DE2731678A1 - Neue 5-aroyl-1,2-dihydro-3h-pyrrolo- eckige klammer auf 1,2-a eckige klammer zu -pyrrol-1-carbonsaeurederivate - Google Patents

Neue 5-aroyl-1,2-dihydro-3h-pyrrolo- eckige klammer auf 1,2-a eckige klammer zu -pyrrol-1-carbonsaeurederivate

Info

Publication number
DE2731678A1
DE2731678A1 DE19772731678 DE2731678A DE2731678A1 DE 2731678 A1 DE2731678 A1 DE 2731678A1 DE 19772731678 DE19772731678 DE 19772731678 DE 2731678 A DE2731678 A DE 2731678A DE 2731678 A1 DE2731678 A1 DE 2731678A1
Authority
DE
Germany
Prior art keywords
pyrrolo
dihydro
pyrrole
carboxylic acid
namely
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
DE19772731678
Other languages
German (de)
English (en)
Other versions
DE2731678C2 (fr
Inventor
Arthur F Kluge
Joseph M Muchowski
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syntex USA LLC
Original Assignee
Syntex USA LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27107410&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE2731678(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US05/771,286 external-priority patent/US4089969A/en
Application filed by Syntex USA LLC filed Critical Syntex USA LLC
Publication of DE2731678A1 publication Critical patent/DE2731678A1/de
Application granted granted Critical
Publication of DE2731678C2 publication Critical patent/DE2731678C2/de
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
DE19772731678 1976-07-14 1977-07-13 Neue 5-aroyl-1,2-dihydro-3h-pyrrolo- eckige klammer auf 1,2-a eckige klammer zu -pyrrol-1-carbonsaeurederivate Granted DE2731678A1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US70490976A 1976-07-14 1976-07-14
US05/771,286 US4089969A (en) 1976-07-14 1977-02-23 5-Aroyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid derivatives and process for the production thereof

Publications (2)

Publication Number Publication Date
DE2731678A1 true DE2731678A1 (de) 1978-03-16
DE2731678C2 DE2731678C2 (fr) 1989-06-08

Family

ID=27107410

Family Applications (2)

Application Number Title Priority Date Filing Date
DE19772731678 Granted DE2731678A1 (de) 1976-07-14 1977-07-13 Neue 5-aroyl-1,2-dihydro-3h-pyrrolo- eckige klammer auf 1,2-a eckige klammer zu -pyrrol-1-carbonsaeurederivate
DE2760330A Expired DE2760330C2 (fr) 1976-07-14 1977-07-13

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE2760330A Expired DE2760330C2 (fr) 1976-07-14 1977-07-13

Country Status (27)

Country Link
JP (1) JPS539788A (fr)
AR (1) AR224997A1 (fr)
CA (1) CA1102809A (fr)
CH (3) CH641458A5 (fr)
CS (1) CS204954B2 (fr)
DE (2) DE2731678A1 (fr)
DK (1) DK151886C (fr)
ES (2) ES460706A1 (fr)
FI (1) FI63406C (fr)
FR (2) FR2358406A1 (fr)
GB (1) GB1554075A (fr)
GR (1) GR61111B (fr)
HK (1) HK15981A (fr)
HU (1) HU174224B (fr)
IE (1) IE45253B1 (fr)
IL (2) IL52493A (fr)
IT (1) IT1117313B (fr)
MX (1) MX163202B (fr)
MY (1) MY8100357A (fr)
NL (2) NL186318C (fr)
NO (1) NO147564C (fr)
NZ (1) NZ184610A (fr)
PL (4) PL124444B1 (fr)
PT (1) PT66780B (fr)
SE (1) SE434643B (fr)
SU (1) SU695558A3 (fr)
YU (1) YU40816B (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0284076A1 (fr) * 1987-03-25 1988-09-28 Syntex (U.S.A.) Inc. Procédé pour la préparation de l'acide (+)-1,2-dihydro-3H-pyrrolo-[1,2-a]pyrrole-1-carboxylique et des composés similaires
EP0307034A1 (fr) * 1987-09-10 1989-03-15 Hisamitsu Pharmaceutical Co., Inc. Dérivés d'acides 3-aroyl-6,7-dihydro-5H-pyrrolo-[1,2-c]imidazole-7-carboxyliques
EP0606657A1 (fr) * 1993-01-13 1994-07-20 Roemmers S.A.I.C.F. Dérivé de kétorolac à activité d'irritation et d'ulcération gastrointestinale diminuée

