MX19185A - Procedimiento para preparar 3-(1,2,5,6-tretrahidropiridil)-pirrolopiridinas. - Google Patents

Procedimiento para preparar 3-(1,2,5,6-tretrahidropiridil)-pirrolopiridinas.

Info

Publication number
MX19185A
MX19185A MX1918590A MX1918590A MX19185A MX 19185 A MX19185 A MX 19185A MX 1918590 A MX1918590 A MX 1918590A MX 1918590 A MX1918590 A MX 1918590A MX 19185 A MX19185 A MX 19185A
Authority
MX
Mexico
Prior art keywords
alkyl
tretrahidropiridil
pirrolopiridinas
preparing
procedure
Prior art date
Application number
MX1918590A
Other languages
English (en)
Inventor
John Eugene Macor
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of MX19185A publication Critical patent/MX19185A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
MX1918590A 1989-01-20 1989-01-20 Procedimiento para preparar 3-(1,2,5,6-tretrahidropiridil)-pirrolopiridinas. MX19185A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1989/000231 WO1990007926A1 (en) 1989-01-20 1989-01-20 3-(1,2,5,6-tetrahydropyridyl)-pyrrolopyridines

Publications (1)

Publication Number Publication Date
MX19185A true MX19185A (es) 1993-12-01

Family

ID=22214793

Family Applications (1)

Application Number Title Priority Date Filing Date
MX1918590A MX19185A (es) 1989-01-20 1989-01-20 Procedimiento para preparar 3-(1,2,5,6-tretrahidropiridil)-pirrolopiridinas.

Country Status (26)

