DK591688D0 - Benzothiazindioxid-derivater og farmaceutiske praeparater indeholdende disse - Google Patents
Benzothiazindioxid-derivater og farmaceutiske praeparater indeholdende disseInfo
- Publication number
- DK591688D0 DK591688D0 DK591688A DK591688A DK591688D0 DK 591688 D0 DK591688 D0 DK 591688D0 DK 591688 A DK591688 A DK 591688A DK 591688 A DK591688 A DK 591688A DK 591688 D0 DK591688 D0 DK 591688D0
- Authority
- DK
- Denmark
- Prior art keywords
- methyl
- dioxide
- benzothiazine
- pyridinyl
- compounds
- Prior art date
Links
- GHNLJDPNIAIWOQ-UHFFFAOYSA-N 2h-1$l^{6},2-benzothiazine 1,1-dioxide Chemical class C1=CC=C2S(=O)(=O)NC=CC2=C1 GHNLJDPNIAIWOQ-UHFFFAOYSA-N 0.000 title 1
- 239000000825 pharmaceutical preparation Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- QYSPLQLAKJAUJT-UHFFFAOYSA-N piroxicam Chemical class OC=1C2=CC=CC=C2S(=O)(=O)N(C)C=1C(=O)NC1=CC=CC=N1 QYSPLQLAKJAUJT-UHFFFAOYSA-N 0.000 abstract 2
- BYUVCUAQZBLBRF-UHFFFAOYSA-N 4-(2-hydroxyethoxy)-2-methyl-n-pyridin-2-yl-1,2-benzothiazine-3-carboxamide Chemical compound CN1SC2=CC=CC=C2C(OCCO)=C1C(=O)NC1=CC=CC=N1 BYUVCUAQZBLBRF-UHFFFAOYSA-N 0.000 abstract 1
- 230000001760 anti-analgesic effect Effects 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 229940111133 antiinflammatory and antirheumatic drug oxicams Drugs 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 229960002702 piroxicam Drugs 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US1987/002783 WO1989003682A1 (en) | 1987-10-26 | 1987-10-26 | Benzothiazine dioxide derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DK591688D0 true DK591688D0 (da) | 1988-10-25 |
| DK591688A DK591688A (da) | 1989-04-27 |
Family
ID=22202629
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK591688A DK591688A (da) | 1987-10-26 | 1988-10-25 | Benzothiazindioxid-derivater og farmaceutiske praeparater indeholdende disse |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US5081118A (da) |
| EP (1) | EP0314329B1 (da) |
| JP (1) | JPH0641465B2 (da) |
| KR (1) | KR900006724B1 (da) |
| AT (1) | ATE71376T1 (da) |
| AU (1) | AU590485B2 (da) |
| CA (1) | CA1294276C (da) |
| DE (1) | DE3867593D1 (da) |
| DK (1) | DK591688A (da) |
| ES (1) | ES2038767T3 (da) |
| FI (1) | FI893111A (da) |
| GR (1) | GR3003659T3 (da) |
| IL (1) | IL88114A (da) |
| MY (1) | MY103788A (da) |
| NO (1) | NO892638L (da) |
| NZ (1) | NZ226688A (da) |
| PT (1) | PT88834B (da) |
| WO (1) | WO1989003682A1 (da) |
| ZA (1) | ZA887928B (da) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1241088B (it) * | 1990-03-27 | 1993-12-29 | Chiesi Farma Spa | Procedimento per la preparazione di complessi piroxicam/ciclodestrina,prodotti ottenuti e loro composizioni farmaceutiche |
| US5436241A (en) * | 1994-01-14 | 1995-07-25 | Bristol-Myers Squibb Company | Topical anti-inflammatory compositions containing piroxicam |
| US5703073A (en) * | 1995-04-19 | 1997-12-30 | Nitromed, Inc. | Compositions and methods to prevent toxicity induced by nonsteroidal antiinflammatory drugs |
| JP2002528495A (ja) * | 1998-10-30 | 2002-09-03 | ニトロメド インコーポレーテッド | ニトロソ化およびニトロシル化された非ステロイド抗炎症性化合物、組成物および使用方法 |
| US20080312435A1 (en) * | 2004-11-15 | 2008-12-18 | Taisho Pharmaceutical Co., Ltd. | Imine Compound |
| US20090221703A1 (en) | 2006-07-09 | 2009-09-03 | Chongxi Yu | High penetration composition and uses thereof |
| US20090238763A1 (en) | 2006-07-09 | 2009-09-24 | Chongxi Yu | High penetration compositions and uses thereof |
| CN103980228B (zh) * | 2006-10-11 | 2020-03-17 | 于崇曦 | 具有快速皮肤穿透速度的带正电荷的水溶性的昔康及其相关化合物的前药 |
| CN101522692A (zh) * | 2006-10-11 | 2009-09-02 | 于崇曦 | 具有快速皮肤穿透速度的带正电荷的水溶性的昔康及其相关化合物的前药 |
