FR2367053A1 - Nouveaux derives de phenoxy-amino-propanol, leur preparation et leur application en tant que medicaments - Google Patents

Nouveaux derives de phenoxy-amino-propanol, leur preparation et leur application en tant que medicaments

Info

Publication number
FR2367053A1
FR2367053A1 FR7730071A FR7730071A FR2367053A1 FR 2367053 A1 FR2367053 A1 FR 2367053A1 FR 7730071 A FR7730071 A FR 7730071A FR 7730071 A FR7730071 A FR 7730071A FR 2367053 A1 FR2367053 A1 FR 2367053A1
Authority
FR
France
Prior art keywords
amino
preparation
application
medicinal products
propanol derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7730071A
Other languages
English (en)
Other versions
FR2367053B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Publication of FR2367053A1 publication Critical patent/FR2367053A1/fr
Application granted granted Critical
Publication of FR2367053B1 publication Critical patent/FR2367053B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/58—Radicals substituted by nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/28—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines
    • C07C217/30—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring
    • C07C217/32—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/78—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C07C217/80—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
    • C07D303/24—Ethers with hydroxy compounds containing no oxirane rings with polyhydroxy compounds

Abstract

Nouveaux dérivés de phénoxy-amino-propanol, leur préparation et leur application en tant que médicaments. Les composes de l'invention repondent à la formule générale I :
FR7730071A 1976-10-09 1977-10-06 Nouveaux derives de phenoxy-amino-propanol, leur preparation et leur application en tant que medicaments Granted FR2367053A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2645710A DE2645710C2 (de) 1976-10-09 1976-10-09 Phenoxy-amino-propanole, Verfahren zu ihrer Herstellung und pharmazeutische Zubereitung

Publications (2)

Publication Number Publication Date
FR2367053A1 true FR2367053A1 (fr) 1978-05-05
FR2367053B1 FR2367053B1 (fr) 1981-11-27

Family

ID=5990109

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7730071A Granted FR2367053A1 (fr) 1976-10-09 1977-10-06 Nouveaux derives de phenoxy-amino-propanol, leur preparation et leur application en tant que medicaments

Country Status (21)

Country Link
US (2) US4171370A (fr)
JP (1) JPS5346930A (fr)
AT (1) AT357143B (fr)
AU (1) AU520307B2 (fr)
BE (1) BE859425A (fr)
CA (1) CA1110253A (fr)
CH (1) CH630337A5 (fr)
DE (1) DE2645710C2 (fr)
ES (1) ES463022A1 (fr)
FR (1) FR2367053A1 (fr)
GB (1) GB1532380A (fr)
HK (1) HK39483A (fr)
HU (1) HU177868B (fr)
IL (1) IL53063A (fr)
IT (1) IT1091303B (fr)
NL (2) NL185665C (fr)
PT (1) PT67083B (fr)
SE (1) SE441827B (fr)
SG (1) SG7192G (fr)
YU (1) YU40820B (fr)
ZA (1) ZA776018B (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1982000141A1 (fr) * 1980-07-09 1982-01-21 Ag Sandoz Derives du 3-amino-propoxy-phenyle, leur preparation et remedes les contenant
EP0074873A1 (fr) * 1981-09-10 1983-03-23 Synthelabo Dérivés de phénoxy-3 propanol-2, leur préparation et leur application en thérapeutique
EP0764640A1 (fr) * 1995-09-21 1997-03-26 Eli Lilly And Company Agonistes adrénergiques bêta-3 spécifiques
WO2017182754A1 (fr) 2016-04-20 2017-10-26 Les Laboratoires Servier Composition pharmaceutique comprenant un betabloquant, un inhibiteur de l'enzyme de conversion et un antihypertenseur ou un ains

