FR2385719A1 - Derives d'acides 5-(2-pyrroyl)-1,2-dihydro-3h-pyrrolo (1,2-a)pyrrole-1-carboxiliques, leur procede de preparation et medicaments en contenant - Google Patents

Derives d'acides 5-(2-pyrroyl)-1,2-dihydro-3h-pyrrolo (1,2-a)pyrrole-1-carboxiliques, leur procede de preparation et medicaments en contenant

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Publication number
FR2385719A1
FR2385719A1 FR7809294A FR7809294A FR2385719A1 FR 2385719 A1 FR2385719 A1 FR 2385719A1 FR 7809294 A FR7809294 A FR 7809294A FR 7809294 A FR7809294 A FR 7809294A FR 2385719 A1 FR2385719 A1 FR 2385719A1
Authority
FR
France
Prior art keywords
pyrrolo
dihydro
preparation process
acid derivatives
pyrroyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7809294A
Other languages
English (en)
Other versions
FR2385719B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syntex USA LLC
Original Assignee
Syntex USA LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex USA LLC filed Critical Syntex USA LLC
Publication of FR2385719A1 publication Critical patent/FR2385719A1/fr
Application granted granted Critical
Publication of FR2385719B1 publication Critical patent/FR2385719B1/fr
Granted legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La présente invention concerne des dérivés d'acide 5-(2-pyr-royl)- 1,2-dihydro-3H-pyrrolo-Ø1,2-aõpyrrole- 1 -carboxyliques et leur procédé de préparation. Les nouveaux composés de la présente invention répondent à la formule :
FR7809294A 1977-03-31 1978-03-30 Derives d'acides 5-(2-pyrroyl)-1,2-dihydro-3h-pyrrolo (1,2-a)pyrrole-1-carboxiliques, leur procede de preparation et medicaments en contenant Granted FR2385719A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/783,090 US4097579A (en) 1977-03-31 1977-03-31 5-(2-Pyrroyl)-1,2-dihydro-3H-pyrrolo 1,2-a!pyrrole-1-carboxylic acid derivatives and process for the production thereof

Publications (2)

Publication Number Publication Date
FR2385719A1 true FR2385719A1 (fr) 1978-10-27
FR2385719B1 FR2385719B1 (fr) 1980-07-18

Family

ID=25128138

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7809294A Granted FR2385719A1 (fr) 1977-03-31 1978-03-30 Derives d'acides 5-(2-pyrroyl)-1,2-dihydro-3h-pyrrolo (1,2-a)pyrrole-1-carboxiliques, leur procede de preparation et medicaments en contenant

Country Status (14)

