FR2361396A1 - Derives d'acides 5-(2-furoyl)-, 5-(2-thenoyl)-, 5-(3-furoyl et 5-(3-thenoyl)-1,2-dihydro-3h-pyrrolo(1,2-a)pyrrole-1 carboxyliques et leur procede de preparation - Google Patents
Derives d'acides 5-(2-furoyl)-, 5-(2-thenoyl)-, 5-(3-furoyl et 5-(3-thenoyl)-1,2-dihydro-3h-pyrrolo(1,2-a)pyrrole-1 carboxyliques et leur procede de preparationInfo
- Publication number
- FR2361396A1 FR2361396A1 FR7721559A FR7721559A FR2361396A1 FR 2361396 A1 FR2361396 A1 FR 2361396A1 FR 7721559 A FR7721559 A FR 7721559A FR 7721559 A FR7721559 A FR 7721559A FR 2361396 A1 FR2361396 A1 FR 2361396A1
- Authority
- FR
- France
- Prior art keywords
- thenoyl
- furoyl
- dihydro
- pyrrolo
- preparation process
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
L'invention concerne des dérivés 5-(2-furoyl)-, 5-(2-thénoyl)-, 5-(3-furoyl)- et 5-(3-thénoyl)- 1,2-dihydro- 3H-pyrroloØ1,2-alpyrrole- 1-carboxyliques et un procédé pour leur obtention. Les nouveaux composés d'acides 1,2-dihydro-3H-pyrroloØ1,2-aõpyrrole-1-carboxyliques substitués en position 5 répondent aux formules ci-après, dans lesquelles X = O ou S, R = H ou un groupe alkyle inférieur contenant 1 à 4 atomes de carbone et R**1 = H, un groupe méthyle, un atome de chlore ou un atome de brome. Les composés de l'invention sont utilisés comme agents anti-inflammatoires, analgésiques et antipyrétiques, ainsi que comme agents de relaxation des muscles lisses.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US70485776A | 1976-07-14 | 1976-07-14 | |
US05/771,283 US4087539A (en) | 1976-07-14 | 1977-02-23 | 5-(2-Furoyl)-, 5-(2-thenoyl)-, 5-(3-furoyl)- and 5-(3-thenoyl)-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid derivatives and process for the production thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2361396A1 true FR2361396A1 (fr) | 1978-03-10 |
FR2361396B1 FR2361396B1 (fr) | 1981-11-27 |
Family
ID=27107392
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7721559A Granted FR2361396A1 (fr) | 1976-07-14 | 1977-07-12 | Derives d'acides 5-(2-furoyl)-, 5-(2-thenoyl)-, 5-(3-furoyl et 5-(3-thenoyl)-1,2-dihydro-3h-pyrrolo(1,2-a)pyrrole-1 carboxyliques et leur procede de preparation |
Country Status (26)
Country | Link |
---|---|
JP (1) | JPS539789A (fr) |
AR (1) | AR218631A1 (fr) |
AU (1) | AU513385B2 (fr) |
CA (1) | CA1100140A (fr) |
CH (2) | CH644861A5 (fr) |
CS (1) | CS208724B2 (fr) |
DE (1) | DE2731662A1 (fr) |
DK (1) | DK152652C (fr) |
ES (2) | ES460705A1 (fr) |
FI (1) | FI63407C (fr) |
FR (1) | FR2361396A1 (fr) |
GB (1) | GB1554076A (fr) |
GR (1) | GR61607B (fr) |
HK (1) | HK17581A (fr) |
IE (1) | IE45302B1 (fr) |
IL (1) | IL52492A (fr) |
IT (1) | IT1117314B (fr) |
MY (1) | MY8100371A (fr) |
NL (1) | NL7707652A (fr) |
NO (1) | NO147563C (fr) |
NZ (1) | NZ184611A (fr) |
PL (1) | PL111408B1 (fr) |
PT (1) | PT66779B (fr) |
SE (1) | SE434644B (fr) |
SU (2) | SU664566A3 (fr) |
YU (2) | YU43157B (fr) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2385719A1 (fr) * | 1977-03-31 | 1978-10-27 | Syntex Inc | Derives d'acides 5-(2-pyrroyl)-1,2-dihydro-3h-pyrrolo (1,2-a)pyrrole-1-carboxiliques, leur procede de preparation et medicaments en contenant |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4140698A (en) * | 1977-07-25 | 1979-02-20 | Syntex (Usa) Inc. | 1,2-Dihydro-3H-pyrrolo[1,2-a]pyrrole-1-nitriles |
