FI913509A0 - Menetelmä terapeuttisesti käyttökelpoisten 3-(1,2,5,6-tetrahydropyridyyli)pyrrolopyridiinien valmistamiseksi - Google Patents

Menetelmä terapeuttisesti käyttökelpoisten 3-(1,2,5,6-tetrahydropyridyyli)pyrrolopyridiinien valmistamiseksi

Info

Publication number
FI913509A0
FI913509A0 FI913509A FI913509A FI913509A0 FI 913509 A0 FI913509 A0 FI 913509A0 FI 913509 A FI913509 A FI 913509A FI 913509 A FI913509 A FI 913509A FI 913509 A0 FI913509 A0 FI 913509A0
Authority
FI
Finland
Prior art keywords
tetrahydropyridyl
alkyl
pyrrolopyridines
preparation
therapeutically useful
Prior art date
Application number
FI913509A
Other languages
English (en)
Swedish (sv)
Other versions
FI94641B (fi
FI94641C (fi
Inventor
John Eugene Macor
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of FI913509A0 publication Critical patent/FI913509A0/fi
Publication of FI94641B publication Critical patent/FI94641B/fi
Application granted granted Critical
Publication of FI94641C publication Critical patent/FI94641C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
FI913509A 1989-01-20 1991-07-22 Menetelmä terapeuttisesti käyttökelpoisten 3-(1,2,5,6-tetrahydropyridyyli)pyrrolopyridiinien valmistamiseksi FI94641C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8900231 1989-01-20
PCT/US1989/000231 WO1990007926A1 (en) 1989-01-20 1989-01-20 3-(1,2,5,6-tetrahydropyridyl)-pyrrolopyridines

Publications (3)

Publication Number Publication Date
FI913509A0 true FI913509A0 (fi) 1991-07-22
FI94641B FI94641B (fi) 1995-06-30
FI94641C FI94641C (fi) 1995-10-10

Family

ID=22214793

Family Applications (1)

Application Number Title Priority Date Filing Date
FI913509A FI94641C (fi) 1989-01-20 1991-07-22 Menetelmä terapeuttisesti käyttökelpoisten 3-(1,2,5,6-tetrahydropyridyyli)pyrrolopyridiinien valmistamiseksi

Country Status (26)

Country Link
US (2) US5051412A (fi)
EP (1) EP0379314B1 (fi)
JP (1) JPH0751576B2 (fi)
KR (1) KR920010642B1 (fi)
CN (1) CN1025998C (fi)
AT (1) ATE103282T1 (fi)
CA (1) CA2008016A1 (fi)
CS (1) CS277611B6 (fi)
DD (2) DD298398A5 (fi)
DE (1) DE69007501T2 (fi)
DK (1) DK0379314T3 (fi)
EG (1) EG18945A (fi)
ES (1) ES2062319T3 (fi)
FI (1) FI94641C (fi)
HU (1) HU206349B (fi)
IE (1) IE62757B1 (fi)
IL (1) IL93041A (fi)
MX (1) MX19185A (fi)
MY (1) MY106305A (fi)
NO (1) NO912860D0 (fi)
NZ (1) NZ232166A (fi)
PL (2) PL163626B1 (fi)
PT (1) PT92889A (fi)
WO (1) WO1990007926A1 (fi)
YU (1) YU47553B (fi)
ZA (1) ZA90393B (fi)

