ES453869A1 - Procedimiento para la produccion de una preparacion terapeu-tica antitrombotica. - Google Patents

Procedimiento para la produccion de una preparacion terapeu-tica antitrombotica.

Info

Publication number
ES453869A1
ES453869A1 ES453869A ES453869A ES453869A1 ES 453869 A1 ES453869 A1 ES 453869A1 ES 453869 A ES453869 A ES 453869A ES 453869 A ES453869 A ES 453869A ES 453869 A1 ES453869 A1 ES 453869A1
Authority
ES
Spain
Prior art keywords
salts
heparing
formula
pharmaceutical compositions
compositions containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES453869A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE2554533A external-priority patent/DE2554533C3/de
Priority claimed from DE19762625403 external-priority patent/DE2625403A1/de
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of ES453869A1 publication Critical patent/ES453869A1/es
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Inorganic Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Electronic Switches (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Procedimiento para la producción de una preparación terapéutica antitrombótica, que contiene compuestos de fórmula I **(Fórmula)** en donde R es hidrógeno o alquilo de 1 a 4 átomos de carbono, R1 es metilo, etilo o isopropilo, R2 es isopropilo, butilo sec., isobutilo o bencilo, y X es hidrógeno o metoxi, o sales de los mismos, y heparina o sales de la misma, conjuntamente; caracterizado porque se tratan los compuestos de fórmula I o sus sales, con polivinilpirrolidona para obtener un material sólido, preferiblemente por disolución en agua y ulterior secado por congelación, y se mezcla este material con heparina o sus sales.
ES453869A 1975-12-04 1976-12-02 Procedimiento para la produccion de una preparacion terapeu-tica antitrombotica. Expired ES453869A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE2554533A DE2554533C3 (de) 1975-12-04 1975-12-04 Verwendung von Dihydroergotamin und Heparin
DE19762625403 DE2625403A1 (de) 1976-06-05 1976-06-05 Neue therapeutische mischung und verfahren zu deren herstellung

Publications (1)

Publication Number Publication Date
ES453869A1 true ES453869A1 (es) 1978-01-16

Family

ID=25769698

Family Applications (1)

Application Number Title Priority Date Filing Date
ES453869A Expired ES453869A1 (es) 1975-12-04 1976-12-02 Procedimiento para la produccion de una preparacion terapeu-tica antitrombotica.

Country Status (17)

Country Link
JP (1) JPS5270031A (es)
AU (1) AU512782B2 (es)
CS (1) CS216164B2 (es)
ES (1) ES453869A1 (es)
FR (1) FR2333513A1 (es)
GB (1) GB1557331A (es)
HK (1) HK3083A (es)
IE (1) IE44359B1 (es)
IL (1) IL51043A (es)
IT (1) IT7827782A0 (es)
MY (1) MY8400064A (es)
NL (1) NL172401C (es)
NZ (1) NZ182790A (es)
PH (1) PH12759A (es)
PT (1) PT65919B (es)
SE (1) SE441142B (es)
SG (1) SG63482G (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2809618A1 (de) * 1978-03-06 1979-09-20 Sandoz Ag Neues therapeutisches praeparat und verfahren zu dessen herstellung
CH656533A5 (de) * 1982-12-10 1986-07-15 Sandoz Ag Therapeutisches praeparat enthaltend hydrierte ergotalkaloide und niedermolekulares heparin.

Also Published As

Publication number Publication date
GB1557331A (en) 1979-12-05
IE44359B1 (en) 1981-11-04
IE44359L (en) 1977-06-04
FR2333513B1 (es) 1980-03-28
NZ182790A (en) 1979-03-16
HK3083A (en) 1983-01-20
IL51043A (en) 1980-02-29
JPS5270031A (en) 1977-06-10
FR2333513A1 (fr) 1977-07-01
PT65919B (fr) 1978-07-05
AU512782B2 (en) 1980-10-30
IL51043A0 (en) 1977-02-28
NL172401C (nl) 1983-09-01
MY8400064A (en) 1984-12-31
NL7613316A (nl) 1977-06-07
SE7613252L (sv) 1977-06-05
IT7827782A0 (it) 1978-09-18
AU2024976A (en) 1978-06-08
PH12759A (en) 1979-08-09
NL172401B (nl) 1983-04-05
PT65919A (fr) 1977-01-01
SE441142B (sv) 1985-09-16
SG63482G (en) 1983-09-09
CS216164B2 (en) 1982-10-29

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