GB1554075A - 1,2-dihydro-3h-pyrrolo-(1,2-a)-pyrrole-1-carboxylic acid derivatives and process for the production thereof - Google Patents
1,2-dihydro-3h-pyrrolo-(1,2-a)-pyrrole-1-carboxylic acid derivatives and process for the production thereofInfo
- Publication number
- GB1554075A GB1554075A GB28919/77A GB2891977A GB1554075A GB 1554075 A GB1554075 A GB 1554075A GB 28919/77 A GB28919/77 A GB 28919/77A GB 2891977 A GB2891977 A GB 2891977A GB 1554075 A GB1554075 A GB 1554075A
- Authority
- GB
- United Kingdom
- Prior art keywords
- pyrrolo
- pyrrole
- dihydro
- carboxylic acid
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
Abstract
Novel carboxylic acid esters of the formula: <IMAGE> in which R denotes hydrogen or C1-C4-alkyl, R<1> denotes hydrogen, C1-C4-alkyl, C1-C4-alkoxy, fluorine, chlorine or bromine, and R<2> denotes C1-C4-alkyl, are prepared by condensing an amide R<1>C6H4CON(CH3) 2 with a corresponding alkyl 1,2-dihydro-3H-pyrrolo[1,2a]pyrrole-1-carboxylate. The compounds may be used therapeutically as antiinflammatory agents, analgesic agents, fibrinolytic agents and muscle relaxants.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US70490976A | 1976-07-14 | 1976-07-14 | |
| US05/771,286 US4089969A (en) | 1976-07-14 | 1977-02-23 | 5-Aroyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid derivatives and process for the production thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1554075A true GB1554075A (en) | 1979-10-17 |
Family
ID=27107410
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB28919/77A Expired GB1554075A (en) | 1976-07-14 | 1977-07-11 | 1,2-dihydro-3h-pyrrolo-(1,2-a)-pyrrole-1-carboxylic acid derivatives and process for the production thereof |
Country Status (27)
| Country | Link |
|---|---|
| JP (1) | JPS539788A (en) |
| AR (1) | AR224997A1 (en) |
| CA (1) | CA1102809A (en) |
| CH (3) | CH641458A5 (en) |
| CS (1) | CS204954B2 (en) |
| DE (2) | DE2731678A1 (en) |
| DK (1) | DK151886C (en) |
| ES (2) | ES460706A1 (en) |
| FI (1) | FI63406C (en) |
| FR (2) | FR2358406A1 (en) |
| GB (1) | GB1554075A (en) |
| GR (1) | GR61111B (en) |
| HK (1) | HK15981A (en) |
| HU (1) | HU174224B (en) |
| IE (1) | IE45253B1 (en) |
| IL (2) | IL52493A (en) |
| IT (1) | IT1117313B (en) |
| MX (1) | MX163202B (en) |
| MY (1) | MY8100357A (en) |
| NL (2) | NL186318C (en) |
| NO (1) | NO147564C (en) |
| NZ (1) | NZ184610A (en) |
| PL (4) | PL124711B1 (en) |
| PT (1) | PT66780B (en) |
| SE (1) | SE434643B (en) |
| SU (1) | SU695558A3 (en) |
| YU (1) | YU40816B (en) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4140698A (en) * | 1977-07-25 | 1979-02-20 | Syntex (Usa) Inc. | 1,2-Dihydro-3H-pyrrolo[1,2-a]pyrrole-1-nitriles |
| JPS55124633A (en) * | 1979-03-19 | 1980-09-25 | Sohachi Takeuchi | Manufacturing method of tubular vessel |
| US4344943A (en) * | 1980-06-09 | 1982-08-17 | Syntex (U.S.A.) Inc. | 6-Chloro- or 6-bromo-1,2-dihydro-3H-pyrrolo[1,2-a]-pyrrole-1-carboxylic acids and derivatives thereof |
| US4353829A (en) * | 1980-11-21 | 1982-10-12 | Syntex (U.S.A.) Inc. | Process for 5-aroylation of 1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic esters |
| JPS5910589A (en) * | 1982-06-10 | 1984-01-20 | メルク エンド カムパニー インコーポレーテツド | Antiinflammatory and analgesic novel 5-(pyrrol-2-oyl)-1,2-dihydro-3h-pyrrolo(1,2-a) pyrrole derivative |
| US4511724A (en) * | 1982-06-10 | 1985-04-16 | Merck & Co., Inc. | 5-(Pyrrol-2-oyl)-1,2-dihydro-3H-pyrrolo [1,2-a]pyrrole derivatives as anti-inflammatory and analgesic agents |
| US4874871A (en) * | 1987-03-25 | 1989-10-17 | Syntex (U.S.A.) Inc. | Process for preparing (+)-2,3-Dihydro-1H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid and related compounds |
| JPH0739418B2 (en) * | 1987-09-10 | 1995-05-01 | 久光製薬株式会社 | Novel 3-aroyl-6,7-dihydro-5H-pyrrolo [1,2-c] imidazole-7-carboxylic acid derivative |