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4140698A (en) * 1977-07-25 1979-02-20 Syntex (Usa) Inc. 1,2-Dihydro-3H-pyrrolo[1,2-a]pyrrole-1-nitriles
JPS55124633A (en) * 1979-03-19 1980-09-25 Sohachi Takeuchi Manufacturing method of tubular vessel
US4344943A (en) * 1980-06-09 1982-08-17 Syntex (U.S.A.) Inc. 6-Chloro- or 6-bromo-1,2-dihydro-3H-pyrrolo[1,2-a]-pyrrole-1-carboxylic acids and derivatives thereof
US4353829A (en) * 1980-11-21 1982-10-12 Syntex (U.S.A.) Inc. Process for 5-aroylation of 1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic esters
US4511724A (en) * 1982-06-10 1985-04-16 Merck & Co., Inc. 5-(Pyrrol-2-oyl)-1,2-dihydro-3H-pyrrolo [1,2-a]pyrrole derivatives as anti-inflammatory and analgesic agents
JPS5910589A (ja) * 1982-06-10 1984-01-20 メルク　エンド　カムパニー　インコーポレーテツド 抗炎症剤および鎮痛剤として新規な５−（ピロ−ル−２−オイル）−１，２−ジヒドロ−３Ｈ−ピロロ〔１，２−ａ〕ピロ−ル誘導体
JP2649168B2 (ja) * 1988-02-25 1997-09-03 久光製薬株式会社 新規な５，６−ジフェニル−１，２−ジヒドロ−３Ｈ−ピロロ［１，２−ａ］ピロール−１−カルボン酸誘導体
IT1250691B (it) * 1991-07-22 1995-04-21 Giancarlo Santus Composizioni terapeutiche per somministrazione intranasale comprendenti ketorolac.
DK0612521T3 (da) * 1991-11-11 2000-01-17 Hisamitsu Pharmaceutical Co Keterolacholdigt varmt omslag
US5622948A (en) * 1994-12-01 1997-04-22 Syntex (U.S.A.) Inc. Pyrrole pyridazine and pyridazinone anti-inflammatory agents
JP2008210666A (ja) * 2007-02-27 2008-09-11 Okamura Corp 商品陳列棚における照明装置

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CA 37, 1943, Sp. 641·7· *
CA 55, 1961, Sp. 1574h *
CA 59, 1963, Sp. 7463e *
CA 76, 1972, Ref. 25024t *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0284076A1 (fr) * 1987-03-25 1988-09-28 Syntex (U.S.A.) Inc. Procédé pour la préparation de l'acide (+)-1,2-dihydro-3H-pyrrolo-[1,2-a]pyrrole-1-carboxylique et des composés similaires
EP0307034A1 (fr) * 1987-09-10 1989-03-15 Hisamitsu Pharmaceutical Co., Inc. Dérivés d'acides 3-aroyl-6,7-dihydro-5H-pyrrolo-[1,2-c]imidazole-7-carboxyliques
US4895956A (en) * 1987-09-10 1990-01-23 Hisamitsu Pharmaceutical Co., Ltd. 3-aroyl-6,7-dihydro-5H-pyrrolo(1,2-c)imidazole-7-carboxylic acid derivatives
EP0606657A1 (fr) * 1993-01-13 1994-07-20 Roemmers S.A.I.C.F. Dérivé de kétorolac à activité d'irritation et d'ulcération gastrointestinale diminuée
US5508301A (en) * 1993-01-13 1996-04-16 Roemmers S.A.I.C.F. Ketorolac derivatives with considerably reduced gastro-intestinal irritation and ulceration

