FI913509A0 - Förfarande för framställning av terapeutiskt användbara 3-(1,2,5,6-tetrahydropyridyl)pyrrolopyridiner - Google Patents

Förfarande för framställning av terapeutiskt användbara 3-(1,2,5,6-tetrahydropyridyl)pyrrolopyridiner

Info

Publication number
FI913509A0
FI913509A0 FI913509A FI913509A FI913509A0 FI 913509 A0 FI913509 A0 FI 913509A0 FI 913509 A FI913509 A FI 913509A FI 913509 A FI913509 A FI 913509A FI 913509 A0 FI913509 A0 FI 913509A0
Authority
FI
Finland
Prior art keywords
tetrahydropyridyl
alkyl
pyrrolopyridines
preparation
therapeutically useful
Prior art date
Application number
FI913509A
Other languages
English (en)
Finnish (fi)
Other versions
FI94641C (sv
FI94641B (sv
Inventor
John Eugene Macor
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of FI913509A0 publication Critical patent/FI913509A0/sv
Application granted granted Critical
Publication of FI94641B publication Critical patent/FI94641B/sv
Publication of FI94641C publication Critical patent/FI94641C/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyridine Compounds (AREA)
FI913509A 1989-01-20 1991-07-22 Förfarande för framställning av terapeutiskt användbara 3-(1,2,5,6-tetrahydropyridyl)pyrrolopyridiner FI94641C (sv)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/US1989/000231 WO1990007926A1 (en) 1989-01-20 1989-01-20 3-(1,2,5,6-tetrahydropyridyl)-pyrrolopyridines
US8900231 1989-01-20

Publications (3)

Publication Number Publication Date
FI913509A0 true FI913509A0 (sv) 1991-07-22
FI94641B FI94641B (sv) 1995-06-30
FI94641C FI94641C (sv) 1995-10-10

Family

ID=22214793

Family Applications (1)

Application Number Title Priority Date Filing Date
FI913509A FI94641C (sv) 1989-01-20 1991-07-22 Förfarande för framställning av terapeutiskt användbara 3-(1,2,5,6-tetrahydropyridyl)pyrrolopyridiner

Country Status (26)

Country Link
US (2) US5051412A (sv)
EP (1) EP0379314B1 (sv)
JP (1) JPH0751576B2 (sv)
KR (1) KR920010642B1 (sv)
CN (1) CN1025998C (sv)
AT (1) ATE103282T1 (sv)
CA (1) CA2008016A1 (sv)
CS (1) CS277611B6 (sv)
DD (2) DD291559A5 (sv)
DE (1) DE69007501T2 (sv)
DK (1) DK0379314T3 (sv)
EG (1) EG18945A (sv)
ES (1) ES2062319T3 (sv)
FI (1) FI94641C (sv)
HU (1) HU206349B (sv)
IE (1) IE62757B1 (sv)
IL (1) IL93041A (sv)
MX (1) MX19185A (sv)
MY (1) MY106305A (sv)
NO (1) NO912860L (sv)
NZ (1) NZ232166A (sv)
PL (2) PL287840A1 (sv)
PT (1) PT92889A (sv)
WO (1) WO1990007926A1 (sv)
YU (1) YU47553B (sv)
ZA (1) ZA90393B (sv)

Families Citing this family (42)

