ES476786A1 - Procedimiento para preparar nuevos derivados de tetrahidro- piridinilindol. - Google Patents

Procedimiento para preparar nuevos derivados de tetrahidro- piridinilindol.

Info

Publication number
ES476786A1
ES476786A1 ES476786A ES476786A ES476786A1 ES 476786 A1 ES476786 A1 ES 476786A1 ES 476786 A ES476786 A ES 476786A ES 476786 A ES476786 A ES 476786A ES 476786 A1 ES476786 A1 ES 476786A1
Authority
ES
Spain
Prior art keywords
carbon atoms
salts
medicines
preparation
pharmaceutical compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES476786A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Publication of ES476786A1 publication Critical patent/ES476786A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Procedimiento para preparar nuevos derivados de tetrahidropiridinilindol y sus sales de adición de ácidos minerales u orgánicos, que responden a la fórmula general **fórmula** donde R'' representa un átomo de hidrógeno, un átomo de halógeno o un radical alcoxi que contiene de 1 a 3 átomos de carbono, R1 y R2, idénticos o diferentes, representan un átomo de hidrógeno o un radical alcohilo que contiene de 1 a 3 átomos de carbono, X'' representa un radical alcohilo que contiene de 1 a 6 átomos de carbono, un radical cicloalcohilo que contiene de 4 a 7 átomos de carbono, un radical alquenilo o alquinilo que contiene de 2 a 5 átomos de carbono, o un radical aralcohilo que contiene de 7 a 12 átomos de carbono, en el entendimiento de que si K'' representa un radical metilo, al menos uno de los sustituyentes R'' , R1 y r2 comprende más de un átomo de carbono, y que si X'' representa un radical bencilo, al menos uno de los sustituyentes R'' , R1 y R2 no representa un átomo de hidrógeno,
ES476786A 1978-01-16 1979-01-12 Procedimiento para preparar nuevos derivados de tetrahidro- piridinilindol. Expired ES476786A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7801083A FR2421899A1 (fr) 1978-01-16 1978-01-16 Nouveaux derives du tetrahydropyridinyl-indole et leurs sels, le procede de preparation et l'application a titre de medicaments de ces nouveaux produits

Publications (1)

Publication Number Publication Date
ES476786A1 true ES476786A1 (es) 1979-06-01

Family

ID=9203492

Family Applications (1)

Application Number Title Priority Date Filing Date
ES476786A Expired ES476786A1 (es) 1978-01-16 1979-01-12 Procedimiento para preparar nuevos derivados de tetrahidro- piridinilindol.

Country Status (15)