Country Link
US (2) US5051412A (es)
EP (1) EP0379314B1 (es)
JP (1) JPH0751576B2 (es)
KR (1) KR920010642B1 (es)
CN (1) CN1025998C (es)
AT (1) ATE103282T1 (es)
CA (1) CA2008016A1 (es)
CS (1) CS277611B6 (es)
DD (2) DD298398A5 (es)
DE (1) DE69007501T2 (es)
DK (1) DK0379314T3 (es)
EG (1) EG18945A (es)
ES (1) ES2062319T3 (es)
FI (1) FI94641C (es)
HU (1) HU206349B (es)
IE (1) IE62757B1 (es)
IL (1) IL93041A (es)
MX (1) MX19185A (es)
MY (1) MY106305A (es)
NO (1) NO912860L (es)
NZ (1) NZ232166A (es)
PL (2) PL287840A1 (es)
PT (1) PT92889A (es)
WO (1) WO1990007926A1 (es)
YU (1) YU47553B (es)
ZA (1) ZA90393B (es)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990007926A1 (en) * 1989-01-20 1990-07-26 Pfizer Inc. 3-(1,2,5,6-tetrahydropyridyl)-pyrrolopyridines
US5451566A (en) * 1993-11-17 1995-09-19 Zeneca Limited Herbicidal pyrrolopyridine compounds
US6586458B1 (en) 1996-08-16 2003-07-01 Pozen Inc. Methods of treating headaches using 5-HT agonists in combination with long-acting NSAIDs
EP1082958A3 (en) * 1996-11-15 2002-12-11 Eli Lilly And Company 5-HT1F agonists in chronic pain
ZA979961B (en) * 1996-11-15 1999-05-05 Lilly Co Eli 5-HT1F agonists
EP0875513A1 (en) * 1997-04-14 1998-11-04 Eli Lilly And Company Substituted heteroaromatic 5-HT 1F agonists
US5905084A (en) * 1997-11-14 1999-05-18 Eli Lilly And Company 5-HTIF -agonists effective in treating migraine
ZA989389B (en) * 1997-11-14 2000-04-14 Lilly Co Eli Pyrrolo [3,2-b] pyridine processes and intermediates.
US6476034B2 (en) 2000-02-22 2002-11-05 Bristol-Myers Squibb Company Antiviral azaindole derivatives
EP1575566B1 (en) 2002-12-26 2012-02-22 Pozen, Inc. Multilayer dosage forms containing naproxen and triptans
EP1684694A2 (en) * 2003-11-21 2006-08-02 Array Biopharma, Inc. Akt protein kinase inhibitors
US7626021B2 (en) * 2004-07-27 2009-12-01 Sgx Pharmaceuticals, Inc. Fused ring heterocycle kinase modulators
US7361764B2 (en) * 2004-07-27 2008-04-22 Sgx Pharmaceuticals, Inc. Pyrrolo-pyridine kinase modulators
BRPI0513899A (pt) 2004-07-27 2008-05-20 Sgx Pharmaceuticals Inc moduladores de cinase heterocìclica de anel fundido
US7361763B2 (en) 2004-07-27 2008-04-22 Sgx Pharmaceuticals, Inc. Pyrrolo-pyridine kinase modulators
US20060100432A1 (en) 2004-11-09 2006-05-11 Matiskella John D Crystalline materials of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-ethane-1,2-dione
US7851476B2 (en) 2005-12-14 2010-12-14 Bristol-Myers Squibb Company Crystalline forms of 1-benzoyl-4-[2-[4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-YL)-1-[(phosphonooxy)methyl]-1H-pyrrolo[2,3-C]pyridin-3-YL]-1,2-dioxoethyl]-piperazine
US7807671B2 (en) 2006-04-25 2010-10-05 Bristol-Myers Squibb Company Diketo-piperazine and piperidine derivatives as antiviral agents
CA2656618C (en) 2006-07-06 2014-08-26 Array Biopharma Inc. Cyclopenta [d] pyrimidines as akt protein kinase inhibitors
US8063050B2 (en) 2006-07-06 2011-11-22 Array Biopharma Inc. Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors
EP2054418B1 (en) 2006-07-06 2011-11-09 Array Biopharma Inc. Dihydrothieno pyrimidines as akt protein kinase inhibitors
DE602007011628D1 (de) 2006-07-06 2011-02-10 Array Biopharma Inc Dihydrofuropyrimidine als akt-proteinkinaseinhibitoren
DK2114955T3 (da) 2006-12-29 2013-05-06 Rigel Pharmaceuticals Inc Broforbundet, bicyklisk aryl og broforbundet, bicyklisk heteroaryl subsitiuerede triazoler, der er anvendelige som axl-inhibitorer
ES2533557T3 (es) * 2007-07-05 2015-04-13 Array Biopharma, Inc. Pirimidil ciclopentanos como inhibidores de proteína cinasa AKT
US8846683B2 (en) 2007-07-05 2014-09-30 Array Biopharma, Inc. Pyrimidyl cyclopentanes as Akt protein kinase inhibitors
AR067413A1 (es) 2007-07-05 2009-10-07 Genentech Inc Compuestos heterociclicos que contienen ciclopenta[d]pirimidina inhibidores de proteinquinasas akt, composiciones farmaceuticas que los contienen, metodo de preparacion y uso de las mismas para el tratamiento de enfermedades hiperproliferativas, tales como cancer
US9409886B2 (en) 2007-07-05 2016-08-09 Array Biopharma Inc. Pyrimidyl cyclopentanes as AKT protein kinase inhibitors
MX2010007546A (es) * 2008-01-09 2010-09-30 Array Biopharma Inc Pirimidil ciclopentanos hidroxilados en forma de inhibidores de akt proteína quinasa.
WO2009089459A1 (en) * 2008-01-09 2009-07-16 Array Biopharma Inc. Hydroxylated pyrimidyl cyclopentanes as akt protein kinase inhibitors
PT2387395E (pt) 2009-01-16 2015-02-04 Rigel Pharmaceuticals Inc Inibidores de axl para utilização em terapia de combinação para prevenir, tratar ou gerir cancro metastático
GEAP202213376A (en) 2009-06-17 2022-02-25 Vertex Pharmaceuticals Incorporated Us Inhibitors of influenza viruses replication
CN103492381A (zh) 2010-12-16 2014-01-01 沃泰克斯药物股份有限公司 流感病毒复制的抑制剂
CN103841975A (zh) 2011-04-01 2014-06-04 基因泰克公司 Akt抑制剂化合物和厄洛替尼的组合以及使用方法
CN103841976A (zh) 2011-04-01 2014-06-04 基因泰克公司 Akt和mek抑制剂化合物的组合及其使用方法
UA118010C2 (uk) 2011-08-01 2018-11-12 Вертекс Фармасьютікалз Інкорпорейтед Інгібітори реплікації вірусів грипу
JP6440625B2 (ja) 2012-11-14 2018-12-19 ザ・ジョンズ・ホプキンス・ユニバーシティー 精神分裂病を処置するための方法および組成物
HUE052178T2 (hu) 2013-11-13 2021-04-28 Vertex Pharma Eljárások influenzavírus-replikáció inhibitorainak elõállítására
LT3068776T (lt) 2013-11-13 2019-08-12 Vertex Pharmaceuticals Incorporated Gripo virusų replikacijos inhibitoriai
CA2960574C (en) * 2014-10-23 2023-03-07 Janssen Pharmaceutica Nv Pyrazolopyrimidine derivatives as nik inhibitors
JP6603713B2 (ja) 2014-10-23 2019-11-06 ヤンセン ファーマシューティカ エヌ．ベー． Ｎｉｋ阻害剤としての新規のチエノピリミジン誘導体
JP6857617B2 (ja) 2015-05-13 2021-04-14 バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ インフルエンザウイルスの複製の阻害剤
WO2016183116A1 (en) 2015-05-13 2016-11-17 Vertex Pharmaceuticals Incorporated Methods of preparing inhibitors of influenza viruses replication

