ES2011584A6 - Procedimiento industrial para la obtencion de una ariloxipropanolamina. - Google Patents

Procedimiento industrial para la obtencion de una ariloxipropanolamina.

Info

Publication number
ES2011584A6
ES2011584A6 ES8901774A ES8901774A ES2011584A6 ES 2011584 A6 ES2011584 A6 ES 2011584A6 ES 8901774 A ES8901774 A ES 8901774A ES 8901774 A ES8901774 A ES 8901774A ES 2011584 A6 ES2011584 A6 ES 2011584A6
Authority
ES
Spain
Prior art keywords
methoxyethyl
aryloxypropanolamine
phenoxy
obtaining
industrial process
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES8901774A
Other languages
English (en)
Inventor
Olsina Gloria Oranias
Pardo Julio Campon
Baro Miquel Ribalta
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Esteve Quimica SA
Original Assignee
Esteve Quimica SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Esteve Quimica SA filed Critical Esteve Quimica SA
Priority to ES8901774A priority Critical patent/ES2011584A6/es
Publication of ES2011584A6 publication Critical patent/ES2011584A6/es
Priority to US07/525,410 priority patent/US5082969A/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/04—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reaction of ammonia or amines with olefin oxides or halohydrins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Epoxy Compounds (AREA)

Abstract

PROCEDIMIENTO INDUSTRIAL PARA LA OBTENCION DE UNA ARILOXIPROPANOLAMINA, DE NOMBRE QUIMICO 1-[4-(2-METOXIETIL)FENOXI]-3-[(1-METILETIL)AMINOL-2-PROPANO], CARACTERIZADO POR COMPRENDER LAS SIGUIENTES FASES OPERATIVAS. POR REACCION DEL 4-(2-METOXIETIL)FENOL CON EPICLORHIDRINA EN MEDIO ACUOSO ALCALINO A TEMPERATURAS ENTRE 0 Y 25GC SE OBTIENE DESPUES DE LAS OPORTUNAS EXTRACCIONES Y LAVADOS UN CRUDO DE REACCION, COMPUESTO POR UN 75-80% DE 3-[4-(2-METOXIETIL)FENOXI]-1,2-EPOXIPROPANO Y UN 15-20% DE 1-[4-(2-METOXIETIL)FENOXI]-3-CLORO-2-PROPANOL, SIENDO AMBOS COMPUESTOS ADECUADOS PARA REACCIONAR CON ISOPROPILAMINA EN MEDIO ACUOSO Y A TEMPERATURAS COMPRENDIDAS ENTRE LOS 0 Y LOS 30GC PARA OBTENER LA ARILOXIPROPANOLAMINA DESEADA DE FORMULA (I).
ES8901774A 1989-05-26 1989-05-26 Procedimiento industrial para la obtencion de una ariloxipropanolamina. Expired - Lifetime ES2011584A6 (es)

Priority Applications (2)

Application Number Priority Date Filing Date Title
ES8901774A ES2011584A6 (es) 1989-05-26 1989-05-26 Procedimiento industrial para la obtencion de una ariloxipropanolamina.
US07/525,410 US5082969A (en) 1989-05-26 1990-05-16 Industrial process for obtaining an aryloxypropanolamine

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES8901774A ES2011584A6 (es) 1989-05-26 1989-05-26 Procedimiento industrial para la obtencion de una ariloxipropanolamina.

Publications (1)

Publication Number Publication Date
ES2011584A6 true ES2011584A6 (es) 1990-01-16

Family

ID=8262115

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8901774A Expired - Lifetime ES2011584A6 (es) 1989-05-26 1989-05-26 Procedimiento industrial para la obtencion de una ariloxipropanolamina.

Country Status (2)

Country Link
US (1) US5082969A (es)
ES (1) ES2011584A6 (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998022426A1 (en) * 1996-11-20 1998-05-28 Astra Aktiebolag New manufacturing process of metoprolol

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050107635A1 (en) * 2003-11-14 2005-05-19 Mehra Janakraj K. Metoprolol manufacturing process
CA2640876A1 (en) * 2005-12-23 2007-12-13 Medichem, S.A. Process for the preparation of metoprolol and its salts
CN102633660A (zh) * 2011-11-03 2012-08-15 北京华禧联合科技发展有限公司 一种琥珀酸美托洛尔的新晶型
CN105820057B (zh) * 2016-04-22 2017-09-29 上海应用技术学院 一种制备美多心安的方法
GB202102575D0 (en) 2021-02-23 2021-04-07 Teva Pharmaceutical Industries Ltd Fixed-dose pharmaceutical compositions

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE354851B (es) * 1970-02-18 1973-03-26 Haessle Ab
GB1387630A (en) * 1971-05-07 1975-03-19 Ici Ltd Phenoxyalkanolamine derivatives
DE2645710C2 (de) * 1976-10-09 1985-06-27 Merck Patent Gmbh, 6100 Darmstadt Phenoxy-amino-propanole, Verfahren zu ihrer Herstellung und pharmazeutische Zubereitung
US4396629A (en) * 1980-12-29 1983-08-02 Sterling Drug Inc. Compositions, processes and method
FR2512443A1 (fr) * 1981-09-10 1983-03-11 Synthelabo Derives de phenoxy-3 propanol-2, leur preparation et leur application en therapeutique
ES8609190A1 (es) * 1985-02-07 1986-07-16 Pharma Investi S A Un procedimiento para preparar eteres fenolicos

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998022426A1 (en) * 1996-11-20 1998-05-28 Astra Aktiebolag New manufacturing process of metoprolol

Also Published As

Publication number Publication date
US5082969A (en) 1992-01-21

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20060527