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WO1990007926A1 (en) * 1989-01-20 1990-07-26 Pfizer Inc. 3-(1,2,5,6-tetrahydropyridyl)-pyrrolopyridines
US5451566A (en) * 1993-11-17 1995-09-19 Zeneca Limited Herbicidal pyrrolopyridine compounds
US6586458B1 (en) 1996-08-16 2003-07-01 Pozen Inc. Methods of treating headaches using 5-HT agonists in combination with long-acting NSAIDs
EP1082958A3 (en) * 1996-11-15 2002-12-11 Eli Lilly And Company 5-HT1F agonists in chronic pain
ZA979961B (en) * 1996-11-15 1999-05-05 Lilly Co Eli 5-HT1F agonists
EP0875513A1 (en) * 1997-04-14 1998-11-04 Eli Lilly And Company Substituted heteroaromatic 5-HT 1F agonists
ZA989389B (en) * 1997-11-14 2000-04-14 Lilly Co Eli Pyrrolo [3,2-b] pyridine processes and intermediates.
US5905084A (en) * 1997-11-14 1999-05-18 Eli Lilly And Company 5-HTIF -agonists effective in treating migraine
US6476034B2 (en) 2000-02-22 2002-11-05 Bristol-Myers Squibb Company Antiviral azaindole derivatives
MXPA05006954A (es) 2002-12-26 2005-09-22 Pozen Inc Formas de dosificacion de capas multiples que contienen nsaids y triptanos.
EP1684694A2 (en) * 2003-11-21 2006-08-02 Array Biopharma, Inc. Akt protein kinase inhibitors
US7361764B2 (en) 2004-07-27 2008-04-22 Sgx Pharmaceuticals, Inc. Pyrrolo-pyridine kinase modulators
SG156685A1 (en) * 2004-07-27 2009-11-26 Sgx Pharmaceuticals Inc Fused ring heterocycle kinase modulators
AU2005269386A1 (en) * 2004-07-27 2006-02-09 Sgx Pharmaceuticals, Inc. Pyrrolo-pyridine kinase modulators
US7626021B2 (en) * 2004-07-27 2009-12-01 Sgx Pharmaceuticals, Inc. Fused ring heterocycle kinase modulators
US20060100432A1 (en) 2004-11-09 2006-05-11 Matiskella John D Crystalline materials of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-ethane-1,2-dione
US7851476B2 (en) 2005-12-14 2010-12-14 Bristol-Myers Squibb Company Crystalline forms of 1-benzoyl-4-[2-[4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-YL)-1-[(phosphonooxy)methyl]-1H-pyrrolo[2,3-C]pyridin-3-YL]-1,2-dioxoethyl]-piperazine
US7807671B2 (en) 2006-04-25 2010-10-05 Bristol-Myers Squibb Company Diketo-piperazine and piperidine derivatives as antiviral agents
EP2054418B1 (en) 2006-07-06 2011-11-09 Array Biopharma Inc. Dihydrothieno pyrimidines as akt protein kinase inhibitors
ATE493418T1 (de) 2006-07-06 2011-01-15 Array Biopharma Inc Dihydrofuropyrimidine als akt- proteinkinaseinhibitoren
CA2656618C (en) 2006-07-06 2014-08-26 Array Biopharma Inc. Cyclopenta [d] pyrimidines as akt protein kinase inhibitors
US8063050B2 (en) * 2006-07-06 2011-11-22 Array Biopharma Inc. Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors
US8012965B2 (en) 2006-12-29 2011-09-06 Rigel Pharmaceuticals, Inc. Bridged bicyclic aryl and bridged bicyclic heteroaryl substituted triazoles useful as axl inhibitors
CN101801955B (zh) 2007-07-05 2013-05-08 阵列生物制药公司 作为akt蛋白激酶抑制剂的嘧啶基环戊烷
JP5542282B2 (ja) * 2007-07-05 2014-07-09 アレイ バイオファーマ、インコーポレイテッド Ａｋｔプロテインキナーゼ阻害剤としてのピリミジルシクロペンタン
US8846683B2 (en) 2007-07-05 2014-09-30 Array Biopharma, Inc. Pyrimidyl cyclopentanes as Akt protein kinase inhibitors
US9409886B2 (en) 2007-07-05 2016-08-09 Array Biopharma Inc. Pyrimidyl cyclopentanes as AKT protein kinase inhibitors
AU2009204019B2 (en) * 2008-01-09 2014-02-20 Array Biopharma Inc. Hydroxylated pyrimidyl cyclopentane as AKT protein kinase inhibitor
AU2009204025B2 (en) * 2008-01-09 2014-02-20 Array Biopharma Inc. Hydroxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors
CN102281875B (zh) 2009-01-16 2017-09-22 里格尔药品股份有限公司 预防、治疗或应对转移癌的使用axl抑制剂的组合疗法
NZ619259A (en) 2009-06-17 2015-07-31 Vertex Pharma Inhibitors of influenza viruses replication
CN103492381A (zh) 2010-12-16 2014-01-01 沃泰克斯药物股份有限公司 流感病毒复制的抑制剂
RU2631240C2 (ru) 2011-04-01 2017-09-20 Дженентек, Инк. Комбинации соединений-ингибиторов акт и абиратерона, и способы применения
MX2013011333A (es) 2011-04-01 2014-04-16 Genentech Inc Combinaciones de compuestos inhibidores de akt y mek, y metodos de uso.
UA118010C2 (uk) 2011-08-01 2018-11-12 Вертекс Фармасьютікалз Інкорпорейтед Інгібітори реплікації вірусів грипу
JP6440625B2 (ja) 2012-11-14 2018-12-19 ザ・ジョンズ・ホプキンス・ユニバーシティー 精神分裂病を処置するための方法および組成物
CA2930297C (en) 2013-11-13 2022-04-05 Vertex Pharmaceuticals Incorporated Methods of preparing inhibitors of influenza viruses replication
CN105849100B (zh) 2013-11-13 2019-07-16 沃泰克斯药物股份有限公司 流感病毒复制抑制剂
CN107074882B (zh) * 2014-10-23 2019-07-30 詹森药业有限公司 作为nik抑制剂的新的吡唑并嘧啶衍生物
JP6603713B2 (ja) 2014-10-23 2019-11-06 ヤンセン ファーマシューティカ エヌ．ベー． Ｎｉｋ阻害剤としての新規のチエノピリミジン誘導体
JP6704416B2 (ja) 2015-05-13 2020-06-03 バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ インフルエンザウイルスの複製の阻害剤を調製する方法
JP6857617B2 (ja) 2015-05-13 2021-04-14 バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ インフルエンザウイルスの複製の阻害剤