| WO2008149181A1 (en) | 2007-06-04 | 2008-12-11 | Techfields Inc | Pro-drugs of nsaias with very high skin and membranes penetration rates and their new medicinal uses |
| WO2010065936A1 (en) | 2008-12-04 | 2010-06-10 | Chongxi Yu | High penetration compositions and their applications |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3591584A (en) * | 1968-08-27 | 1971-07-06 | Pfizer | Benzothiazine dioxides |
| US3892740A (en) * | 1974-10-15 | 1975-07-01 | Pfizer | Process for the production of carboxamides of oxo-1,2-benzothiazine-1,1-dioxides |
| US4289879A (en) * | 1980-09-29 | 1981-09-15 | Pfizer Inc. | Synthetic method and intermediate for piroxicam |
| IT1194522B (it) * | 1983-12-16 | 1988-09-22 | Prodotti Antibiotici Spa | Metodo di sintesi di derivanti benzotiazinici |
| IN162323B (da) * | 1983-12-21 | 1988-04-30 | Pfizer | |
| US4551452A (en) * | 1983-12-21 | 1985-11-05 | Pfizer Inc. | Anti-inflammatory 2-methyl-2H-1,2-benzo-(or -thieno-)thiazine-3-carboxamide 1,1-dioxide derivatives, compositions, and method of use therefor |
| AU3900685A (en) * | 1984-03-13 | 1985-09-19 | Gkn Kwikform Industries Limited | Rod connnector clip |
| HU199833B (en) * | 1986-05-16 | 1990-03-28 | Pfizer | Process for producing benzothiazine dioxide derivatives |
-
1987
- 1987-10-26 WO PCT/US1987/002783 patent/WO1989003682A1/en active Application Filing
- 1987-10-26 US US07/460,121 patent/US5081118A/en not_active Expired - Lifetime
-
1988
- 1988-10-10 DE DE8888309427T patent/DE3867593D1/de not_active Expired - Fee Related
- 1988-10-10 EP EP88309427A patent/EP0314329B1/en not_active Expired - Lifetime
- 1988-10-10 AT AT88309427T patent/ATE71376T1/de not_active IP Right Cessation
- 1988-10-10 ES ES198888309427T patent/ES2038767T3/es not_active Expired - Lifetime
- 1988-10-20 IL IL8811488A patent/IL88114A/en not_active IP Right Cessation
- 1988-10-21 MY MYPI88001196A patent/MY103788A/en unknown
- 1988-10-24 CA CA000581099A patent/CA1294276C/en not_active Expired - Fee Related
- 1988-10-24 ZA ZA887928A patent/ZA887928B/xx unknown
- 1988-10-24 PT PT88834A patent/PT88834B/pt active IP Right Grant
- 1988-10-25 DK DK591688A patent/DK591688A/da not_active Application Discontinuation
- 1988-10-25 KR KR1019880013918A patent/KR900006724B1/ko not_active IP Right Cessation
- 1988-10-25 AU AU24326/88A patent/AU590485B2/en not_active Ceased
- 1988-10-25 NZ NZ226688A patent/NZ226688A/xx unknown
- 1988-10-26 JP JP63270626A patent/JPH0641465B2/ja not_active Expired - Fee Related
-
1989
- 1989-06-26 NO NO89892638A patent/NO892638L/no unknown
- 1989-06-26 FI FI893111A patent/FI893111A/fi not_active Application Discontinuation
-
1992
- 1992-01-27 GR GR920400088T patent/GR3003659T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE3867593D1 (de) | 1992-02-20 |
| WO1989003682A1 (en) | 1989-05-05 |
| NO892638D0 (no) | 1989-06-26 |
| AU2432688A (en) | 1989-04-27 |
| CA1294276C (en) | 1992-01-14 |
| EP0314329B1 (en) | 1992-01-08 |
| JPH0641465B2 (ja) | 1994-06-01 |
| FI893111A (fi) | 1989-06-26 |
| ATE71376T1 (de) | 1992-01-15 |
| US5081118A (en) | 1992-01-14 |
| ZA887928B (en) | 1990-06-27 |
| MY103788A (en) | 1993-09-30 |
| IL88114A (en) | 1994-08-26 |
| ES2038767T3 (es) | 1993-08-01 |
| KR890006639A (ko) | 1989-06-15 |
| PT88834B (pt) | 1993-01-29 |
| JPH01149781A (ja) | 1989-06-12 |
| DK591688A (da) | 1989-04-27 |
| AU590485B2 (en) | 1989-11-02 |
| EP0314329A1 (en) | 1989-05-03 |
| KR900006724B1 (ko) | 1990-09-20 |
| NZ226688A (en) | 1990-03-27 |
| NO892638L (no) | 1989-08-16 |
| FI893111A0 (fi) | 1987-06-26 |
| GR3003659T3 (da) | 1993-03-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| AHB | Application shelved due to non-payment |