ES8506756A1 - Procedimiento para preparar derivados de afidicolina. - Google Patents

Procedimiento para preparar derivados de afidicolina.

Info

Publication number
ES8506756A1
ES8506756A1 ES531941A ES531941A ES8506756A1 ES 8506756 A1 ES8506756 A1 ES 8506756A1 ES 531941 A ES531941 A ES 531941A ES 531941 A ES531941 A ES 531941A ES 8506756 A1 ES8506756 A1 ES 8506756A1
Authority
ES
Spain
Prior art keywords
preparation
derivatives
aphidicolane
general formula
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES531941A
Other languages
English (en)
Other versions
ES531941A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Imperial Chemical Industries Ltd
Original Assignee
Imperial Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10534162&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES8506756(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Imperial Chemical Industries Ltd filed Critical Imperial Chemical Industries Ltd
Publication of ES531941A0 publication Critical patent/ES531941A0/es
Publication of ES8506756A1 publication Critical patent/ES8506756A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/72—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/08—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to hydrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/14—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by free hydroxyl radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/56—Ring systems containing bridged rings
    • C07C2603/86—Ring systems containing bridged rings containing four rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE AFIDICOLINA, EN PARTICULAR PARA LA PREPARACION DE 17-GLICILOXI-3BAB, 16BBB, 18- TRIHIDROXIAFIDICOLANO, DE FORMULA GENERAL (I), EN LA QUE R1 ES EL GRUPO H2NCH2CO-, Y SUS SALES DE ADICION DE ACIDO FARMACEUTICAMENTE ACEPTABLES.CONSISTE EN HIDROGENIZAR UN COMPUESTO DE FORMULA GENERAL (I), EN LA QUE R1 ES EL GRUPO R2O.CO.NHCH2CO-, EN DONDE R2 ES UN RADICAL BAB -FENIL-ALQUILO DE NO MAS DE NUEVE ATOMOS DE CARBONO.DE APLICACION EN MEDICINA POR SU ACTIVIDAD ANHIBIDORA CONTRA LOS VIRUS QUE CONTIENEN DNA Y POR SU PODER INHIBIDOR CONTRA EL CRECIMIENTO DE CIERTOS TUMORES.
ES531941A 1982-11-10 1984-04-26 Procedimiento para preparar derivados de afidicolina. Expired ES8506756A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8232084 1982-11-10

Publications (2)

Publication Number Publication Date
ES531941A0 ES531941A0 (es) 1985-08-01
ES8506756A1 true ES8506756A1 (es) 1985-08-01

Family

ID=10534162

Family Applications (2)

Application Number Title Priority Date Filing Date
ES525299A Expired ES8604105A1 (es) 1982-11-10 1983-09-01 Procedimiento para preparar derivados de afidicolina
ES531941A Expired ES8506756A1 (es) 1982-11-10 1984-04-26 Procedimiento para preparar derivados de afidicolina.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES525299A Expired ES8604105A1 (es) 1982-11-10 1983-09-01 Procedimiento para preparar derivados de afidicolina

Country Status (18)

Country Link
US (2) US4803201A (es)
EP (1) EP0112603B2 (es)
JP (1) JPS5988438A (es)
AT (1) ATE25661T1 (es)
AU (1) AU572787B2 (es)
CA (1) CA1243025A (es)
DE (1) DE3369965D1 (es)
DK (1) DK332283A (es)
ES (2) ES8604105A1 (es)
FI (1) FI80440C (es)
GR (1) GR78865B (es)
HU (1) HU196159B (es)
IE (1) IE55772B1 (es)
IL (1) IL69319A (es)
NO (1) NO157136C (es)
NZ (1) NZ204933A (es)
PT (1) PT77086B (es)
ZA (1) ZA835252B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5387520A (en) * 1992-08-27 1995-02-07 Worcester Foundation For Experimental Biology Treatment of tumor cells in vitro with neurotrophic factors and cell proliferation inhibitors
US7396534B2 (en) * 2004-05-11 2008-07-08 Unilever Home & Personal Care Usa, Division Of Conopco, Inc. Cosmetic compositions containing Nigrospora sphaerica extracts
CN108947790B (zh) * 2017-12-01 2021-07-06 厦门恩成制药有限公司 二萜类化合物及其在制备抗肿瘤药物中的应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1331520A (en) * 1971-01-27 1973-09-26 Ici Ltd Aphidicolin and derivatives thereof
US3761512A (en) * 1972-02-28 1973-09-25 Ici Ltd Anti-viral compounds
FR2500440A1 (fr) * 1981-02-23 1982-08-27 Roussel Uclaf Nouveaux medicaments derives de la 3-hydroxy dodecahydro benz (e) inden-7-one disubstituee en position 6, produits derives de la 3-hydroxy dodecahydro benz (e) inden-7-one disubstituee en position 6, et leur procede de preparation ainsi que des produits intermediaires
JPS62155232A (ja) * 1985-12-27 1987-07-10 Rikagaku Kenkyusho アフイデイコリン誘導体及びその合成法並びに制癌剤

Also Published As

Publication number Publication date
ATE25661T1 (de) 1987-03-15
NO157136C (no) 1988-01-27
EP0112603A1 (en) 1984-07-04
FI80440C (fi) 1990-06-11
DE3369965D1 (en) 1987-04-09
AU572787B2 (en) 1988-05-19
US4803201A (en) 1989-02-07
NO832574L (no) 1984-05-11
PT77086B (en) 1986-01-24
CA1243025A (en) 1988-10-11
EP0112603B2 (en) 1992-03-18
ES525299A0 (es) 1986-01-16
NO157136B (no) 1987-10-19
AU1720183A (en) 1984-05-17
ES8604105A1 (es) 1986-01-16
ES531941A0 (es) 1985-08-01
GR78865B (es) 1984-10-02
EP0112603B1 (en) 1987-03-04
FI832622A0 (fi) 1983-07-19
DK332283A (da) 1984-05-11
IE55772B1 (en) 1991-01-16
PT77086A (en) 1983-08-01
IE831676L (en) 1984-05-10
NZ204933A (en) 1986-12-05
DK332283D0 (da) 1983-07-19
IL69319A (en) 1987-01-30
FI80440B (fi) 1990-02-28
JPS5988438A (ja) 1984-05-22
FI832622A (fi) 1984-05-11
JPH0480890B2 (es) 1992-12-21
US5039710A (en) 1991-08-13
ZA835252B (en) 1984-06-27
HU196159B (en) 1988-10-28

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20000201