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55124742A (en) * 1979-03-20 1980-09-26 Kyowa Hakko Kogyo Co Ltd Novel aminoalcohol derivative
JPS56144222A (en) * 1980-04-10 1981-11-10 Teijin Ltd False twisted crimped yarn
US4472427A (en) * 1980-12-23 1984-09-18 Merck & Co., Inc. (Aralkylamino-2-OR-propoxy)heterocyclic compounds
DE3125636A1 (de) * 1981-06-30 1983-01-13 Merck Patent Gmbh, 6100 Darmstadt 1-(p-2-isopropoxyethoxymethyl-phenoxy)-3-isopropylamino-propan-2-ol zur senkung des augeninnendrucks und ophtalmikum, enthalten diese verbindung
JPS5891855A (ja) * 1981-11-27 1983-05-31 株式会社クラレ 寝装用ポリエステル繊維ステープル綿およびその製造法
DE3151201A1 (de) * 1981-12-23 1983-07-28 Beiersdorf Ag, 2000 Hamburg Substituierte phenoxyalkanolamine und phenoxyalkanol-cycloalkylamine, verfahren zu ihrer herstellung, diese verbindungen enthaltende pharmazeutische zubereitungen und zwischenprodukte
US5166218A (en) * 1983-10-19 1992-11-24 Hoffmann-La Roche Inc. Phenoxypropanolamines and pharmaceutical compositions thereof
CA1262729A (fr) * 1983-10-19 1989-11-07 Leo Alig Phenoxypropanolamines
SE457505B (sv) * 1984-01-10 1989-01-09 Lejus Medical Ab Laminatbelagd oral farmaceutisk komposition och foerfarande foer dess framstaellning
GB8419683D0 (en) * 1984-08-02 1984-09-05 Erba Farmitalia 3-substituted derivatives of 1-amino-2-hydroxy-propane
US4665094A (en) * 1985-08-29 1987-05-12 Merck & Co., Inc. Oculoselective beta-blockers for treatment of elevated intraocular pressure
US4945182A (en) * 1985-12-24 1990-07-31 Merck & Co., Inc. Oculoselective beta-blockers
AU609788B2 (en) * 1987-03-16 1991-05-09 University Of Florida Labile ketone derivatives of 3-substituted-1-alkylamino- 2-propanols and their use as beta-adrenergic blockers
EP0300290B1 (fr) * 1987-07-21 1991-12-18 F. Hoffmann-La Roche Ag Phénoxypropanolamines
ES2011584A6 (es) * 1989-05-26 1990-01-16 Esteve Quimica Sa Procedimiento industrial para la obtencion de una ariloxipropanolamina.
DE3920369A1 (de) * 1989-06-22 1991-01-10 Merck Patent Gmbh Migraenemittel
US5217994A (en) * 1991-08-09 1993-06-08 Merck & Co., Inc. Method of inhibiting osteoclast-mediated bone resorption by administration of aminoalkyl-substituted phenyl derivatives
US6075040A (en) 1996-09-05 2000-06-13 Eli Lilly And Company Selective β3 adrenergic agonists
ATE215369T1 (de) 1996-09-05 2002-04-15 Lilly Co Eli Carbazolanaloge als selektive beta3-adrenergische agonisten
CO5011072A1 (es) 1997-12-05 2001-02-28 Lilly Co Eli Etanolaminas pirazinil substituidas como agfonistas de los receptores
CN100338026C (zh) * 2002-07-12 2007-09-19 北京四环医药科技股份有限公司 制备比索洛尔及其盐的改进方法
ATE502635T1 (de) 2002-08-19 2011-04-15 Pfizer Kombinationstherapie gegen hyperproliferative erkrankungen
EP1923063A3 (fr) * 2003-01-14 2009-04-08 Gilead Sciences, Inc. Compositions et procédés pour une thérapie antivirale combinée
AP2501A (en) * 2003-05-30 2012-10-22 Ranbaxy Lab Ltd Substituted pyrrole derivatives
US20060281818A1 (en) * 2005-03-21 2006-12-14 Sucampo Ag, North Carolina State University Method for treating mucosal disorders
TWI375560B (en) 2005-06-13 2012-11-01 Gilead Sciences Inc Composition comprising dry granulated emtricitabine and tenofovir df and method for making the same
TWI471145B (zh) 2005-06-13 2015-02-01 Bristol Myers Squibb & Gilead Sciences Llc 單一式藥學劑量型
GT200600381A (es) 2005-08-25 2007-03-28 Compuestos organicos
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
EP1948599A1 (fr) * 2005-11-08 2008-07-30 Ranbaxy Laboratories Limited Procede de preparation de sel hemicalcique d acide (3r,5r)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-[(4-hydroxymethylphenylamino)carbonyl]-pyrrol-1-yl]-3,5-dihydroxy-heptanoique
US7888376B2 (en) 2005-11-23 2011-02-15 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
AR059838A1 (es) * 2006-03-14 2008-04-30 Ranbaxy Lab Ltd Formulaciones para dosis estabilizantes de estatina
TW200811101A (en) * 2006-07-14 2008-03-01 Ranbaxy Lab Ltd Polymorphic forms of an HMG-CoA reductase inhibitor and uses thereof
WO2008070496A2 (fr) 2006-12-01 2008-06-12 Bristol-Myers Squibb Company Inhibiteurs d'amino cetp étendus
WO2008112287A1 (fr) * 2007-03-12 2008-09-18 Nektar Therapeutics Conjugués d'oligomère bêtabloquant
WO2012149266A1 (fr) * 2011-04-28 2012-11-01 University Of Louisville Research Foundation, Inc. Composés utilisés dans des compositions pharmaceutiques, composés à administrer et composés utilisés dans le traitement du cancer
EP2986599A1 (fr) 2013-04-17 2016-02-24 Pfizer Inc. Dérivés de n-pipéridin-3-ylbenzamide dans le traitement des maladies cardiovasculaires
WO2016055901A1 (fr) 2014-10-08 2016-04-14 Pfizer Inc. Composés d'amide substitué
US11248001B2 (en) 2019-01-18 2022-02-15 Astrazeneca Ab PCSK9 inhibitors and methods of use thereof
GB202102575D0 (en) 2021-02-23 2021-04-07 Teva Pharmaceutical Industries Ltd Fixed-dose pharmaceutical compositions