Country Link
US (1) US4278677A (es)
EP (1) EP0003199B1 (es)
JP (1) JPS54100380A (es)
AT (1) AT367418B (es)
AU (1) AU519534B2 (es)
CA (1) CA1115277A (es)
DE (1) DE2961284D1 (es)
DK (1) DK148477C (es)
ES (1) ES476786A1 (es)
FR (1) FR2421899A1 (es)
HU (1) HU180517B (es)
IE (1) IE48366B1 (es)
PT (1) PT69071A (es)
SU (1) SU936812A3 (es)
ZA (1) ZA79154B (es)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2477415A1 (fr) * 1980-03-07 1981-09-11 Roussel Uclaf Application a titre de medicaments de derives du tetrahydropyridin-4-yl indole et compositions les renfermant
US4352811A (en) * 1981-11-12 1982-10-05 Hoechst-Roussel Pharmaceuticals Inc. 3-(1-Substituted-4-piperidyl)-1,2-benzisoxazoles
IE58370B1 (en) * 1985-04-10 1993-09-08 Lundbeck & Co As H Indole derivatives
US4659717A (en) * 1985-08-21 1987-04-21 Eli Lilly And Company Dihydropyridines useful in the treatment of angina and stroke
US4742057A (en) * 1985-12-05 1988-05-03 Fujisawa Pharmaceutical Co., Ltd. Antiallergic thiazole compounds
GB8719167D0 (en) * 1987-08-13 1987-09-23 Glaxo Group Ltd Chemical compounds
US4997841A (en) * 1987-08-13 1991-03-05 Glaxo Group Limited Indole derivatives
GB8819024D0 (en) * 1988-08-10 1988-09-14 Glaxo Group Ltd Chemical compounds
MX19185A (es) * 1989-01-20 1993-12-01 Pfizer Procedimiento para preparar 3-(1,2,5,6-tretrahidropiridil)-pirrolopiridinas.
US5521197A (en) * 1994-12-01 1996-05-28 Eli Lilly And Company 3-<1-alkylenearyl>-4-<1,2,3,6-tetrahydropyridinyl>-and 3-<1-alkylenearyl>-4-piperidinyl-1h-indoles: new 5-HT1F agonists
KR19980703048A (ko) * 1995-03-20 1998-09-05 피터쥐.스트링거 5-치환-3-(1,2,3,6-테트라히드로피리딘-4-일)- 및 3-(피페리딘-4-일)-1ｈ-인돌: 신규한 5-ｈｔ1ｆ 아고니스트
US5846982A (en) * 1996-06-14 1998-12-08 Eli Lilly And Company Inhibition of serotonin reuptake
AR013669A1 (es) * 1997-10-07 2001-01-10 Smithkline Beecham Corp Compuestos y metodos
SE9903544D0 (sv) * 1999-10-01 1999-10-01 Astra Pharma Prod Novel compounds
GB2359078A (en) * 2000-02-11 2001-08-15 Astrazeneca Uk Ltd Pharmaceutically active pyrimidine derivatives
GB2359081A (en) 2000-02-11 2001-08-15 Astrazeneca Uk Ltd Pharmaceutically active thiazolopyrimidines
GB2359551A (en) * 2000-02-23 2001-08-29 Astrazeneca Uk Ltd Pharmaceutically active pyrimidine derivatives
GB0005642D0 (en) * 2000-03-10 2000-05-03 Astrazeneca Uk Ltd Chemical compounds
SE0003828D0 (sv) * 2000-10-20 2000-10-20 Astrazeneca Ab Novel compounds
SE0101322D0 (sv) * 2001-04-12 2001-04-12 Astrazeneca Ab Novel compounds
SE0102716D0 (sv) * 2001-08-14 2001-08-14 Astrazeneca Ab Novel compounds
GB0221829D0 (en) * 2002-09-20 2002-10-30 Astrazeneca Ab Novel compound
GB0221828D0 (en) * 2002-09-20 2002-10-30 Astrazeneca Ab Novel compound
GB0328243D0 (en) * 2003-12-05 2004-01-07 Astrazeneca Ab Methods
WO2015082499A2 (en) * 2013-12-03 2015-06-11 Iomet Pharma Ltd Pharmaceutical compound

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2872453A (en) * 1959-02-03 Indole derivatives
US3429886A (en) * 1964-11-11 1969-02-25 Ciba Geigy Corp 1-tertiaryaminoalkyl-3-(4-pyridyl)-indoles
US3501484A (en) * 1968-01-15 1970-03-17 Miles Lab Certain substituted 3 - (2-indolyl)-1,2,5,6-tetrahydropyridines and derivatives thereof
DE2322470A1 (de) * 1973-05-04 1974-11-21 Boehringer Sohn Ingelheim Neue indolyl-piperidino-(bzw. 1,2,5,6tetrahydro-pyridyl-)butyrophenone und verfahren zu ihrer herstellung
FR2258843B1 (es) * 1974-01-30 1977-09-09 Roussel Uclaf
IL48508A (en) * 1974-12-09 1979-10-31 Roussel Uclaf Pharmaceutical compositions comprising piperidylindole derivatives
JPS5283766A (en) * 1976-01-01 1977-07-12 Roussel Uclaf Piperidyl indole derivative and its salts and medicine comprising same
FR2362628A1 (fr) * 1976-08-26 1978-03-24 Roussel Uclaf Nouveaux derives du piperidyl-indole et leurs sels, procede de preparation et application a titre de medicaments

Also Published As

Publication number Publication date
SU936812A3 (ru) 1982-06-15
ZA79154B (en) 1980-01-30
CA1115277A (fr) 1981-12-29
DK148477C (da) 1986-04-01
DK148477B (da) 1985-07-15
IE48366B1 (en) 1984-12-26
DK15279A (da) 1979-07-17
JPS54100380A (en) 1979-08-08
AT367418B (de) 1982-07-12
US4278677A (en) 1981-07-14
AU4338379A (en) 1979-07-26
FR2421899B1 (es) 1981-06-19
JPS6340792B2 (es) 1988-08-12
AU519534B2 (en) 1981-12-10
ATA29079A (de) 1981-11-15
IE790064L (en) 1979-07-16
HU180517B (en) 1983-03-28
EP0003199A2 (fr) 1979-07-25
EP0003199A3 (en) 1979-09-05
FR2421899A1 (fr) 1979-11-02
DE2961284D1 (en) 1982-01-14
EP0003199B1 (fr) 1981-11-11
PT69071A (fr) 1979-02-01

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