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WO1990007926A1 (en) * 1989-01-20 1990-07-26 Pfizer Inc. 3-(1,2,5,6-tetrahydropyridyl)-pyrrolopyridines
US5451566A (en) * 1993-11-17 1995-09-19 Zeneca Limited Herbicidal pyrrolopyridine compounds
US6586458B1 (en) 1996-08-16 2003-07-01 Pozen Inc. Methods of treating headaches using 5-HT agonists in combination with long-acting NSAIDs
ZA979961B (en) * 1996-11-15 1999-05-05 Lilly Co Eli 5-HT1F agonists
EP1082958A3 (en) * 1996-11-15 2002-12-11 Eli Lilly And Company 5-HT1F agonists in chronic pain
EP0875513A1 (en) * 1997-04-14 1998-11-04 Eli Lilly And Company Substituted heteroaromatic 5-HT 1F agonists
ZA989389B (en) * 1997-11-14 2000-04-14 Lilly Co Eli Pyrrolo [3,2-b] pyridine processes and intermediates.
US5905084A (en) * 1997-11-14 1999-05-18 Eli Lilly And Company 5-HTIF -agonists effective in treating migraine
US6476034B2 (en) 2000-02-22 2002-11-05 Bristol-Myers Squibb Company Antiviral azaindole derivatives
JP4616009B2 (ja) 2002-12-26 2011-01-19 ポーゼン インコーポレイテッド ＮＳＡＩＤｓおよびトリプタンを含有する多層剤型
RU2006121990A (ru) * 2003-11-21 2007-12-27 Эррэй Биофарма Инк. (Us) Ингибиторы протеинкиназ акт
US7626021B2 (en) * 2004-07-27 2009-12-01 Sgx Pharmaceuticals, Inc. Fused ring heterocycle kinase modulators
US7361764B2 (en) 2004-07-27 2008-04-22 Sgx Pharmaceuticals, Inc. Pyrrolo-pyridine kinase modulators
BRPI0513916A (pt) 2004-07-27 2008-05-20 Sgx Pharmaceuticals Inc moduladores de pirrol-piridina cinase
AU2005269387A1 (en) 2004-07-27 2006-02-09 Sgx Pharmaceuticals, Inc. Fused ring heterocycle kinase modulators
US20060100432A1 (en) 2004-11-09 2006-05-11 Matiskella John D Crystalline materials of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-ethane-1,2-dione
US7851476B2 (en) 2005-12-14 2010-12-14 Bristol-Myers Squibb Company Crystalline forms of 1-benzoyl-4-[2-[4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-YL)-1-[(phosphonooxy)methyl]-1H-pyrrolo[2,3-C]pyridin-3-YL]-1,2-dioxoethyl]-piperazine
US7807671B2 (en) 2006-04-25 2010-10-05 Bristol-Myers Squibb Company Diketo-piperazine and piperidine derivatives as antiviral agents
US8063050B2 (en) * 2006-07-06 2011-11-22 Array Biopharma Inc. Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors
DE602007011628D1 (de) 2006-07-06 2011-02-10 Array Biopharma Inc Dihydrofuropyrimidine als akt-proteinkinaseinhibitoren
CA2656364C (en) 2006-07-06 2014-11-25 Array Biopharma Inc. Dihydrothieno pyrimidines as akt protein kinase inhibitors
ATE523499T1 (de) 2006-07-06 2011-09-15 Array Biopharma Inc Cyclopenta [d]-pyrimidine als akt-proteinkinasehemmer
PL2114955T3 (pl) * 2006-12-29 2013-06-28 Rigel Pharmaceuticals Inc Triazole podstawione mostkowanym bicyklicznym arylem oraz mostkowanym bicyklicznym heteroarylem użyteczne jako inhibitory Axl
US8846683B2 (en) 2007-07-05 2014-09-30 Array Biopharma, Inc. Pyrimidyl cyclopentanes as Akt protein kinase inhibitors
US9409886B2 (en) 2007-07-05 2016-08-09 Array Biopharma Inc. Pyrimidyl cyclopentanes as AKT protein kinase inhibitors
TWI450720B (zh) 2007-07-05 2014-09-01 Array Biopharma Inc 作為ａｋｔ蛋白質激酶抑制劑之嘧啶環戊烷
US8377937B2 (en) * 2007-07-05 2013-02-19 Array Biopharma Inc. Pyrimidyl cyclopentanes as AKT protein kinase inhibitors
AU2009204025B2 (en) * 2008-01-09 2014-02-20 Array Biopharma Inc. Hydroxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors
ES2401685T3 (es) * 2008-01-09 2013-04-23 Array Biopharma, Inc. Pirimidil ciclopentano hidroxilado como inhibidor de la proteína quinasa AKT
JP5858789B2 (ja) 2009-01-16 2016-02-10 ライジェル ファーマシューティカルズ， インコーポレイテッド 転移性癌の予防、治療、または管理のための併用療法に用いるためのａｘｌ阻害薬
PE20120508A1 (es) 2009-06-17 2012-05-09 Vertex Pharma Inhibidores de la replicacion de los virus de la gripe
CN103492381A (zh) 2010-12-16 2014-01-01 沃泰克斯药物股份有限公司 流感病毒复制的抑制剂
CN103874689B (zh) 2011-04-01 2016-04-27 基因泰克公司 Akt抑制剂化合物和威罗菲尼的组合及使用方法
CN103841976A (zh) 2011-04-01 2014-06-04 基因泰克公司 Akt和mek抑制剂化合物的组合及其使用方法
UA118010C2 (uk) 2011-08-01 2018-11-12 Вертекс Фармасьютікалз Інкорпорейтед Інгібітори реплікації вірусів грипу
JP6440625B2 (ja) 2012-11-14 2018-12-19 ザ・ジョンズ・ホプキンス・ユニバーシティー 精神分裂病を処置するための方法および組成物
EP3068776B1 (en) 2013-11-13 2019-05-29 Vertex Pharmaceuticals Incorporated Inhibitors of influenza viruses replication
SG10201804021TA (en) 2013-11-13 2018-07-30 Vertex Pharma Methods of preparing inhibitors of influenza viruses replication
WO2016062790A1 (en) * 2014-10-23 2016-04-28 Janssen Pharmaceutica Nv New pyrazolopyrimidine derivatives as nik inhibitors
CN107074881B (zh) 2014-10-23 2019-07-30 詹森药业有限公司 作为nik抑制剂的新的噻吩并嘧啶衍生物
JP6857617B2 (ja) 2015-05-13 2021-04-14 バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ インフルエンザウイルスの複製の阻害剤
WO2016183116A1 (en) 2015-05-13 2016-11-17 Vertex Pharmaceuticals Incorporated Methods of preparing inhibitors of influenza viruses replication

