KR890006639A - 벤조티아진 디옥사이드 유도체 - Google Patents

벤조티아진 디옥사이드 유도체 Download PDF

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Publication number
KR890006639A
KR890006639A KR1019880013918A KR880013918A KR890006639A KR 890006639 A KR890006639 A KR 890006639A KR 1019880013918 A KR1019880013918 A KR 1019880013918A KR 880013918 A KR880013918 A KR 880013918A KR 890006639 A KR890006639 A KR 890006639A
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KR
South Korea
Prior art keywords
compound
hydrogen
formula
dioxide derivatives
benzothiazine dioxide
Prior art date
Application number
KR1019880013918A
Other languages
English (en)
Other versions
KR900006724B1 (ko
Inventor
챨스 브레이스 테드 앤드류
디엣트리취 하멘 필립
Original Assignee
알렌 제이.스피겔
화이자 인코포레이티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 알렌 제이.스피겔, 화이자 인코포레이티드 filed Critical 알렌 제이.스피겔
Publication of KR890006639A publication Critical patent/KR890006639A/ko
Application granted granted Critical
Publication of KR900006724B1 publication Critical patent/KR900006724B1/ko

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

내용 없음

Description

벤조티아진 디옥사이드 유도체
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (10)

  1. 하기 일단식(I) 또는 (II)의 화합물 :
    상기식에서, Rl은 수소, 메틸, 불소 또는 염소이고; R2는 수소 또는 -COOR3이며, 여기에서 R3는 탄소원자 1 내지 8개를 갖는 알킬이다.
  2. 제l항에 있어서, R1이 수소인 화합물.
  3. 제1항에 있어서, R1이 메틸인 화합물.
  4. 제2항에있어서, R2가 수소인 화합물.
  5. 제4항에 있어서, 일반식(I)의 화합물.
  6. 제4항에 있어서, 일반식(II)의 화합물.
  7. 제3항에 있어서, R2가 수소인 화합물.
  8. 제7항에 있어서, 일반식(I)의 화합물.
  9. 제1항에 있어서, R2가 -COOR3이고, R3가 단소원자 1 내지 8개를 갖는 알킬인 화합물.
  10. 약제학적으로 허용될 수 있는 담체와 소염 효과량의 제1항의 학합물을 포항하는 약학조성물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019880013918A 1987-10-26 1988-10-25 벤조티아진 디옥사이드 유도체 KR900006724B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/US1987/002783 WO1989003682A1 (en) 1987-10-26 1987-10-26 Benzothiazine dioxide derivatives
US87/02783 1987-10-26
USPCT/8702783 1987-10-26

Publications (2)

Publication Number Publication Date
KR890006639A true KR890006639A (ko) 1989-06-15
KR900006724B1 KR900006724B1 (ko) 1990-09-20

Family

ID=22202629

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019880013918A KR900006724B1 (ko) 1987-10-26 1988-10-25 벤조티아진 디옥사이드 유도체

Country Status (19)