Family Cites Families (8)

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Publication number Priority date Publication date Assignee Title
US3272804A (en) * 1963-12-23 1966-09-13 Sterling Drug Inc Process and intermediates for preparing indoles
GB1141949A (en) * 1966-02-23 1969-02-05 Sterling Drug Inc 7-azaindole derivatives
IL48508A (en) * 1974-12-09 1979-10-31 Roussel Uclaf Pharmaceutical compositions comprising piperidylindole derivatives
FR2362628A1 (fr) * 1976-08-26 1978-03-24 Roussel Uclaf Nouveaux derives du piperidyl-indole et leurs sels, procede de preparation et application a titre de medicaments
FR2421899A1 (fr) * 1978-01-16 1979-11-02 Roussel Uclaf Nouveaux derives du tetrahydropyridinyl-indole et leurs sels, le procede de preparation et l'application a titre de medicaments de ces nouveaux produits
FR2444678A2 (fr) * 1978-12-22 1980-07-18 Roussel Uclaf Nouveau procede de preparation de derives du piperidyl-indole et de leurs sels
US5025096A (en) * 1985-08-22 1991-06-18 Mine Safety Appliances Company Preparation of indole and indole derivatives
WO1990007926A1 (en) * 1989-01-20 1990-07-26 Pfizer Inc. 3-(1,2,5,6-tetrahydropyridyl)-pyrrolopyridines

Also Published As

Publication number Publication date
IE62757B1 (en) 1995-02-22
PL163626B1 (pl) 1994-04-29
US5051412A (en) 1991-09-24
YU9990A (en) 1992-05-28
MX19185A (es) 1993-12-01
CN1044465A (zh) 1990-08-08
JPH0751576B2 (ja) 1995-06-05
NO912860D0 (no) 1991-07-22
PL287840A1 (en) 1991-07-15
NZ232166A (en) 1992-10-28
KR920010642B1 (ko) 1992-12-12
PL283354A1 (en) 1991-08-12
YU47553B (sh) 1995-10-03
AU4867390A (en) 1990-07-26
ATE103282T1 (de) 1994-04-15
ES2062319T3 (es) 1994-12-16
DE69007501D1 (de) 1994-04-28
KR900011772A (ko) 1990-08-02
FI94641C (sv) 1995-10-10
DE69007501T2 (de) 1994-06-30
PT92889A (pt) 1990-07-31
CS277611B6 (en) 1993-03-17
JPH02247175A (ja) 1990-10-02
IL93041A0 (en) 1990-11-05
EP0379314B1 (en) 1994-03-23
DD298398A5 (de) 1992-02-20
DK0379314T3 (da) 1994-05-09
EP0379314A1 (en) 1990-07-25
IL93041A (en) 1994-02-27
IE900210L (en) 1990-07-23
DD291559A5 (de) 1991-07-04
WO1990007926A1 (en) 1990-07-26
FI94641B (sv) 1995-06-30
CN1025998C (zh) 1994-09-28
HUT57762A (en) 1991-12-30
NO912860L (no) 1991-07-22
AU613259B2 (en) 1991-07-25
CA2008016A1 (en) 1990-07-20
CS26090A3 (en) 1992-02-19
EG18945A (en) 1994-09-29
US5169947A (en) 1992-12-08
MY106305A (en) 1995-04-29
HU206349B (en) 1992-10-28
ZA90393B (en) 1991-08-28

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Legal Events

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BB Publication of examined application
MM Patent lapsed