IL67839A0 - Novel carbacyclins,process for the preparation thereof,and pharmaceutical compositions containing the same - Google Patents

Novel carbacyclins,process for the preparation thereof,and pharmaceutical compositions containing the same

Info

Publication number
IL67839A0
IL67839A0 IL67839A IL6783983A IL67839A0 IL 67839 A0 IL67839 A0 IL 67839A0 IL 67839 A IL67839 A IL 67839A IL 6783983 A IL6783983 A IL 6783983A IL 67839 A0 IL67839 A0 IL 67839A0
Authority
IL
Israel
Prior art keywords
preparation
same
pharmaceutical compositions
compositions containing
carbacyclins
Prior art date
Application number
IL67839A
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of IL67839A0 publication Critical patent/IL67839A0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/72—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/005—Analogues or derivatives having the five membered ring replaced by other rings
    • C07C405/0075—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system
    • C07C405/0083—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system which is only ortho or peri condensed, e.g. carbacyclins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/56—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
    • C07C45/57—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom
    • C07C45/59—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom in five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/78—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4015—Esters of acyclic unsaturated acids

Abstract

1. Carbacyclin derivatives of the general formula I see diagramm : EP0086404,P12,F1 wherein R1 , R2 , R3 and R4 are hydrogen or alkyl of 1-2 C-atoms. R5 is alkyl of 1-2 C-atoms, as well as their salts with pharmaceutically acceptable bases.
IL67839A 1982-02-08 1983-02-06 Novel carbacyclins,process for the preparation thereof,and pharmaceutical compositions containing the same IL67839A0 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19823204443 DE3204443A1 (en) 1982-02-08 1982-02-08 NEW CARBACYCLINE, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS MEDICINAL PRODUCTS

Publications (1)

Publication Number Publication Date
IL67839A0 true IL67839A0 (en) 1983-06-15

Family

ID=6155190

Family Applications (1)

Application Number Title Priority Date Filing Date
IL67839A IL67839A0 (en) 1982-02-08 1983-02-06 Novel carbacyclins,process for the preparation thereof,and pharmaceutical compositions containing the same

Country Status (19)

Country Link
EP (1) EP0086404B1 (en)
JP (1) JPH0611728B2 (en)
AT (1) ATE24487T1 (en)
AU (1) AU567867B2 (en)
CA (1) CA1215362A (en)
CS (1) CS235307B2 (en)
DD (1) DD207901A5 (en)
DE (2) DE3204443A1 (en)
DK (1) DK156563C (en)
ES (1) ES519627A0 (en)
FI (1) FI78064C (en)
GR (1) GR77967B (en)
HU (1) HU191197B (en)
IE (1) IE54554B1 (en)
IL (1) IL67839A0 (en)
NO (1) NO155729C (en)
NZ (1) NZ203115A (en)
SU (1) SU1145926A3 (en)
ZA (1) ZA83851B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3225287A1 (en) * 1982-07-02 1984-01-05 Schering AG, 1000 Berlin und 4709 Bergkamen NEW CARBACYCLINAMIDES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS MEDICINAL PRODUCTS
DE3408699A1 (en) * 1984-03-08 1985-09-12 Schering AG, 1000 Berlin und 4709 Bergkamen NEW CARBACYCLINE, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS MEDICINAL PRODUCTS
US4927963A (en) * 1989-04-28 1990-05-22 Syntex (U.S.A.) Inc. Novel processes for the synthesis of certain bicyclo(4.2.0)octane derivatives with valuable therapeutic properties
DE4135193C1 (en) * 1991-10-22 1993-03-11 Schering Ag Berlin Und Bergkamen, 1000 Berlin, De

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2845770A1 (en) * 1978-10-19 1980-04-30 Schering Ag NEW PROSTACYCLINE DERIVATIVES AND METHOD FOR THE PRODUCTION THEREOF
CA1201712A (en) * 1980-02-28 1986-03-11 Paul A. Aristoff Carbacyclin analogs
DE3104044A1 (en) * 1981-02-02 1982-08-26 Schering Ag, 1000 Berlin Und 4619 Bergkamen NEW PROSTACYCLIN DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS MEDICINAL PRODUCTS

Also Published As

Publication number Publication date
EP0086404B1 (en) 1986-12-30
DE3368609D1 (en) 1987-02-05
NO155729B (en) 1987-02-09
DE3204443A1 (en) 1983-08-18
CA1215362A (en) 1986-12-16
NZ203115A (en) 1986-03-14
DK52383D0 (en) 1983-02-08
FI78064B (en) 1989-02-28
FI830414L (en) 1983-08-09
GR77967B (en) 1984-09-25
ES8400384A1 (en) 1983-11-16
CS235307B2 (en) 1985-05-15
JPS58146531A (en) 1983-09-01
AU567867B2 (en) 1987-12-10
IE830246L (en) 1983-08-08
FI830414A0 (en) 1983-02-07
DK156563C (en) 1990-01-29
ZA83851B (en) 1983-10-26
FI78064C (en) 1989-06-12
DK52383A (en) 1983-08-09
NO830399L (en) 1983-08-09
DD207901A5 (en) 1984-03-21
DK156563B (en) 1989-09-11
HU191197B (en) 1987-01-28
ATE24487T1 (en) 1987-01-15
AU1118083A (en) 1983-08-18
ES519627A0 (en) 1983-11-16
EP0086404A1 (en) 1983-08-24
SU1145926A3 (en) 1985-03-15
IE54554B1 (en) 1989-11-22
JPH0611728B2 (en) 1994-02-16
NO155729C (en) 1987-05-20

Similar Documents

Publication Publication Date Title
CA2036876A1 (en) Derivatives having a naphthalenic structure; process for preparing the same and pharmaceutical compositions containing them
IL64905A (en) Process for the preparation of 2-penems,carbapenems,carbacephams,oxapenems,and azapenems,some novel such compounds and pharmaceutical compositions containing them
EP0150937A3 (en) Dihydropyridazinones
MY100095A (en) 2-oxo-imidazolidine compounds, a process for preparing the same and a pharmaceutical composition.
AU580728B2 (en) Novel carbacyclins, process for their manufacture and their use as medicaments
HUT40101A (en) Process for producing quinolin-carboxylic acid derivatives and pharmaceutical compositions containing them as active agents
IE872588L (en) Compounds
DE3362504D1 (en) 1-carboxyalkanoylindoline-2-carboxylic-acid esters, their preparation, pharmaceutical compositions containing them, and their therapeutic use
DE3477488D1 (en) Polymethoxybenzyl piperazine derivatives, processes for their preparation and pharmaceutical compositions containing said derivatives
IL67839A0 (en) Novel carbacyclins,process for the preparation thereof,and pharmaceutical compositions containing the same
JPS55141478A (en) Phenylpiperazine derivative*its manufacture and its composition
DE3465085D1 (en) Derivatives of 4-(3-alkynyloxy-2-hydroxy-propyl)-piperazin-1-yl-n-phenyl acetamide, their preparation and their therapeutical use
GB8515212D0 (en) Thiazolidine derivatives
HUT45059A (en) Process for producing abeoergoline derivatives
ES464753A1 (en) D-6-allyl-8-ergol-I-ylacetamide
MY103509A (en) Indole derivatives.
MY101746A (en) 1,5-benzothiazepine derivatives, a process for preparing the same, pharmaceutical compositions as well as the use thereof.
ES8307812A1 (en) Beta-lactam antibacterial agents, their preparation and use.
ES8402303A1 (en) Antibiotics, their preparation and use.

Legal Events

Date Code Title Description
RH Patent void