DE2830211A1 - Substituierte indol-derivate, ihre herstellung und verwendung - Google Patents

Substituierte indol-derivate, ihre herstellung und verwendung

Info

Publication number
DE2830211A1
DE2830211A1 DE19782830211 DE2830211A DE2830211A1 DE 2830211 A1 DE2830211 A1 DE 2830211A1 DE 19782830211 DE19782830211 DE 19782830211 DE 2830211 A DE2830211 A DE 2830211A DE 2830211 A1 DE2830211 A1 DE 2830211A1
Authority
DE
Germany
Prior art keywords
carbon atoms
hydrogen
formula
compounds
halogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
DE19782830211
Other languages
German (de)
English (en)
Inventor
Richard Dr Berthold
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CH907777A external-priority patent/CH632246A5/de
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of DE2830211A1 publication Critical patent/DE2830211A1/de
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE19782830211 1977-07-21 1978-07-10 Substituierte indol-derivate, ihre herstellung und verwendung Ceased DE2830211A1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CH907777A CH632246A5 (en) 1977-07-21 1977-07-21 Process for preparing novel 3-aminopropoxyindoles
CH907077 1977-07-21
CH907377 1977-07-21
CH906577 1977-07-21

Publications (1)

Publication Number Publication Date
DE2830211A1 true DE2830211A1 (de) 1979-02-01

Family

ID=27429188

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19782830211 Ceased DE2830211A1 (de) 1977-07-21 1978-07-10 Substituierte indol-derivate, ihre herstellung und verwendung

Country Status (18)

Country Link
JP (1) JPS5422364A (fr)
AU (1) AU523105B2 (fr)
BE (1) BE869133A (fr)
CA (1) CA1098909A (fr)
DE (1) DE2830211A1 (fr)
DK (1) DK312878A (fr)
ES (1) ES471863A1 (fr)
FI (1) FI782229A (fr)
FR (1) FR2398058A1 (fr)
GB (1) GB2001971B (fr)
IE (1) IE47131B1 (fr)
IL (1) IL55170A (fr)
IT (1) IT1105092B (fr)
NL (1) NL7807626A (fr)
NZ (1) NZ187909A (fr)
PT (1) PT68317A (fr)
SE (1) SE435374B (fr)
SU (1) SU843740A3 (fr)

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0014951A2 (fr) * 1979-02-16 1980-09-03 Roche Diagnostics GmbH Dérivés hétérocycliques d'oxypropanolamine, procédé pour leur préparation et médicaments contenant ces composés
EP0045910A1 (fr) * 1980-08-08 1982-02-17 Roche Diagnostics GmbH Dérivés de l'indol et leur procédé de préparation
EP0045911A1 (fr) * 1980-08-08 1982-02-17 Roche Diagnostics GmbH Dérivés de propanolamine, procédé pour leur préparation et médicaments contenant ces composés
EP0071950A1 (fr) * 1981-08-06 1983-02-16 Roche Diagnostics GmbH Hétéroarylpropanolamines, procédé pour leur fabrication et médicaments contenant ces composés
WO1997010825A1 (fr) * 1995-09-21 1997-03-27 Eli Lilly And Company AGONISTES SELECTIFS DU RECEPTEUR ADRENERGIQUE β¿3?
EP0827746A1 (fr) * 1996-09-05 1998-03-11 Eli Lilly And Company Analogues de carbazole étant agonistes B3-adrénergiques sélectifs
US6022894A (en) * 1996-04-09 2000-02-08 Nps Pharmaceuticals, Inc. Method of using calcilytic compounds
WO2001036412A1 (fr) * 1999-11-15 2001-05-25 Eli Lilly And Company Procede de preparation d'aryloxypropanolamines
US6432656B1 (en) 1996-12-03 2002-08-13 Nps Pharmaceuticals, Inc. Calcilytic compounds
US6818660B2 (en) 1996-04-09 2004-11-16 Nps Pharmaceuticals, Inc. Calcilytic compounds
US7202261B2 (en) 1996-12-03 2007-04-10 Nps Pharmaceuticals, Inc. Calcilytic compounds

