CA1100140A - Procede d'obtention de derives des acides 5-(2- furoyl)-,5-(2-thenoyl)-,5-(3-furoyl)-et 5-(3-thenoyl)- 1,2-dihydro-3h-pyrrolo¬1,2-a|pyrrole-1- carboxyliques - Google Patents

Procede d'obtention de derives des acides 5-(2- furoyl)-,5-(2-thenoyl)-,5-(3-furoyl)-et 5-(3-thenoyl)- 1,2-dihydro-3h-pyrrolo¬1,2-a|pyrrole-1- carboxyliques

Info

Publication number
CA1100140A
CA1100140A CA282,600A CA282600A CA1100140A CA 1100140 A CA1100140 A CA 1100140A CA 282600 A CA282600 A CA 282600A CA 1100140 A CA1100140 A CA 1100140A
Authority
CA
Canada
Prior art keywords
prepared
dihydro
pyrrole
pyrrolo
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA282,600A
Other languages
English (en)
Inventor
Joseph M. Muchowski
Arthur F. Kluge
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syntex USA LLC
Original Assignee
Syntex USA LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/771,283 external-priority patent/US4087539A/en
Application filed by Syntex USA LLC filed Critical Syntex USA LLC
Application granted granted Critical
Publication of CA1100140A publication Critical patent/CA1100140A/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA282,600A 1976-07-14 1977-07-12 Procede d'obtention de derives des acides 5-(2- furoyl)-,5-(2-thenoyl)-,5-(3-furoyl)-et 5-(3-thenoyl)- 1,2-dihydro-3h-pyrrolo¬1,2-a|pyrrole-1- carboxyliques Expired CA1100140A (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US70485776A 1976-07-14 1976-07-14
US704,857 1976-07-14
US05/771,283 US4087539A (en) 1976-07-14 1977-02-23 5-(2-Furoyl)-, 5-(2-thenoyl)-, 5-(3-furoyl)- and 5-(3-thenoyl)-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid derivatives and process for the production thereof
US771,283 1991-10-03

Publications (1)

Publication Number Publication Date
CA1100140A true CA1100140A (fr) 1981-04-28

Family

ID=27107392

Family Applications (1)

Application Number Title Priority Date Filing Date
CA282,600A Expired CA1100140A (fr) 1976-07-14 1977-07-12 Procede d'obtention de derives des acides 5-(2- furoyl)-,5-(2-thenoyl)-,5-(3-furoyl)-et 5-(3-thenoyl)- 1,2-dihydro-3h-pyrrolo¬1,2-a|pyrrole-1- carboxyliques

Country Status (26)

Country Link
JP (1) JPS539789A (fr)
AR (1) AR218631A1 (fr)
AU (1) AU513385B2 (fr)
CA (1) CA1100140A (fr)
CH (2) CH644861A5 (fr)
CS (1) CS208724B2 (fr)
DE (1) DE2731662A1 (fr)
DK (1) DK152652C (fr)
ES (2) ES460705A1 (fr)
FI (1) FI63407C (fr)
FR (1) FR2361396A1 (fr)
GB (1) GB1554076A (fr)
GR (1) GR61607B (fr)
HK (1) HK17581A (fr)
IE (1) IE45302B1 (fr)
IL (1) IL52492A (fr)
IT (1) IT1117314B (fr)
MY (1) MY8100371A (fr)
NL (1) NL7707652A (fr)
NO (1) NO147563C (fr)
NZ (1) NZ184611A (fr)
PL (1) PL111408B1 (fr)
PT (1) PT66779B (fr)
SE (1) SE434644B (fr)
SU (2) SU664566A3 (fr)
YU (2) YU43156B (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4097579A (en) * 1977-03-31 1978-06-27 Syntex (U.S.A.) Inc. 5-(2-Pyrroyl)-1,2-dihydro-3H-pyrrolo 1,2-a!pyrrole-1-carboxylic acid derivatives and process for the production thereof
US4140698A (en) * 1977-07-25 1979-02-20 Syntex (Usa) Inc. 1,2-Dihydro-3H-pyrrolo[1,2-a]pyrrole-1-nitriles
US4353829A (en) * 1980-11-21 1982-10-12 Syntex (U.S.A.) Inc. Process for 5-aroylation of 1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic esters
US4511724A (en) * 1982-06-10 1985-04-16 Merck & Co., Inc. 5-(Pyrrol-2-oyl)-1,2-dihydro-3H-pyrrolo [1,2-a]pyrrole derivatives as anti-inflammatory and analgesic agents
JPS5910589A (ja) * 1982-06-10 1984-01-20 メルク　エンド　カムパニー　インコーポレーテツド 抗炎症剤および鎮痛剤として新規な５−（ピロ−ル−２−オイル）−１，２−ジヒドロ−３Ｈ−ピロロ〔１，２−ａ〕ピロ−ル誘導体
HU198927B (en) * 1987-01-14 1989-12-28 Richter Gedeon Vegyeszet Process for producing 1-/substituted aminomethyl/-octa-hydroindolo-(2,3-a)quinolizine derivatives, pharmaceutically applicable acid addition salts thereof, as well as pharmaceutical compositions comprising same
US4874871A (en) * 1987-03-25 1989-10-17 Syntex (U.S.A.) Inc. Process for preparing (+)-2,3-Dihydro-1H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid and related compounds