Also Published As

Publication number Publication date
DK151886C (da) 1988-06-06
FR2375234B1 (fr) 1980-11-07
PT66780A (fr) 1977-08-01
NL930021I1 (nl) 1993-05-03
GB1554075A (en) 1979-10-17
AU513384B2 (en) 1980-11-27
NZ184610A (en) 1979-03-28
HK15981A (en) 1981-05-01
DK307577A (da) 1978-01-15
FI772153A (fr) 1978-01-15
SE7708141L (sv) 1978-01-15
IE45253B1 (en) 1982-07-14
DK151886B (da) 1988-01-11
IT1117313B (it) 1986-02-17
NL7707651A (nl) 1978-01-17
SE434643B (sv) 1984-08-06
FR2375234A1 (fr) 1978-07-21
NL186318C (nl) 1990-11-01
MX163202B (es) 1992-02-20
PL124711B1 (en) 1983-02-28
CH641458A5 (en) 1984-02-29
HU174224B (hu) 1979-11-28
DE2731678C2 (fr) 1989-06-08
CS204954B2 (en) 1981-04-30
FI63406B (fi) 1983-02-28
YU172177A (en) 1983-09-30
IL52493A0 (en) 1977-10-31
FI63406C (fi) 1983-06-10
PL124444B1 (en) 1983-01-31
YU40816B (en) 1986-06-30
CH646972A5 (en) 1984-12-28
ES460706A1 (es) 1978-12-01
NO147564B (no) 1983-01-24
IL58779A0 (en) 1980-02-29
CH646973A5 (en) 1984-12-28
NO147564C (no) 1983-05-18
NL930021I2 (nl) 1997-03-03
FR2358406A1 (fr) 1978-02-10
PL199603A1 (pl) 1978-04-24
NO772494L (no) 1978-01-17
AR224997A1 (es) 1982-02-15
JPS539788A (en) 1978-01-28
FR2358406B1 (fr) 1981-04-17
IL52493A (en) 1982-02-28
CA1102809A (fr) 1981-06-09
MY8100357A (en) 1981-12-31
PT66780B (fr) 1978-12-18
NL186318B (nl) 1990-06-01
PL109390B1 (en) 1980-05-31
SU695558A3 (ru) 1979-10-30
JPS6254109B2 (fr) 1987-11-13
PL124445B1 (en) 1983-01-31
IE45253L (en) 1978-01-14
AU2697577A (en) 1979-01-18
GR61111B (en) 1978-09-12
DE2760330C2 (fr) 1989-06-15
ES470214A1 (es) 1979-09-16