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3068678D1 (en) * 1979-08-10 1984-08-30 Sandoz Ag 3-aminopropoxyaryl derivatives, their preparation and pharmaceutical compositions containing them
CN109310651A (zh) * 2016-05-13 2019-02-05 小利兰·斯坦福大学董事会 肾上腺素能受体调节化合物及其使用方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2508251A1 (de) * 1975-02-26 1976-09-09 Boehringer Mannheim Gmbh Neue derivate des indols, verfahren zu deren herstellung sowie diese enthaltende arzneimittel
DE2635209A1 (de) * 1975-08-15 1977-02-24 Sandoz Ag Neue 2- methylindolderivate, ihre herstellung und verwendung
DE2633839A1 (de) * 1975-08-07 1977-02-24 Sandoz Ag Neue 4-aminopropoxyindolderivate, ihre herstellung und verwendung

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1547056A (fr) * 1966-12-13 1968-11-22 Sandoz Sa Dérivés de l'indole et leur préparation
FR2019185A1 (en) * 1968-09-30 1970-06-26 Sandoz Sa 4-(2-hydroxy-3-amino-propoxy)-indole-2-carboxy- - lic acids and esters and 2-hydroxymethylindoles as beta
US3699123A (en) * 1970-03-24 1972-10-17 Sandoz Ltd 4-(3-amino-2-hydroxy-propoxy) indole derivatives
US4076829A (en) * 1974-11-16 1978-02-28 Boehringer Mannheim Gmbh Aminopropanol compounds and compositions for the treatment of cardiac and circulatory diseases

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2508251A1 (de) * 1975-02-26 1976-09-09 Boehringer Mannheim Gmbh Neue derivate des indols, verfahren zu deren herstellung sowie diese enthaltende arzneimittel
DE2633839A1 (de) * 1975-08-07 1977-02-24 Sandoz Ag Neue 4-aminopropoxyindolderivate, ihre herstellung und verwendung
DE2635209A1 (de) * 1975-08-15 1977-02-24 Sandoz Ag Neue 2- methylindolderivate, ihre herstellung und verwendung

Cited By (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0014951A2 (fr) * 1979-02-16 1980-09-03 Roche Diagnostics GmbH Dérivés hétérocycliques d'oxypropanolamine, procédé pour leur préparation et médicaments contenant ces composés
JPS55120559A (en) * 1979-02-16 1980-09-17 Boehringer Mannheim Gmbh Heterocyclic oxypropanolamine derivative*its manufacture and drug containing it and having vasolidating and betaaintercepting activity
EP0014951A3 (en) * 1979-02-16 1981-02-04 Boehringer Mannheim Gmbh Heterocyclic oxypropanolamine derivatives, process for their preparation and medicines containing these compounds
JPS6348864B2 (fr) * 1979-02-16 1988-09-30 Boehringer Mannheim Gmbh
EP0045910A1 (fr) * 1980-08-08 1982-02-17 Roche Diagnostics GmbH Dérivés de l'indol et leur procédé de préparation
EP0045911A1 (fr) * 1980-08-08 1982-02-17 Roche Diagnostics GmbH Dérivés de propanolamine, procédé pour leur préparation et médicaments contenant ces composés
US4468520A (en) * 1980-08-08 1984-08-28 Boehringer Mannheim Gmbh 3-Cyano-indoles as cardioselective agents
EP0071950A1 (fr) * 1981-08-06 1983-02-16 Roche Diagnostics GmbH Hétéroarylpropanolamines, procédé pour leur fabrication et médicaments contenant ces composés
WO1997010825A1 (fr) * 1995-09-21 1997-03-27 Eli Lilly And Company AGONISTES SELECTIFS DU RECEPTEUR ADRENERGIQUE β¿3?
AU715175B2 (en) * 1995-09-21 2000-01-20 Eli Lilly And Company Selective B3 adrenergic agonists
US6022894A (en) * 1996-04-09 2000-02-08 Nps Pharmaceuticals, Inc. Method of using calcilytic compounds
US6521667B1 (en) 1996-04-09 2003-02-18 Nps Pharmaceuticals, Inc. Calcilytic compounds
US6818660B2 (en) 1996-04-09 2004-11-16 Nps Pharmaceuticals, Inc. Calcilytic compounds
EP0827746A1 (fr) * 1996-09-05 1998-03-11 Eli Lilly And Company Analogues de carbazole étant agonistes B3-adrénergiques sélectifs
US6432656B1 (en) 1996-12-03 2002-08-13 Nps Pharmaceuticals, Inc. Calcilytic compounds
US7202261B2 (en) 1996-12-03 2007-04-10 Nps Pharmaceuticals, Inc. Calcilytic compounds
WO2001036412A1 (fr) * 1999-11-15 2001-05-25 Eli Lilly And Company Procede de preparation d'aryloxypropanolamines