Also Published As

Publication number Publication date
AU513385B2 (en) 1980-11-27
FI772154A (fr) 1978-01-15
PT66779A (fr) 1977-08-01
NZ184611A (en) 1979-03-28
DK307677A (da) 1978-01-15
AU2697677A (en) 1979-01-18
IE45302L (en) 1978-01-14
YU47583A (en) 1984-06-30
PL111408B1 (en) 1980-08-30
ES460705A1 (es) 1979-10-01
PT66779B (fr) 1978-12-18
NO147563C (no) 1983-05-18
IL52492A (en) 1981-06-29
FI63407B (fi) 1983-02-28
JPS6254110B2 (fr) 1987-11-13
NO772493L (no) 1978-01-17
GB1554076A (en) 1979-10-17
CH651045A5 (en) 1985-08-30
YU43157B (en) 1989-04-30
AR218631A1 (es) 1980-06-30
FI63407C (fi) 1983-06-10
DE2731662A1 (de) 1978-01-19
FR2361396B1 (fr) 1981-11-27
IL52492A0 (en) 1977-10-31
SU793400A3 (ru) 1980-12-30
IE45302B1 (en) 1982-07-28
DK152652B (da) 1988-04-05
CS208724B2 (en) 1981-09-15
GR61607B (en) 1978-12-02
PL199602A1 (pl) 1979-01-29
HK17581A (en) 1981-05-08
ES470213A1 (es) 1979-09-16
SE434644B (sv) 1984-08-06
IT1117314B (it) 1986-02-17
JPS539789A (en) 1978-01-28
SU664566A3 (ru) 1979-05-25
DE2731662C2 (fr) 1989-11-09
CH644861A5 (en) 1984-08-31
MY8100371A (en) 1981-12-31
FR2361396A1 (fr) 1978-03-10
YU47683A (en) 1984-04-30
DK152652C (da) 1988-09-12
NL7707652A (nl) 1978-01-17
NO147563B (no) 1983-01-24
YU43156B (en) 1989-04-30
SE7708142L (sv) 1978-01-15

Similar Documents

Publication Publication Date Title
US4087539A (en) 5-(2-Furoyl)-, 5-(2-thenoyl)-, 5-(3-furoyl)- and 5-(3-thenoyl)-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid derivatives and process for the production thereof
US4089969A (en) 5-Aroyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid derivatives and process for the production thereof
CA1113938A (fr) Procede d'obtention de derives des acides 5-(2-pyrroyl)-1,2 - dihydro - 3h - pyrrolo ¬1,2- a| - pyrrole -1- carboxyliques
US4232038A (en) 5-Alkylsulfinylbenzoyl- and 5-alkylsulfonylbenzoyl-1,2-dihydro-3H-pyrrolo[1,]pyrrole-1-carboxylic acids
CA1102809A (fr) Procede d'obtention de derives d'acides 5-aroyl-1,2- dihydro-3h-pyrrolo ¬1,2-a|-pyrrole-1- carboxyliques
CA1100140A (fr) Procede d'obtention de derives des acides 5-(2- furoyl)-,5-(2-thenoyl)-,5-(3-furoyl)-et 5-(3-thenoyl)- 1,2-dihydro-3h-pyrrolo¬1,2-a|pyrrole-1- carboxyliques
US4344943A (en) 6-Chloro- or 6-bromo-1,2-dihydro-3H-pyrrolo[1,2-a]-pyrrole-1-carboxylic acids and derivatives thereof
US4581364A (en) 1-substituted-4-hydroxymethyl-pyrrolidin-2-ones
US4560699A (en) 5-(4-Vinylbenzoyl)-1,2-dihydro-3H-pyrrolo-[1,2-a]-pyrrole-1-carboxylic acids and derivatives thereof and use as analgesics and anti-inflammatories
US3931286A (en) Novel benzoylphenylacetic acid derivatives
US3795681A (en) Aminothiophene-carboxylic acid esters
US4410534A (en) 3-Substituted-5,6,7,8-tetrahydropyrrolo[1,2-a]-pyridine-and 6,7,8,9-tetrahydro-5H-pyrrolo[1,2-a]-azepine carboxylic acid derivatives useful as blood platelet aggregation inhibitors
GB2063868A (en) 1-(8-quinolyl)-2-pyrrolidinone
CA2032421A1 (fr) Derive du pyrrolecarbaldehyde
US4810722A (en) 1-styrenesulphonyl-2-oxo-5-hydroxy pyrrolidines and their use for memory restoration after electoshock treatment
US4000288A (en) 6,11-dihydrodibenzo-thiepin-11-ones, compositions and uses thereof
US4000308A (en) 6,11-Dihydrodibenzo-thiepin-11-ones, compositions and uses thereof
DK152653B (da) Analogifremgangsmaade til fremstilling af (dl)-eller (l)-5-(2-furoyl)-, 5-(2-thenoyl)-, 5-(3-furoyl)- eller 5-(3-thenoyl)-1,2-dihydro-3h-pyrrolooe1,2-aaapyrrol-1-carboxylsyreestere eller salte
US3868390A (en) Spiro dibenzocycloheptene isoindoline
DK151336B (da) Analogifremgangsmaade til fremstilling af en (dl)- eller (l)-5-benzoyl-1,2-dihydro-3h-pyrrol(1,2-a)pyrrol-1-carboxylsyre
CH644862A5 (en) 5-(2- and 3-furoyl)- and 5-(2- and 3-thenoyl)-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acids and their salts and esters

Legal Events

Date Code Title Description
MKEX Expiry