ZA83851B - Carbacyclins, process for the preparation thereof, and use thereof as medicinal agents - Google Patents

Carbacyclins, process for the preparation thereof, and use thereof as medicinal agents

Info

Publication number
ZA83851B
ZA83851B ZA83851A ZA83851A ZA83851B ZA 83851 B ZA83851 B ZA 83851B ZA 83851 A ZA83851 A ZA 83851A ZA 83851 A ZA83851 A ZA 83851A ZA 83851 B ZA83851 B ZA 83851B
Authority
ZA
South Africa
Prior art keywords
carbacyclins
preparation
medicinal agents
atoms
alkyl
Prior art date
Application number
ZA83851A
Inventor
Werner Skuballa
Bernd Raduechel
Helmut Vorbrueggen
Jorge Casals-Stenzel
Gerda Mannesmann
Michael Harold Town
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of ZA83851B publication Critical patent/ZA83851B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/72—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/005—Analogues or derivatives having the five membered ring replaced by other rings
    • C07C405/0075—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system
    • C07C405/0083—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system which is only ortho or peri condensed, e.g. carbacyclins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/56—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
    • C07C45/57—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom
    • C07C45/59—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom in five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/78—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4015—Esters of acyclic unsaturated acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Ink Jet Recording Methods And Recording Media Thereof (AREA)
  • Lubricants (AREA)
  • Medicinal Preparation (AREA)

Abstract

1. Carbacyclin derivatives of the general formula I see diagramm : EP0086404,P12,F1 wherein R1 , R2 , R3 and R4 are hydrogen or alkyl of 1-2 C-atoms. R5 is alkyl of 1-2 C-atoms, as well as their salts with pharmaceutically acceptable bases.
ZA83851A 1982-02-08 1983-02-08 Carbacyclins, process for the preparation thereof, and use thereof as medicinal agents ZA83851B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19823204443 DE3204443A1 (en) 1982-02-08 1982-02-08 NEW CARBACYCLINE, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS MEDICINAL PRODUCTS

Publications (1)

Publication Number Publication Date
ZA83851B true ZA83851B (en) 1983-10-26

Family

ID=6155190

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA83851A ZA83851B (en) 1982-02-08 1983-02-08 Carbacyclins, process for the preparation thereof, and use thereof as medicinal agents

Country Status (19)

Country Link
EP (1) EP0086404B1 (en)
JP (1) JPH0611728B2 (en)
AT (1) ATE24487T1 (en)
AU (1) AU567867B2 (en)
CA (1) CA1215362A (en)
CS (1) CS235307B2 (en)
DD (1) DD207901A5 (en)
DE (2) DE3204443A1 (en)
DK (1) DK156563C (en)
ES (1) ES8400384A1 (en)
FI (1) FI78064C (en)
GR (1) GR77967B (en)
HU (1) HU191197B (en)
IE (1) IE54554B1 (en)
IL (1) IL67839A0 (en)
NO (1) NO155729C (en)
NZ (1) NZ203115A (en)
SU (1) SU1145926A3 (en)
ZA (1) ZA83851B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3225287A1 (en) * 1982-07-02 1984-01-05 Schering AG, 1000 Berlin und 4709 Bergkamen NEW CARBACYCLINAMIDES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS MEDICINAL PRODUCTS
DE3408699A1 (en) * 1984-03-08 1985-09-12 Schering AG, 1000 Berlin und 4709 Bergkamen NEW CARBACYCLINE, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS MEDICINAL PRODUCTS
US4927963A (en) * 1989-04-28 1990-05-22 Syntex (U.S.A.) Inc. Novel processes for the synthesis of certain bicyclo(4.2.0)octane derivatives with valuable therapeutic properties
DE4135193C1 (en) * 1991-10-22 1993-03-11 Schering Ag Berlin Und Bergkamen, 1000 Berlin, De

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2845770A1 (en) * 1978-10-19 1980-04-30 Schering Ag NEW PROSTACYCLINE DERIVATIVES AND METHOD FOR THE PRODUCTION THEREOF
CA1201712A (en) * 1980-02-28 1986-03-11 Paul A. Aristoff Carbacyclin analogs
DE3104044A1 (en) * 1981-02-02 1982-08-26 Schering Ag, 1000 Berlin Und 4619 Bergkamen NEW PROSTACYCLIN DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS MEDICINAL PRODUCTS

Also Published As

Publication number Publication date
NO830399L (en) 1983-08-09
HU191197B (en) 1987-01-28
DK156563C (en) 1990-01-29
DE3204443A1 (en) 1983-08-18
FI78064C (en) 1989-06-12
IE830246L (en) 1983-08-08
AU567867B2 (en) 1987-12-10
DD207901A5 (en) 1984-03-21
EP0086404B1 (en) 1986-12-30
IL67839A0 (en) 1983-06-15
FI830414A0 (en) 1983-02-07
FI78064B (en) 1989-02-28
DK156563B (en) 1989-09-11
DK52383A (en) 1983-08-09
DK52383D0 (en) 1983-02-08
ATE24487T1 (en) 1987-01-15
GR77967B (en) 1984-09-25
NO155729B (en) 1987-02-09
NO155729C (en) 1987-05-20
IE54554B1 (en) 1989-11-22
DE3368609D1 (en) 1987-02-05
CA1215362A (en) 1986-12-16
EP0086404A1 (en) 1983-08-24
JPH0611728B2 (en) 1994-02-16
AU1118083A (en) 1983-08-18
FI830414L (en) 1983-08-09
JPS58146531A (en) 1983-09-01
SU1145926A3 (en) 1985-03-15
NZ203115A (en) 1986-03-14
ES519627A0 (en) 1983-11-16
CS235307B2 (en) 1985-05-15
ES8400384A1 (en) 1983-11-16

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