Family Cites Families (8)

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Publication number Priority date Publication date Assignee Title
US3272804A (en) * 1963-12-23 1966-09-13 Sterling Drug Inc Process and intermediates for preparing indoles
GB1141949A (en) * 1966-02-23 1969-02-05 Sterling Drug Inc 7-azaindole derivatives
IL48508A (en) * 1974-12-09 1979-10-31 Roussel Uclaf Pharmaceutical compositions comprising piperidylindole derivatives
FR2362628A1 (fr) * 1976-08-26 1978-03-24 Roussel Uclaf Nouveaux derives du piperidyl-indole et leurs sels, procede de preparation et application a titre de medicaments
FR2421899A1 (fr) * 1978-01-16 1979-11-02 Roussel Uclaf Nouveaux derives du tetrahydropyridinyl-indole et leurs sels, le procede de preparation et l'application a titre de medicaments de ces nouveaux produits
FR2444678A2 (fr) * 1978-12-22 1980-07-18 Roussel Uclaf Nouveau procede de preparation de derives du piperidyl-indole et de leurs sels
US5025096A (en) * 1985-08-22 1991-06-18 Mine Safety Appliances Company Preparation of indole and indole derivatives
WO1990007926A1 (en) * 1989-01-20 1990-07-26 Pfizer Inc. 3-(1,2,5,6-tetrahydropyridyl)-pyrrolopyridines

Also Published As

Publication number Publication date
EP0379314A1 (en) 1990-07-25
PT92889A (pt) 1990-07-31
AU613259B2 (en) 1991-07-25
NO912860L (no) 1991-07-22
HU206349B (en) 1992-10-28
FI94641B (fi) 1995-06-30
NZ232166A (en) 1992-10-28
FI94641C (fi) 1995-10-10
KR900011772A (ko) 1990-08-02
EG18945A (en) 1994-09-29
CN1025998C (zh) 1994-09-28
CS26090A3 (en) 1992-02-19
MY106305A (en) 1995-04-29
IL93041A0 (en) 1990-11-05
DE69007501D1 (de) 1994-04-28
EP0379314B1 (en) 1994-03-23
DD298398A5 (de) 1992-02-20
HUT57762A (en) 1991-12-30
ZA90393B (en) 1991-08-28
DK0379314T3 (da) 1994-05-09
WO1990007926A1 (en) 1990-07-26
PL163626B1 (pl) 1994-04-29
CS277611B6 (en) 1993-03-17
MX19185A (es) 1993-12-01
CA2008016A1 (en) 1990-07-20
PL287840A1 (en) 1991-07-15
YU47553B (sh) 1995-10-03
ATE103282T1 (de) 1994-04-15
AU4867390A (en) 1990-07-26
JPH02247175A (ja) 1990-10-02
IE62757B1 (en) 1995-02-22
JPH0751576B2 (ja) 1995-06-05
DE69007501T2 (de) 1994-06-30
NO912860D0 (no) 1991-07-22
IE900210L (en) 1990-07-23
US5051412A (en) 1991-09-24
US5169947A (en) 1992-12-08
CN1044465A (zh) 1990-08-08
DD291559A5 (de) 1991-07-04
ES2062319T3 (es) 1994-12-16
KR920010642B1 (ko) 1992-12-12
PL283354A1 (en) 1991-08-12
IL93041A (en) 1994-02-27
YU9990A (en) 1992-05-28

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Legal Events

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