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3483221A (en) * 1964-09-10 1969-12-09 Ciba Geigy Corp 1 - (isopropylamino)-2-hydroxy-3-(alkenyloxyphenoxy) - propanes and the salts thereof
CH477400A (de) * 1964-09-10 1969-10-15 Ciba Geigy Verfahren zur Herstellung neuer Amine
DK129447B (da) * 1967-12-18 1974-10-14 Boehringer Sohn Ingelheim Analogifremgangsmåde til fremstilling af racemiske eller optisk aktive 1-phenoxy-2-hydroxy-3-sek.-alkylaminopropaner eller syreadditionssalte heraf.
GB1285038A (en) * 1969-02-21 1972-08-09 Ici Ltd Alkanolamine derivatives
DE2065985A1 (de) * 1969-05-16 1977-08-04 Yoshitomi Pharmaceutical Phenoxyaminopropanolverbindungen
SE372762B (fr) * 1969-05-21 1975-01-13 Haessle Ab
GB1276968A (en) * 1970-01-15 1972-06-07 Lepetit Spa Improvements in or relating to phenylacetamides and the preparation thereof
SE354851B (fr) * 1970-02-18 1973-03-26 Haessle Ab
US3929856A (en) * 1971-12-14 1975-12-30 Parke Davis & Co 1-(3,4-Dimethoxyphenethylamino)-3-(phenoxy)-2-propanols
US4145442A (en) * 1972-04-04 1979-03-20 Aktiebolaget Hassle Phenoxy-hydroxypropylamines, their preparation, and method and pharmaceutical preparations for treating cardiovascular diseases
SE386892B (sv) * 1972-07-06 1976-08-23 Haessle Ab Forfarande for framstellning av oxaminoforeningar
US4084002A (en) * 1973-02-28 1978-04-11 Boehringer Ingelheim Gmbh Pharmaceutical compositions containing a 1-phenoxy-2-hydroxy-3-alkynylamino-propane and method of use
US3966770A (en) * 1975-03-25 1976-06-29 Smithkline Corporation 4-Hydroxy-α-[(3,4-methylenedioxyphenyl)isopropylaminoethyl]-3-(methylsulfonylmethyl)benzyl alcohol
US4067904A (en) * 1975-12-19 1978-01-10 Mead Johnson & Company Alkylsulfonylphenoxypropanolamine derivatives

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1982000141A1 (fr) * 1980-07-09 1982-01-21 Ag Sandoz Derives du 3-amino-propoxy-phenyle, leur preparation et remedes les contenant
FR2489316A1 (fr) * 1980-07-09 1982-03-05 Sandoz Sa
EP0074873A1 (fr) * 1981-09-10 1983-03-23 Synthelabo Dérivés de phénoxy-3 propanol-2, leur préparation et leur application en thérapeutique
EP0764640A1 (fr) * 1995-09-21 1997-03-26 Eli Lilly And Company Agonistes adrénergiques bêta-3 spécifiques
WO2017182754A1 (fr) 2016-04-20 2017-10-26 Les Laboratoires Servier Composition pharmaceutique comprenant un betabloquant, un inhibiteur de l'enzyme de conversion et un antihypertenseur ou un ains

Also Published As

Publication number Publication date
JPS5346930A (en) 1978-04-27
NL7711042A (nl) 1978-04-11
NL185665C (nl) 1990-06-18
SG7192G (en) 1992-07-24
HU177868B (en) 1982-01-28
IT1091303B (it) 1985-07-06
NL930020I1 (nl) 1993-05-03
IL53063A0 (en) 1977-12-30
NL185665B (nl) 1990-01-16
SE441827B (sv) 1985-11-11
CH630337A5 (de) 1982-06-15
ATA717377A (de) 1979-11-15
DE2645710A1 (de) 1978-04-13
AU2946477A (en) 1979-04-12
CA1110253A (fr) 1981-10-06
YU236877A (en) 1983-01-21
JPS6210220B2 (fr) 1987-03-05
AU520307B2 (en) 1982-01-28
US4258062A (en) 1981-03-24
DE2645710C2 (de) 1985-06-27
SE7711278L (sv) 1978-04-10
FR2367053B1 (fr) 1981-11-27
YU40820B (en) 1986-06-30
ZA776018B (en) 1978-05-30
PT67083B (de) 1979-02-22
HK39483A (en) 1983-10-13
ES463022A1 (es) 1978-12-16
GB1532380A (en) 1978-11-15
IL53063A (en) 1981-06-29
AT357143B (de) 1980-06-25
NL930020I2 (nl) 1993-09-16
BE859425A (nl) 1978-04-06
US4171370A (en) 1979-10-16
PT67083A (de) 1977-10-01

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Legal Events

Date Code Title Description
CC Supplementary protection certificate (spc) laid open to the public (law of 25 june 1990)

Free format text: 92C0075, 920415

CB Supplementary protection certificate (spc) granted (law of 25 june 1990)

Free format text: 92C0075, 771006

CL Concession to grant licences