US4353829A (en) * | 1980-11-21 | 1982-10-12 | Syntex (U.S.A.) Inc. | Process for 5-aroylation of 1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic esters |
US4511724A (en) * | 1982-06-10 | 1985-04-16 | Merck & Co., Inc. | 5-(Pyrrol-2-oyl)-1,2-dihydro-3H-pyrrolo [1,2-a]pyrrole derivatives as anti-inflammatory and analgesic agents |
JPS5910589A (ja) * | 1982-06-10 | 1984-01-20 | メルク エンド カムパニー インコーポレーテツド | 抗炎症剤および鎮痛剤として新規な5−(ピロ−ル−2−オイル)−1,2−ジヒドロ−3H−ピロロ〔1,2−a〕ピロ−ル誘導体 |
HU198927B (en) * | 1987-01-14 | 1989-12-28 | Richter Gedeon Vegyeszet | Process for producing 1-/substituted aminomethyl/-octa-hydroindolo-(2,3-a)quinolizine derivatives, pharmaceutically applicable acid addition salts thereof, as well as pharmaceutical compositions comprising same |
US4874871A (en) * | 1987-03-25 | 1989-10-17 | Syntex (U.S.A.) Inc. | Process for preparing (+)-2,3-Dihydro-1H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid and related compounds |
-
1977
- 1977-05-17 JP JP5697877A patent/JPS539789A/ja active Granted
- 1977-07-07 GR GR53906A patent/GR61607B/el unknown
- 1977-07-07 DK DK307677A patent/DK152652C/da not_active IP Right Cessation
- 1977-07-07 AR AR268357A patent/AR218631A1/es active
- 1977-07-08 CH CH848877A patent/CH644861A5/de not_active IP Right Cessation
- 1977-07-08 NL NL7707652A patent/NL7707652A/xx not_active Application Discontinuation
- 1977-07-08 CH CH4005/84A patent/CH651045A5/de not_active IP Right Cessation
- 1977-07-08 IE IE1422/77A patent/IE45302B1/en unknown
- 1977-07-08 IL IL52492A patent/IL52492A/xx unknown
- 1977-07-08 PT PT66779A patent/PT66779B/fr unknown
- 1977-07-11 NZ NZ184611A patent/NZ184611A/xx unknown
- 1977-07-11 GB GB28923/77A patent/GB1554076A/en not_active Expired
- 1977-07-11 FI FI772154A patent/FI63407C/fi not_active IP Right Cessation
- 1977-07-12 CS CS774647A patent/CS208724B2/cs unknown
- 1977-07-12 FR FR7721559A patent/FR2361396A1/fr active Granted
- 1977-07-12 CA CA282,600A patent/CA1100140A/fr not_active Expired
- 1977-07-13 ES ES460705A patent/ES460705A1/es not_active Expired
- 1977-07-13 PL PL1977199602A patent/PL111408B1/pl unknown
- 1977-07-13 IT IT68631/77A patent/IT1117314B/it active
- 1977-07-13 NO NO772493A patent/NO147563C/no unknown
- 1977-07-13 SU SU772504151A patent/SU664566A3/ru active
- 1977-07-13 AU AU26976/77A patent/AU513385B2/en not_active Expired
- 1977-07-13 DE DE19772731662 patent/DE2731662A1/de active Granted
- 1977-07-13 SE SE7708142A patent/SE434644B/xx not_active IP Right Cessation
- 1977-12-29 SU SU772558960A patent/SU793400A3/ru active
-
1978
- 1978-05-24 ES ES470213A patent/ES470213A1/es not_active Expired
-
1981
- 1981-04-30 HK HK175/81A patent/HK17581A/xx unknown
- 1981-12-30 MY MY371/81A patent/MY8100371A/xx unknown
-
1983
- 1983-02-28 YU YU476/83A patent/YU43157B/xx unknown
- 1983-02-28 YU YU475/83A patent/YU43156B/xx unknown
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2385719A1 (fr) * | 1977-03-31 | 1978-10-27 | Syntex Inc | Derives d'acides 5-(2-pyrroyl)-1,2-dihydro-3h-pyrrolo (1,2-a)pyrrole-1-carboxiliques, leur procede de preparation et medicaments en contenant |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ST | Notification of lapse |