Country Link
US (1) US4097579A (fr)
JP (1) JPS53121792A (fr)
AU (1) AU518169B2 (fr)
BE (1) BE865247A (fr)
CA (1) CA1113938A (fr)
DE (1) DE2813373A1 (fr)
ES (2) ES468267A1 (fr)
FR (1) FR2385719A1 (fr)
GB (1) GB1581411A (fr)
IE (1) IE46506B1 (fr)
IT (1) IT1107833B (fr)
NL (1) NL7803378A (fr)
NZ (1) NZ186797A (fr)
SE (1) SE436648B (fr)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4140698A (en) * 1977-07-25 1979-02-20 Syntex (Usa) Inc. 1,2-Dihydro-3H-pyrrolo[1,2-a]pyrrole-1-nitriles
US4232038A (en) * 1979-08-31 1980-11-04 Syntex (U.S.A.) Inc. 5-Alkylsulfinylbenzoyl- and 5-alkylsulfonylbenzoyl-1,2-dihydro-3H-pyrrolo[1,]pyrrole-1-carboxylic acids
US4344943A (en) * 1980-06-09 1982-08-17 Syntex (U.S.A.) Inc. 6-Chloro- or 6-bromo-1,2-dihydro-3H-pyrrolo[1,2-a]-pyrrole-1-carboxylic acids and derivatives thereof
US4456759A (en) * 1980-10-20 1984-06-26 Syntex (U.S.A.) Inc. 5-Benzoyl-7-halo-1,2-dihydro-3H-pyrrolo-[1,2-a]pyrrole-1,1-dicarboxylic acids and esters thereof
US4353829A (en) * 1980-11-21 1982-10-12 Syntex (U.S.A.) Inc. Process for 5-aroylation of 1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic esters
US4434175A (en) 1981-08-10 1984-02-28 Merck & Co., Inc. Nonsteroidal compounds as anti-inflammatory and analgesic agents
WO1983001382A1 (fr) * 1981-10-13 1983-04-28 Mroszczak, Edward Promedicaments de thioesters menageant le systeme gastrointestinal
EP0091181B1 (fr) * 1982-02-25 1986-12-17 Beecham Group Plc Composés aroyliques de pyrrolizine, procédé pour leur préparation et compositions pharmaceutiques les contenant
US4457941A (en) * 1982-03-22 1984-07-03 Syntex (U.S.A.) Inc. Use of pyrrolo-pyrrole in treating microvascular diseases associated with diabetes
US4454151A (en) * 1982-03-22 1984-06-12 Syntex (U.S.A.) Inc. Use of pyrrolo pyrroles in treatment of ophthalmic diseases
US4612325A (en) * 1982-06-08 1986-09-16 Syntex (U.S.A) Inc. 5-Aroyl-6-alkylthio-1,2-dihydro-3H-pyrrolo(1,2-A)pyrrole-1-carboxylic acids and use thereof as analgesics and anti-inflammatories
JPS5910589A (ja) * 1982-06-10 1984-01-20 メルク　エンド　カムパニー　インコーポレーテツド 抗炎症剤および鎮痛剤として新規な５−（ピロ−ル−２−オイル）−１，２−ジヒドロ−３Ｈ−ピロロ〔１，２−ａ〕ピロ−ル誘導体
US4511724A (en) * 1982-06-10 1985-04-16 Merck & Co., Inc. 5-(Pyrrol-2-oyl)-1,2-dihydro-3H-pyrrolo [1,2-a]pyrrole derivatives as anti-inflammatory and analgesic agents
US4533671A (en) * 1982-10-08 1985-08-06 Merck & Co., Inc. 5-(2,3-Dihydro-1H-pyrrolizin-5-oyl)-2-alkanoic or carboxylic acids and analogs as anti-inflammatory and analgesic agents
US4536512A (en) * 1982-10-08 1985-08-20 Merck & Co., Inc. 5-(2,3-Dihydro-1H-pyrrolizin-5-oyl)-2,3-dihydro-1H-pyrrolizine-1-alkanoic or carboxylic acids and use thereof as anti-inflammatory and analgesic agents
EP0117675B1 (fr) * 1983-02-19 1986-07-23 Beecham Group Plc Dérivés d'acide benzofuranne- et benzothiophène carboxylique
US4622407A (en) * 1984-04-26 1986-11-11 Merck & Co., Inc. Resolution of racemic derivatives of 5-(1-methyl-5-methylthiopyrrol-2-oyl)-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-2-carboxylic acid and analogs
US4873340A (en) * 1986-05-29 1989-10-10 Syntex (U.S.A.) Inc. Process for preparing 5-aroyl-1,2-dihydro-3H-pyrrolo[1,2-A]pyrrole-1,1-dicarboxylates
US4988822A (en) * 1986-05-29 1991-01-29 Syntex (U.S.A.) Inc. Intermediates for preparing 5-aroyl-1,2-dihydro-3H-pyrrolo(1,2-A)pyrrole-1,1-dicarboxylates
US4835288A (en) * 1987-01-14 1989-05-30 Syntex Inc. Process for preparing (+)-2,3-dihydro-1H-pyrrolo[1,2-a]pyrrole-1,7-dicarboxylates
HU198927B (en) * 1987-01-14 1989-12-28 Richter Gedeon Vegyeszet Process for producing 1-/substituted aminomethyl/-octa-hydroindolo-(2,3-a)quinolizine derivatives, pharmaceutically applicable acid addition salts thereof, as well as pharmaceutical compositions comprising same
US4849526A (en) * 1987-01-14 1989-07-18 Syntex (U.S.A.) Inc. Process for preparing (±)-2,3-dihydro-1H-pyrrolo[1,2-A]pyrrole-1,7-dicarboxylates
US4874872A (en) * 1987-01-14 1989-10-17 Syntex (U.S.A.) Inc. Process for preparing (+)-2,3-dihydro-1H-pyrrolo[1,2-A]pyrrole-1,7-dicarboxylates
US4874871A (en) * 1987-03-25 1989-10-17 Syntex (U.S.A.) Inc. Process for preparing (+)-2,3-Dihydro-1H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid and related compounds
US5414011A (en) * 1987-09-11 1995-05-09 Syntex (U.S.A.) Inc. Preservative system for ophthalmic formulations
US5110493A (en) * 1987-09-11 1992-05-05 Syntex (U.S.A.) Inc. Ophthalmic NSAID formulations containing a quaternary ammonium preservative and a nonionic surfactant
WO1995001767A1 (fr) * 1993-07-08 1995-01-19 Cygnus Therapeutic Systems Systeme d'apports transdermique par matrice monolithe
US5621115A (en) * 1996-02-21 1997-04-15 Ohmeda Pharmaceutical Products Division Inc. Methods for preparing 5-aroyl-1,2-dihydro-3H-pyrrolo-[1,2-A]pyrrole-1-carboxylic acids
US6191285B1 (en) 1997-07-03 2001-02-20 Abbott Laboratories Process for the preparation of ketorolac tromethamine

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2361396A1 (fr) * 1976-07-14 1978-03-10 Syntex Inc Derives d'acides 5-(2-furoyl)-, 5-(2-thenoyl)-, 5-(3-furoyl et 5-(3-thenoyl)-1,2-dihydro-3h-pyrrolo(1,2-a)pyrrole-1 carboxyliques et leur procede de preparation

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL293572A (fr) * 1962-06-07
US3846447A (en) * 1972-08-03 1974-11-05 Mcneilab Inc Preparation of 5-aroyl-pyrroles and intermediates therefor

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2361396A1 (fr) * 1976-07-14 1978-03-10 Syntex Inc Derives d'acides 5-(2-furoyl)-, 5-(2-thenoyl)-, 5-(3-furoyl et 5-(3-thenoyl)-1,2-dihydro-3h-pyrrolo(1,2-a)pyrrole-1 carboxyliques et leur procede de preparation

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
NV914/74 *

Also Published As

Publication number Publication date
IE780605L (en) 1978-09-30
JPS647997B2 (fr) 1989-02-10
JPS53121792A (en) 1978-10-24
US4097579A (en) 1978-06-27
BE865247A (fr) 1978-09-25
SE436648B (sv) 1985-01-14
IT1107833B (it) 1985-12-02
AU518169B2 (en) 1981-09-17
ES468267A1 (es) 1979-10-01
FR2385719B1 (fr) 1980-07-18
IT7867706A0 (it) 1978-03-30
ES476535A1 (es) 1979-12-01
IE46506B1 (en) 1983-06-29
AU3461178A (en) 1979-10-04
NZ186797A (en) 1979-12-11
CA1113938A (fr) 1981-12-08
GB1581411A (en) 1980-12-10
NL7803378A (nl) 1978-10-03
DE2813373C2 (fr) 1989-11-09
SE7803549L (sv) 1978-10-01
DE2813373A1 (de) 1978-10-05

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