A GB588108A GB 588108 A GB588108 A GB 588108A GB 2054744 A GB2054744 A GB 2054744A GB 2054744 A GB2054744 A GB 2054744A GB 588108 A GB588108 A GB 588108A
Authority
GB
United Kingdom
Prior art keywords
chlorine
maleic anhydride
aluminium chloride
group
carbon bisulphide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2054744A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ALBERT RONALD MOSS
Roche Products Ltd
Original Assignee
ALBERT RONALD MOSS
Roche Products Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ALBERT RONALD MOSS, Roche Products Ltd filed Critical ALBERT RONALD MOSS
Priority to GB2054744A priority Critical patent/GB588108A/en
Publication of GB588108A publication Critical patent/GB588108A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/373—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of functional groups containing oxygen only in doubly bound form

Abstract

Acids of the general formula <FORM:0588108/IV/1> wherein X1 represents chlorine or an acylamino-group and X2 represents hydrogen (or chlorine when X1 represents chlorine) are obtained by treating the appropriate substituted p benzene derivative of the general formula <FORM:0588108/IV/2> with maleic anhydride in the presence of a Friedel-Crafts' condensing agent, e.g. anhydrous aluminium chloride, in the absence of a solvent or in solution in an inert solvent, e.g. carbon bisulphide or petroleum ether. The products exert a strongly bacteriostatic action. In examples: (1) chlorobenzene and maleic anhydride in dry petroleum ether are heated on a water-bath with aluminium chloride to produce p-chlorobenzoylacrylic acid; (2) acetanilide and maleic anhydride in dry carbon bisulphide are treated with anhydrous aluminium chloride and the reaction-mixture is heated on a water-bath to yield p-acetaminobenzoyl acrylic acid; (3) 1 : 3-dichlorobenzene and maleic anhydride in dry carbon bisulphide are treated under reflux with anhydrous aluminium chloride to give 2 : 4-dichlorobenzoyl acrylic acid. The Provisional Specification states that, in the above general formul , X1 may represent chlorine or a substituted amino-group, and X2 hydrogen, chlorine or a substituted amino-group.
GB2054744A 1944-10-23 1944-10-23 Manufacture of bacteriostatic substances Expired GB588108A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB2054744A GB588108A (en) 1944-10-23 1944-10-23 Manufacture of bacteriostatic substances

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB2054744A GB588108A (en) 1944-10-23 1944-10-23 Manufacture of bacteriostatic substances

Publications (1)

Publication Number Publication Date
GB588108A true GB588108A (en) 1947-05-14

Family

ID=10147686

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2054744A Expired GB588108A (en) 1944-10-23 1944-10-23 Manufacture of bacteriostatic substances

Country Status (1)

Country Link
GB (1) GB588108A (en)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2481118A1 (en) * 1980-04-24 1981-10-30 Roussel Uclaf APPLICATION AS MEDICAMENTS OF DERIVATIVES SUBSTITUTED WITH PHENYL-4-OXO-2-BUTENOIC ACID
US4402978A (en) 1980-04-24 1983-09-06 Roussel-Uclaf Gastro-protecting activity of substituted derivatives of 4-phenyl-4-oxo-2-hydroxy-butanoic acid
US4436752A (en) 1981-04-17 1984-03-13 Roussel Uclaf Treatment of gastric and gastro-duodenal disorders with derivatives of phenyl aliphatic carboxylic acids
US4454155A (en) * 1981-10-22 1984-06-12 Roussel Uclaf Pharmaceutical compositions containing a mono-substituted derivative of 4-phenyl-4-oxobuten-2-oic acid, and methods of using them in treating gastric and gastroduodenal ailments
US4473583A (en) * 1981-10-22 1984-09-25 Roussel Uclaf Compositions containing certain derivatives of 4-phenyl-4-oxobuten-2-oic acid and methods of treatment using them
US4486429A (en) * 1981-10-22 1984-12-04 Roussel Uclaf Amino derivatives of 4-phenyl 4-oxobuten-2-oic acid, pharmaceutical compositions containing them, and methods for preparing and therapeutically using them
US4594443A (en) * 1983-08-25 1986-06-10 Roussel-Uclaf Derivatives of 4-phenyl-4-oxo-buten-2-oic acid and therapeutic use thereof
US4814348A (en) * 1983-01-24 1989-03-21 Roussel Uclaf Therapeutic compositions containing derivatives of acrylic acid having an oxygen-containing heterocycle, therapeutic treatment therewith and new compounds

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2481118A1 (en) * 1980-04-24 1981-10-30 Roussel Uclaf APPLICATION AS MEDICAMENTS OF DERIVATIVES SUBSTITUTED WITH PHENYL-4-OXO-2-BUTENOIC ACID
US4402978A (en) 1980-04-24 1983-09-06 Roussel-Uclaf Gastro-protecting activity of substituted derivatives of 4-phenyl-4-oxo-2-hydroxy-butanoic acid
US4483868A (en) * 1980-04-24 1984-11-20 Roussel Uclaf Gastro-protecting activity
US4436752A (en) 1981-04-17 1984-03-13 Roussel Uclaf Treatment of gastric and gastro-duodenal disorders with derivatives of phenyl aliphatic carboxylic acids
US4454155A (en) * 1981-10-22 1984-06-12 Roussel Uclaf Pharmaceutical compositions containing a mono-substituted derivative of 4-phenyl-4-oxobuten-2-oic acid, and methods of using them in treating gastric and gastroduodenal ailments
US4473583A (en) * 1981-10-22 1984-09-25 Roussel Uclaf Compositions containing certain derivatives of 4-phenyl-4-oxobuten-2-oic acid and methods of treatment using them
US4486429A (en) * 1981-10-22 1984-12-04 Roussel Uclaf Amino derivatives of 4-phenyl 4-oxobuten-2-oic acid, pharmaceutical compositions containing them, and methods for preparing and therapeutically using them
US4814348A (en) * 1983-01-24 1989-03-21 Roussel Uclaf Therapeutic compositions containing derivatives of acrylic acid having an oxygen-containing heterocycle, therapeutic treatment therewith and new compounds
US4594443A (en) * 1983-08-25 1986-06-10 Roussel-Uclaf Derivatives of 4-phenyl-4-oxo-buten-2-oic acid and therapeutic use thereof

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