FR2398058A1 - Nouveaux derives de l'indole, leur preparation et leur application comme medicaments - Google Patents

Nouveaux derives de l'indole, leur preparation et leur application comme medicaments

Info

Publication number
FR2398058A1
FR2398058A1 FR7821679A FR7821679A FR2398058A1 FR 2398058 A1 FR2398058 A1 FR 2398058A1 FR 7821679 A FR7821679 A FR 7821679A FR 7821679 A FR7821679 A FR 7821679A FR 2398058 A1 FR2398058 A1 FR 2398058A1
Authority
FR
France
Prior art keywords
preparation
indole
application
medicinal products
new derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7821679A
Other languages
English (en)
Other versions
FR2398058B1 (fr
Inventor
Richard Berthold
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CH907777A external-priority patent/CH632246A5/de
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of FR2398058A1 publication Critical patent/FR2398058A1/fr
Application granted granted Critical
Publication of FR2398058B1 publication Critical patent/FR2398058B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring

Abstract

L'invention concerne de nouveaux dérivés de l'indole et leur préparation. Les composés de l'invention répondent à la formule :
FR7821679A 1977-07-21 1978-07-21 Nouveaux derives de l'indole, leur preparation et leur application comme medicaments Granted FR2398058A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CH907777A CH632246A5 (en) 1977-07-21 1977-07-21 Process for preparing novel 3-aminopropoxyindoles
CH907077 1977-07-21
CH906577 1977-07-21
CH907377 1977-07-21

Publications (2)

Publication Number Publication Date
FR2398058A1 true FR2398058A1 (fr) 1979-02-16
FR2398058B1 FR2398058B1 (fr) 1982-08-06

Family

ID=27429188

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7821679A Granted FR2398058A1 (fr) 1977-07-21 1978-07-21 Nouveaux derives de l'indole, leur preparation et leur application comme medicaments

Country Status (18)

Country Link
JP (1) JPS5422364A (fr)
AU (1) AU523105B2 (fr)
BE (1) BE869133A (fr)
CA (1) CA1098909A (fr)
DE (1) DE2830211A1 (fr)
DK (1) DK312878A (fr)
ES (1) ES471863A1 (fr)
FI (1) FI782229A (fr)
FR (1) FR2398058A1 (fr)
GB (1) GB2001971B (fr)
IE (1) IE47131B1 (fr)
IL (1) IL55170A (fr)
IT (1) IT1105092B (fr)
NL (1) NL7807626A (fr)
NZ (1) NZ187909A (fr)
PT (1) PT68317A (fr)
SE (1) SE435374B (fr)
SU (1) SU843740A3 (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2905877A1 (de) * 1979-02-16 1980-08-28 Boehringer Mannheim Gmbh Neue aminopropanolderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE3068678D1 (en) * 1979-08-10 1984-08-30 Sandoz Ag 3-aminopropoxyaryl derivatives, their preparation and pharmaceutical compositions containing them
DE3029980A1 (de) * 1980-08-08 1982-03-11 Boehringer Mannheim Gmbh, 6800 Mannheim Indolderivate und verfahren zu ihrer herstellung
DE3030047A1 (de) * 1980-08-08 1982-03-11 Boehringer Mannheim Gmbh, 6800 Mannheim Neue aminopropanol-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE3131146A1 (de) * 1981-08-06 1983-02-24 Boehringer Mannheim Gmbh, 6800 Mannheim Neue heteroaryloxypropanolamine, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
ZA967892B (en) * 1995-09-21 1998-03-18 Lilly Co Eli Selective β3 adrenergic agonists.
US6818660B2 (en) 1996-04-09 2004-11-16 Nps Pharmaceuticals, Inc. Calcilytic compounds
SG99290A1 (en) * 1996-04-09 2003-10-27 Nps Pharma Inc Calcilytic compounds
ATE215369T1 (de) * 1996-09-05 2002-04-15 Lilly Co Eli Carbazolanaloge als selektive beta3-adrenergische agonisten
US7202261B2 (en) 1996-12-03 2007-04-10 Nps Pharmaceuticals, Inc. Calcilytic compounds
TW483881B (en) 1996-12-03 2002-04-21 Nps Pharma Inc Calcilytic compounds
AU1580001A (en) * 1999-11-15 2001-05-30 Eli Lilly And Company Process for the preparation of aryloxy propanolamines
CN109310651A (zh) 2016-05-13 2019-02-05 小利兰·斯坦福大学董事会 肾上腺素能受体调节化合物及其使用方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1547056A (fr) * 1966-12-13 1968-11-22 Sandoz Sa Dérivés de l'indole et leur préparation
FR2019185A1 (en) * 1968-09-30 1970-06-26 Sandoz Sa 4-(2-hydroxy-3-amino-propoxy)-indole-2-carboxy- - lic acids and esters and 2-hydroxymethylindoles as beta
FR2085732A1 (fr) * 1970-03-24 1971-12-31 Sandoz Sa
FR2290897A1 (fr) * 1974-11-16 1976-06-11 Boehringer Mannheim Gmbh Nouveaux derives d'aminopropanol, leur procede de preparation et des medicaments les contenant

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2508251C2 (de) * 1975-02-26 1983-12-29 Boehringer Mannheim Gmbh, 6800 Mannheim Derivate des Indols, Verfahren zu deren Herstellung sowie diese enthaltende Arzneimittel
DE2633839A1 (de) * 1975-08-07 1977-02-24 Sandoz Ag Neue 4-aminopropoxyindolderivate, ihre herstellung und verwendung
DE2635209C2 (de) * 1975-08-15 1983-01-27 Sandoz-Patent-GmbH, 7850 Lörrach 4-(2-Benzoyloxy-3-tert.butylamino-propoxy)-2-methylindol, dessen (S)-Enantiomeres, deren Säureadditionssalze, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Heilmittel

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1547056A (fr) * 1966-12-13 1968-11-22 Sandoz Sa Dérivés de l'indole et leur préparation
FR2019185A1 (en) * 1968-09-30 1970-06-26 Sandoz Sa 4-(2-hydroxy-3-amino-propoxy)-indole-2-carboxy- - lic acids and esters and 2-hydroxymethylindoles as beta
FR2085732A1 (fr) * 1970-03-24 1971-12-31 Sandoz Sa
FR2290897A1 (fr) * 1974-11-16 1976-06-11 Boehringer Mannheim Gmbh Nouveaux derives d'aminopropanol, leur procede de preparation et des medicaments les contenant

Also Published As

Publication number Publication date
IT7850299A0 (it) 1978-07-14
BE869133A (fr) 1979-01-19
DE2830211A1 (de) 1979-02-01
AU523105B2 (en) 1982-07-15
SE435374B (sv) 1984-09-24
SE7807753L (sv) 1979-01-22
NZ187909A (en) 1981-04-24
JPS5422364A (en) 1979-02-20
NL7807626A (nl) 1979-01-23
IL55170A0 (en) 1978-09-29
IE47131B1 (en) 1983-12-28
PT68317A (fr) 1978-08-01
IT1105092B (it) 1985-10-28
GB2001971B (en) 1982-02-10
GB2001971A (en) 1979-02-14
IE781448L (en) 1979-01-21
IL55170A (en) 1982-07-30
FI782229A (fi) 1979-01-22
DK312878A (da) 1979-01-22
ES471863A1 (es) 1979-10-01
FR2398058B1 (fr) 1982-08-06
SU843740A3 (ru) 1981-06-30
AU3818278A (en) 1980-01-24
CA1098909A (fr) 1981-04-07

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Legal Events

Date Code Title Description
ST Notification of lapse