IT1194522B - Metodo di sintesi di derivanti benzotiazinici - Google Patents
Metodo di sintesi di derivanti benzotiaziniciInfo
- Publication number
- IT1194522B IT1194522B IT24214/83A IT2421483A IT1194522B IT 1194522 B IT1194522 B IT 1194522B IT 24214/83 A IT24214/83 A IT 24214/83A IT 2421483 A IT2421483 A IT 2421483A IT 1194522 B IT1194522 B IT 1194522B
- Authority
- IT
- Italy
- Prior art keywords
- sub
- derivatives
- benzothiazinic
- hydroxy
- radical
- Prior art date
Links
- 238000001308 synthesis method Methods 0.000 title 1
- ICSNLGPSRYBMBD-UHFFFAOYSA-N 2-aminopyridine Chemical compound NC1=CC=CC=N1 ICSNLGPSRYBMBD-UHFFFAOYSA-N 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- YAIJCYICFZACKO-UHFFFAOYSA-N 2-methyl-1,1-dioxo-n-pyridin-2-yl-1$l^{6},2-benzothiazine-3-carboxamide Chemical class C=1C2=CC=CC=C2S(=O)(=O)N(C)C=1C(=O)NC1=CC=CC=N1 YAIJCYICFZACKO-UHFFFAOYSA-N 0.000 abstract 1
- HTZOXRHYFAORSJ-UHFFFAOYSA-N 4-hydroxy-2-methyl-1,1-dioxo-1$l^{6},2-benzothiazine-3-carboxylic acid Chemical compound C1=CC=C2S(=O)(=O)N(C)C(C(O)=O)=C(O)C2=C1 HTZOXRHYFAORSJ-UHFFFAOYSA-N 0.000 abstract 1
- 150000001263 acyl chlorides Chemical class 0.000 abstract 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 150000008064 anhydrides Chemical class 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/02—1,2-Thiazines; Hydrogenated 1,2-thiazines
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Priority Applications (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT24214/83A IT1194522B (it) | 1983-12-16 | 1983-12-16 | Metodo di sintesi di derivanti benzotiazinici |
| EP84115102A EP0146102B1 (en) | 1983-12-16 | 1984-12-10 | Process for preparing benzothiazine compounds |
| AT84115102T ATE41000T1 (de) | 1983-12-16 | 1984-12-10 | Verfahren zur herstellung von benzothiazinverbindungen. |
| DE8484115102T DE3476879D1 (en) | 1983-12-16 | 1984-12-10 | Process for preparing benzothiazine compounds |
| US06/681,186 US4599406A (en) | 1983-12-16 | 1984-12-13 | Process for preparing 2-methyl-N-(2-pyridyl)-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide derivatives and intermediates therefor |
| JP59266049A JPS60152485A (ja) | 1983-12-16 | 1984-12-17 | ベンゾチアジン化合物の製造方法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT24214/83A IT1194522B (it) | 1983-12-16 | 1983-12-16 | Metodo di sintesi di derivanti benzotiazinici |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IT8324214A0 IT8324214A0 (it) | 1983-12-16 |
| IT1194522B true IT1194522B (it) | 1988-09-22 |
Family
ID=11212579
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT24214/83A IT1194522B (it) | 1983-12-16 | 1983-12-16 | Metodo di sintesi di derivanti benzotiazinici |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US4599406A (it) |
| EP (1) | EP0146102B1 (it) |
| JP (1) | JPS60152485A (it) |
| AT (1) | ATE41000T1 (it) |
| DE (1) | DE3476879D1 (it) |
