FR2358406A1 - Derives d'acides 5-aroyl-1,2-dihydro-3h-pyrrolo (1,2-a)pyrrole-1-carboxyliques, leur obtention et leur application a titre de medicament - Google Patents

Derives d'acides 5-aroyl-1,2-dihydro-3h-pyrrolo (1,2-a)pyrrole-1-carboxyliques, leur obtention et leur application a titre de medicament

Info

Publication number
FR2358406A1
FR2358406A1 FR7721356A FR7721356A FR2358406A1 FR 2358406 A1 FR2358406 A1 FR 2358406A1 FR 7721356 A FR7721356 A FR 7721356A FR 7721356 A FR7721356 A FR 7721356A FR 2358406 A1 FR2358406 A1 FR 2358406A1
Authority
FR
France
Prior art keywords
aroyl
pyrrole
dihydro
pyrrolo
obtaining
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7721356A
Other languages
English (en)
Other versions
FR2358406B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syntex USA LLC
Original Assignee
Syntex USA LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27107410&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FR2358406(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US05/771,286 external-priority patent/US4089969A/en
Application filed by Syntex USA LLC filed Critical Syntex USA LLC
Publication of FR2358406A1 publication Critical patent/FR2358406A1/fr
Application granted granted Critical
Publication of FR2358406B1 publication Critical patent/FR2358406B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Abstract

L'invention concerne des dérivés d'acides 5-aroyl-1,2-dihydro-3H-pyrroloØ1,2-aõ pyrrole-1-carboxyliques. Les nouveaux composés répondent à la formule :
FR7721356A 1976-07-14 1977-07-11 Derives d'acides 5-aroyl-1,2-dihydro-3h-pyrrolo (1,2-a)pyrrole-1-carboxyliques, leur obtention et leur application a titre de medicament Granted FR2358406A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US70490976A 1976-07-14 1976-07-14
US05/771,286 US4089969A (en) 1976-07-14 1977-02-23 5-Aroyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid derivatives and process for the production thereof

Publications (2)

Publication Number Publication Date
FR2358406A1 true FR2358406A1 (fr) 1978-02-10
FR2358406B1 FR2358406B1 (fr) 1981-04-17

Family

ID=27107410

Family Applications (2)

Application Number Title Priority Date Filing Date
FR7721356A Granted FR2358406A1 (fr) 1976-07-14 1977-07-11 Derives d'acides 5-aroyl-1,2-dihydro-3h-pyrrolo (1,2-a)pyrrole-1-carboxyliques, leur obtention et leur application a titre de medicament
FR7738508A Granted FR2375234A1 (fr) 1976-07-14 1977-12-20 1,2-dihydro-3h-pyrrolo(1,2-a)pyrrole-1-carboxylates et leur obtention

Family Applications After (1)

Application Number Title Priority Date Filing Date
FR7738508A Granted FR2375234A1 (fr) 1976-07-14 1977-12-20 1,2-dihydro-3h-pyrrolo(1,2-a)pyrrole-1-carboxylates et leur obtention

Country Status (27)

Country Link
JP (1) JPS539788A (fr)
AR (1) AR224997A1 (fr)
CA (1) CA1102809A (fr)
CH (3) CH641458A5 (fr)
CS (1) CS204954B2 (fr)
DE (2) DE2731678A1 (fr)
DK (1) DK151886C (fr)
ES (2) ES460706A1 (fr)
FI (1) FI63406C (fr)
FR (2) FR2358406A1 (fr)
GB (1) GB1554075A (fr)
GR (1) GR61111B (fr)
HK (1) HK15981A (fr)
HU (1) HU174224B (fr)
IE (1) IE45253B1 (fr)
IL (2) IL52493A (fr)
IT (1) IT1117313B (fr)
MX (1) MX163202B (fr)
MY (1) MY8100357A (fr)
NL (2) NL186318C (fr)
NO (1) NO147564C (fr)
NZ (1) NZ184610A (fr)
PL (4) PL109390B1 (fr)
PT (1) PT66780B (fr)
SE (1) SE434643B (fr)
SU (1) SU695558A3 (fr)
YU (1) YU40816B (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0096816A2 (fr) * 1982-06-10 1983-12-28 Merck & Co. Inc. Dérivés du (pyrrol-2-oyl)-1,2-dihydro-3H-pyrrolo(1,2-a)pyrrole comme anti-inflammatoires et analgésiques