Country Link
US (1) US5081118A (ko)
EP (1) EP0314329B1 (ko)
JP (1) JPH0641465B2 (ko)
KR (1) KR900006724B1 (ko)
AT (1) ATE71376T1 (ko)
AU (1) AU590485B2 (ko)
CA (1) CA1294276C (ko)
DE (1) DE3867593D1 (ko)
DK (1) DK591688A (ko)
ES (1) ES2038767T3 (ko)
FI (1) FI893111A (ko)
GR (1) GR3003659T3 (ko)
IL (1) IL88114A (ko)
MY (1) MY103788A (ko)
NO (1) NO892638L (ko)
NZ (1) NZ226688A (ko)
PT (1) PT88834B (ko)
WO (1) WO1989003682A1 (ko)
ZA (1) ZA887928B (ko)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1241088B (it) * 1990-03-27 1993-12-29 Chiesi Farma Spa Procedimento per la preparazione di complessi piroxicam/ciclodestrina,prodotti ottenuti e loro composizioni farmaceutiche
US5436241A (en) * 1994-01-14 1995-07-25 Bristol-Myers Squibb Company Topical anti-inflammatory compositions containing piroxicam
US5703073A (en) * 1995-04-19 1997-12-30 Nitromed, Inc. Compositions and methods to prevent toxicity induced by nonsteroidal antiinflammatory drugs
WO2000025776A1 (en) 1998-10-30 2000-05-11 Nitromed, Inc. Nitrosated and nitrosylated nonsteroidal antiinflammatory compounds, compositions and methods of use
EP1820504A1 (en) * 2004-11-15 2007-08-22 Taisho Pharmaceutical Co., Ltd Imine compound
US20090238763A1 (en) 2006-07-09 2009-09-24 Chongxi Yu High penetration compositions and uses thereof
US20090221703A1 (en) 2006-07-09 2009-09-03 Chongxi Yu High penetration composition and uses thereof
WO2008044095A1 (en) * 2006-10-11 2008-04-17 Techfields Biochem Co. Ltd Positively charged water-soluble prodrugs of oxicams and related compounds with very high skin penetration rate
CN103980228B (zh) * 2006-10-11 2020-03-17 于崇曦 具有快速皮肤穿透速度的带正电荷的水溶性的昔康及其相关化合物的前药
AU2007354632B2 (en) * 2007-06-04 2014-06-26 Techfields Inc Pro-drugs of NSAIAs with very high skin and membranes penetration rates and their new medicinal uses
MX362949B (es) 2008-12-04 2019-02-27 Yu Chongxi Composiciones de alta penetracion y sus aplicaciones.

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3591584A (en) * 1968-08-27 1971-07-06 Pfizer Benzothiazine dioxides
US3892740A (en) * 1974-10-15 1975-07-01 Pfizer Process for the production of carboxamides of oxo-1,2-benzothiazine-1,1-dioxides
US4289879A (en) * 1980-09-29 1981-09-15 Pfizer Inc. Synthetic method and intermediate for piroxicam
IT1194522B (it) * 1983-12-16 1988-09-22 Prodotti Antibiotici Spa Metodo di sintesi di derivanti benzotiazinici
IN162323B (ko) * 1983-12-21 1988-04-30 Pfizer
US4551452A (en) * 1983-12-21 1985-11-05 Pfizer Inc. Anti-inflammatory 2-methyl-2H-1,2-benzo-(or -thieno-)thiazine-3-carboxamide 1,1-dioxide derivatives, compositions, and method of use therefor
AU3900685A (en) * 1984-03-13 1985-09-19 Gkn Kwikform Industries Limited Rod connnector clip
US4829062A (en) * 1986-05-16 1989-05-09 Pfizer Inc. Benzothiazine dioxide derivatives

Also Published As

Publication number Publication date
EP0314329B1 (en) 1992-01-08
MY103788A (en) 1993-09-30
NO892638L (no) 1989-08-16
JPH01149781A (ja) 1989-06-12
GR3003659T3 (ko) 1993-03-16
PT88834B (pt) 1993-01-29
ATE71376T1 (de) 1992-01-15
DK591688D0 (da) 1988-10-25
FI893111A (fi) 1989-06-26
IL88114A (en) 1994-08-26
NZ226688A (en) 1990-03-27
US5081118A (en) 1992-01-14
NO892638D0 (no) 1989-06-26
FI893111A0 (fi) 1987-06-26
WO1989003682A1 (en) 1989-05-05
AU590485B2 (en) 1989-11-02
DE3867593D1 (de) 1992-02-20
CA1294276C (en) 1992-01-14
ZA887928B (en) 1990-06-27
JPH0641465B2 (ja) 1994-06-01
ES2038767T3 (es) 1993-08-01
DK591688A (da) 1989-04-27
AU2432688A (en) 1989-04-27
KR900006724B1 (ko) 1990-09-20
EP0314329A1 (en) 1989-05-03

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