| IT (1) | IT1194522B (it) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2002646A6 (es) * | 1987-03-27 | 1988-09-01 | Induspol Sa | Procedimiento para la obtencion de 4-hidroxi-2-metil-n-(2-piri-dil)-2h-1,2-benzotiacina-3-carboxamida 1,1-dioxido |
| US5081118A (en) * | 1987-10-26 | 1992-01-14 | Pfizer Inc. | Benzothiazine dioxide derivatives |
| ES2053395B1 (es) * | 1992-11-16 | 1995-02-16 | S A L V A T Lab Sa | "4-cinnamoiloxi-2-metil-n-(2-piridil)-2h-1,2-benzotiazina-3-carboxamida 1,1-dioxido, procedimiento para la obtencion del mismo y nuevos intermedios utilizados en su preparacion. |
| RS49867B (sr) * | 1999-12-06 | 2008-08-07 | Ad. Zdravlje, | Postupak za sintezu 4-hidroksi-2h-1,2-benzotiazin-3-karboksamida |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3646020A (en) * | 1970-07-16 | 1972-02-29 | Warner Lambert Pharmaceutical | 4-acyloxy-3-phenylcarbamyl-2h-1 2-benzothiazine 1 1-dioxides |
| US3960856A (en) * | 1975-06-20 | 1976-06-01 | Warner-Lambert Company | Process for the preparation of 4-hydroxy-3-(5-methyl-3-isoxazolylcarbamoyl)-2-methyl-2H-1,2-benzothiazine 1,1-dioxide |
| US4100347A (en) * | 1976-06-10 | 1978-07-11 | Pfizer Inc. | 3,4-Dihydro-2-methyl-4-oxo-2H-1,2-benzothiazine-3-carboxylic acid-1,1-dioxide |
| US4309427A (en) * | 1981-01-15 | 1982-01-05 | Pfizer Inc. | Benzothiazine dioxide derivatives |
| GT198276334A (es) * | 1981-08-03 | 1984-01-10 | Procedimiento e inter-medios para la produccion de carboxamidas de benzotiazina. | |
| IN158333B (it) * | 1981-08-03 | 1986-10-18 | Pfizer | |
| IT1168064B (it) * | 1981-11-12 | 1987-05-20 | Prodotti Antibiotici Spa | Composto ad azione antinfiammatoria |
| DE3212485A1 (de) * | 1982-04-03 | 1983-10-13 | Gödecke AG, 1000 Berlin | Verfahren zur herstellung von 4-hydroxy-3-(heterocyclocarbamoyl)-2h-1,2-benzothiazin-1,1-dioxiden |
| JPS58177984A (ja) * | 1982-04-09 | 1983-10-18 | Mitsui Toatsu Chem Inc | ベンゾチアジンカルボン酸の製造法 |
| CA1197244A (en) * | 1982-04-16 | 1985-11-26 | Medichem, S.A. | Process for the preparation of 4-hydroxy-2-methyl-2h- 1,2-benzothiazine-3-carboxamide-1,1-dioxides |
| DE3374865D1 (en) * | 1982-07-07 | 1988-01-21 | Siegfried Ag | Process for preparing 4-hydroxy-2-methyl-n-2-pyridyl-2h-1,2-benzothiazine-3-carboxamide 1,1-dioxide |
-
1983
- 1983-12-16 IT IT24214/83A patent/IT1194522B/it active
-
1984
- 1984-12-10 EP EP84115102A patent/EP0146102B1/en not_active Expired
- 1984-12-10 DE DE8484115102T patent/DE3476879D1/de not_active Expired
- 1984-12-10 AT AT84115102T patent/ATE41000T1/de not_active IP Right Cessation
- 1984-12-13 US US06/681,186 patent/US4599406A/en not_active Expired - Fee Related
- 1984-12-17 JP JP59266049A patent/JPS60152485A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| DE3476879D1 (en) | 1989-04-06 |
| EP0146102A2 (en) | 1985-06-26 |
| EP0146102B1 (en) | 1989-03-01 |
| IT8324214A0 (it) | 1983-12-16 |
| US4599406A (en) | 1986-07-08 |
| JPS60152485A (ja) | 1985-08-10 |
| EP0146102A3 (en) | 1985-07-31 |
| ATE41000T1 (de) | 1989-03-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19931227 |