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4140698A (en) * 1977-07-25 1979-02-20 Syntex (Usa) Inc. 1,2-Dihydro-3H-pyrrolo[1,2-a]pyrrole-1-nitriles
JPS55124633A (en) * 1979-03-19 1980-09-25 Sohachi Takeuchi Manufacturing method of tubular vessel
US4344943A (en) * 1980-06-09 1982-08-17 Syntex (U.S.A.) Inc. 6-Chloro- or 6-bromo-1,2-dihydro-3H-pyrrolo[1,2-a]-pyrrole-1-carboxylic acids and derivatives thereof
US4353829A (en) * 1980-11-21 1982-10-12 Syntex (U.S.A.) Inc. Process for 5-aroylation of 1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic esters
JPS5910589A (ja) * 1982-06-10 1984-01-20 メルク　エンド　カムパニー　インコーポレーテツド 抗炎症剤および鎮痛剤として新規な５−（ピロ−ル−２−オイル）−１，２−ジヒドロ−３Ｈ−ピロロ〔１，２−ａ〕ピロ−ル誘導体
US4874871A (en) * 1987-03-25 1989-10-17 Syntex (U.S.A.) Inc. Process for preparing (+)-2,3-Dihydro-1H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid and related compounds
JPH0739418B2 (ja) * 1987-09-10 1995-05-01 久光製薬株式会社 新規な３−アロイル−６，７−ジヒドロ−５Ｈ−ピロロ〔１，２−ｃ〕イミダゾール−７−カルボン酸誘導体
JP2649168B2 (ja) * 1988-02-25 1997-09-03 久光製薬株式会社 新規な５，６−ジフェニル−１，２−ジヒドロ−３Ｈ−ピロロ［１，２−ａ］ピロール−１−カルボン酸誘導体
IT1250691B (it) * 1991-07-22 1995-04-21 Giancarlo Santus Composizioni terapeutiche per somministrazione intranasale comprendenti ketorolac.
WO1993009768A1 (fr) * 1991-11-11 1993-05-27 Hisamitsu Pharmaceutical Co., Inc. Fomentation contenant du cetorolac
DE4300697C1 (de) * 1993-01-13 1994-05-19 Roemmers Sa Keterolac-Derivat mit wesentlich geringerer gastrointestinaler Reizung und Ulzeration
US5622948A (en) * 1994-12-01 1997-04-22 Syntex (U.S.A.) Inc. Pyrrole pyridazine and pyridazinone anti-inflammatory agents
JP2008210666A (ja) * 2007-02-27 2008-09-11 Okamura Corp 商品陳列棚における照明装置

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0096816A2 (fr) * 1982-06-10 1983-12-28 Merck & Co. Inc. Dérivés du (pyrrol-2-oyl)-1,2-dihydro-3H-pyrrolo(1,2-a)pyrrole comme anti-inflammatoires et analgésiques
EP0096816A3 (en) * 1982-06-10 1984-08-22 Merck & Co. Inc. New 5-(pyrrol-2-oyl)-1,2-dihydro-3h-pyrrolo(1,2-a)pyrrole derivatives as anti-inflammatory and analgesic agents

Also Published As

Publication number Publication date
SE7708141L (sv) 1978-01-15
NL930021I1 (nl) 1993-05-03
PL109390B1 (en) 1980-05-31
MX163202B (es) 1992-02-20
IL52493A0 (en) 1977-10-31
ES470214A1 (es) 1979-09-16
PT66780A (fr) 1977-08-01
PL124445B1 (en) 1983-01-31
JPS6254109B2 (fr) 1987-11-13
NL7707651A (nl) 1978-01-17
NO772494L (no) 1978-01-17
AU2697577A (en) 1979-01-18
NO147564B (no) 1983-01-24
CA1102809A (fr) 1981-06-09
SU695558A3 (ru) 1979-10-30
FI63406B (fi) 1983-02-28
FR2375234A1 (fr) 1978-07-21
IT1117313B (it) 1986-02-17
AU513384B2 (en) 1980-11-27
CH646973A5 (en) 1984-12-28
NO147564C (no) 1983-05-18
DK307577A (da) 1978-01-15
DE2760330C2 (fr) 1989-06-15
HU174224B (hu) 1979-11-28
IE45253L (en) 1978-01-14
HK15981A (en) 1981-05-01
FI63406C (fi) 1983-06-10
NL186318C (nl) 1990-11-01
CS204954B2 (en) 1981-04-30
MY8100357A (en) 1981-12-31
YU172177A (en) 1983-09-30
FR2358406B1 (fr) 1981-04-17
IL52493A (en) 1982-02-28
DK151886C (da) 1988-06-06
IE45253B1 (en) 1982-07-14
NZ184610A (en) 1979-03-28
DE2731678C2 (fr) 1989-06-08
PL199603A1 (pl) 1978-04-24
PL124711B1 (en) 1983-02-28
CH641458A5 (en) 1984-02-29
SE434643B (sv) 1984-08-06
NL930021I2 (nl) 1997-03-03
AR224997A1 (es) 1982-02-15
GR61111B (en) 1978-09-12
DK151886B (da) 1988-01-11
NL186318B (nl) 1990-06-01
JPS539788A (en) 1978-01-28
FI772153A (fr) 1978-01-15
PT66780B (fr) 1978-12-18
ES460706A1 (es) 1978-12-01
DE2731678A1 (de) 1978-03-16
CH646972A5 (en) 1984-12-28
PL124444B1 (en) 1983-01-31
GB1554075A (en) 1979-10-17
FR2375234B1 (fr) 1980-11-07
IL58779A0 (en) 1980-02-29
YU40816B (en) 1986-06-30

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Legal Events

Date Code Title Description
CC Supplementary protection certificate (spc) laid open to the public (law of 25 june 1990)

Free format text: 92C0231, 920520

CB Supplementary protection certificate (spc) granted (law of 25 june 1990)

Free format text: 92C0231, 770711

CL Concession to grant licences
CP Supplementary protection certificate (spc) filed
CX Request for supplementary protection certificate (spc) rejected

Free format text: 93C0012, 19930405

CP Supplementary protection certificate (spc) filed