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3272804A (en) * 1963-12-23 1966-09-13 Sterling Drug Inc Process and intermediates for preparing indoles
GB1141949A (en) * 1966-02-23 1969-02-05 Sterling Drug Inc 7-azaindole derivatives
IL48508A (en) * 1974-12-09 1979-10-31 Roussel Uclaf Pharmaceutical compositions comprising piperidylindole derivatives
FR2362628A1 (fr) * 1976-08-26 1978-03-24 Roussel Uclaf Nouveaux derives du piperidyl-indole et leurs sels, procede de preparation et application a titre de medicaments
FR2421899A1 (fr) * 1978-01-16 1979-11-02 Roussel Uclaf Nouveaux derives du tetrahydropyridinyl-indole et leurs sels, le procede de preparation et l'application a titre de medicaments de ces nouveaux produits
FR2444678A2 (fr) * 1978-12-22 1980-07-18 Roussel Uclaf Nouveau procede de preparation de derives du piperidyl-indole et de leurs sels
US5025096A (en) * 1985-08-22 1991-06-18 Mine Safety Appliances Company Preparation of indole and indole derivatives
WO1990007926A1 (en) * 1989-01-20 1990-07-26 Pfizer Inc. 3-(1,2,5,6-tetrahydropyridyl)-pyrrolopyridines

Also Published As

Publication number Publication date
MY106305A (en) 1995-04-29
ATE103282T1 (de) 1994-04-15
HUT57762A (en) 1991-12-30
EP0379314B1 (en) 1994-03-23
PT92889A (pt) 1990-07-31
DE69007501T2 (de) 1994-06-30
DK0379314T3 (da) 1994-05-09
KR920010642B1 (ko) 1992-12-12
HU206349B (en) 1992-10-28
CS26090A3 (en) 1992-02-19
CN1044465A (zh) 1990-08-08
IE900210L (en) 1990-07-23
CS277611B6 (en) 1993-03-17
US5051412A (en) 1991-09-24
PL287840A1 (en) 1991-07-15
IL93041A0 (en) 1990-11-05
AU613259B2 (en) 1991-07-25
ES2062319T3 (es) 1994-12-16
NO912860D0 (no) 1991-07-22
PL163626B1 (pl) 1994-04-29
DE69007501D1 (de) 1994-04-28
DD298398A5 (de) 1992-02-20
YU47553B (sh) 1995-10-03
JPH0751576B2 (ja) 1995-06-05
FI913509A0 (fi) 1991-07-22
ZA90393B (en) 1991-08-28
YU9990A (en) 1992-05-28
IL93041A (en) 1994-02-27
FI94641B (fi) 1995-06-30
EP0379314A1 (en) 1990-07-25
IE62757B1 (en) 1995-02-22
US5169947A (en) 1992-12-08
AU4867390A (en) 1990-07-26
EG18945A (en) 1994-09-29
NZ232166A (en) 1992-10-28
JPH02247175A (ja) 1990-10-02
KR900011772A (ko) 1990-08-02
CN1025998C (zh) 1994-09-28
FI94641C (fi) 1995-10-10
NO912860L (no) 1991-07-22
DD291559A5 (de) 1991-07-04
CA2008016A1 (en) 1990-07-20
WO1990007926A1 (en) 1990-07-26
PL283354A1 (en) 1991-08-12

Similar Documents

Publication Publication Date Title
MX19185A (es) Procedimiento para preparar 3-(1,2,5,6-tretrahidropiridil)-pirrolopiridinas.
PT77645B (en) Process for preparing epimeril aza homoerytheomycin a derivati-ves and intermediates therefor
EP0157572A3 (en) Acyltripeptide immunostimulants
ES2057899T3 (es) Procedimiento para la preparacion estereoselectiva de derivados de la fenilisoserina.
GB8821758D0 (en) Substituted cycloalkanols
NZ228632A (en) Topical otopathic preparations containing ofloxacin
MX159930A (es) Procedimiento para preparar esteroides substituidos
HUT47537A (en) Process for producing new 2,3-diamino-acrylic acid-nitrile derivatives
ZA200003035B (en) Compounds of 7-oxo-2,3,7,14-tetrahydro-1H-benzo[B]-pyrano[3,2-H] acridin carboxylate, a process for their preparation and pharmaceutical compositions containing them.
ZA83851B (en) Carbacyclins, process for the preparation thereof, and use thereof as medicinal agents
FR2263752A1 (en) 1,8-Naphthyridine derivs - tranquillizers and anti-convulsants
BR8706053A (pt) Processo para a preparacao de cepa mutante aperfeicoada de bordetella bronchiseptica,e vacina de germe atenuado ar produzida da mesma
PT81324A (en) Process for the preparation of s-aralkyltrithiophosphonate having an insecticidal effect
EP0171812A3 (en) Cephem derivatives
PT79860A (en) Process for the preparation of 2-thiazoline and 2-oxozoline with antidote activity against non-selective herbicides
BR9905348A (pt) Antibacterianos furopiridinas
HUT41364A (en) Process for preparing triphenyl-alkenes by means of the dehydratation of triphenyl-alkanols