Similar Documents

Publication Publication Date Title
DE2813373C2 (fr)
EP0005205B1 (fr) 5.6-Diméthylpyrrolo(2,3-d)pyrimidines substituées, leur procédé de préparation et médicamentsles contenant
DE2731678C2 (fr)
DE2414680C2 (de) Substituierte 2-Furancarbonsäuren und 2-Furancarbonsäureester, Verfahren zu ihrer Herstellung und Arzneimittel, die diese Verbindungen enthalten
DE2149249A1 (de) 6-Arylpyrimidine
EP0149840A1 (fr) Dihydro-5,11 6h-dibenzo[b,e]azépinones-6 substituées, procédé pour leur préparation et médicaments contenant ces composés
DE2234651A1 (de) Eckige klammer auf 1-(p-chlorbenzoyl)5-methoxy-2-methyl-3-indol eckige klammer zu acetoxyessigsaeure, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln
DE2731662C2 (fr)
DE1959898A1 (de) ortho-substituierte Phenaethylamine und Verfahren zu ihrer Herstellung
EP0059388B1 (fr) Imidazodiazépines, procédé et produits intermédiaires pour leur préparation ainsi que médicaments les contenant
CH637646A5 (de) Analgetisch wirksame triazindione, herstellungsverfahren und pharmazeutische zusammensetzungen.
EP0313935B1 (fr) Enoléthers de 6-chloro-4-hydroxy-2-méthyl-N-(2-pyridyl)-2H-thiéno(2,3-e)-1,2-thiazin-3-carboxamides-1,1-dioxyde, un procédé pour leur préparation et leur utilisation
AT364844B (de) Verfahren zur herstellung von neuen 5-aroyl-1,2 -dihydro-3h-pyrrolo-(1,2-a)-pyrrol-1-carbonsaeuren und ihren salzen
AT369003B (de) Verfahren zur herstellung von neuen 5-aroyl-1,2dihydro-3h-pyrrolo(1,2-a)-pyrrol-1-carbons[ure
DE2259471C2 (de) 2-Halogen-9-phenyl-5,6-dihydro-7H-pyrido [2,3-f] [1,4] diazepinderivate
CH641461A5 (en) 5-Aroyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid derivatives
LU82435A1 (de) Verfahren zur herstellung von 3-substituierten tetrahydropyrrolo(1,2-a)pyrimidinen,und die verbindungen enthaltende pharmazeutische praeparate sowie neue 3-substituierte-tetrahydropyrrolo(1,2-a)pyrimidine
EP0045519B1 (fr) Pyrrolo-(3,4-d)-benzazépines, procédé et intermédiaires pour leur préparation et compositions pharmaceutiques les contenant
AT364846B (de) Verfahren zur herstellung von neuen in stellung 5 substituierten 1,2-dihydro-3h-pyrrolo-(1,2-a) -pyrrol-1-carbonsaeuren und von deren einzelnen 1-saeureisomeren und d-saeureisomeren
AT364845B (de) Verfahren zur herstellung von neuen in stellung 5 substituierten 1,2-dihydro-3h-pyrrolo-(1,2-a) -pyrrol-1-carbonsaeuren, von deren einzelnen 1-saeureisomeren und d-saeureisomeren und von deren pharmazeutisch unbedenklichen salzen
EP0088323A2 (fr) Amides d'acides imidazothiadiazolealcanecarboxyliques, produits intermédiaires pour leur fabrication, leur fabrication et leur application en médicaments
DE3204401A1 (de) Pyridobenzodiazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE2142792A1 (de) Heterocyclische Verbindungen
DE2441206A1 (de) 1- oder 2-mono- und -dialkylsubstituierte thienobenzopyrane
EP0120439B1 (fr) Tétrahydro-7,8,9,10 thiéno(3,2-e)pyrido(4,3-b)indoles, procédé pour leur préparation et médicaments les contenant

Legal Events

Date Code Title Description
8110 Request for examination paragraph 44
8172 Supplementary division/partition in:

Ref country code: DE

Ref document number: 2760330

Format of ref document f/p: P

Q171 Divided out to:

Ref country code: DE

Ref document number: 2760330

AH Division in

Ref country code: DE

Ref document number: 2760330

Format of ref document f/p: P

D2 Grant after examination
AH Division in

Ref country code: DE

Ref document number: 2760330

Format of ref document f/p: P

8364 No opposition during term of opposition
V448 Application of spc

Free format text: PRODUCT NAME: KETOROLAC UND DESSEN PHARMAZEUTISCH ANNEHMBARE SALZE, INSBESONDERE KETOROLAC-TROMETAMOL; REGISTRATION NO/DATE: 13753.00.00, 19911126

Spc suppl protection certif: 193 75 010

Filing date: 19930326

V472 Application for supplementary protection certificate rejected

Free format text: PRODUCT NAME: KETOROLAC UND DESSEN PHARMAZEUTISCH ANNEHMBARE SALZE, INSBESONDERE KETOROLAC-TROMETAMOL; REGISTRATION NO/DATE: 13753.00.00, 19911126

Spc suppl protection certif: 193 75 010

Filing date: 19930326