Also Published As

Publication number Publication date
IL55170A (en) 1982-07-30
DK312878A (da) 1979-01-22
SE7807753L (sv) 1979-01-22
IT1105092B (it) 1985-10-28
IE781448L (en) 1979-01-21
AU3818278A (en) 1980-01-24
SE435374B (sv) 1984-09-24
FR2398058B1 (fr) 1982-08-06
JPS5422364A (en) 1979-02-20
IE47131B1 (en) 1983-12-28
FR2398058A1 (fr) 1979-02-16
NZ187909A (en) 1981-04-24
IL55170A0 (en) 1978-09-29
CA1098909A (fr) 1981-04-07
FI782229A (fi) 1979-01-22
SU843740A3 (ru) 1981-06-30
ES471863A1 (es) 1979-10-01
BE869133A (fr) 1979-01-19
GB2001971A (en) 1979-02-14
PT68317A (fr) 1978-08-01
NL7807626A (nl) 1979-01-23
IT7850299A0 (it) 1978-07-14
AU523105B2 (en) 1982-07-15
GB2001971B (en) 1982-02-10

Similar Documents

Publication Publication Date Title
DE2513916C2 (de) N-(2-Piperidylmethyl)-2,5-bis (2,2,2-trifluoräthoxy)-benzamid
DE2434911C2 (de) Phenyläthylamin-Derivate und pharmazeutische Zusammensetzungen
DE1443599A1 (de) Ungesaettigte Amine
DE2500110A1 (de) 3-aryloxy-3-phenylpropylamine und verfahren zu ihrer herstellung
DE69305276T2 (de) Arylglycinamidderivate, Verfahren zur deren Herstellung und deren Verwendung zur Therapie der Dysurie
DE2925448A1 (de) 3-aminopropoxyaryl-derivate, ihre herstellung und verwendung
DE2830211A1 (de) Substituierte indol-derivate, ihre herstellung und verwendung
DE3781174T2 (de) Verwendung von aromatischen diaminen fuer die behandlung von angina pectoris und diamine dafuer.
AT368130B (de) Verfahren zur herstellung von neuen 9-aminoalkyl- fluorenen und von deren salzen
DE1670753A1 (de) Verfahren zur Herstellung von 2-Cycloalkylaminooxazolinen
DE1620449B2 (de) Substituierte benzimidazole und verfahren zu ihrer herstellung
DE1445675C3 (de) Pyridylharnstoffe und Verfahren zu ihrer Herstellung
DD145104B3 (de) Verfahren zur herstellung von polyalkoxyphenylpyrrolidone
CH636856A5 (en) 4-(3-Aminopropoxy)indole derivatives, their preparation and medicines containing them
WO1985000169A1 (fr) Derives de 1,4-dihydropyridine, leur fabrication et les preparations pharmaceutiques les contenant
DE3424586A1 (de) 3-aminocarbonylmethoxy-5-phenyl-pyrazol-verbindungen sowie verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE2314114A1 (de) Neue thiazolcarbonsaeurederivate, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen
EP0271099A2 (fr) Amides d'acide aminopropionique substitués, leur procédé de préparation, agents les contenant et leur utilisation, ainsi que les produits intermédiaires formés pendant la préparation
DE2844497C2 (de) Phenoxyalkanolamin-Derivate und Verfahren zu deren Herstellung
DE1620342C3 (fr)
DE3886125T2 (de) Harnstoff-Derivate.
DD151447A1 (de) Verfahren zur herstellung von amidinen und deren salzen
AT371111B (de) Verfahren zur herstellung neuer indole und von deren salzen
AT238181B (de) Verfahren zur Herstellung neuer Pyrrolidinverbindungen
EP0462150B1 (fr) Nouvelles aryloxy-alkylamines, leur fabrication et medicaments les contenant

Legal Events

Date Code Title Description
8110 Request for examination paragraph 44
8131 Rejection