| JP2649168B2 (en) * | 1988-02-25 | 1997-09-03 | 久光製薬株式会社 | Novel 5,6-diphenyl-1,2-dihydro-3H-pyrrolo [1,2-a] pyrrole-1-carboxylic acid derivatives |
| IT1250691B (en) * | 1991-07-22 | 1995-04-21 | Giancarlo Santus | THERAPEUTIC COMPOSITIONS FOR INTRANASAL ADMINISTRATION INCLUDING KETOROLAC. |
| DE69229506T2 (en) * | 1991-11-11 | 1999-10-28 | Hisamitsu Pharmaceutical Co., Inc. | WARM ENVELOPE CONTAINING KETOROLAC |
| DE4300697C1 (en) * | 1993-01-13 | 1994-05-19 | Roemmers Sa | New 2-pyrrolidino-ethyl ester of ketorolac - useful as analgesic, antiinflammatory and antipyretic agent with low ulcerogenicity |
| US5622948A (en) * | 1994-12-01 | 1997-04-22 | Syntex (U.S.A.) Inc. | Pyrrole pyridazine and pyridazinone anti-inflammatory agents |
| JP2008210666A (en) * | 2007-02-27 | 2008-09-11 | Okamura Corp | Lighting system in merchandise display shelf |
-
1977
- 1977-05-17 JP JP5697777A patent/JPS539788A/en active Granted
- 1977-07-07 AR AR268356A patent/AR224997A1/en active
- 1977-07-07 GR GR53907A patent/GR61111B/en unknown
- 1977-07-07 DK DK307577A patent/DK151886C/en active
- 1977-07-08 IE IE1423/77A patent/IE45253B1/en not_active IP Right Cessation
- 1977-07-08 PT PT66780A patent/PT66780B/en unknown
- 1977-07-08 IL IL52493A patent/IL52493A/en unknown
- 1977-07-08 NL NLAANVRAGE7707651,A patent/NL186318C/en not_active IP Right Cessation
- 1977-07-08 CH CH850077A patent/CH641458A5/en not_active IP Right Cessation
- 1977-07-11 YU YU1721/77A patent/YU40816B/en unknown
- 1977-07-11 GB GB28919/77A patent/GB1554075A/en not_active Expired
- 1977-07-11 NZ NZ184610A patent/NZ184610A/en unknown
- 1977-07-11 FI FI772153A patent/FI63406C/en not_active IP Right Cessation
- 1977-07-11 FR FR7721356A patent/FR2358406A1/en active Granted
- 1977-07-12 CS CS774646A patent/CS204954B2/en unknown
- 1977-07-12 CA CA282,599A patent/CA1102809A/en not_active Expired
- 1977-07-13 NO NO772494A patent/NO147564C/en unknown
- 1977-07-13 DE DE19772731678 patent/DE2731678A1/en active Granted
- 1977-07-13 ES ES460706A patent/ES460706A1/en not_active Expired
- 1977-07-13 SU SU772501050A patent/SU695558A3/en active
- 1977-07-13 PL PL1977227289A patent/PL124711B1/en unknown
- 1977-07-13 SE SE7708141A patent/SE434643B/en not_active IP Right Cessation
- 1977-07-13 DE DE2760330A patent/DE2760330C2/de not_active Expired
- 1977-07-13 PL PL1977227290A patent/PL124444B1/en unknown
- 1977-07-13 PL PL1977227291A patent/PL124445B1/en unknown
- 1977-07-13 IT IT68630/77A patent/IT1117313B/en active Protection Beyond IP Right Term
- 1977-07-13 PL PL1977199603A patent/PL109390B1/en unknown
- 1977-07-14 HU HU77SI1582A patent/HU174224B/en unknown
- 1977-12-20 FR FR7738508A patent/FR2375234A1/en active Granted
-
1978
- 1978-05-24 ES ES470214A patent/ES470214A1/en not_active Expired
-
1979
- 1979-11-22 IL IL58779A patent/IL58779A0/en unknown
-
1981
- 1981-04-23 HK HK159/81A patent/HK15981A/en unknown
- 1981-12-30 MY MY357/81A patent/MY8100357A/en unknown
-
1984
- 1984-02-22 CH CH86684A patent/CH646973A5/en not_active IP Right Cessation
- 1984-02-22 CH CH86584A patent/CH646972A5/en not_active IP Right Cessation
-
1991
- 1991-07-05 MX MX9100104A patent/MX163202B/en unknown
-
1993
- 1993-03-23 NL NL930021C patent/NL930021I2/en unknown
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| 704A | Declaration that licence is not available as of right for an excepted use (par. 4a/1977) | ||
| CTFF | Supplementary protection certificate filed |
Free format text: SPC/GB93/023, 930402 |
|
| CTFG | Supplementary protection certificate granted |
Free format text: SPC/GB93/023, 931119, EXPIRES:20020710 |
|
| PE20 | Patent expired after termination of 20 years |
Effective date: 19970710 |
|
| CTFE | Supplementary protection certificate entered into force |
Free format text: SPC/GB93/023, 970711, EXPIRES:20020710 |
|
| SPCE | Supplementary protection certificate expired |
Free format text: SPC/GB93/023, 20020710 |